Daniel Drucker

Daniel Drucker

@danieljdrucker.bsky.social

A clinician scientist at LTRI @sinaihealth studying Glucagon, GIP, GLP-1, GLP-2, diabetes, obesity, metabolism and the gut endocrine system

1.3K followers165 following1.3K posts

Daniel Drucker
@danieljdrucker.bsky.social

Cohort studies across the lifespan for type 2 #diabetes Progress, clinical implementation and future directions @diabetologiajnl.bsky.social link.springer.com/article/10.1...

link.springer.comA narrative review of what cohorts have taught us and how they have laid the foundation for much of our understanding of type 2 diabetes - DiabetologiaThis narrative review provides a historical perspective on how observational research on type 2 diabetes has been developed and consolidated over the last 50 years and how well-designed cohort studies...
Daniel Drucker
@danieljdrucker.bsky.social

In an open label study up to 26 weeks, dulaglutide was associated with greater improvements in glycaemic control and variability compared with insulin among adolescents with transfusion-dependent β-thalassaemia (TDT)-induced #diabetes @diabetologiajnl.bsky.social link.springer.com/article/10.1...

link.springer.comDulaglutide vs insulin in adolescents with thalassaemia-induced diabetes: effect on metabolism and atherogenesis (DIADEMA) - DiabetologiaAims/hypothesis Chronic iron overload represents a significant morbidity in transfusion-dependent β-thalassaemia (TDT), leading to various complications, including diabetes and CVDs. The glucagon-like...
Daniel Drucker
@danieljdrucker.bsky.social

From TMAO to DNICs the expanding concepts linking microbiota metabolism to cardiovascular and metabolic pathways. Modulating DNIC formation by the gut microbiota could be a strategy to support cardiometabolic health @CellCellPress www.cell.com/cell/fulltex...

cell.comGut microbiota generate dinitrosyl iron complexes with cardiometabolic benefitsGut bacteria convert inorganic nitrate and non-heme iron into bioactive dinitrosyl iron complexes (DNICs) that distribute systemically and signal independently of free nitric oxide. These microbe-deri...
Daniel Drucker
@danieljdrucker.bsky.social

New studies in Drosophila and mice redefine the intestinal muscle as a responder to specific signals that adjust adult organ (intestine) features and sustain reproductive demands. www.cell.com/cell/fulltex...

cell.comThe sex and reproductive plasticity of intestinal muscles instruct gut sizeAdult intestinal size plasticity is driven not only by epithelial stem cells but also by remodeling of the surrounding visceral musculature. Sex- and reproduction-dependent muscle remodeling controls ...
Daniel Drucker
@danieljdrucker.bsky.social

A framework identifying ten priorities in #T2D prevention, toward context-specific, actionable interventions capable of altering the natural history of disease early in the life course and restoring metabolic health. www.nature.com/articles/s41...

nature.comType 2 diabetes prevention across the life course - Nature MedicineRather than intervening when dysglycemia is established, prevention efforts should focus on prediabetes remission and restoration of normoglycemia. Here the authors call for a new agenda informed by m...
Daniel Drucker
@danieljdrucker.bsky.social

The decades long quest for reprogramming islet cell phenotypes #diabetes continues here using a metabolic pathway approach www.nature.com/articles/s41...

nature.comMetabolic reprogramming drives pancreatic β cell neogenesis from α cells - Nature Chemical BiologyA chemical screen identified a PRC2–AR–ETV1–PPP axis that regulates β cell identity features in α cells. An intermediate PPP metabolite, methyl esterified 6-phosphogluconate, induced metabolic reprogr...
Daniel Drucker
@danieljdrucker.bsky.social

More evidence from studies of mice deficient in α cells that α cells are required for nutrient homeostasis by regulating the dynamics of β cell networks, notably under conditions of amino acid exposure www.science.org/doi/10.1126/...

science.orgPancreatic α cells are required for nutrient homeostasis by regulating dynamic β cell networks in isletsIslet α cells are required for meal tolerance by tuning synchrony, cluster size, and signal propagation of β cell networks.
Daniel Drucker
@danieljdrucker.bsky.social

Irisin induction in response to exercise confers direct neuroprotective effects in an inflammation-driven neurodegenerative condition in mice, making it an attractive therapeutic candidate for multiple sclerosis @natmetabolism.nature.com www.nature.com/articles/s42...

nature.comThe exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis - Nature MetabolismExercise-mediated neuroprotection in a mouse model of multiple sclerosis is reduced in mice lacking the irisin-encoding gene, Fndc5, and can be recapitulated by peripheral administration of irisin.
Daniel Drucker
@danieljdrucker.bsky.social

Amyloid-dependent StAR upregulation in beta cells under conditions of islet amyloid deposition could contribute to mitochondrial dysfunction @diabetologiajnl.bsky.social link.springer.com/article/10.1...

link.springer.comHuman islet amyloid polypeptide aggregation upregulates the mitochondrial cholesterol transport protein StAR and induces mitochondrial dysfunction in beta cells - DiabetologiaAims/hypothesis Loss of islet beta cell function and mass are critical in the pathogenesis of type 2 diabetes, a disease in which ~90% of individuals exhibit islet amyloid deposition. Amyloid deposits...

Daniel Drucker reposted

Harvard Molecular Metabolism
@met-hsph.bsky.social

Honored to share that Dr. Gökhan Hotamışlıgil has been elected to the National Academy of Sciences, one of the highest distinctions in science recognizing outstanding, sustained contributions to research. Huge congratulations to Dr. Hotamışlıgil on this remarkable and well-deserved honor!

nasonline.orgNational Academy of Sciences Elects Members and International Members - NASWASHINGTON — The National Academy of Sciences announced today the election of 120 members and 25 international members in recognition of their distinguished and continuing achievements in original res...
Daniel Drucker
@danieljdrucker.bsky.social

Here the authors highlight potential therapeutic benefits of 4 weeks of β2-AR stimulation for improving muscle-specific glucose uptake in individuals with or at risk for developing diabetes #T2D www.nature.com/articles/s41...

nature.comProlonged β2-agonist treatment enhances muscle-specific glucose uptake in individuals with overweight and obesity: a randomized placebo-controlled trial - Nature CommunicationsThe study showed in a placebo-controlled crossover design that 4-week treatment with β2-adrenergic agonist clenbuterol enhances insulin-stimulated glucose uptake in skeletal muscle but not brown adipo...
Daniel Drucker
@danieljdrucker.bsky.social

Although #weightloss is highly beneficial to reduce fat and inflammation in the liver, posthoc analysis of the ESSENCE trial reveals substantial weight loss-independent benefits of semaglutide #MASH How does this happen?

Daniel Drucker
@danieljdrucker.bsky.social

How do GLP-1 meds improve liver health through #weightloss independent mechanisms? Here Dr. Gonzalez Rellan & colleagues identify Liver Sinusoidal Endothelial Cells as direct targets of semaglutide, linking LSECs to reduction of #inflammation #Fibrosis #MASH www.cell.com/cell-metabol...

cell.comThe weight-loss-independent hepatoprotective benefits of semaglutide are orchestrated by intrahepatic sinusoidal endothelial GLP-1 receptorsGLP-1 medicines are used to treat people with type 2 diabetes, obesity, and metabolic dysfunction-associated steatohepatitis (MASH). Here, Gonzalez-Rellan et al. demonstrate that semaglutide activates...
Daniel Drucker
@danieljdrucker.bsky.social

Neuronal lipid droplet-derived lipids support neuron function by providing fatty acids and phospholipids to sustain mitochondrial and endoplasmic reticulum function and homeostasis. www.nature.com/articles/s42...

nature.comNeuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis - Nature MetabolismIn vivo regulation of neuronal lipid droplet formation mediates whole-body energy homeostasis in a sex-specific manner in Drosophila and mice.
Daniel Drucker
@danieljdrucker.bsky.social

Here the authors propose that TOX3 in POMC-lineage cells are essential for maintaining energy homeostasis in mice, driving thermogenesis, thereby revealing therapeutic opportunities for metabolic disorders #obesity www.nature.com/articles/s41...

nature.comTOX3 in hypothalamic POMC-lineage cells regulates energy balance via the PTEN-AKT signaling axis - Nature CommunicationsHypothalamic POMC neurons are critical for energy balance. Here, authors show that TOX3 in these neurons regulates metabolism by promoting PTEN degradation and AKT activation, enhancing thermogenesis ...
Daniel Drucker
@danieljdrucker.bsky.social

New from Professor Belsham @denisebelsham.bsky.social The naturally ocurring phytohormone BAP causes #weightloss in obese mice via sex-specific mechanisms www.sciencedirect.com/science/arti...

sciencedirect.comThe plant hormone, 6-benzylaminopurine, ameliorates obesity in male and female mice while on a high-fat dietObesity is a global health crisis. Currently available treatments, while effective, show several undesirable side effects that hinder their long-term …
Daniel Drucker
@danieljdrucker.bsky.social

A new chapter from the Scherer lab on adipose tissue communication via extracellular vesicles www.nature.com/articles/s41...

nature.comAdipocytes signal to recruit specific mRNAs from surrounding cells to restore expression deficits - Nature CommunicationsExtracellular vesicles (EVs) mediate intercellular communication by transferring signaling macromolecules. Unexpectedly, the author here identifies that adipocyte-specific loss of SMPD3 triggers neighboring preadipocytes to release EVs containing SMPD3 mRNA, restoring SMPD3 expression in genetically null adipocytes.
Daniel Drucker
@danieljdrucker.bsky.social

GLP-1 medicines and #pancreatitis After 21 years, lots of smoke, no fire. Here a look at Tirzepatide www.sciencedirect.com/science/arti... www.google.com/imgres?q=pan...

sciencedirect.comDose–response analysis of tirzepatide and acute pancreatitis: An international systematic review and quantitative meta-analysis of randomised trialsTirzepatide, a dual GIP/GLP-1 receptor agonist for type 2 diabetes and obesity, carries a theoretical risk of pancreatitis. Whether risk varies by dos…
Daniel Drucker
@danieljdrucker.bsky.social

Novel irisin-driven cell–cell and inter-tissue immune interactions improve #obesity and glucose intolerance, and increase energy expenditure, with no reduced food intake and muscle loss in obese mice. www.nature.com/articles/s42...

nature.comIrisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells - Nature MetabolismThis study demonstrates that overexpression of irisin, an exercise-induced myokine, ameliorates obesity and insulin resistance in high-fat-diet-fed mice by increasing local IL-33 production and preser...
Daniel Drucker
@danieljdrucker.bsky.social

Studies of mouse adipose tissue biology continue to underpin the enthusiastic pursuit of new targets to enhance thermogenesis in humans www.nature.com/articles/s41...

nature.comInhibition of adipocyte RUNX1/2 enhances adipose tissue thermogenesis through distinct mechanisms - Nature CommunicationsThermogenic adipocytes are a potential therapy to combat obesity, although the process underlying their activation remains unclear. Here, the authors use epigenetic profiling to demonstrate RUNX1 and ...
Daniel Drucker
@danieljdrucker.bsky.social

The epidemiology of GLP-1 medicines-suggestive protective associations with reduced rates of respiratory diseases and serious infections require further confirmation jamanetwork.com/journals/jam...

jamanetwork.comGLP-1 Receptor Agonists and Noncardiometabolic OutcomesThis meta-analysis evaluates the reported outcomes of glucagon-like peptide-1 (GLP-1) receptor agonists beyond glycemic control, weight management, and cardiorenal protection and assesses the credibil...
Daniel Drucker
@danieljdrucker.bsky.social

Preclinical studies define potential strategies against hepatic insulin resistance by targeting sulfenylated or ‘oxidatively activated’ p-GSK-3β. www.nature.com/articles/s42...

nature.comRevitalizing p-GSK-3β via cysteine sulfenylation promotes hepatic insulin resistance by differentially regulating glycogenesis and gluconeogenesis - Nature MetabolismROS-mediated sulfenylation or ‘oxidative activation’ of p-GSK-3β can terminate glycogenesis and initiate gluconeogenesis by modulating Gys2 and FoxO1, leading to hepatic insulin resistance.
Daniel Drucker
@danieljdrucker.bsky.social

Prespecified analyses reveal semaglutide reduced MACE in patients at risk for substantial liver fibrosis, in the overall SELECT population www.nature.com/articles/s41...

nature.comSemaglutide on liver fibrosis and heart outcomes in patients at high risk of liver fibrosis: a prespecified analysis of the SELECT randomized trial - Nature MedicineA prespecified analysis from the SELECT trial showed that semaglutide reduces major adverse cardiovascular events by 20% compared with placebo, particularly in patients at high risk of fibrosis, as in...