Don Sharkey

Don Sharkey

@donsharkey.bsky.social

Prof of Neonatal Medicine & Technologies @Uni Nottingham. Views my own. Neonatal technologies & transport research.

280 followers125 following60 posts

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So the new scrubs have arrived! We move into our new futuristic NICU next week @ Nottingham Centre for Newborn Care. So, so excited for our babies, families and staff.

Amazing, well done all. Looking forward to 👀 results, next week 😉?

research4babies.bsky.social@research4babies.bsky.social

We’re proud to announce that the HiLo-Trial has completed recruitment. Congratulations to every site, and heartfelt thanks to the parents who consented. This will help our understanding of oxygen management at birth. wix.to/mMyr4V0 #HiLoTrial #Neonatology #ClinicalResearch #PatientSafety

This signal suggests larger adequately powered (90%) studies are required especially in low resource settings where treatment is harder and burden of visual impairment greater. Safety data will be crucial inc. eye infections.

JAMA Pediatrics@jamapediatrics.com

In severe #RetinopathyOfPrematurity, #Dexamethasone eye drops showed no clinically significant differences in adverse events vs placebo and may offer a noninvasive alternative to reduce invasive treatment. ja.ma/4waJsrj

Interesting how the two studies (www.nejm.org/doi/full/10....) @nejm.org were very similar but powered very differently. Hopefully an planned IPMA will come next but I'd say the writing is on the wall for EPO. Where next, melatonin? @ebneo.bsky.social

nejm.orgTrial of Erythropoietin for Hypoxic–Ischemic Encephalopathy in Newborns | NEJMNeonatal hypoxic–ischemic encephalopathy is an important cause of death as well as long-term disability in survivors. Erythropoietin has been hypothesized to have neuroprotective effects in infants...
Evidence-based Neonatology@ebneo.bsky.social

Similar to the HEAL trial, the PAEAN trial in @jamapediatrics.com found no difference in EPO + TH vs TH alone in the reduction of death or disability in newborns with HIE. jamanetwork.com/journals/jamap… #EBNEOalerts #neoEBM #neoSky

Small but crucial gains, we suspected this but great to see in RCT. Also fabulous to see @jama.com publishing trials in these populations.

JAMA@jama.com

Among term infants born #SmallForGestationalAge, an integrated intervention improved weight and weight-for-age z score at 12 months vs usual care and was associated with less underweight, stunting, wasting, and anemia. ja.ma/4baYztc

Factor in pregnancy and this becomes even harder to understand for babies exposed (or not)....

NEJM.org@nejm.org

In a new Voices blog post, Paul Sax, MD, takes us on a guided tour through EIAs, RPRs, false negatives, false positives, and the strange endurance of a test from 1906. Read the latest: https://nej.md/4wGhQLo

Thanks. May not have spotted this one without excellent @ebneo.bsky.social summary. Will now hunt it out....

Evidence-based Neonatology@ebneo.bsky.social

Faust et al. conducted a cluster-randomized crossover trial comparing Standard Hand Hygiene with Extended Barrier Precautions in NICU infants colonized with third-generation cephalosporins–resistant GN bacteria (3GCR-GNB). buff.ly/blxB0kw #EBNeoAlerts #NeoEBM #NeoSky @jamanetworkopen.com

Don Sharkey@donsharkey.bsky.social

Finally awarded the neonatal transport grant I've been building for 5yrs. 🙏 @ukri.org for funding our team £1.5 million ($2M) to finally make interhospital transfer safer for all babies and provide the research community with next generation research tools to accelerate Neonatal Transport care.

Finally awarded the neonatal transport grant I've been building for 5yrs. 🙏 @ukri.org for funding our team £1.5 million ($2M) to finally make interhospital transfer safer for all babies and provide the research community with next generation research tools to accelerate Neonatal Transport care.

Fascinating, would be good to understand the implications for preterm birth, nutrition of the preterm infant and impact on outcomes. One for you @jamespboardman.bsky.social

Don Sharkey reposted

"Every 1% increase in military spending drives a 0·62% reduction in public health spending." On the cover, a new letter examines the relationship between military spending and public health expenditure during conflicts. Find out more in our latest issue: spkl.io/63325ANG6W

Don Sharkey reposted

Replying to @surepulsemedical.bsky.social

Dr James Carpenter will present our new multi-parameter, wireless, vital sign monitoring for newborns to an audience of 90+ investors, strategics, clinicians, and industry leaders helping shape the future of medtech. #MedTechInnovator #MTIRadarForum

Don Sharkey@donsharkey.bsky.social

journals.plos.org/digitalhealt... New paper out today from @tngchang.bsky.social from University of Nottingham with many collaborators (thanks). Excellent OA online extreme preterm mortality prediction tool with neat explainable element. Great for all perinatal teams.

Don Sharkey reposted

Editor-in-Chief Eric Rubin asks why, under an administration that says it is focused on making America healthy again, we are denigrating and discarding our single most cost-effective public health tools — vaccines. Read the full editorial: nej.md/4mtH8Xm #MedSky #PublicHealth

Very thorough review and highlights early challenges FGR infants need to overcome. As highlighted, tricky to identify who truly is FGR vs constitutionally small.

Beth Allison@bethjallison.bsky.social

NEW PAPER Compromised cardiopulmonary transition in fetal growth restricted and small for gestational age neonates Suboptimal fetal growth → altered cardiac structure/function → higher risk of impaired adaptation at birth, respiratory morbidity, and long-term CV risk. doi.org/10.1113/JP28...

Early days but a promising approach. Likely to be more challenging in my population of newborn infants but would be great to explore....

Science Magazine@science.org

A soft, robotic device can autonomously navigate the trachea to support rapid and self-guided intubation outside of hospitals and could expand and democratize intubation for emergency responders and resource-limited environments. #ScienceTranslationalMedicine https://scim.ag/4n0bxxt

I've listened to almost all of these and they are great. Chatting about neonatal research and care. Well worth a listen for all involved in the care of newborns. Good work Mario and @espr-esn.bsky.social

🚀 Now live! Listen to Prof Dr Barbara Schmidt on #NeonatologyNow. Today's topic: Apnoea of prematurity and the use of caffeine for #preterm infants below 30 weeks of gestation. Tune in to hear Dr Schmidt's suggestions for preterms with a diagnosis of #apnea. 🎧 #NeonatalHealth #Neonatology #Podcast

Really interesting study pushing the boundaries on this tricky and often poor outcome condition. Perhaps a condition that one day will have a handful of centres with expertise to treat and hopefully improve outcomes.

JAMA@jama.com

In utero embolization for vein of Galen malformation is feasible and may reduce mortality and neurodevelopmental delays, but poses a risk of unscheduled, preterm delivery. ja.ma/45v3hOy

Don Sharkey reposted

Ivermectin is an antiparasitic drug that kills mosquitoes feeding on treated persons. In this trial in Kenya, ivermectin given once per month for 3 months led to a 26% lower incidence of malaria than albendazole. Full trial results: nej.md/4lIyNzB #MedSky #IDSky

Don Sharkey reposted

Impressive technological advancement.

JAMA@jama.com

Robotic surgery for middle or low rectal cancer demonstrated lower 3-year locoregional recurrence rates and improved functional outcomes compared with conventional laparoscopic surgery. https://ja.ma/4eDwStq

Don Sharkey reposted

Don Sharkey reposted

Delighted to see the @nihr funded CCD study published today in @lancetrh-europe.bsky.social Lots to celebrate: sex, ethnicity and IMD does not impact time to diagnosis for CYP w cancer. But also lots to improve: young people and certain diagnostic groups need urgent attention. #earlydiagnosis

📢 News: The Childhood Cancer Diagnosis Study, led by Dr Sharna Shanmugavadivel, has found that young people with certain types of cancer are facing lengthy times to diagnosis 🎗 Find out more at bit.ly/3Hg0rVl #ChildCancerSmart #EarlyDiagnosis @uniofnottingham.bsky.social

Very interesting analysis. 3% difference in mortality if PDA actively treated. Perhaps results in more morbidity in expectant group survivors - not the case. One for the reading pile....

Abdul Razak@drabdulrazak.bsky.social

New meta-analysis on PDA management suggesting harm associated with active treatment compared to expectant management jamanetwork.com/journals/jam...

Wonderful, getting over many challenges to reach this accolade- well done!

Neonatal Nurses Association (NNA)@neonatalnursesuk.bsky.social

What is it like working in as an international neonatal nurse in the UK? In our latest blog, find out more about the career of NNA Nurse of the Year 2024 Rachna Sharma, who arrived in England in 2010. Read Rachna's blog here: nna.org.uk/working-as-a... #InternationalNurse

Don Sharkey reposted

We’re honoured to receive a Medilink Midlands Business Award with the University of Nottingham, celebrating our collaboration in the Partnership Between Academia and Business category.

Such a powerful tool. MRI born in my University, really recommend watching this fascinating 3 min video of where it started. Never be able to do research like this now, "I may have a cardiac arrest"! The images have moved on somewhat and we are just installing an 11T! m.youtube.com/watch?v=3nIX...

m.youtube.com1978: Dr Mansfield's MRI MEDICAL MARVEL | Tomorrow's World | Science and Nature | BBC ArchiveYouTube video by BBC Archive
Daniel Vijlbrief@neonatoloog.bsky.social

This week in Quantum Neonatology, the MRI. It’s all in the spin! open.substack.com/pub/danvijl/...

Strong conclusions "Their use should be standard of care for very preterm infants, or offering their use to parents should be standard practice. Just don’t expect them to improve neurological or developmental outcomes" - do you agree?

Don Sharkey reposted

🚀 Today, we launch #ForgingAhead—a £16M initiative uniting 15 Midlands universities. The project will transform the commercialisation ecosystem by: 🔹 Developing top-tier talent 🔹 Scaling accelerators 🔹 Attracting investment 🔹 Boosting key sectors 🔗 Read more: buff.ly/WyGEssg

midlandsinnovation.org.uk‘Forging Ahead’ initiative to transform innovation and entrepreneurship across the Midlands - Midlands Innovation‘Forging Ahead’ initiative to transform innovation and entrepreneurship across the Midlands

What a refreshing read. Could apply in many settings. This "Forget the idea that a bubble bath or an essential oil diffuser will magically solve this." is so true. Recommend you read and share.

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