Stephanie Borgland

Stephanie Borgland

@borglandlab.bsky.social

Neuroscientist at Hotchkiss Brain Institute University of Calgary. Interested in appetitive behaviours, bad decisions, neuropeptide neuromodulators, and puppies.

3.3K followers1.6K following109 posts

Now work by Aida Mohammadkhani form our lab on how opioids modulate the neuromodulation of VTA projections by orexin and dynorphin

bioRxiv Neuroscience@biorxiv-neursci.bsky.social

Divergent roles of orexin and dynorphin in modulating VTA dopamine projections to the BLA after morphine exposure https://www.biorxiv.org/content/10.64898/2026.10.24.761541v1

Stephanie Borgland reposted

**Recruitment** We are looking to hire a psychiatrist/scientist (MD or MD/PhD) who focuses on neuromodulation, particularly rTMS in the Department of Psychiatry at the University of Calgary. Come join myself, @mayoonthebrain.bsky.social and more. Details 👇 careers.ucalgary.ca/jobs/1829278...

careers.ucalgary.caAcademic Position in Neuromodulation Research, Department of Psychiatry, Cumming School of Medicine in Calgary, ...Academic Position in Neuromodulation Research, Department of Psychiatry, Cumming School of Medicine in Calgary, ...

Stephanie Borgland reposted

Congratulations to our first Nobel Prize laureate of 2026 🎉 Early this morning Karl Deisseroth found out he was awarded this year's Nobel Prize in Physiology or Medicine. He seems very happy with the news!

Stephanie Borgland reposted

Out today in @naturemetabolism.bsky.social ! www.nature.com/articles/s42... Excited to see this one out. I’ve been yapping about it forever! @fralinbiomed.bsky.social

nature.comMetabolic and neural responses to ultraprocessed foods: a randomized, controlled, crossover study - Nature MetabolismIn a randomized study in 57 healthy-weight adults, researchers compared nutritionally matched ultraprocessed and non-ultraprocessed meals and found that ultraprocessed foods elicited greater insulin a...
Alex DiFeliceantonio@difeliceantonio.bsky.social

New preprint from the lab🧵🧪 Eating ultraprocessed foods leads to poor health outcomes, but HOW they do it isn't understood. "HOW?" is important, as "how" can allow targeted policy, reformulaiton, or recommendations to reduce harmful effects. We started to ask that question doi.org/10.64898/202...

Stephanie Borgland reposted

Hi Folks, with @lisataxier.bsky.social moving on to open her own lab at Stony Brook, I am in the market for a new postdoctoral fellow who wants to do slice electrophysiology. We have a number of really exciting projects, translational to basic science, that are ephys focused.

Stephanie Borgland reposted

CIHR has launched a trial ballon that suggests shifting to one competition a year. This is the worst idea I have heard in a long time. The only benefit is making top-line success rates look better than they are. Keep it as is, do in-person reviews, and keep the pain in the open.

Stephanie Borgland reposted

The fMRI outcomes are here (preprinted) www.medrxiv.org/content/10.6... The story is surprisingly similar! Little effect of intervention in the overall group but changes occurring in our younger participants. 1/ 🧪

medrxiv.orgEffects of Controlled Diets High in and Free of Ultraprocessed Food on the Brain of Emerging AdultsObjective: The average American consumes 55% of their daily energy from ultraprocessed foods (UPF) created through industrial processes and additives not used at home. We investigated if a high-UPF di...
Alex DiFeliceantonio@difeliceantonio.bsky.social

@davybrenda.bsky.social and I’s UPF RCT is finally published! We tested the effects of a eucaloric UPF vs no UPF diet on energy intake in young people. Our age subgroup analysis found adolescents ate more in a buffet meal after the UPF diet. 🧵🧪 onlinelibrary.wiley.com/doi/10.1002/...

Stephanie Borgland reposted

Our work on sex-dependent impact of high-fat diets during adolescence on action control is now published in @npp-journal.bsky.social Thank you to the amazing work from my team and the positive feedback from reviewers @rowettinstitute.bsky.social @aberdeenneuro.bsky.social doi.org/10.1038/s413...

doi.orgAdolescent obesity induces sex-specific alterations of action control - NeuropsychopharmacologyNeuropsychopharmacology - Adolescent obesity induces sex-specific alterations of action control
Fabien Naneix@fabnaneix.bsky.social

So grateful to share the "first" preprint from the lab. Long overdue but I am very happy about the work which has been done in my team. We explored how the consumption of different obesogenic diets during adolescence was having long-term impact impact goal-directed and habitual behaviours. A thread

Stephanie Borgland reposted

If Bad Bunny can cover the history of Puerto Rico, colonialism, transatlantic slavery, hemispheric consciousness, as well as contemporary life and politics in under 14 minutes, you can do your 15- or 20-minute conference presentation with time to spare.

Stephanie Borgland reposted

Stephanie Borgland reposted

Awesome article on medical breakthroughs that came from basic neuroscience research in rodents. Major success examples in postpartum depression, non-opioid pain and migraine treatment. This is exactly why funding basic science is so important! www.thetransmitter.org/drug-develop...

thetransmitter.orgHow basic neuroscience has paved the path to new drugsA growing list of medications—such as zuranolone for postpartum depression, suzetrigine for pain, and the gepants class of migraine medicines—exist because of insights from basic research.

Stephanie Borgland reposted

Stephanie Borgland reposted

Replying to @jmgilligan.org

I didn't just go to college to become a good worker in a profession. I went to prepare myself to have a rich life of the mind and to be a good and well-informed citizen. That sounds super corny, but it was and remains a worthy reason to get a liberal arts education.

Stephanie Borgland reposted

Today, we honour the lives of those murdered at Polytechnique Montreal in 1989 and all people impacted by gender-based violence. CAUT remembers them and reaffirms its commitment to fight gender-based violence, hatred and misogyny. Read our full statement: www.caut.ca/news/caut-ma...

Stephanie Borgland reposted

New lab paper drop, this one has been a long time coming! Driven by Rob Aukema (now a postdoc with Kerry Ressler) this paper in Science Advances answered the lingering question of what role the amygdala plays in stress-induced neuroendocrine responses. www.science.org/doi/10.1126/...

science.orgA network of basolateral amygdala projection neurons contributes to stress-induced activation of the hypothalamic-pituitary-adrenal axisA network of basolateral amygdala neurons, but not singular projections, contributes to the neuroendocrine response to stress.

That the Alberta Govt invoked the notwithstanding clause for this during Transgender Awareness Week is the chef’s kiss of cruelty. Please support Skipping Stone’s legal fund

Jennifer Koshan@jenniferkoshan.bsky.social

One of the “activist” groups the premier refers to is the Canadian Medical Assn. The other two, Egale + Skipping Stone, backed up their injunction claim with reams of medical and other evidence. Evidence that the gov’t itself is lacking. The UCP is the real activist here. ablawg.ca/2025/11/19/t...

Yesterday I got invited to submit a nomination for a Nobel Prize in Physiology or Medicine for 2026. I am still trying to figure out if this is phishing, as I am a weird person to ask, and have mixed feelings about these big prizes...but now it has me thinking about it. Who would you nominate?

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Another one could be related to how we think about gliomas and brain cancers and how neural activity promotes brain tumor growth and resistance. This is a growing 'cancer neuroscience' field and has really important implications for treatment of brain cancers.

Yesterday I got invited to submit a nomination for a Nobel Prize in Physiology or Medicine for 2026. I am still trying to figure out if this is phishing, as I am a weird person to ask, and have mixed feelings about these big prizes...but now it has me thinking about it. Who would you nominate?

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Another breakthrough discoveries in my field are optical and chemical actuators (eg. optogenetics/chemogenetics). These have led to a revolution in circuit-based neuroscience and discoveries on how the brain functions. These are just starting to be translated to clinical applications.. we will see?

Yesterday I got invited to submit a nomination for a Nobel Prize in Physiology or Medicine for 2026. I am still trying to figure out if this is phishing, as I am a weird person to ask, and have mixed feelings about these big prizes...but now it has me thinking about it. Who would you nominate?

View full thread

I also think that the discovery of orexin/hypocretin is a major breakthrough. This discovery (DOI: 10.1073/pnas.95.1.322 and DOI: 10.1016/s0092-8674(02)09256-5) led new approaches for treatment for narcolepsy and insomnia, new ideas about how arousal and reward systems are intertwined...

It is also one of the fastest translation of fundamental discovery (in 1998) to treatments on the market (eg. suvorexant approved 2014). For more info on the peptides and drugs see DOI: 10.1124/pharmrev.123.000953. I've wondered why this discovery hasn't won big prizes.

Yesterday I got invited to submit a nomination for a Nobel Prize in Physiology or Medicine for 2026. I am still trying to figure out if this is phishing, as I am a weird person to ask, and have mixed feelings about these big prizes...but now it has me thinking about it. Who would you nominate?

I think GLP-1 agonists are an exciting and impactful discovery. The fundamental discoveries set the field up for discovery and translation to the variety of commercially available GLP-1 agonists used for diabetes and obesity - with impact in comorbidity.

It has also changed the stigma around obesity from being a problem of making poor health choices to being a treatable physical illness. This is an interesting (older) article about this...https://www.nytimes.com/2023/01/31/opinion/ozempic-weight-loss-drugs.html. I hope this can happen for addiction.