FXR proteins and BICD2 cooperate to promote dynein-mediated RNP transport and stress granule assembly https://www.biorxiv.org/content/10.64898/2026.09.25.754448v1
Ready to take the next step in your research career?
The LMB is now accepting applications for PhD placements starting in October 2027.
Deadline: 08 December 2026 (allow time for reference submission).
Discover what we offer here: https://mrclmb.ac.uk/careers-and-people/phd-students/
Deeply honored to be elected as an EMBO member. This would not have been possible without the incredible past and present members of my lab - thank you for your dedication, creativity and total lack of fear over the years π¬πͺ°π§ͺ
Congratulations to LMB Group Leaders Emmanuel Derivery, Kelly Nguyen and Julian Sale, who have all been elected members of @EMBO.org!
Read more about their research at the LMB here: mrclmb.ac.uk/news-events/...#LMBNews@deriverylab.bsky.social@kellythd-nguyen.bsky.social@juliansalelab.bsky.social
It was an honor to introduce @alisonkickuth.bsky.social during the Otto Hahn medal ceremony from the @maxplanck.de in recognition for her amazing PhD, where she discovered a new mechanism for unilateral cytokinesis (www.nature.com/articles/s41...)
It was an absolute honour to win the #BSCB poster prize at #DynamicCellVI ! Its my first ever dynamic cell and I already can't wait for the next one!
Make sure to come to our other talk today on using this tech to study endosomal dynamics?
Delighted to announce the posting of our latest preprint, which links stress-induced relocalisation of multiple organelles by dynein to adaptive changes in gene expression in the nucleus (1/n) π§΅
www.biorxiv.org/content/10.6...
π¨π¨π¨Check out this new preprint from the LΓΆwe lab proposing that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis! Happy to have had a little contribution by showing that Asgard tubulin displays a key hallmark of eukaryotic tubulins: dynamic instability! π¨π¨π¨
Our latest preprint: Together with the team of Jan LΓΆwe, @danieltamarit.bsky.social and many others we discovered and characterized several Asgard tubulin genes and propose that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis
www.biorxiv.org/content/10.6...
Steven has joined us as an RA to assist in the design, production and characterization of a panel of binders to be used as biosensors to image sorting of endogenous cargos in cells using multispectral microscopy, or as modulators of activities of sorting machineries!
Welcome to the lab, Steven!
Thereβs just ONE WEEK left to apply to join our amazing PhD programme next year!
Visit our website for more information: www2.mrc-lmb.cam.ac.uk/students/int...
Applications close on 2nd DEC 2025
We present a simple method to easily increase the imageable depth of an expansion microscopy gel on a typical inverted microscope ten-fold, using some carefully placed FEP film and a water dipping objective lens:
The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41...
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
π¨Publication alertπ¨
My first, first-author paper is now out in @natphoton.nature.com! Our paper describes an iterative spectral unmixing algorithm and eight-channel camera-based hardware we developed enabling unmixing of low SNR live-cell data at video rates. www.nature.com/articles/s41...
π¨ JOB ALERT π¨
We're hiring a Research Assistant β no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired π§«π¬
Apply now π www.nature.com/naturecareer...#STEMCareers#ResearchJobs
Are you an undergraduate student considering a career in academic research?
Donβt miss the opportunity to gain hands-on experience at the LMB with our Student Placement Scheme β open now for applications!
Apply by 30th March.
More info: www2.mrc-lmb.cam.ac.uk/students/stu...
Congratulations to @lara-kruger.bsky.social, postdoc in @deriverylab.bsky.social in @cellbiol-mrclmb.bsky.social, who is leaving the LMB to establish her own research group at @institutcurie.bsky.social in Paris!
Best of luck to you Lara!
#LMBAlumni
Our automatic parameter-free deconvolution code is now 2β3Γ faster while still producing exactly the same results as before. If you want to try it out, we have a Google Notebook implementation available at beryl.mrc-lmb.cam.ac.uk/rlgc_notebook/. Manuscript WIP.
Congrats to @juliemiesch.bsky.social who was awarded a Postdoc Mobility grant by @snf-ch.bsky.social to support her research for two years. Her postdoc research will focus on the biophysical regulation of water buffering in the cell.
How does tRNA-modifier #Elongator stabilize microtubules during asymmetric cell division?
Vicente Planelles Herrero @deriverylab.bsky.social et al find subcomplexes binding to microtubule ends & tubulin dimers, & enriching microtubules with polyglutamylated tubulin
www.embopress.org/doi/full/10....
π¨ Paper Alert π¨
Our preprint describing Elongator as a selective microtubule polymerase that rewrites PTMs on microtubules is now published! Check it out: www.embopress.org/doi/full/10....
In the original draft, we showed that Elongator binds to microtubules irrespective of their PTMs, but selectively elongates them using polyglutamylated tubulin subunits. As a result, Elongator rewrites the tubulin code of dynamic microtubules. How cool is that?
During revisions, we've added lots of exciting new data, so be sure to check out the paper! Most importantly, we now demonstrate that Elongator regulates polyglutamylation levels of spindle microtubules, both in cells and in vivo.
Congrats to @akaashkumar.bsky.social , a postdoc in the lab, for winning the PhD Award from the Cambridge Centre for Physical Biology. His PhD research worked on the development of a multispectral imaging system to image up to 8 fluorophores similtaneously for tackling complex biological questions!
An overview of Akaash's multispectral camera tree can be seen in the graphical abstract (which you can read more about here: www.physbiol.cam.ac.uk/prizes ). Peek at some colourful cells!
Catching the blue-world up with the last 6 months of Derivery group shenanigans:
First up: in April Manu was the recipient of the 2024 Hooke Medal from BSCB!
Then, only last week, post-doc @vicenteph.bsky.social was promoted to Senior Investigator Scientist and will remain in the group to develop new methods in protein design, in vitro reconstitutions, multispectral imaging assays and his work on Elongator!
Catching the blue-world up with the last 6 months of Derivery group shenanigans:
First up: in April Manu was the recipient of the 2024 Hooke Medal from BSCB!
Then, in September @akaashkumar.bsky.social passed his PhD viva, becoming the latest doctor to emerge from the lab! He then won the RMS Early Career Award 2024 in October.
Later in October, the LMB had their yearly annual symposium with Post-doc Lara Kruger winning the Steitz Prize for her talk and @akaashkumar.bsky.social winning the Perutz Prize for his PhD work!
Catching the blue-world up with the last 6 months of Derivery group shenanigans:
First up: in April Manu was the recipient of the 2024 Hooke Medal from BSCB!