DZNE research center

DZNE research center

@dzne.science

Dedicated to advancing the scientific understanding of neurodegenerative diseases - from mechanisms to diagnosis, therapy, and prevention (such as AD, PD or ALS). đź”— Imprint: https://dzne.de/en/imprint đź”— Data Protection: https://dzne.de/en/data-protection/

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DZNE research center
@dzne.science

New paper out: SOD1 co-pathologies in the brain: insights from neuropathological evidence and implications.: de Azevedo, Evellyn Mayla; Bernardo, Victoria Simões; Lima, Marcelo M S; et al. Acta neuropathologica Vol. 152, no. 1, p. 43 Superoxide dismutase 1 (SOD1),… | Thanks for sharing #dzne #papers

dlvr.itSOD1 co-pathologies in the brain: insights from neuropathological evidence and implications.de Azevedo, Evellyn Mayla; Bernardo, Victoria Simões; Lima, Marcelo M S; et al. Acta neuropathologica Vol. 152, no. 1, p. 43 Superoxide dismutase 1 (SOD1), originally regarded as an antioxidant enzyme, is now recognized as a multifunctional protein whose conformational instability and aggregation contribute to neurodegeneration. The emerging evidence suggests that SOD1 pathology extends beyond amyotrophic lateral sclerosi
DZNE research center
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New paper out: Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis.: Blazhenets, Ganna; Soleimani-Meigooni, David N; Chiotis, Konstantinos; et al. The journal of the American Medical… | Thanks for sharing #dzne #papers

dlvr.itAmyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis.Blazhenets, Ganna; Soleimani-Meigooni, David N; Chiotis, Konstantinos; et al. The journal of the American Medical Association Vol. 336, no. 13, p. 1135 - Amyloid positron emission tomography (PET) is increasingly used in research and clinical settings to determine the etiology of cognitive decline and eligibility for amyloid-targeting therapies. To assist with amyloid PET evaluation and to guide clinical decision-making, images can be quantified in a
DZNE research center
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New paper out: Intermittent fasting modulates immune signatures but not TNF-dependent pathology in mice with constitutive STING activation: Höfs, Lennart; Luksch, Hella; Schulze, Felix; et al. Scientific reports Vol. 16, no. 1, p. 29148 The cGAS–STING pathway is a… | Thanks for sharing #dzne #papers

dlvr.itIntermittent fasting modulates immune signatures but not TNF-dependent pathology in mice with constitutive STING activationHöfs, Lennart; Luksch, Hella; Schulze, Felix; et al. Scientific reports Vol. 16, no. 1, p. 29148 The cGAS–STING pathway is a central mediator of antiviral immunity, yet its constitutive activation causes severe systemic autoinflammatory disease and neurodegeneration. Intermittent fasting (IF) has been proposed as a non-pharmacological strategy to attenuate inflammation and neurodegeneration. We
DZNE research center
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New paper out: Biased connectivity shapes food odor categorization in the Drosophila mushroom body.: Chan, Ivy Chi Wai; Kalle Kossio, Felipe Yaroslav; Tavosanis, Gaia Cell reports Vol. 45, no. 10, p. 117911 - Animals rely on neural representations of sensory… | Thanks for sharing #dzne #papers

dlvr.itBiased connectivity shapes food odor categorization in the Drosophila mushroom body.Chan, Ivy Chi Wai; Kalle Kossio, Felipe Yaroslav; Tavosanis, Gaia Cell reports Vol. 45, no. 10, p. 117911 - Animals rely on neural representations of sensory stimuli to rapidly recognize familiar environments and precisely identify salient cues. In the Drosophila mushroom body, odors are represented by the activity of Kenyon cells (KCs), whose random wiring with olfactory projection neurons (PNs) is gener
DZNE research center
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New paper out: Comparison of amyloid-β, total tau and phospho-tau in clinical AD patients with and without epileptiform EEG patterns.: Ott, Livia Rabea; Hermann, Wiebke; Köhling, Rüdiger; et al. Epilepsy research Vol. 228, p. 107921 - Epilepsy is a relevant… | Thanks for sharing #dzne #papers

dlvr.itComparison of amyloid-β, total tau and phospho-tau in clinical AD patients with and without epileptiform EEG patterns.Ott, Livia Rabea; Hermann, Wiebke; Köhling, Rüdiger; et al. Epilepsy research Vol. 228, p. 107921 - Epilepsy is a relevant comorbidity of dementia due to Alzheimer's Disease (AD) and probably directly related to its pathology. We aimed to generate hypotheses how interictal epileptiform discharges (IEDs) may be associated with pathological levels of AD markers from cerebrospinal fluid (CSF).To perf

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Helmholtz-Gemeinschaft
@helmholtz.de

🧠 Ein goldenes Zeitalter der #Demenzforschung? KI, Immunologie & neue Therapieansätze machen Hoffnung im Kampf gegen Alzheimer und Parkinson. 🔬 Doch was hat eine Impfung mit dem Demenzrisiko zu tun? 🤔 Das erklärt @dzne.science -Chef Joachim Schultze im Interview. www.helmholtz.de/newsroom/art...

helmholtz.de„Wir stehen am Anfang eines goldenen Zeitalters“Joachim Schultze im Gespräch über die Chancen von Big Data und KI für die Therapie von neurodegenerativen Erkrankungen – und darüber, was er als
DZNE research center
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Single-nucleotide polymorphism-directed design of allele-specific antisense oligonucleotides for spinocerebellar ataxia type 3. Jacob Helm et al. Science Translational Medicine (2026). DOI: 10.1126/scitranslmed.adz2140; URL: www.science.org/doi/10.1126/....

science.orgSingle-nucleotide polymorphism–directed design of allele-specific antisense oligonucleotides for spinocerebellar ataxia type 3Haplotype-informed sequencing identified target SNPs in ATXN3 for selective reduction of mutant ataxin-3 by ASOs.
DZNE research center
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New paper out: Software: QCima Studio, v1.1.0: Varga, Daniel Peter; Shumanska, Magdalena; Stappert, Dominik; et al.   QCima Studio is a standalone software application for quality control of MACSima spatial proteomics datasets. It provides convenient access to… | Thanks for sharing #dzne #papers

dlvr.itSoftware: QCima Studio, v1.1.0Varga, Daniel Peter; Shumanska, Magdalena; Stappert, Dominik; et al.   QCima Studio is a standalone software application for quality control of MACSima spatial proteomics datasets. It provides convenient access to review individual antibody signals alongside their corresponding background and autofluorescence reference images.Users can adjust visualization settings, cl
DZNE research center
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New paper out: Model: Pre-trained model weights for YADO (You Accurately Denoise real Observations) Denoiser and Renoising DM (ECCV 2026), v1: Rassmann, Sebastian; Kügler, David; Reuter, Martin   Model weights for YADO (You Accurately Denoise real Observations)… | Thanks for sharing #dzne #papers

dlvr.itModel: Pre-trained model weights for YADO (You Accurately Denoise real Observations) Denoiser and Renoising DM (ECCV 2026), v1Rassmann, Sebastian; Kügler, David; Reuter, Martin   Model weights for YADO (You Accurately Denoise real Observations) Denoiser and Renoiser as introduced in the paper "Rethinking Real-World MRI Denoising: Learning from Physical Noise" accepted to ECCV 2026. See also the Project Page.The code and docs are at: github.com/Deep-MI/YADO, and the weights a
DZNE research center
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New paper out: Data and code: A novel analysis method for condensate wetting identifies charge-dependent Tau-membrane interactions, v1: Sporbeck, Katharina; Ghosh, Subhadip; Sankar, Rithika; et al.   Data and code for the publication "A novel analysis method for… | Thanks for sharing #dzne #papers

dlvr.itData and code: A novel analysis method for condensate wetting identifies charge-dependent Tau-membrane interactions, v1Sporbeck, Katharina; Ghosh, Subhadip; Sankar, Rithika; et al.   Data and code for the publication "A novel analysis method for condensate wetting identifies charge-dependent Tau-membrane interactions", located at [DOI will be updated when available].
DZNE research center
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New paper out: All-optical closed-loop control of human cardiomyocyte networks exploiting holographic optogenetics.: Wendland, Robert; Schmieder, Felix; Sikandar, Muhammad Atif; et al. Communications engineering Vol. 5, no. 1, p. 159 | Thanks for sharing #dzne #papers

dlvr.itAll-optical closed-loop control of human cardiomyocyte networks exploiting holographic optogenetics.Wendland, Robert; Schmieder, Felix; Sikandar, Muhammad Atif; et al. Communications engineering Vol. 5, no. 1, p. 159
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New paper out: 4-Repeat Tauopathien – Progressive Supranukleäre Blickparese und kortikobasale Degeneration | 4-Repeat Tauopathies: Progressive Supranuclear Palsy andCorticobasal Degeneration: Palleis, Carla Teresa; Bernhardt, Alexander; Höglinger, Günter… | Thanks for sharing #dzne #papers

dlvr.it4-Repeat Tauopathien – Progressive Supranukleäre Blickparese und kortikobasale Degeneration | 4-Repeat Tauopathies: Progressive Supranuclear Palsy andCorticobasal DegenerationPalleis, Carla Teresa; Bernhardt, Alexander; Höglinger, Günter Fortschritte der Neurologie, Psychiatrie Vol. 94, no. 9, p. 389 - 399
DZNE research center
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New paper out: Neuroradiologic Findings in Patients With SCN2A Disease: A Systematic Review and Retrospective Multicenter Cohort Study.: Bamborschke, Daniel; Bendella, Zeynep; Allen, Meagan; et al. Neurology Vol. 107, no. 7, p. e218541 | Thanks for sharing #dzne #papers

dlvr.itNeuroradiologic Findings in Patients With SCN2A Disease: A Systematic Review and Retrospective Multicenter Cohort Study.Bamborschke, Daniel; Bendella, Zeynep; Allen, Meagan; et al. Neurology Vol. 107, no. 7, p. e218541

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MPI for Biological Intelligence
@mpiforbi.bsky.social

How do neurons grow during their early stages of development? And how can these processes be reactivated so that damaged neurons can regenerate? Don’t miss Frank Bradke, Professor at the DZNE Bonn @dzne.science, at our next keynote lecture! 📅 September 29 at 11:00 a.m. 📍 Room NQ105, Martinsried

DZNE research center
@dzne.science

New paper out: Association of oral anticoagulation persistence and health-related quality of life in stroke survivors with atrial fibrillation: long-term results of the Berlin atrial fibrillation registry.: Steindorf-Sabath, Lena; Olma, Manuel C; Tütüncü, Serdar;… | Thanks for sharing #dzne #papers

dlvr.itAssociation of oral anticoagulation persistence and health-related quality of life in stroke survivors with atrial fibrillation: long-term results of the Berlin atrial fibrillation registry.Steindorf-Sabath, Lena; Olma, Manuel C; Tütüncü, Serdar; et al. Neurological research and practice Vol. 8, no. 1, p. 78
DZNE research center
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New paper out: Inconsistent subthalamic local field potential beta activity amid in- and antiphasic neuronal bursts.: Scherer, Maximilian; Wiedemann, Nina; Bötzel, Kai; et al. npj Parkinson's Disease Vol. 12, no. 1, p. 222 | Thanks for sharing #dzne #papers

dlvr.itInconsistent subthalamic local field potential beta activity amid in- and antiphasic neuronal bursts.Scherer, Maximilian; Wiedemann, Nina; Bötzel, Kai; et al. npj Parkinson's Disease Vol. 12, no. 1, p. 222
DZNE research center
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New paper out: Associations of physical fitness with brain structure, pathology and cognition in cognitively normal older adults.: Schwarck, Svenja; Behrenbruch, Niklas; Schumann-Werner, Beate; et al. npj aging Vol. 12, no. 1, p. 129 | Thanks for sharing #dzne #papers

dlvr.itAssociations of physical fitness with brain structure, pathology and cognition in cognitively normal older adults.Schwarck, Svenja; Behrenbruch, Niklas; Schumann-Werner, Beate; et al. npj aging Vol. 12, no. 1, p. 129
DZNE research center
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New paper out: Structural Brain Changes Are Linked to Clinical and Cognitive Outcomes in Anti-LGI1 Encephalitis.: Zhao, Wei; Wurdack, Katharina; Bartels, Frederik; et al. Neurology: Neuroimmunology & Neuroinflammation ; official journal of the American Academy of… | Thanks for sharing #dzne #papers

dlvr.itStructural Brain Changes Are Linked to Clinical and Cognitive Outcomes in Anti-LGI1 Encephalitis.Zhao, Wei; Wurdack, Katharina; Bartels, Frederik; et al. Neurology: Neuroimmunology & Neuroinflammation ; official journal of the American Academy of Neurology Vol. 13, no. 6, p. e200649
DZNE research center
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New paper out: Individualized antisense oligonucleotide treatment eligibility of patients living with neurodevelopmental diseases.: Aartsma-Rus, Annemieke; de Gusmao, Claudio Melo; Demarest, Scott; et al. Cell reports / Medicine Vol. 7, no. 9, p. 102989 - | Thanks for sharing #dzne #papers

dlvr.itIndividualized antisense oligonucleotide treatment eligibility of patients living with neurodevelopmental diseases.Aartsma-Rus, Annemieke; de Gusmao, Claudio Melo; Demarest, Scott; et al. Cell reports / Medicine Vol. 7, no. 9, p. 102989 -
DZNE research center
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New paper out: Functional network reorganization after magnetic resonance-guided focused ultrasound thalamotomy in tremor-dominant Parkinson's disease patients.: Liu, Jinlong; Purrer, Veronika; Krauss, Jonas; et al. NeuroImage: Clinical Vol. 52, p. 104058 - | Thanks for sharing #dzne #papers

dlvr.itFunctional network reorganization after magnetic resonance-guided focused ultrasound thalamotomy in tremor-dominant Parkinson's disease patients.Liu, Jinlong; Purrer, Veronika; Krauss, Jonas; et al. NeuroImage: Clinical Vol. 52, p. 104058 -
DZNE research center
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New paper out: Type, severity, frequency and management of adverse reactions associated with ultrasound contrast agents: a systematic review and meta-analysis.: Ocagli, Honoria; Romanini, Laura; Llane, Adea; et al. European radiology Vol. 36, no. 10, p. 7671 - 7683 | Thanks for sharing #dzne #papers

dlvr.itType, severity, frequency and management of adverse reactions associated with ultrasound contrast agents: a systematic review and meta-analysis.Ocagli, Honoria; Romanini, Laura; Llane, Adea; et al. European radiology Vol. 36, no. 10, p. 7671 - 7683
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New paper out: NLRP3 Regulation in Neonatal Hypoxic-Ischemic Encephalopathy-Focus on Microglial Activation.: Burkard, Hannah; Bernis, Maria Eugenia; Bremer, Anna-Sophie; et al. International journal of molecular sciences Vol. 27, no. 17, p. 7853 - | Thanks for sharing #dzne #papers

dlvr.itNLRP3 Regulation in Neonatal Hypoxic-Ischemic Encephalopathy-Focus on Microglial Activation.Burkard, Hannah; Bernis, Maria Eugenia; Bremer, Anna-Sophie; et al. International journal of molecular sciences Vol. 27, no. 17, p. 7853 -
DZNE research center
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New paper out: Learning reorganizes dendritic and stabilizes axon initial segment inhibitory synapses in CA1 pyramidal neurons.: Klimmt, Hannah; Kuhn, Felix; Kappel, David; et al. Nature Communications Vol. 17, no. 1, p. 9791 | Thanks for sharing #dzne #papers

dlvr.itLearning reorganizes dendritic and stabilizes axon initial segment inhibitory synapses in CA1 pyramidal neurons.Klimmt, Hannah; Kuhn, Felix; Kappel, David; et al. Nature Communications Vol. 17, no. 1, p. 9791
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New paper out: Fibronectin mediates APOE4-driven blood-brain barrier dysfunction in Alzheimer's disease.: Bhattarai, Prabesh; Yilmaz, Elanur; Cakir, Elif Öykü; et al. Nature aging Vol. 6, no. 9, p. 1901 - 1927 | Thanks for sharing #dzne #papers

dlvr.itFibronectin mediates APOE4-driven blood-brain barrier dysfunction in Alzheimer's disease.Bhattarai, Prabesh; Yilmaz, Elanur; Cakir, Elif Öykü; et al. Nature aging Vol. 6, no. 9, p. 1901 - 1927
DZNE research center
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New paper out: Cyclosporin A triggers a RIG-I-mediated interferon response through multiple cellular processes.: Meier, Lars; Schauflinger, Martin; Neubecker, Pauline; et al. Scientific reports Vol. 16, no. 1, p. 28863 | Thanks for sharing #dzne #papers

dlvr.itCyclosporin A triggers a RIG-I-mediated interferon response through multiple cellular processes.Meier, Lars; Schauflinger, Martin; Neubecker, Pauline; et al. Scientific reports Vol. 16, no. 1, p. 28863
DZNE research center
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New paper out: Deep FLASH-seq profiling of purified canine sensory neurons uncovers species-specific signatures relevant to pain and itch.: Ledesma Fernandez, Paula; Butler, Brandi; Theis, Heidi; et al. Pain Vol. 167, no. 10, p. 2391 - 2407 | Thanks for sharing #dzne #papers

dlvr.itDeep FLASH-seq profiling of purified canine sensory neurons uncovers species-specific signatures relevant to pain and itch.Ledesma Fernandez, Paula; Butler, Brandi; Theis, Heidi; et al. Pain Vol. 167, no. 10, p. 2391 - 2407
DZNE research center
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New paper out: Positioning equity at the core of European dementia research: a pan-European co-produced perspective from the PANEUCARE consortium.: Cardona, Maria Isabel; Giebel, Clarissa; Scerri, Anthony; et al. Frontiers in medicine Vol. 13, p. 1828363 | Thanks for sharing #dzne #papers

dlvr.itPositioning equity at the core of European dementia research: a pan-European co-produced perspective from the PANEUCARE consortium.Cardona, Maria Isabel; Giebel, Clarissa; Scerri, Anthony; et al. Frontiers in medicine Vol. 13, p. 1828363
DZNE research center
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New paper out: A world view: Considerations of sociocultural diversity in the study of subjective cognitive decline in Alzheimer's disease and related dementias.: Dubbelman, Mark A; Hill-Jarrett, Tanisha G; Chapman, Silvia; et al. Alzheimer's and dementia Vol. 22,… | Thanks for sharing #dzne #papers

dlvr.itA world view: Considerations of sociocultural diversity in the study of subjective cognitive decline in Alzheimer's disease and related dementias.Dubbelman, Mark A; Hill-Jarrett, Tanisha G; Chapman, Silvia; et al. Alzheimer's and dementia Vol. 22, no. 9, p. e71779
DZNE research center
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New paper out: Which methodologies and methods should be used for psychosocial intervention research in dementia? Protocol for a stakeholder-driven, multi-method Delphi study.: Bartels, Sara Laureen; D'Andrea, Federica; Burnand, Alice; et al. BMJ open Vol. 16, no.… | Thanks for sharing #dzne #papers

dlvr.itWhich methodologies and methods should be used for psychosocial intervention research in dementia? Protocol for a stakeholder-driven, multi-method Delphi study.Bartels, Sara Laureen; D'Andrea, Federica; Burnand, Alice; et al. BMJ open Vol. 16, no. 9, p. e122720 -
DZNE research center
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New paper out: Innervated human cardiac muscle model reveals sympathetic drivers of KCNH2-associated arrhythmias.: Schneider, Lennart Valentin; Setya, Michael Gani; Bao, Guobin; et al. Nature Communications Vol. 17, no. 1, p. 9404 | Thanks for sharing #dzne #papers

dlvr.itInnervated human cardiac muscle model reveals sympathetic drivers of KCNH2-associated arrhythmias.Schneider, Lennart Valentin; Setya, Michael Gani; Bao, Guobin; et al. Nature Communications Vol. 17, no. 1, p. 9404
DZNE research center
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New paper out: Mechanistic characterization and inhibition of PAD4-dependent NETosis following experimental neonatal hypoxic-ischemic brain injury.: Bremer, Anna-Sophie; Bernis, Maria Eugenia; Burkard, Hannah; et al. Experimental neurology Vol. 406, p. 115994 - | Thanks for sharing #dzne #papers

dlvr.itMechanistic characterization and inhibition of PAD4-dependent NETosis following experimental neonatal hypoxic-ischemic brain injury.Bremer, Anna-Sophie; Bernis, Maria Eugenia; Burkard, Hannah; et al. Experimental neurology Vol. 406, p. 115994 -
DZNE research center
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New paper out: Authors' Comments on 'Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation'.: Koeglsperger, Thomas; Scherer, Maximilian; Kühn, Andrea A; et al. Movement disorders Vol. 41, no. 8, p. 2225 - 2226 | Thanks for sharing #dzne #papers

dlvr.itAuthors' Comments on 'Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation'.Koeglsperger, Thomas; Scherer, Maximilian; Kühn, Andrea A; et al. Movement disorders Vol. 41, no. 8, p. 2225 - 2226
DZNE research center
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Associations between diet quality, epigenetic aging and epigenome in two population-based cohorts. Juliana F. Tavares, Dan Liu et al. @natcomms.nature.com (2026). DOI/URL: doi.org/10.1038/s414...

doi.orgAssociations between diet quality, epigenetic aging and epigenome in two population-based cohorts - Nature CommunicationsThe specific healthy diet may matter less than eating healthily overall. In two German cohorts, several healthy diets were each linked to slower biological aging, with distinct DNA methylation pattern...
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New paper out: Prion protein (PrP) profiles in blood and CSF: insights into pre-symptomatic and symptomatic prion disease.: Laginha, Inês; Schmitz, Matthias; da Silva Correia, Ângela; et al. Brain communications Vol. 8, no. 5, p. fcag321 | Thanks for sharing #dzne #papers

dlvr.itPrion protein (PrP) profiles in blood and CSF: insights into pre-symptomatic and symptomatic prion disease.Laginha, Inês; Schmitz, Matthias; da Silva Correia, Ângela; et al. Brain communications Vol. 8, no. 5, p. fcag321
DZNE research center
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New paper out: Diagnostic performance of plasma pTau217 in genetically admixed South American populations.: Martino-Adami, Pamela V; Coutinho de Alvarenga, Joice; Freccero, Pilar; et al. Nature Communications Vol. 17, no. 1, p. 9464 | Thanks for sharing #dzne #papers

dlvr.itDiagnostic performance of plasma pTau217 in genetically admixed South American populations.Martino-Adami, Pamela V; Coutinho de Alvarenga, Joice; Freccero, Pilar; et al. Nature Communications Vol. 17, no. 1, p. 9464
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New paper out: Choosing the optimal mouse model for the study of late-onset spinal muscular atrophy: Why the 4-copy SMN2 model offers ideal translational relevance.: Leo, Markus; Schmitt, Linda-Isabell; Liebig, Kai Christine; et al. Journal of neuromuscular… | Thanks for sharing #dzne #papers

dlvr.itChoosing the optimal mouse model for the study of late-onset spinal muscular atrophy: Why the 4-copy SMN2 model offers ideal translational relevance.Leo, Markus; Schmitt, Linda-Isabell; Liebig, Kai Christine; et al. Journal of neuromuscular diseases Vol. 13, no. 5, p. 869 - 874
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New paper out: Expanding the TBL1XR1 Disease Spectrum: Generalized Dystonia Associated with a New Genetic Variant.: Löw, Maximilian Johannes; Bernsdorff, Felix; Weinrich, Christiane; et al. Tremor and other hyperkinetic movements Vol. 16, no. 1, p. 51 | Thanks for sharing #dzne #papers

dlvr.itExpanding the TBL1XR1 Disease Spectrum: Generalized Dystonia Associated with a New Genetic Variant.Löw, Maximilian Johannes; Bernsdorff, Felix; Weinrich, Christiane; et al. Tremor and other hyperkinetic movements Vol. 16, no. 1, p. 51
DZNE research center
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New paper out: Fully-automated sleep staging for Parkinson's disease and isolated REM sleep behavior disorder.: Strøm, Jesper; Skjærbæk, Casper; Bertelsen, Natasha Becker; et al. npj digital medicine Vol. 9, no. 1, p. 629 | Thanks for sharing #dzne #papers

dlvr.itFully-automated sleep staging for Parkinson's disease and isolated REM sleep behavior disorder.Strøm, Jesper; Skjærbæk, Casper; Bertelsen, Natasha Becker; et al. npj digital medicine Vol. 9, no. 1, p. 629