David Jones

So much of Behavioral Neurology’s knowledge can be visualized through a data-driven, self-assembled graph of FDG-PET metabolic patterns across neurodegenerative and non-degenerative clinical diagnoses. 📊✨ #Neurology #FDGPET #BrainImaging #DataScience #Neurodegeneration #endalz

Exciting update! You can run Image Based Meta-Analyses (IBMA) on our platform 🚀 We've known for ~TWO decades that images are better than coordinates, but data has never been shared/organized properly to make that an accessible reality. We did it, enjoy: compose.neurosynth.org

How many have untreated NPH? What percentage would that answer need to be in order to use resources for proper diagnostics?

Dementia impacts cognition and individual’s conscious experience and FDG-PET best indexes these disturbances across all dementia etiologies in routine clinical settings. The Global Functional State Space is a useful model of this. These results in perturbation of consciousness reflect this as well.

🧠 New paper out in 𝘉𝘳𝘢𝘪𝘯 Why does tau pathology often begin in the entorhinal cortex in Alzheimer’s disease? We show that brain-wide gradients of neuronal activity and amyloid-β may make this region particularly vulnerable to tau pathology. academic.oup.com/brain/articl...

New results! The prefrontal cortex uses a compact, low-dimensional “coding space”. Information can be captured in just 3–6 dimensions. The brain compresses what we remember. Low-dimensional prefrontal representations of objects during working memory doi.org/10.64898/202... #neuroscience

How does the brain rapidly distinguish similar memories? We use 7T fMRI to show dynamic shifts between pattern separation and reinstatement signals in hippocampal CA3 and DG with changing task demands: doi.org/10.64898/202...

Using a detection task with stimuli right at threshold, whole cell recordings in NHP primary visual cortex, and choice probabilities, we demonstrate how internal fluctuations related to anticipation of a stimulus multiplicatively interact with sensory responses.

Every brain tells a story. We need to listen better! #FDG-PET

What would a degenerative disease of this process look like in human beings?

Interesting! What about the reverse? If you damage oligodendrocytes, do you damage CA1 electrophysiology?

Every brain tells a story. We need to listen better! #FDG-PET

Cortical oscillations reflect opponent ensemble dynamics through coordinated multifrequency activity https://www.biorxiv.org/content/10.64898/2026.02.20.707132v1

Beyond metaphor: quantitative reconstruction of Waddington's landscape and exploration of cellular behavior academic.oup.com/bib/article/... - really nice review of how big data and new computational methods and reviving an old conceptual framework

🚨PREPRINT In our new paper, we link RNNs and neural manifolds by introducing the DDM framework. We can train networks to embed an arbitary dynamical system in a latent subspace. We illustrate this with simple models of input-driven and autonomous associative memory. Enjoy! arxiv.org/abs/2602.14885

Our paper is out in @natneuro.nature.com! www.nature.com/articles/s41... We develop a geometric theory of how neural populations support generalization across many tasks. @zuckermanbrain.bsky.social @flatironinstitute.org @kempnerinstitute.bsky.social 1/14

Here are individual FDG-PET brain scans from 4 patients with dysexecutive Alzheimer’s disease displayed in StateViewer. Does this look variation along the principal gradient of functional connectivity? Is this biology contributing to your model of Alzheimer’s disease?

Most people can call up pictures in their minds, visualizing the past & summoning images of the future. But for ~4% of us, such mental imagery is weak or absent. New edition of @nature.com has a nice introduction to how research on this phenomenon (aphantasia) opens up novel windows into the brain.🧪

Fascinating neuropsych article from 1919 of a patient with spatial disorientation, with a loss of mental imagery for routes: watermark02.silverchair.com/archneurpsyc...

Bruce Springsteen released a pointedly emotional protest song Wednesday, amid widespread outrage over sweeping immigration raids that have led to violence and fatal shootings at the hands of federal agents.

Block that acetylcholine and just doesn't feel worth it any more... Cholinergic modulation of dopamine release drives effortful behaviour www.nature.com/articles/s41...

The hippocampal map has its own attentional control signal! Our new study reveals that theta #sweeps can be instantly biased towards behaviourally relevant locations. See 📹 in post 4/6 and preprint here 👉 www.biorxiv.org/content/10.6... 🧵(1/6)

While AI systems have advanced tremendously, they still lag behind real brains in reliability & efficiency. A new computational unit developed at #FlatironCCN could help close that gap: https://www.simonsfoundation.org/biological-brains-inspire-a-new-building-block-for-artificial-neural-networks

Seems fitting to use #GenAI to help explain our new model of dementia and the hippocampus as a latent diffusion engine! Here is NotebookLM generated podcast on these topics: open.substack.com/pub/consilie...

People have been looking at "AI & brains" through the lens of LLMs/transformers. But what latent diffusion? (think text-to-image/video platforms such as Midjourney). **Class conditioned latent diffusion and semantically cued hippocampus share a remarkably similar computational architecture...**

It bears repeating today: real patriots do not murder people. #RIPAlexPretti

Does this look like a reductionist bias? #endalz

Pretty amazing to give this lecture here! Thank you University of Iowa Department of Neurology!

Excited to head out to Iowa City @universityofiowa.bsky.social for the Baden Lecture Neurology Grand Rounds on 01/06/26: "Dementia as a Disorder of Generative Human Intelligence" #endalz #neuro #AI @mayoclinic.org

As we are having a discussion on neural codes: @earlkmiller.bsky.social is entirely right that the "only spike rates matter" idea that is so prominent in neuroscience has no credible evidence. We simply do not currently know how neurons code relevant information. Oscillations are likely part of it.

www.nature.com/articles/s44...

Listen to "AI Precision and Breakthrough in Diagnosing Dementia Types" by Boomers Today via #spreaker www.spreaker.com/episode/ai-p...

NPH is real, it’s common, and it’s treatable! #NPH #endalz www.nejm.org/doi/full/10....

NPH is common and reversible cause of dementia symptoms. It’s obviously cost effective for health systems to prioritize proper diagnosis and treatment of all patients presenting with cognitive decline. doi.org/10.1212/WN9....

This was so much fun to do with @renegadesynapse.bsky.social #neurology @greenjournal.bsky.social #endalz #fdgforall youtu.be/GTOzwUALePM

Electromagnetic waves enable low-energy, parallel computation. Your brain has them. If humans can figure this out, 4 billion years of evolution could too. Programmable wave-based analog computing machine: a metastructure that designs metastructures www.nature.com/articles/s41... #neuroscience

www.govtech.com/artificial-i...

🚨Pre-print alert🚨 We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭 How is this possible? Strap in! (1/9) 👇🧵 doi.org/10.1101/2025...