Brock Kirwan

Brock Kirwan

@brockkirwan.com

Cognitive neuroscientist studying memory and decision making. How do we remember episodes and how do those memories help us make better decisions?

438 followers341 following138 posts

I loved this paper. The "triune brain" model is pretty silly, which is why I hate the term "limbic system". Is there a better anatomical term for subcortical structures including hippocampus and amygdala, though?

Russ Poldrack@russpoldrack.org

I just came across this paper by Cesario et al. that has one of the greatest titles ever: " journals.sagepub.com/doi/10.1177/...

New paper! We tested mnemonic discrimination at extended delays in healthy young adults and an amnesic patient and found that when target memories are strong similar lures are more likely to be mistakenly called "old" and less-similar lures are correctly rejected. However... doi.org/10.1002/hipo...

doi.orgThe Strength of Target Representations Drives Mnemonic Discrimination: Evidence From Extended Delay and Hippocampal DamageMnemonic discrimination is critical for episodic memory and is dependent on the computational process of pattern separation, which allows the memory system to disambiguate prior memories from potenti...
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sensitive to target-lure similarity, even at 1-week delay in healthy young adults and after a 1-day delay in a patient with hippocampal damage. Many thanks to commenters on the earlier preprint and to the reviewers (sincerely, they made this version better). bsky.app/profile/broc...

Brock Kirwan@brockkirwan.com

Preprint day! Mnemonic discrimination is required to keep overlapping or similar experiences from interfering with each other in memory. We've done a lot of work on how this happens at short delays, but we've never examined this process at longer delays, like over a week osf.io/preprints/ps...

New paper! We tested mnemonic discrimination at extended delays in healthy young adults and an amnesic patient and found that when target memories are strong similar lures are more likely to be mistakenly called "old" and less-similar lures are correctly rejected. However... doi.org/10.1002/hipo...

doi.orgThe Strength of Target Representations Drives Mnemonic Discrimination: Evidence From Extended Delay and Hippocampal DamageMnemonic discrimination is critical for episodic memory and is dependent on the computational process of pattern separation, which allows the memory system to disambiguate prior memories from potenti...

when target memories are weaker (as in delay or hippocampal damage), the relationship between target-lure similarity and behavioral performance becomes much weaker. At first it looked like it went away all together, but in a 2nd exp. we added confidence measures and show that discrimination is still

Paper accepted at Imaging Neuroscience! Watch this space for links to the final open-access version. Also, thank you to the commenters on the original post--we incorporated some of your suggestions, which I think made for a better paper.

Brock Kirwan@brockkirwan.com

In honor of International Left-Handers Day, we have an updated preprint on scanning left-handed participants in fMRI studies. Although they're 11% of the population, we routinely screen LH people out of fMRI studies due to concerns about functional lateralization 1/n www.biorxiv.org/content/10.1...

In honor of International Left-Handers Day, we have an updated preprint on scanning left-handed participants in fMRI studies. Although they're 11% of the population, we routinely screen LH people out of fMRI studies due to concerns about functional lateralization 1/n www.biorxiv.org/content/10.1...

biorxiv.orgLeft Out: The Effect of Handedness on fMRI Activation in Memory ParadigmsAbout 11% of the population is left-handed, a significant minority of the potential participant pool for functional MRI (fMRI) studies. However, convention in fMRI research dictates these potential pa...
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Activation maps overlap considerably between an all-RH sample and samples including 10% LH (representative of the population prevalence), with dice similarity > 0.8 for all samples with n≥30. Conclusion: you should be including left-handed folks in your fMRI studies (at least for memory). 6/n

In honor of International Left-Handers Day, we have an updated preprint on scanning left-handed participants in fMRI studies. Although they're 11% of the population, we routinely screen LH people out of fMRI studies due to concerns about functional lateralization 1/n www.biorxiv.org/content/10.1...

biorxiv.orgLeft Out: The Effect of Handedness on fMRI Activation in Memory ParadigmsAbout 11% of the population is left-handed, a significant minority of the potential participant pool for functional MRI (fMRI) studies. However, convention in fMRI research dictates these potential pa...
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right-lateralized language (as determined with a language localizer task) and compared with everyone else. Right-lateralized LH participants had more activation in the right hemisphere for word retrieval. Notably, they did not have any less activation in the left hemisphere than RH. 4/n

Finally, we asked what happens to the pattern of activation when we include LH participants in our samples of mostly RH. Conventional wisdom is this should add variability causing us to "lose significance". I.e., we should have more false negatives when including LH. We didn't see this. 5/n

In honor of International Left-Handers Day, we have an updated preprint on scanning left-handed participants in fMRI studies. Although they're 11% of the population, we routinely screen LH people out of fMRI studies due to concerns about functional lateralization 1/n www.biorxiv.org/content/10.1...

biorxiv.orgLeft Out: The Effect of Handedness on fMRI Activation in Memory ParadigmsAbout 11% of the population is left-handed, a significant minority of the potential participant pool for functional MRI (fMRI) studies. However, convention in fMRI research dictates these potential pa...

Language processing happens in the left hemisphere for most folks but it's more frequently right-lateralized in LH. This is obviously a concern if you're doing an fMRI study on language, but why screen out LH's in a memory study? This was lead-author Loriana Goulding's question. She recruited 2/n

and scanned about 50 LH and 50 RH participants in word and face encoding and retrieval tasks. When comparing LH and RH groups against each other, we do not observe any significant differences in activation. The only time we could get group differences was when we isolated LH participants with 3/n

Brock Kirwan reposted

Looking to work with a postdoc. Prior experience with fMRI and computational modeling required, interest in psychiatry desired. Fellowship provides three years salary plus independent travel/equipment funds. Send CV and 2-3 manuscripts (preprints OK).

I’ve received a request to review a tenure file. When I was chair of our P&T committee we offered a couple hundred dollars for these and I thought that was pretty standard but this request does not mention $. Is it gauche to ask if it’s paid?

This was my experience as an assoc editor at Frontiers as well. The system sent out auto-invitations in my name to random reviewers.

Michael Okun@michael-okun.bsky.social

I’ve officially resigned as Associate Editor for Frontiers in Systems Neuroscience. It used to be a reputable journal, but became a case study in how forced automation destroys academic integrity. 👇

Really cool study of hippocampal morphology changes across the lifespan. Analyses were based on publicly available MRI datasets, which included 2 from our lab hosted on openneuro.org. Really great to see our data continuing to be useful beyond our own publications.

Marc L Seal @parkvillegeek.bsky.social

Lamellar Normative Modelling of the Hippocampus Across the Human Lifespan | bioRxiv www.biorxiv.org/content/10.6...

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The one thing that we found to be associated with prestige was journal impact factor--higher prestige predicted higher impact factors. I have theories about why this might be (perhaps pressure to publish in high-IF journals at some institutions), but we'd need to do an intervention to say more.

This was another project that took a few years to get out the door. Shout out to Ari Hedges-Muncy and Nate Muncy for formalizing the research question, Sam Chipman for data collection and analysis, and to Moe Mansour for picking it up and seeing it across the finish line.

We thought that authors from higher prestige universities might get a break on the number of subjects needed to publish an fMRI study. In fact, the opposite is true--higher prestige is associated with larger sample sizes.

We also asked if journal review style (single- vs. double-anonymous) interacted with prestige to predict sample size. It does not. In other words, it doesn't matter if authors are anonymous to reviewers in terms of acceptable sample sizes.

Brock Kirwan reposted

Thanks to all who attended the AFNI Bootcamp in Philly! We enjoyed hosting the 3-day intensive course that brought together clinicians & scientists to learn to process raw MRI data from start to finish w/ expert guidance from the AFNI team of the Scientific & Statistical Computing Core in the NIMH.

Preprint day! Mnemonic discrimination is required to keep overlapping or similar experiences from interfering with each other in memory. We've done a lot of work on how this happens at short delays, but we've never examined this process at longer delays, like over a week osf.io/preprints/ps...

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As targets are forgotten over a week, this pattern becomes more pronounced. All this indicates that mnemonic discrimination performance depends on both the strength of the target memory and the similarity of the lure to the original target.

Preprint day! Mnemonic discrimination is required to keep overlapping or similar experiences from interfering with each other in memory. We've done a lot of work on how this happens at short delays, but we've never examined this process at longer delays, like over a week osf.io/preprints/ps...

osf.ioOSF
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We found people forget! Which of course we were expecting (Ebbinghaus showed the forgetting curve in 1885). What's interesting is that as people forget the original targets, their responses to the similar lures change in interesting ways. When target memory is strong, people are able to discriminate

lures successfully with high confidence, especially when the lures are not very similar to targets. However, when lures are highly similar, they false alarm (call them "old") with high confidence. Consequently, we see that low-confidence responses are _more_ accurate than high conf. for those items

Preprint day! Mnemonic discrimination is required to keep overlapping or similar experiences from interfering with each other in memory. We've done a lot of work on how this happens at short delays, but we've never examined this process at longer delays, like over a week osf.io/preprints/ps...

osf.ioOSF

We had participants complete the Mnemonic Similarity Task (MST) where they study everyday objects and then take a recognition memory test with exact repeats, similar lures, and novel items. Usually, we only wait a couple minutes between study and test phases, but here we included delays up to 1 wk

Brock Kirwan reposted

Penn people can stop in anytime from 3-5 PM this Weds-Fri to make a sign/poster in our 200 Goddard Suite. We will have cardstock and large markers available. You bring the smart arguments.

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