Yao D Cai

Yao D Cai

@drummonk.bsky.social

Biologist, Drummer

19 followers24 following10 posts

Yao D Cai reposted

Joanna Chiu
@joanna-chiu.bsky.social

@drummonk.bsky.social and I wrote a @plosbiology.org Primer to highlight a fantastic study by Aalim Weljie’s and Amita Sehgal’s groups that reveals time-of-day dependent activities of glucose metabolic pathways. journals.plos.org/plosbiology/...

journals.plos.orgCircadian clock gates diurnal glucose utilizationThe circadian clock and cellular metabolism are tightly coupled. This primer discusses a recent PLOS study that elucidates how glucose metabolism changes over the course of the day in Drosophila and h...
PLOS Biology@plosbiology.org

How do #circadian clocks regulate glucose processing? By integrating human metabolite profiling with isotope-tracing in #Drosophila, this study defines daily rhythms in #glucose utilization that are influenced by circadian timing @plosbiology.org 🧪 plos.io/3Olm1M1

Yao D Cai
@drummonk.bsky.social

Adaptation to daily environmental changes shaped self-sustained circadian oscillators. We wrote a dispatch on Current Biology to highlight the new papers from Carl Johnson and Michael Rust group. They found seasonal environmental changes select for self-sustained oscillators. Read their works!!

Joanna Chiu@joanna-chiu.bsky.social

Self-sustained Circadian Oscillators Confer Enhanced Fitness Under Changing Photoperiods ☀️ @currentbiology.bsky.social @drummonk.bsky.social and I wrote a dispatch on fascinating back to back pubs from the labs of Carl Johnson and Michael Rust. www.sciencedirect.com/science/arti...

sciencedirect.comBiological timing: Changing photoperiods select for self-sustaining clocksSelf-sustained oscillation under constant conditions is a fundamental property of circadian clocks found in all domains of life, despite the rarity of…

Yao D Cai reposted

Sergio Hidalgo Sotelo
@sergiohidalgo.bsky.social

Thrilled to share our new work! In this study, we have expanded on the role of the circadian clock in integrating seasonal environmental cues through splicing. Thanks to @joanna-chiu.bsky.social for the continuous mentorship and to all co-authors! www.biorxiv.org/content/10.1...

biorxiv.orgSplicing of a core clock gene regulates seasonal adaptations by a winter gating mechanismSeasons bring changes to the environment. Many organisms adjust their physiology and behavior in response to seasonal changes in order to survive. Although the molecular mechanisms mediating the integ...
Yao D Cai
@drummonk.bsky.social

We started out asking how mealtime regulates genome-wide rhythmic gene expression. We knew several nutrient-sensitive pathways are involved. We knew O-GlcNAcylation, a nutrient-sensitive protein modification, modulates CLOCK, BMAL1 and PER2.

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