Baptiste Lacoste

Baptiste Lacoste

@blacoste.bsky.social

Senior Scientist, Professor & Program Director @ OHRI & uOttawa 🇨🇦. Fascinated by vascular & metabolic causes of neurodevelopmental disorders, SciArt and the night sky 🔬 🎨 🔭 Follow for 🧪 news and more! Look for #cerebrovascular

1.5K followers347 following514 posts

Baptiste Lacoste
@blacoste.bsky.social

🚨 Excited to share that our new paper is published today in Neuron ! We show that P2Y2 receptor activation restores cerebrovascular function and reverses behavioural impairments in mice carrying a 16p11.2 deletion. #Autism #Publication #BasicScience www.cell.com/neuron/fullt...

cell.comPurinergic receptor activation rectifies autism-associated endothelial dysfunctionOuellette et al. report that a 16p11.2 deletion induces a bioenergetic failure in brain endothelial cells. Activation of purinergic signaling via P2Y2 receptors restored endothelial function and impro...
Baptiste Lacoste
@blacoste.bsky.social

This study marks a major milestone for our research program: moving from discovering vascular dysfunction in autism to identifying a way to treat it. Importantly, it opens a new therapeutic avenue for the autism community (with validation in humans still ahead). Happy reading !

Baptiste Lacoste
@blacoste.bsky.social

🚨 Want to isolate astrocytes and study their function? With Nicole Blakeley, PhD Candidate in our lab, we are happy to present a new protocol, which hopefully will help labs dive into glial biology with less hurdles. Cheers ! #glia #astrocytes

cell.comProtocol for assessing molecular signatures and metabolic function of primary murine cortical astrocytesAstrocytes are the most numerous brain cells and are central to the regulation of brain metabolism. Here, we present a protocol for identifying molecular signatures and assessing the metabolic functio...
Baptiste Lacoste
@blacoste.bsky.social

Beautiful new paper by @dablab.bsky.social and team! "Pericyte KATP channel hyperactivity redistributes cortical blood flow in a CADASIL mouse model" #cerebrovascular

nature.comPericyte KATP channel hyperactivity redistributes cortical blood flow in a CADASIL mouse model - Nature Cardiovascular ResearchBy integrating spatial transcriptomics, advanced in vivo imaging, ex vivo myography, electrophysiology, in vitro functional assays and in silico modeling, Jeffrey et al. delineate a previously unrecog...
Baptiste Lacoste
@blacoste.bsky.social

I am delighted to welcome Dr. Aida Oryza Lopez-Ortiz in our lab ! Aida now joins our efforts to understand how astrocytes regulate cerebrovascular remodeling and repair. And to do so, she just received a prestigious Canada Impact+ Post-doctoral Training Award, what a great way to start !

Baptiste Lacoste reposted

Wuhyun Koh
@wuhyunkoh.bsky.social

Excited to share that one of the very first research projects initiated in our ABCD lab, "Astrocytic Ankyrin-2 Enables Memory Persistence in the Mouse Hippocampus," has now been published in Nature Communications (DOI: 10.1038/s41467-026-75009-5). www.drkohlab.com/post/our-art...

drkohlab.comAstrocytic Ankyrin-2 Enables Memory Persistence in the Mouse HippocampusWhy do some memories last for weeks, months, or even years, while others quickly fade away? Astrocytes may hold the key.
Baptiste Lacoste
@blacoste.bsky.social

🚨 We are recruiting at the Ottawa Hospital Research Institute, in the Regenerative Medicine Program ! If your are passionate about basic science, and dream to develop your own research program, please apply! #Ottawa #Canada #Recruitment #Scientist #Research Full description at the link below:

uottawa.wd3.myworkdayjobs.comTier 2 Canada Research Chair in Vascular Links to NeurodevelopmentFollow us on LinkedIn Posting Reason: New Position Job Type: Contingent Worker Anticipated Duration in Months (for contracts and temporary assignments): Job Family: Academic Leadership and Faculty # o...
Baptiste Lacoste
@blacoste.bsky.social

A really elegant study by @alexdubrac.bsky.social & team, published at @natureportfolio.nature.com ! #cerebrovascular

nature.comMapping neuro-vascular unit communications reveals distinct angiogenic programs across developing mouse brain regions - Nature CommunicationsBrain blood vessels interact with neural cells to shape brain development, yet how these communications differ across regions remains unclear. Here, the authors show that region-specific neurovascular...

Baptiste Lacoste reposted

Tom Longden
@talongden.bsky.social

Very happy to share our latest work out in PNAS this week, led by Amy Xiang. We show that capillary thin-strand pericytes express TMEM16A calcium-activated chloride channels, which set the operating point for capillary control of cerebral blood flow in vivo. www.pnas.org/doi/10.1073/...

Baptiste Lacoste
@blacoste.bsky.social

New study clarifies the role of Angiopoietin 2 in the brain vasculature #Cerebrovascular 👇

JCI insight@insight.jci.org

Angiopoietin 2 promotes vascular permeability in peripheral organs, but its role in brain is unclear. doi.org/10.1172/jci.... Li et al. show ANGPT2 loss in mice leads to region-specific brain malformations and blood-brain barrier leakage.

Baptiste Lacoste
@blacoste.bsky.social

New insights into brain imaging by @annadevor.bsky.social just dropped 🧠✨ This study shows that neuromodulators, especially norepinephrine, actively reshape how neural activity translates into blood flow signals across the cortex. A powerful step toward more accurate brain mapping! #cerebrovascular

nature.comThe neurovascular impulse response function differentially reflects intrinsic neuromodulation across cortical regions - Nature NeuroscienceA new optical imaging study demonstrates that norepinephrine and the state of arousal influence hemodynamic correlations across cerebral cortex, calling for a conceptual shift in interpreting function...
Baptiste Lacoste
@blacoste.bsky.social

🚨 For astrocyte lovers 👇👇

Ciaran Murphy-Royal@murphyroyallab.org

Incredibly proud of this paper led by @ossamaghenissa.bsky.social and @mathiasgua.bsky.social titled Basolateral 'Amygdala Astrocytes Encode Anxiety States'. www.cell.com/neuron/fullt... 🧵 below

cell.comBasolateral amygdala astrocytes encode anxiety statesGhenissa et al. provide evidence that basolateral amygdala astrocytes reliably encode anxiety states. Using simultaneous in vivo calcium recordings across an array of behavioral tasks, combined with g...
Baptiste Lacoste
@blacoste.bsky.social

Professional advice: when celebrating your 10th year lab anniversary🍻, bring your trainees to an axe throwing club, so they can release all the anger accumulated. Let them imaging your face is on the wall 😂

Baptiste Lacoste
@blacoste.bsky.social

Excellent new review on the blood-brain barrier, by Alon Friedman and colleague @natureportfolio.nature.com #Cerebrovascular #BloodBrainBarrier

nature.comDynamic modulation of the blood–brain barrier in the healthy brain - Nature Reviews NeuroscienceThe blood–brain barrier was conventionally seen as a static protective structure, but a more complex, dynamic view of this barrier has now emerged. In this Review, Friedman et al. discuss the dynamic ...