Centre for Structural Systems Biology CSSB

🔬This week at @cssbhamburg.bsky.social, we’re testing #holotomography on real participant samples: from bacteria and biofilms to cells, 3D cultures, tissues, and whole organisms. ✨Our carousel gives a quick technical overview of the method and the @tomocube.bsky.social HT-X1™ Plus. #LabelFreeImaging

🔬 High-res 3D imaging without labels: #holotomography uses refractive index as intrinsic contrast for quantitative imaging of living samples. Next week at @cssbhamburg.bsky.social , we’ll demo the @tomocube.bsky.social HT-X1™ Plus hands-on with participant samples. Book your spot: shorturl.at/Pu2U3

🔥 New from our group in Protein Science! We introduce CheMelt, a tool for analyzing thermal & chemical protein denaturation, integrated into the EMBL Hamburg eSPC platform. 📖 Read the paper: onlinelibrary.wiley.com/doi/10.1002/... @embl.org @cssbhamburg.bsky.social @au.dk #Biophysics #CheMelt

During their 2-day visit, our SAB members learned about the latest developments at CSSB, met our newest group leader, and exchanged ideas with postdocs and PhD students during our poster session. Thank you to all our SAB members for your engagement! @thamlab.bsky.social @oneyrolles.bsky.social

What brings clathrin adaptors, phase separation & membrane trafficking together? 🧬🔬 Our new paper in Communications Biology explores just that! Discover how clathrin adaptors drive LLPS during endocytosis—and what we found 👇 www.nature.com/articles/s42... @embl.org @cssbhamburg.bsky.social

What role do membrane contact sites play in bacterial pathogenesis and infection? To explore this question, 24 PIs from across Germany, representing two scientific communities - lipid biology and infection biology - came together at CSSB. More info:https://t1p.de/xe7u0 @carobarisch.bsky.social

The MHH Virology Retreat took place at CSSB last week. Participants had a great time getting to know CSSB and sharing their latest research. Thanks to all who attended! @bosse-lab.bsky.social

Researchers from CSSB and the @uwmadison.bsky.social have discovered that a layer of cellular energy regulation lies in proteoforms — unique chemical variants of proteins. A new study reveals how these proteoforms arise through the activity of AMPK. More Information: t1p.de/orr75

P. aeruginosa kann viele verschiedene Gewebe infizieren. HZI-Forscher Michael Kolbe am @cssbhamburg.bsky.social hat nun mit Kolleg:innen Proteine des Bakteriums strukturbiologisch untersucht & konnte zeigen, wie sie Poren in der Zellmembran des Wirts verursachen. www.helmholtz-hzi.de/media-center...

Congratulations to @deep-dv-for5200.bsky.social social for receiving the 2026 North German Science Award! Congrats to all the scientist who are part of the DEEP-DV team including CSSB group leader Jens Bosse @bosse-lab.bsky.social .

Researchers from CSSB's Kolbe group (@uni-hamburg.de, @helmholtzhzi.bsky.social), along with collaborators from Research Center Jülich, EMBL Hamburg, DESY and BIOTECH Thailand have uncovered novel virulence mechansims of phospholipase C from P. aeruginosa. More info: t1p.de/sbjpq

The NordInfect Symposium is in full swing at CSSB! The symposium brings together the bacteriology community from Northern Germany for a one-day event highlighting a broad range of cutting-edge research. NordInfect website: nordinfect.cssb-hamburg.de @carobarisch.bsky.social @itzenlab.bsky.social

Researchers from CSSB in collaboration with the NCBI traced the lineage of two bacterial enzymes. By reconstructing their common ancestral protein, the team uncovered novel insights into the molecular mechanisms of these nucleases. More: t1p.de/mf3qk @uni-kiel.de @holgersondermann.bsky.social

@cssbhamburg.bsky.social

🔬 Just a few days to go until the 28th International Workshop on Kaposi’s Sarcoma Herpesvirus (KSHV) & Related Agents (28 June – 1 July 2026, @cssbhamburg.bsky.social Hamburg). On-site registration is available. More info about the event: https://leibniz-liv.pulse.ly/wxetp8mn26 @ksvirus.org

Thanks to everyone who joined us on Monday for the panel discussion "Coding Life" hosted by @adwhamburg.bsky.social & CSSB. Our experts had a lively discussion about the use of AI in in synthetic biology and medicine as well as its impact on the future of scientific research. @bosse-lab.bsky.social

🧬🤖 Kann man Leben programmieren? Und wo sollten wir Grenzen ziehen? Bei Coding Life diskutieren Expert:innen über synthetische Biologie, KI und die Zukunft des Lebens. 📅 08.06.2026 | 📍 Hamburg 👉 www.cssb-hamburg.de/codinglife

First international VISION symposium on Integrated Structural Virology 📅 8 – 9 September 2026 📍 @cssbhamburg.bsky.social , Hamburg, Germany 📝 Registration Open| Deadline: 19 July 2026 🔗

More great talks this afternoon at the Instruct-ERIC Biennial conference, as well as two poster sessions. We had speakers from @helmholtzmunich.bsky.social , ThermoFisher, @viblifesciences.bsky.social , @psi.ch , @cssbhamburg.bsky.social , and @eu-openscreen.bsky.social

Am Montag, dem 8. Juni, um 19:00 Uhr laden das @cssbhamburg.bsky.social und @adwhamburg.bsky.social zu einer Podiumsdiskussion zum Thema „Coding Life: Das Leben mit KI und biologischen Werkzeugen gestalten“ ein. Anmeldung: lnkd.in/dCnygtGX @bosse-lab.bsky.social @landaulabcssb.bsky.social

Excited to be attending the Biennial Conference of Instruct-ERIC in Brussels. @instruct-eric.bsky.social Looking forward to engaging discussions on structural biology, research infrastructures, technology development, and scientific collaboration across Europe. @embl.org @cssbhamburg.bsky.social

Speakers for Session 2: New Technologies at our Biennial Conference in Brussels, 28-29 May 2026 You can see the full agenda and find out more information about the talks on our website: instruct-eric.org/ibsbc2026-sp...

Join us for the Nordinfect Symposium on August 26th at the CSSB in Hamburg. This meeting will bring together the Northern German bacteriology community for a day of cutting-edge science and networking. More information and registration: lnkd.in/ev5F3Rbm @uni-hamburg.de @fzborstel.bsky.social

Was wäre, wenn wir das Leben nicht nur verstehen, sondern auch aktiv programmieren? #Podiumsdiskussion zu „Coding Life“ am 8. Juni 2026. Eintritt frei. Anmeldung unter 👉 indico.desy.de/event/53406// Zur PM 👉 www.awhamburg.de/aktuell/pres... @cssbhamburg.bsky.social @bosse-lab.bsky.social

On June 8 at 19:00, CSSB together with @adwhamburg.bsky.social will be hosting a panel discussion entitled “Coding Life: Leben gestalten mit biologischen Werkzeugen.” Registration: www.cssb-hamburg.de/codinglife @bosse-lab.bsky.social @uni-hamburg.de @leibnizliv.bsky.social @embl.org

28th International Workshop from @ksvirus.org is coming to Hamburg. Can't wait to welcome you to our harbour city. We are very excited for the scientific discussion and exchange at @cssbhamburg.bsky.social. Register here: https://ksvirus.pulse.ly/ioh7jdxmmg

Last week, CSSB and EMBL Hamburg hosted students from the Business Academy Aarhus in Denmark. The group of students learned about the life science research conducted at both institutions. @amyloid-sam.bsky.social @embl.org

Happy to see the preprint of our VULCROM setup online! Thanks to our amazing collaborators we've managed to get some pretty cool cryo-CLEM images by combining cryo super-resolution and cryo-ET: doi.org/10.64898/202...

28 children spent the day at CSSB for Girls' and Boys' Day yesterday! The kids built microscopes, conducted chemistry and chromatography experiments, tried VR goggles@ and much more. @landaulabcssb.bsky.social @topf-lab.bsky.social @kaufmannlab.bsky.social

🧪 3rd Leuven Protein Aggregation Meeting | 9–11 Sep 2026 📍 Great Beguinage of Leuven Our illustrious speakers list also includes @meytallandau.bsky.social (@cssbhamburg.bsky.social) & @ruferbus.bsky.social (@uni-goettingen.de). Don't miss it! More info: vibbio.tech/ProAgg26 #ProAgg26

CSSB’s first flagship project “PLASMOFRACTION” has successfully deciphered membrane protein complexes in the malaria parasite Plasmodium falciparum. Find out more: t1p.de/wthx2 @jankosinski.bsky.social, @embl.org, @uni-hamburg.de, @unituebingen.bsky.social, @fmp-berlin.de

New preprint out 🚀 De novo designed proteins are often too stable — but why? Using CheMelt, we show that their exceptional thermostability is largely driven by unusually low heat capacity changes (ΔCp). 👉 www.biorxiv.org/content/10.6... @embl.org @osvalb.bsky.social @proteinmagnus.bsky.social

Last Friday, the President of the Hannover Medical School , Prof. Denise Hilfiker-Kleiner, together with the Vice President of @uni-hamburg.de Prof. Tilo Böhmann visited CSSB. The visit included tours of PETRA III beamlines as well as CSSB’s four core facilities. @bosse-lab.bsky.social

Check out the new @spidocs.bsky.social comic entitled Training the Next Generation SPIDoc‘s: A tale of laser beams and building teams designed by Véro Mischitz. @leibnizliv.bsky.social @europeanxfel.bsky.social @ebi.embl.org

Very exciting demo on smFRET &FCCS measurements in our SPC facility this week with Exciting Instruments @ei-science.bsky.social ✨🧮 Thank you for allowing us to measure single molecule resolution using your technology. It has been again, very exciting 🔍🤩 @embl.org @cssbhamburg.bsky.social

Congratulations to the @uni-hamburg.de for once again being awarded the University of Excellence title! 🎉

Universität Hamburg gewinnt Exzellenztitel erneut 👏 Damit erhält die UHH weiterhin als eine von wenigen Universitäten diese bedeutende Förderung. Künftig liegt der Fokus noch stärker auf der Twin Transformation, die Nachhaltigkeit und Digitalisierung als Querschnittsaufgabe verbindet: uhh.de/n87ie

Hello BlueSky Community, do you know of any European Cryo-EM facility which possess a High-pressure freezer being used under BSL-2 safety level? The sample would be a bacterial biofilm.

Happy International Women's Day! #IWD2026 CSSB supports women in science and we pledge to elevate & celebrate women’s achievements. @carobarisch.bsky.social, @landaulabcssb.bsky.social @topf-lab.bsky.social, @mariarosenthal.bsky.social

Today’s CSSB @cssbhamburg.bsky.social Seminar Series featured Paul Guichard @centriolelab.bsky.social from Geneva who shared their beautiful discoveries of the centriole assembly, conoid molecular architecture, and the connecting cilium of the eye! ♡ 🫧 @uni-hamburg.de

Such a fun collaboration with @mel-foulon.bsky.social from the TS lab 🤝-👀 We combined dual RNA-Seq 🧬 and advanced imaging 🔬 to uncover how intracellular compartmentalization drives niche-specific metabolic phenotypes in mycobacteria!! Fantastic team effort ✨ #Tbsky #microsky

The year has just started, a lot already happened at SPIDocs! 🎉Charlotte Uetrecht - new Scientific Director @cssbhamburg.bsky.social 🚀Secondments at @uppsalauniversity.bsky.social and Fasmatech Science and Technology 🚀Internships at SLAC ✨Course 'Ion trap and advanced MS techniques' at MSVision

New preprint from @carobarisch.bsky.social lab!

Integrated structural biology at its best with fantastic talks in cryo-EM, NMR, and X-ray techniques Also integration with other Instruct Centres, in this case Kay Grünewald Instruct-DE @cssbhamburg.bsky.social 'Conformational flexibility and molecular plasticity in herpesvirus entry and egress'

New protocol out now! 📕🖊️🔍 A practical workflow for analyzing CD thermal unfolding of short RNAs — from SVD decomposition to two-state fitting to extract melting temp and enthalpy with ChiraKit. A must-see if you’re working with RNA structure and CD data. DOI: 10.1007/978-1-0716-5084-4_12 

My colleagues have put together a nice book chapter on amyloid polymorphism. Have a look! 🧪🧬🧶 #amyloids #cryoem @landaulabcssb.bsky.social @meytallandau.bsky.social @cssbhamburg.bsky.social @stratifa.bsky.social

Fun in the snow!