Christopher Langdon

Christopher Langdon

@cmlangdon.bsky.social

Postdoc @ Princeton Neuroscience Institute

85 followers72 following5 posts

(4/5) A latent circuit model of PFC responses similarly reveals low-dimensional projections of neural activity in which irrelevant stimuli are suppressed. Larger representations of irrelevant stimuli on error trials further confirms the behavioral relevance of the inferred latent circuit.

(2/5) To discover these latent mechanisms from high-dimensional responses, we developed the latent circuit model which simultaneously learns a low-dimensional recurrent neural network and an orthonormal embedding to jointly explain heterogeneous neural responses.

(3/5) The orthonormal embedding allows validating the latent circuit mechanism via low-dimensional projections of activity and low-rank perturbations of connectivity. In contrast to previous studies, we find representations of stimuli are suppressed when they are irrelevant.

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