Centre for Craniofacial & Regenerative Biology (CCRB)

A new paper from the Tucker lab at @ccrb27.bsky.social has just been published in the journal of Anatomy! Secondary cartilage in the murine medial pterygoid plate has a critical role in the pathfinding of the tensor veli palatini Link:  doi.org/10.1111/joa.... (1/5)

This work has been published at the Journal of Anatomy. Congratulations to all authors! #Craniofacial #Embryogenesis #Cartilage #Pterygoid (5/5)

A new paper from the Tucker lab at @ccrb27.bsky.social has just been published in the journal of Anatomy! Secondary cartilage in the murine medial pterygoid plate has a critical role in the pathfinding of the tensor veli palatini Link:  doi.org/10.1111/joa.... (1/5)

They show that the pterygoid plate is formed from two distinct developmental processes (membranous and endochondral ossification) and that it is composed entirely of neural crest. This study broadens our understanding of the embryonic development of a significant part of mammal evolution. (3/5)

A new paper from the Tucker lab at @ccrb27.bsky.social has just been published in the journal of Anatomy! Secondary cartilage in the murine medial pterygoid plate has a critical role in the pathfinding of the tensor veli palatini Link:  doi.org/10.1111/joa.... (1/5)

New paper from the Tucker lab at @ccrb27.bsky.social published in @dev-journal.bsky.social ! Analysis of Eya1 and Tbx1 mutants highlights interactions between the muscle and developing cartilage during external ear formation. Link: doi.org/10.1242/dev.... (1/4)

This work could provide framework for understanding the mechanisms underlying microtia, a birth defect affecting pinna morphology and often associated with hearing loss in individuals with congenital disorders. Congratulations to all authors! (4/4)

New paper from the Tucker lab at @ccrb27.bsky.social published in @dev-journal.bsky.social ! Analysis of Eya1 and Tbx1 mutants highlights interactions between the muscle and developing cartilage during external ear formation. Link: doi.org/10.1242/dev.... (1/4)

In this paper that the authors show the role of the auricular muscle in regulating pinna development. The muscle (mesoderm-derived) instructs differentiation of the cartilage (derived from neural crest). (2/4)

New paper from the Streit lab at @ccrb27.bsky.social published in @dev-journal.bsky.social ! Dynamic changes in chromatin accessibility during cell fate specification at the neural plate border. Link: doi.org/10.1242/dev.... (1/4)

Integrating this new data with previously published scRNA-seq from the lab, the paper explores dynamics of chromatin accessibility across emerging cell types and infers a gene regulatory network controlling the specification of cranial placodes. (3/4)

New paper from the Streit lab at @ccrb27.bsky.social published in @dev-journal.bsky.social ! Dynamic changes in chromatin accessibility during cell fate specification at the neural plate border. Link: doi.org/10.1242/dev.... (1/4)

New paper from the Tucker lab at @ccrb27.bsky.social ! Authors Ticha Tuwatnawanit, @nanthwal.bsky.social and collagues analysed the formation and molecular identity of the glenoid fossa of the temporomandibular joint (TMJ). Link: onlinelibrary.wiley.com/doi/10.1111/... (1/3)

In the paper authors show that the fibrocartilage of the murine glenoid fossa and condyle of the TMJ are shown to form at distinct times with distinct molecular identities. Changes in the condyle during disease lead to remodelling of the fossa to maintain joint alignment. (2/3)

New paper from @ccrb27.bsky.social out in Aging Cell! Work from Robert Knight’s group showed an exciting effect for a metalloprotease inhibitor in enhancing muscle regeneration in a zebrafish model of accelerated ageing. @kingsdentistry.bsky.social #Regeneration #Zebrafish #MuscleRepair (1/3)

First author Dr. Julie Yue Yuan showed MMP9 inhibition acted on inflammatory cells to promote a more effective migratory response of muscle stem cells, resulting in improved muscle repair in telomerase mutants. (2/3)

New review from our centre published in the Journal of Dental Research! Activating Endogenous Condylar Stem Cells to Enhance TMJ Repair doi.org/10.1177/0022... Congratulations Ticha Tuwatnawanit, @nanthwal.bsky.social and Abigail for this publication! @kingsdentistry.bsky.social (1/3)

The temporomandibular joint (TMJ) is a crucial part of our daily lives, playing a role in mastication and communication. Temporomandibular disorders (TMDs) are highly prevalent ( 34%-38% of world population), but therapies are challenging due to the limited self-repair capability of the TMJ. (2/3)

CCRB paper alert! Most snakes can open their mouths so wide they can consume food that is much larger than their own head. This is partly due to their ‘free’ mandibular symphysis, found to be both bone and cartilage-free. So, how ‘free’ is that symphyseal gap? (1/3)

Follow the link below for myth-busting snake ‘chin’ descriptions that will leave your mouth agape 🐍😮 onlinelibrary.wiley.com/doi/10.1111/... "The wide gape of snakes: A comparison of the developing mandibular symphysis in sauropsids" #ComparativeAnatomy #Evolution #Snakes #Jaws (2/3)