Deng Pan

Deng Pan

@dengpan.bsky.social

DPhil(PhD) candidate @ox.ac.uk, @oxexppsy.bsky.social studying #CognitiveNeuroscience | B.S. from @pku1898.bsky.social. Website: https://www.psy.ox.ac.uk/people/deng-pan Twitter: https://x.com/DengPan18

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🚨We believe this is a major step forward in how we study hippocampus function in healthy humans. Using novel behavioral tasks, fMRI, RL & RNN modeling, and transcranial ultrasound stimulation (TUS), we demonstrate the causal role of hippocampus in relational structure learning.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social

Causal necessity of human hippocampus for structure-based inference in learning https://www.biorxiv.org/content/10.1101/2025.08.19.664920v1

Deng Pan reposted

New perspective paper from our lab: “The hippocampus as a generative model” out now !! royalsocietypublishing.org/rstb/article... The traditional view of the hippocampus is that it creates a cognitive map. Here we extend this view to conceptualise the hippocampus as a “generative model”.

royalsocietypublishing.orgThe hippocampus as a generative modelAbstract. A generative model can be defined as a model of the latent causes of sensory input that can be used to generate new data samples. By examining em

Deng Pan reposted

My undergraduate thesis, "Distinct patterns of social contagion under risk and ambiguity", is now published online at @commspsychol.nature.com Deeply grateful for the guidance and constant support of Dr. Qingtian Mi, Prof. Jian Li, and Prof. Lusha Zhu.

Communications Psychology@commspsychol.nature.com

Two experiments show that observing others shifts both risk and ambiguity preferences. Risk contagion is asymmetric, with stronger alignment toward risk-averse others, whereas ambiguity contagion is more symmetric. www.nature.com/articles/s44... @dengpan.bsky.social @qingtianmi.bsky.social

My undergraduate thesis, "Distinct patterns of social contagion under risk and ambiguity", is now published online at @commspsychol.nature.com Deeply grateful for the guidance and constant support of Dr. Qingtian Mi, Prof. Jian Li, and Prof. Lusha Zhu.

Communications Psychology@commspsychol.nature.com

Two experiments show that observing others shifts both risk and ambiguity preferences. Risk contagion is asymmetric, with stronger alignment toward risk-averse others, whereas ambiguity contagion is more symmetric. www.nature.com/articles/s44... @dengpan.bsky.social @qingtianmi.bsky.social

Deng Pan reposted

Oops, wrong time in the original post! It will be 15:30 CET 😉

CMC Unit@cmc-unit.bsky.social

In our Learning Club @cmc-lab.bsky.social today (Sep 25, Thu, 2pm CET), @dengpan.bsky.social will tell us about his recent paper (👇) [joint work w/ Rushworth lab]. Want to attend, send an empty email to virtual-talk-link-request@cmclab.org to get the link!

Deng Pan reposted

Might focused ultrasound one day replace DBS? UK Scientists built a 256-panel focused ultrasound helmet that can precisely target deep brain regions. Using theta-burst TUS, they stimulated the LGN and found visual cortex activity with effects lasting up to 40 minutes. #neuroskyence #ultrasound

nature.comUltrasound system for precise neuromodulation of human deep brain circuits - Nature CommunicationsModulating deep brain structure can lead to therapies for neurological conditions. Here, the authors show a transcranial ultrasound stimulation (TUS) system featuring a 256-element helmet-shaped trans...

Deng Pan reposted

📢 We're hiring a Research Assistant in cognitive neuroscience & computational psychiatry! 📢 Join us at UCL to conduct an MEG study of reward & memory, exploring how brain signals link to variability in apathy and anhedonia. 🔗 apply from next week: lmdlab.github.io 🚨closes September 12th!

Deng Pan reposted

Some scientists haven't yet internalized the "why" behind science writing for the public - not just as a service, but for themselves. (I didn't always get it). In this piece for @natrevneuro.nature.com, I draw on the neuroscience of curiosity & decision making to unpack its value. rdcu.be/eCGr7

rdcu.beThe unexpected value of communicating science to the publicNature Reviews Neuroscience - As a group, our scientific community has a responsibility to unpack the ‘what’ and ‘why’ behind our work for the public, not least because much...

Also check out the TUS study from @mkflugge.bsky.social lab! Hope TUS opens up a new avenue for exploring deep brain functions in healthy humans!

Miriam Klein-Flügge 🧠@mkflugge.bsky.social

We are super excited about the first human transcranial ultrasound study from our lab which is now on BiorXiv, showing the amygdala‘s role in processing ambiguous emotions and showing TUS changed resting-state connectivity and metabolite concentrations (GABA) in the amygdala - a huge team effort! 🥳🙏🏼

🚨We believe this is a major step forward in how we study hippocampus function in healthy humans. Using novel behavioral tasks, fMRI, RL & RNN modeling, and transcranial ultrasound stimulation (TUS), we demonstrate the causal role of hippocampus in relational structure learning.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social

Causal necessity of human hippocampus for structure-based inference in learning https://www.biorxiv.org/content/10.1101/2025.08.19.664920v1

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🚨We believe this is a major step forward in how we study hippocampus function in healthy humans. Using novel behavioral tasks, fMRI, RL & RNN modeling, and transcranial ultrasound stimulation (TUS), we demonstrate the causal role of hippocampus in relational structure learning.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social

Causal necessity of human hippocampus for structure-based inference in learning https://www.biorxiv.org/content/10.1101/2025.08.19.664920v1

View full thread

🚨We believe this is a major step forward in how we study hippocampus function in healthy humans. Using novel behavioral tasks, fMRI, RL & RNN modeling, and transcranial ultrasound stimulation (TUS), we demonstrate the causal role of hippocampus in relational structure learning.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social

Causal necessity of human hippocampus for structure-based inference in learning https://www.biorxiv.org/content/10.1101/2025.08.19.664920v1

View full thread

5. 🌟Empirical evidence: Using TUS to temporarily modulate hippocampal activity in healthy humans, we primarily disrupted their ability to use relational knowledge for inference, confirming its causal necessity for relational structure learning.

6. 🚀 This is enabled by transcranial ultrasound stimulation (TUS)—a safe, reversible, precise method to non-invasively probe deep brain function, which finally makes the hippocampus accessible in healthy humans. Here is me being stimulated to test the TUS effect myself.

🚨We believe this is a major step forward in how we study hippocampus function in healthy humans. Using novel behavioral tasks, fMRI, RL & RNN modeling, and transcranial ultrasound stimulation (TUS), we demonstrate the causal role of hippocampus in relational structure learning.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social

Causal necessity of human hippocampus for structure-based inference in learning https://www.biorxiv.org/content/10.1101/2025.08.19.664920v1

View full thread

3. 🧠 Neural basis: using fMRI, we show that such relational knowledge is consistently represented in the hippocampus across diverse contexts, in a manner distinct from other brain regions. Next, we asked: Is this representation causally necessary for structure-based inference?

4. ⏩Computational predictions: An RNN trained on our task developed hippocampus-like units encoding relational structure. Lesioning these units selectively disrupted inference — predicting the hippocampus’s causal role.

🚨We believe this is a major step forward in how we study hippocampus function in healthy humans. Using novel behavioral tasks, fMRI, RL & RNN modeling, and transcranial ultrasound stimulation (TUS), we demonstrate the causal role of hippocampus in relational structure learning.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social

Causal necessity of human hippocampus for structure-based inference in learning https://www.biorxiv.org/content/10.1101/2025.08.19.664920v1

1. 👥 When meeting new people, we don’t learn about them from scratch — in our “Goalkeeper Game”, participants showed structure-based inference by leveraging relational knowledge to rapidly learn new relationships in changing environments.

Deng Pan reposted

📢 Job announcement: Two (!) 3-year postdoc jobs in our lab at UCL 📢 🧠💫🔊 We are looking for postdocs interested in the abstract mechanisms underlying social cognition. Modelling, fMRI and non-invasive ultrasound, a new deep-brain stimulation method. Please RT www.ucl.ac.uk/work-at-ucl/...

ucl.ac.ukUCL – University College LondonUCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

Deng Pan reposted

Thrilled to see our TinyRNN paper in @nature! We show how tiny RNNs predict choices of individual subjects accurately while staying fully interpretable. This approach can transform how we model cognitive processes in both healthy and disordered decisions. doi.org/10.1038/s415...

doi.orgDiscovering cognitive strategies with tiny recurrent neural networks - NatureModelling biological decision-making with tiny recurrent neural networks enables more accurate predictions of animal choices than classical cognitive models and offers insights into the underlying cog...

Deng Pan reposted

Our study using layer fMRI to study the direction of communication between the hippocampus and cortex during perceptual predictions is finally out in Science Advances! Predicted-but-omitted shapes are represented in CA2/3 and correlate specifically with deep layers of PHC, suggesting feedback. 🧠🟦

science.orgCommunication of perceptual predictions from the hippocampus to the deep layers of the parahippocampal cortexHigh-resolution neuroimaging reveals stimulus-specific predictions sent from hippocampus to the neocortex during perception.

Deng Pan reposted

Deng Pan reposted

Deng Pan reposted

Deng Pan reposted

👨‍🎤COSMOS strikes back🌠! This time in Tokyo 🇯🇵 with a fantastic new program designed to teach computational modeling of social phenomena. As always, it's free to attend & we will offer travel stipends to ensure diverse attendance. For details visit 👉 cosmossummerschool.github.io/application/ pls share🙏

Wataru Toyokawa@watarutoyokawa.bsky.social

🚀COSMOS is BACK!!!💫 The Computational School on Modeling Social and collective behavior (COSMOS) will take place in RIKEN, Tokyo, between 29 Sept - 3 Oct, organised by me and fantastic @thecharleywu.bsky.social ! Application deadline: 25th April. For more details see 👉️ cosmossummerschool.github.io

Deng Pan reposted

New paper from our lab now in @nature.com . We show that our brains use basis functions or "building blocks" to navigate social interactions. Rather than tracking every individual separately, social information is compressed into patterns that can be flexibly combined. www.nature.com/articles/s41...

nature.comBasis functions for complex social decisions in dorsomedial frontal cortex - NatureA study combining group decision-making tasks with fMRI shows that the brain’s dorsomedial prefrontal cortex uses basis functions, similar to those in the visual, motor and spatial domains, to re...

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