Brain Communications

Canori et al. found at-home Microtesla Magnetic Therapy feasible and well tolerated in 30 adults with cognitive impairment from long COVID, with improvements in working memory, verbal learning, processing speed and emotional well-being largest at follow-up. Read it at 👉https://buff.ly/q3zvMoV

Canaslan et al. showed that ubiquitin C-hydrolase L1 levels in CSF and blood accurately distinguished sporadic Creutzfeldt–Jakob disease and fatal familial insomnia patients from controls, supporting it as a promising diagnostic biomarker. Read it at 👉https://buff.ly/Ao5n0bl

Effiong et al. propose the Metabolic Debt Model, a hypothesis-generating framework that links four metabolic constraints to network dysfunction and clinical symptoms in myalgic encephalomyelitis and long COVID. Read it at 👉https://buff.ly/rLazwQr #neuroscience #LongCovid #ME_CFS

Mirloo et al. describe how dynamic contrast-enhanced MRI detects age-related blood–brain barrier dysfunction independent of the mild cognitive impairment diagnosis and associated with domain-specific cognitive deficits. Read it at 👉https://buff.ly/DWcNUvD #neuroscience

Meet Dr Nicola Pavese, a Professor of Clinical Neuroscience at Newcastle University and Professor of PET Imaging and Translational Research at Aarhus University👋 He investigates non-motor symptoms in Parkinson’s disease and neuroinflammation in neurodegenerative diseases. #meettheteam

Using a large dataset of COVID-19 patients, Higgins et al. show Long COVID-specific memory and attention deficits, with structural equation modelling implicating on-task fatigue and subjective symptoms in post-COVID cognitive impairment. Read it at 👉https://buff.ly/Tn0mJmw #neuroscience #longcovid

Pérez-Millan et al. link MRI markers of subcortical sleep–wake regions to polysomnographic patterns in ageing and Alzheimer’s disease. Anterior hypothalamic volume related to longer sleep, while locus coeruleus and posterior hypothalamic related to arousals. Read it at 👉https://buff.ly/WSK8Qoj

Öijerstedt et al. found elevated, progressively increasing plasma cardiac troponin T in amyotrophic lateral sclerosis compared with benign fasciculation syndrome, with multimodal evidence indicating a skeletal muscle origin rather than myocardial injury. Read it at 👉https://buff.ly/E2JA3Ke #ALS

Meyer et al. show that subthalamic deep brain stimulation improves movement but can increase impulsivity in Parkinson’s disease by altering response inhibition through a shared subthalamic nucleus-supplementary motor cortex pathway. Read it at 👉https://buff.ly/UuSQMO0 #neuroscience

Mouraux et al. review fluid biomarkers in hereditary cerebellar ataxias, highlighting neurofilament light chain as a sensitive marker of disease activity, progression and treatment response, detectable before symptom onset. Read it at 👉https://buff.ly/ywx1GJy #neuroscience

Fotouhi et al. highlight heterogeneity in Alzheimer’s progression, including CSF and PET biomarker discordance and mismatches between clinical diagnosis and cognitive trajectories, underscoring the need to account for this variability. Read it at 👉https://buff.ly/dDu3Nfx #neuroscience

Meet Dr Francesco Papaleo, a group leader of the Genetics of Cognition Laboratory at the IIT👋 He combines genetically modified mouse models with human clinical studies, using advanced neural techniques to link cell- and circuit-specific mechanisms to socio-cognitive behaviours. #meettheteam

Rodríguez Nieto et al. showed that changes in GABA+/Glx balance in two executive brain hubs relate to functional connectivity during cognitive flexibility performance, with important differences between young and older adults. Read it at 👉https://buff.ly/19L8nHM #neuroscience #braincommunications

Monopoli et al. demonstrate that Parkinson’s disease patients with early hallucination-related phenomena show reduced MRI-derived volume of neuromodulatory brainstem nuclei, most robustly the left laterodorsal tegmental nucleus. Read it at 👉https://buff.ly/ychshPw #neuroscience #Parkinsons

Zich et al. report that in acute stroke, initial severity relates to structural brain damage, whereas 6-months outcome is linked to neural activity, with combined measures providing the most accurate model of outcomes. Read it at 👉https://buff.ly/vnMnc8v #neuroscience #braincommunications

Vonk et al. report that an AI system detects clinically recognizable speech errors from a brief reading task, correlating with expert motor speech ratings and distinguishing nonfluent from logopenic primary progressive aphasia. Read it at 👉https://buff.ly/S4Yx9aG #neuroscience #braincommunications

Leo et al. report that serum cell-free mRNA distinguishes adult-onset spinal muscular atrophy from controls and shifts with risdiplam, supporting it as a biomarker to monitor treatment and reveal residual pathology. Read it at 👉https://buff.ly/V4kSSNT #neuroscience #braincommunications

Using meta-analysis of differential gene expression datasets and clinical validation, de Oliveira et al. report that glial fibrillary acidic protein is a candidate biomarker for spinal muscular atrophy. Read it at 👉https://buff.ly/qGgpINb #neuroscience #braincommunications

Meet Dr Devesh Pant, an Instructor in the Department of Cell Biology at Emory's School of Medicine 👋 He studies molecular mechanisms underlying amyotrophic lateral sclerosis and related motor neuron disorders, such as hereditary spastic paraplegia and spinal muscular atrophy. #meettheteam

Zeissler et al. describe the development of the first multi-arm, multi-stage platform trial for Parkinson’s disease, which encorporated the insights from multiple workstreams, statistical analyses, and patient and public involvement. Read it at 👉https://buff.ly/zXHoi3p #neuroscience #PPIE

Wang et al. found altered EEG brain-state dynamics in Parkinson’s disease with mild cognitive impairment, with state transitions correlating with cognitive scores and potentially serving as biomarkers of cognitive decline. Read it at 👉https://buff.ly/l3h2nsO #neuroscience #braincommunications

Mendonça et al. report promising therapeutic effects of repetitive transcranial magnetic stimulation in Parkinson’s disease, strongest for motor symptoms and depression, but evidence remains limited by small trials, heterogeneous protocols and short follow-up. Read it at 👉https://buff.ly/jxeV29B

Veldeman et al. report largely preserved cerebral autoregulation within an hour of experimental subarachnoid haemorrhage in rats, with transient pressure-reactivity impairment occuring in a subset of rats proportional to intracranial pressure elevation. Read it at 👉https://buff.ly/ZnGVOCn

Theofanopoulou et al. report that resting state functional MRI in Parkinson’s disease, shows both increased and decreased connectivity across movement-related brain regions, with some of these alterations being linked to disease burden. Read it at 👉https://buff.ly/zEvFKpZ #neuroscience #Parkinsons

Zhou et al. report that adolescents with ADHD segment ongoing experience less sensitively: EEG reveals neural overstabilization before and reduced re-engagement after event transitions, which might restrict adaptive updating. Read it at 👉https://buff.ly/AWQFcLV #neuroscience #braincommunications

Meet Dr Marco Palombo, an Associate Professor and Head of Microstructure Imaging at Cardiff University👋 His research bridges quantitative MRI, biophysical modelling and machine learning, developing new methods to characterise brain tissue microstructure non-invasively. #meettheteam

Why do some brain networks age faster than others? Chesebro et al. show diabetes and male sex independently accelerate functional decline in the same regions, where genes for insulin signaling, dopaminergic and GABAergic synapses are overexpressed. Read it at 👉https://buff.ly/7uOnRul #neuroscience

Filip et al. link long COVID to cognitive impairment and altered cerebral microstructure. The prominence of neuroinflammation-sensitive MRI in the modelled latent axis suggests immune and vascular rather than neurodegenerative substrate. Read it at 👉https://buff.ly/7Wbbp0V #neuroscience #longcovid

D’Amelio et al. report that, in a triple-transgenic Alzheimer’s disease mouse model, susceptibility to retroactive interference reveals early, sex-specific memory fragility before overt deficits appear. Read it at 👉https://buff.ly/bqkae4S #neuroscience #braincommunications

Fujita et al. report that serial MRI up to 15 years reveals marked individual differences in brain volume loss among cognitively normal adults, including rapid-atrophy and atrophy-resistant phenotypes linked to modifiable lifestyle factors. Read it at 👉https://buff.ly/eec4u3P #braincommunications

Rhymes et al. report that ciliary neurotrophic factor selectively slows the retrograde transport of signalling endosomes in motor neurons in vivo, highlighting the specificity with which neurotrophic factors shape axonal transport and motor neuron connectivity. Read it at 👉https://buff.ly/jfwxif1

What Kafka’s Metamorphosis reveals about consciousness without communication? In his essay, Demas uses Gregor Samsa’s example to explore the limits of observable behaviour as a measure of consciousness. Read it at 👉https://buff.ly/4vwMY2D #neuroscience #braincommunications

Meet Prof Tiago Outeiro, Professor at Newcastle University and Director of the Department of Experimental Neurodegeneration at the University Medical Center Goettingen 👋 He researches the molecular basis of neurodegenerative disorders, fousing on Alzheimer’s and Parkinson’s disease. #meettheteam

Thompson et al. report the generation and characterization of novel gene-edited mice expressing the human superoxide dismutase 1 (SOD1) gene and carrying the pathogenic SOD1A5V mutation associated with amyotrophic lateral sclerosis. Read it at 👉https://buff.ly/J8mz8dt #neuroscience #ALS

Orlando et al. show that heart rate variability is preserved in people with Parkinson’s disease receiving an acute dose of atomoxetine, supporting a safe cardiovascular profile for the drug. Read it at 👉https://buff.ly/hvluO1e #neuroscience #braincommunications

Falconer et al. report that dynamic functional connectivity predicts treatment response in post-stroke aphasia with higher temporal variability, greater community stability, and more time spent in a high-modularity state predicting greater gains. Read it at 👉https://buff.ly/x3goq2v #neuroscience

Lukyova et al. provide an overview of the genetic background of Alzheimer’s disease in the era of next-generation sequencing, highlighing mechanisms that may explain missing heritability and the potential of multi-omics for precision medicine. Read it at 👉https://buff.ly/tJgmAVp #neuroscience

Sintini et al. report that MRI and 18F-FDG PET principal components diagnostic outperformed tau-PET, with the highest sensitivity for the semantic variant of primary progressive aphasia and progressive supranuclear palsy. Read it at 👉https://buff.ly/lLfZKxN #neuroscience #braincommunications

Meier et al. found that increase in white matter volume, diffusivity and inositol, and abnormal magnetization transfer indicate pre-symptomatic white and grey matter involvement in asymptomatic adolescent adrenoleukodystrophy patients. Read it at 👉https://buff.ly/TbzGb2P #neuroscience

The letter to the editor by Kapadia et al. highlights that the study by Bechkos et al. (2026) independently corroborate previous evidence that electrical stimulation reduces α-synuclein oligomerisation in Parkinson’s disease models. Read it at 👉https://buff.ly/c3RWM5j #neuroscience

Meet Alfred Kongnyu Njamnshi, a Professor of Neurology and Neuroscience at the University of Yaoundé I and the founder of Brain Research Africa Initiative (BRAIN)👋 His team studies neurological and cognitive effects of parasitic infections, HIV and stroke-related neurocognitive disorders and sleep.

Zoellin et al. report that autologous haematopoietic stem cell transplantation is associated with reduced retinal tissue loss in relapsing-remitting multiple sclerosis, with baseline inner nuclear layer thickness predicting better outcomes. Read it at 👉https://buff.ly/qTHPDO4 #neuroscience

Pini et al. review developmental biomarker changes and propose that elevations of p-tau217 and glial fibrillary acidic protein in Alzheimer'’s disease may reflect unresolved adaptive brain programmes rather than intrinsically toxic responses. Read it at 👉https://buff.ly/epphj5D #neuroscience

Leveraro et al. report that patients with aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder show altered functional brain organization despite preserved cognition. Read it at 👉https://buff.ly/BOaMba0 #neuroscience #braincommunications

Conti et al. report that impaired awareness of visual hallucinations in Lewy body disease involves reduced resting-state connectivity between right visual association and prediction-error systems. Read it at 👉https://buff.ly/ItuMXvA #neuroscience #braincommunications

Xiong et al. report that susceptibility-weighted MRI of the substantia nigra and adjacent structures, analysed with a multi-task deep learning model, predicts motor outcome after subthalamic nucleus deep brain stimulation in Parkinson’s disease. Read it at 👉https://buff.ly/oLYnHD2 #neuroscience

Norouzi et al. studied periodic and aperiodic resting-state features in Parkinson’s patients across six EEG and MEG datasets, finding elevated alpha power, slower alpha peak frequency, and higher aperiodic offset and exponent. Read it at 👉https://buff.ly/ouVad3F #neuroscience #braincommunications

Keute et al. report that verbal and visuospatial working memory outcomes after deep brain stimulation in Parkinson’s disease were linked to baseline cortical activity and stimulation-related spectral changes. Read it at 👉https://buff.ly/IVZQIgn #neuroscience #braincommunications

Braun et al. report that human synucleinopathy is associated with mislocalization of the astroglial water channel aquaporin-4 and glymphatic clearance of alpha-synuclein is impaired in a transgenic mouse model with loss of perivascular aquaporin-4. Read it at 👉https://buff.ly/KfcwH7V #neuroscience

Oatman et al. studied how brain gene expression relates to levels of key Alzheimer’s disease proteins: amyloid-β, tau, and APOE. Most changes were related to levels of tau protein. Read it at 👉https://buff.ly/HmQxdUW #neuroscience