Daniel Krüger

Daniel Krüger

@danielkrueger.bsky.social

Researcher in the Netherlands. Postdoc with Hans Clevers. Organoid models. Sozi aus Deutschland.

214 followers213 following12 posts

Daniel Krüger
@danielkrueger.bsky.social

Great to see our conclusions align with the beautiful work from @marija-matejcic.bsky.social in the Trepat lab 3D force mapping, Ca²⁺-triggered myosin-IIA meshwork dissolution, and neighbour lamellipodia generating traction. Great synergy, highlighting the role of tension in extrusion regulation.

Levayer Lab@levayerr.bsky.social

www.biorxiv.org/content/10.1...

biorxiv.orgMechanical Coordination of Intestinal Cell Extrusion by Supracellular 3D Force PatternsEvery day, the mammalian intestinal epithelium extrudes millions of cells to sustain tissue self-renewal. Despite its fundamental role in intestinal homeostasis, the mechanisms that trigger, compartme...
Daniel Krüger
@danielkrueger.bsky.social

Thanks for highlighting this! My background in fly morphogenesis shaped how I think about tissue forces, their interplay with signaling, and experimental design. An experience I’d wholeheartedly recommend — Drosophila remains a rich source of inspiration, continuing to reveal fundamental concepts.

Levayer Lab@levayerr.bsky.social

I may have a biased interpretation here, but I suspect the background of @danielkrueger.bsky.social in fly morphogenesis brought a lot here (congrat for the impressive work !) , a good example of virtuous background mixing and work built on important conceptual/technical premise from model organism

Daniel Krüger
@danielkrueger.bsky.social

👉 Check out our key findings in this detailed thread by Hans Clevers.

Hans Clevers@hansclevers.bsky.social

1/11 In @science.org: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. www.science.org/doi/10.1126/...

science.orgEpithelial tension controls intestinal cell extrusionCell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...
Daniel Krüger
@danielkrueger.bsky.social

The gut constantly renews itself. Cells keep the tissue under tension, engaging in a tug-of-war. Weaker cells that can’t counter their neighbours’ pull extrude. This maintains mechanical homeostasis, ensuring stability and protecting the intestinal barrier.

Daniel Krüger reposted

Vlad Bondarenko
@vladbndk.bsky.social

📣 It is my pleasure to announce our recent review with Margherita on the current approaches, challenges, and perspectives in studying human maternal-fetal interface using in vitro models www.cell.com/cell-stem-ce... 🚀✨️

cell.comModeling the human maternal-fetal interfaceThis review explores the advances in stem cell and organoid models of the endometrium, placenta, and embryo, outlining challenges in integrating them to capture spatiotemporal dynamics and functional ...
FMI science@fmiscience.bsky.social

In a Review just published in @cp-cellstemcell.bsky.social, @vladbndk.bsky.social and Margherita Turco explore how stem cell and organoid models can be used and combined to better study the maternal–fetal interface. A 🧵

Daniel Krüger reposted

Henning Falk Illustrations
@falk-illustrations.de

First time that my cartoons are printed on postcards! Have a look 👇

NFDI4BIOIMAGE@nfdi4bioimage.bsky.social

Oh yes, we did! Here are our new postcards - educational outreach material that pinpoints challenges in bioimaging #RDM complexity. Turn them around to find out about solutions and support! And all illustrations are free for reuse (CC-BY). doi.org/10.5281/zeno... Many thanks to Henning Falk!

Daniel Krüger reposted

Hans Clevers
@hansclevers.bsky.social

Exciting study by Amanda Andersson Rolf et al: In vitro expansion of a human fetal #pancreas #stemcell that generates all three pancreatic cell lineages”. www.cell.com/cell/fulltex... New #organoid protocol allows the seemingly indefinite expansion of human fetal pancreatic Lgr5+ stem cell 1/

cell.comLong-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineagesIdentification of an LGR5 as a marker for a tripotent stem/progenitor cell of the human fetal pancreas. Organoids derived from single LGR5+ cells are capable of long-term expansion in vitro and genera...

Daniel Krüger reposted

Annette Dittert
@annettedittert.bsky.social

"The state of German-Polish relations is a European tragedy in the same way that the Warschauer Kniefall was a moment of European reconciliation." Brilliant analysis by @JeremyCliffe and also an important read before the Polish elections this weekend. There is so much at stake.

newstatesman.comEurope’s east-west divide is wideningRelations between Germany and Poland define the continent. But, ahead of the latter’s election this weekend, they are in crisis and getting worse.

Daniel Krüger reposted

Akrotelm 🌾
@akrotelm.bsky.social

Anhören! Wie sich große branchenfremde Investoren (ALDI, Immobilien etc) riesengroße Ackerflächen 🚜 in Ostdeutschland kaufen. Am Staat vorbei, ohne Steuern zu zahlen, mit dem Segen des Bauernverbandes und zum Schaden der kleinen Landwirtschaftsbetriebe. 👇

share.deutschlandradio.deWarum Investoren immer mehr Ackerland kaufenÜberregionale Investoren kaufen immer mehr Ackerland in Sachsen-Anhalt auf, die Preise sind stark gestiegen. Seit der Energiewende gibt es noch mehr Konkurrenz.

Daniel Krüger reposted

Markus Winkler
@markuswinkler.bsky.social

Jugendarbeitslosigkeit in der EU, August 2023: 🇪🇸26.8% 🇪🇪23.5% 🇬🇷22.5% 🇷🇴22.3% 🇮🇹22.0% 🇸🇪21.1% 🇵🇹20.3% 🇭🇷20.0% 🇸🇰19.8% 🇱🇺19.2% 🇨🇾16.3% 🇫🇮16.1% 🇫🇷16.0% 🇧🇪14.2% 🇪🇺14.0% 🇭🇺12.8% 🇧🇬11.8% 🇩🇰11.6% 🇦🇹11.4% 🇮🇪11.2% 🇵🇱11.1% 🇸🇮10.4% 🇱🇻9.0% 🇲🇹9.0% 🇳🇱8.7% 🇱🇹8.6% 🇨🇿8.5% 🇩🇪5.7% via: ec.europa.eu/eurostat/doc...

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