Bruce Appel

Bruce Appel

@bruceappel.bsky.social

Developmental neurobiologist in the Section of Developmental Biology, Department of Pediatrics, at University of Colorado Anschutz Medical Campus. Zebrafish, neural cell fate specification, glia, myelin, and the great Colorado outdoors.

2K followers265 following32 posts

Well deserved! Here is to a terrific colleague!

Christian Mosimann@chrmosimann.bsky.social

* Addendum to full professor promotion. Tremendously grateful to @cuanschutz.bsky.social @cupediatrics.bsky.social @cudevbio.bsky.social, all my fantastic lab members past and present, collaborators, friends, family, and #zebrafish. 🐟🧬🧪 Onwards, always. #PILife

Bruce Appel reposted

Open-rank search: 2 (!) PI positions in Pulmonary Biology at @cuanschutz.bsky.social 🌄 We are looking for new colleagues @cupediatrics.bsky.social, working in lung fibrosis, focusing on #devbio, stem cell, & regen.biology of the lung 🫁🫀. Please help spread the word! cu.taleo.net/careersectio...

cu.taleo.netOpen Rank- Assistant Professor, Associate Professor, or ProfessorClick the link provided to see the complete job description.

We've had a great collaboration with Dr. Elena Alberdi's group at the Achurcarro Basque Center for Neuroscience for which we got to host two terrific grad students, Adhara and Uxue, for 4 months each. Our first joint publication is now out! onlinelibrary.wiley.com/doi/epdf/10....

onlinelibrary.wiley.comAmyloid‐β Dysregulates Oligodendroglial Lineage Cell Dynamics and Myelination via PKC in the Zebrafish Spinal CordYou have to enable JavaScript in your browser's settings in order to use the eReader.

Luuli has been a terrific colleague and friend. It was a true pleasure and privilege to serve on her thesis committee!

One of our stars defended today! Dr. @luulitran.bsky.social from the @thefrancolab.bsky.social lab gave a stellar seminar describing her deep, insightful, and highly productive investigations of the neuron-glia switch. #devbio @cupediatrics.bsky.social @cuanschutz.bsky.social

This has the most information I have been able to learn about the situation at NIH. Unfortunately, the chaos, worry, and hold-up on grant reviewing and awards seems even worse than I had thought.

Katherine J. Wu@katherinejwu.com

I talked to NIH officials, current and former, about what's been happening inside the agency since the Trump administration shut down their grantmaking pipeline in January. Their stories showed just how willing our new leaders are to break the law: www.theatlantic.com/health/archi...

Bruce Appel reposted

Big congrats to this year's awardees! Basic science matters more than ever - the awardees represent key aspects of what makes #devbio a central biomedical research endeavor of widespread impact. Applause!

Society for Developmental Biology@socdevbio.bsky.social

Congrats to the 2025 SDB Award Winners! Conklin Medal: Blanche Capel DB-SDB Lifetime Achievement Award: Billie Swalla Hamburger Outstanding Educator Prize: Erica Crespi Hay New Investigator Award: Mubarak Syed SDB Trainee Science Communication Award: Joaquin Navajas Acedo bit.ly/4bcrFap

Bruce Appel reposted

Great to see collaborations such as this "develop" between the Section of Developmental Biology @cupediatrics.bsky.social @cuanschutz.bsky.social and our friends @colorado.edu. Looking forward to many more!

Santos Franco@thefrancolab.bsky.social

Congrats to Justin @brumbaugh-lab.bsky.social and his his team and Peter Dempsey and our colleagues in @cudevbio.bsky.social for this great paper in Nature Cell Biology on epigenetic regulation of intestinal stem cell fate specification! #weCUdevbio

Bruce Appel reposted

Congratulations to Dr. Peter Dempsey, Professor in the Section of Developmental Biology, for recieving the 2025 Pediatric Gastroenterology & Developmental Biology Section Research Mentor Award from the American Gastroenterological Association! #devbio 🧪

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We found that low DHA status during development is associated with an abnormal eye phenotype. We also showed that even morphologically normal siblings exhibit dysregulated vision and stress response gene pathways.

Future work using our zebrafish model could reveal the underlying mechanisms by which low DHA status leads to neurodevelopmental abnormalities. These studies will also provide foundational support for maternal interventions that improve infant eye & brain health.

Docosahexaenoic acid (DHA), an omega-3 fatty acid crucial for vision & brain development, is lacking in Western diets. How does low DHA status impact neurodevelopment at the cellular & molecular level? With help from a zebrafish model, we can fill this knowledge gap and improve infant health.

We created a novel DHA-deficient larval zebrafish model using a two “finned” approach. This included: 1) disrupting elovl2, a critical gene in the DHA biosynthesis pathway with CRISPR/Cas9 genome editing, and 2) feeding mothers a DHA-deficient diet.

Love the super creative work from my Dev Bio colleagues JP and Santos. I would never be able to master IU electroporation, but, wow, the things people who have skills can do with it! #devbio 🧪

JP Martin, grad student in @thefrancolab.bsky.social lab, is about to tell us how he proposes to discover mechanisms that drove human brain evolution for his thesis research! Stay tuned for the answer- in about 3 years when he defends!

Bruce Appel reposted

Postdoc Austin Adkins noticed that mutant zebrafish he had inherited behaved oddly in their tanks. So he turned them into a new research project. Great demonstration of serendipity and creativity at today's Dev Bio Section meeting. #devbio #zebrafish 🧪

Thanks! It’s been awhile since we had a cover!

Crystal D. Rogers@rogerslabucd.bsky.social

New issue of Differentiation out now! Congratulations to Samantha Bromley-Coolidge and co-authors, Diego Iruegas and @bruceappel.bsky.social for getting the cover of the journal! www.sciencedirect.com/journal/diff...

Sure, study section can be a be a grind but there is a huge perk - the chance to connect with special former students who have relocated to DC. Here with the incomparable Alex Hughes and Nick George. #myelin 🧠🧪

Love to see the results of great collaborations between my wonderful colleagues (and hoping I might get picked for the team next time….)!

Matthew Taliaferro@jmtali.bsky.social

Excited to share our latest work! In it, we develop a new method for studying RNA localization via proximity labeling: OINC-seq! In contrast to other proximity-based methods, labels deposited on RNAs are read directly by sequencing without the need for biotinylation. biorxiv.org/cgi/content/...

Hey, I think I see some myelin on that lineup! 🧠

Tim@timisstuck.bsky.social

This is your way-too-early notice that JCB is sponsoring its first-ever scientific session at CellBio2024!! Hosted by yours truly and one of our beloved leaders, Arshad Desai. Check it out + our presence at the meeting: t.co/79Ceo3PAFd

For any of you aiming to advance your biomedical scientific training or pursue your research career among fabulous colleagues in a wonderful part of the world, check us out! 🧪

University of Colorado Anschutz@cuanschutz.bsky.social

The largest academic health center in the Rocky Mountain region is excited to officially be on Bluesky! Follow us for the latest #healthscience news and breakthroughs straight from #CUAnschutz experts. Learn more about who we are, here: cuanschutz.edu

I encourage y’all to check out this work from @emilybateslab.bsky.social. I still remember the first time I heard Emily talk about her fly work that led to this - at a regional SDB meeting in Salt Lake City about 12 years when she was still at BYU. It’s been great to watch the story unfold.

emilybateslab.bsky.social@emilybateslab.bsky.social

We discovered that mouse embryonic palate mesenchymal cells are electrically active and send out BMP when they depolarize. We are excited to announce this work is published in Nature Communications. #womeninstem #devbio rdcu.be/dZX7V

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