Daniel Keedy

The Keedy Lab at the CUNY ASRC in NYC is looking for a postdoc! Our lab uses avant-garde structural biology experiments and computational analyses to reveal conformational ensembles that underlie biological function. See attached flyer and keedylab.org. Come join us! Please share!

More evidence that the @asrc-gc.bsky.social is a special place! I’m happy to play a small part in this bigger picture.

It was a true pleasure to catch up multiple eras of RLabbers at "Richardson Fest" this weekend! 20+ of us spoke about the impact Dave & Jane had on us. They are titans of the field of structural biology -- yet intimately focused on the small things in life... Wonderful people all-around!

Pleased to report my lab's new NSF CAREER award to dissect how motions underlie function in natural vs. designed proteins: www.nsf.gov/awardsearch/... I do not take this federal support of our science lightly! @asrc-gc.bsky.social @ccnyscience.bsky.social @cuny.edu = excellent place for this work.

Julia Zhang & I just wrote our lab's second @prereview.bsky.social "pre-review"! It covers a really impressive preprint by Anum Glasgow & crew, just a few blocks north of us. We forgot to use the phrase "tour de force" but that feels applicable. Here's the link: prereview.org/reviews/1971...

Jane Richardson was born #OTD in 1941 + Developed the Richardson (ribbon) diagram to represent proteins' 3D structure (becoming a standard representation for protein structures) + MacArthur Fellow, 1985 + Elected, Nat'l Academy of Sciences, 1991 + President, Biophysical Society, 2012 #WomenInSTEM

New preprint! Entropy drives molecular recognition, yet most structure-based drug design ignores it because it is difficult to measure. X-ray crystallography captures ensembles, not single structures. Can we extract thermodynamically meaningful entropy from them? www.biorxiv.org/content/10.1...

Props to my colleague here at the @asrc-gc.bsky.social , @fravallese.bsky.social , for this wonderful piece about the uniquely strong structural biology community here in NYC. I often feel lucky to be here. Let's keep up the good vibes and forward momentum -- exciting times for struct bio!

I'm pleased to report that my job title has changed! (Except for the 1st 3 letters of the 1st word & the entire 2nd word... 😉) keedylab.org/members/ Grateful that I get to do fun science & train young scientists in an inspiring environment here at @asrc-gc.bsky.social & @ccnyscience.bsky.social!

Summer 2025 #keedylab news round-up: come read about what we did on our summer vacation! keedylab.org/news/ Associated with this website update, I also embedded the lab's Bluesky feed on the website's news page -- thus creating an infinite cycle of delightful lab news links 🔁 💯

We wrote a review article about dynamics, allostery, and function in the PTP enzyme family! Covers experimental and computational approaches, regulatory domains & mechanisms, mutations, ligands, etc. Was hard to fit in ~all the cool advances in recent years!... pmc.ncbi.nlm.nih.gov/articles/PMC...

Gift link www.nytimes.com/2025/07/22/s...

Happy to say our recent @biorxiv-biophys.bsky.social preprint about 3 unexpected structures of STEP, in its new & improved form, is now published at Proteins! pubmed.ncbi.nlm.nih.gov/40616465/ & doi.org/10.1002/prot...

250 years ago, Americans rejected the rule of a mad king. In two days, we’re taking to the streets again to say NO KINGS. 2,000 peaceful protests are planned in small towns and major cities across the country. Join your community on Saturday for #NoKings Day: www.nokings.org?SQF_SOURCE=i...

We are looking to hire (yes, even in this economy!) a jr. specialist to train in protein prep/structural biology related to our AVOID-ome work as part of openadmet.org. A great position for someone who is looking to be a tech for a few years before grad or med school. aprecruit.ucsf.edu/JPF05424

The third episode of The Tortured Proteins Department is out now! We chatted about grant cancellations, exciting regional meetings and reunions, two fun new preprints, community norms around code release, and the importance of giving kudos. @fraserlab.com

Definitely worth a read and a share...

We're hiring for three positions: Asst./Assoc./Prof. of Neuroscience: bit.ly/43ScWzE Research Associate in the MRI Facility: bit.ly/3Ey1ONY Asst./Assoc./Prof. of Photonics: bit.ly/4ijNVkh

Nothing else to say.

Roses are red Violets are blue If you fall in love with your hypothesis You’ll be biased to prove it true 🧪

Are you interested in understanding how the wiggles & jiggles of proteins impact the thermodynamics of ligand binding or catalysis? Well, you are in luck! We are searching for a postdoc to explore these concepts. More details: www.vanderbilt.edu/postdoc/pros... or email stephanie@wankowiczlab.com

"Being a first-generation college student, I’m excited by the idea of training & mentoring other first-generation students & taking on this important responsibility." —Prof. Francesca Vallese. Get to know SBI's new member & her critical area of research. bit.ly/3UYHKcN @thegraduatecenter.bsky.social

Check out our lab's first pub since the great X->Bsky exodus! We used crystallography under different conditions to map new conformational & chemical features of an atypical phosphatase enzyme. Fantastic work by Liliana, Ali, and Blake as well as collabs near (Bishop) & far (Tautz)!

I'm excited to share our lab's latest @biorxiv-biophys.bsky.social preprint: www.biorxiv.org/content/10.1... This was a really rewarding collaboration between many folks here at the CUNY ASRC and the Farooqi lab at Cambridge, bridging the human genetics of obesity and some cool molecular biophysics!

We were incredibly disappointed with the lack of code or executable accompanying the publication of AF3 in @Nature . This contradicts scientific principles of the ability to evaluate, use, and build upon existing work. zenodo.org/records/1117.... Sign to endorse: docs.google.com/forms/d/e/1F...

Earthquake just now in upper Manhattan... Biggest I've ever felt (and I lived in the Bay Area for 5 years)... Reports of the same thing simultaneously in Queens... Everyone here is safe!...

Got back last night from a great visit to Baylor Chemistry & Biochemistry! Thanks to Jonathan Clinger for inviting + hosting -- and was nice to meet @trakselis.bsky.social (& many others not on Bsky)!

Just returned from a wonderful visit to UC Irvine Molecular Biology & Biochemistry! Was nice to be back in the UC system for a day, meet many great folks doing cool science, and get to talk about what we've been up to in the Keedy lab. Special thanks to Melanie Cocco for hosting!

This is the 1957 plasticine model of myoglobin by Kendrew. It is based on X-ray data and shows the polypeptide chain as a large 💩. It is an aesthetic failure but, as the first-ever protein model, it was a huge breakthrough in protein structure 🙂 collection.sciencemuseumgroup.org.uk/objects/co13...

'024 New Year lab news roundup: keedylab.org/news/ It's not too late to say Happy New Year yet, right?!

The Barad lab is hiring across all levels. Open positions here: baradlab.com/join/. If you are interested in doing cutting edge tomography and computational methods development to study intracellular bacterial infection, and living in Portland, OR, but don't fit the openings, reach out anyway!

baradlab.com (aka tomo.science ) is now online! Beginning to feel like a real lab!

When it rains, it pours... Another '024 lab paper update! Our comparison of high temperature vs. high pressure for the same protein structure is now out in Comms Bio: www.nature.com/articles/s42...

The #keedylab '024 paper deluge continues! Tamar and I worked with Helen to computationally reveal, model, and analyze 50% more ligand-bound structures that had been lurking unnoticed in our fragment screening data. Here's the @biorxiv-biophys.bsky.social preprint: www.biorxiv.org/content/10.1...