Edgar V. Lerma 🇵🇭

Renal Physiology for the Clinician Series #Nephpearls 👉 journals.lww.com/cjasn/pages/...

Among patients w/ IgA nephropathy #IgAN, treatment w/ sibeprenlimab stabilized the eGFR slope over 24 months, consistent w/ a reduced risk of kidney-function decline ca. 2026 from @nejm.org #Nephpearls #KidneyWk #NephSky Visual Abstract by @cristinapopa.bsky.social 👉 www.nejm.org/doi/full/10....

Diagnosis of ADPKD remains radiological/ clinical in most cases #Nephpearls #KidneyWk #NephSky 👉 pubmed.ncbi.nlm.nih.gov/40126492/

Trends in Mortality of Patients with Central Venous Catheters (CVC) vs Arteriovenous (AV) Accesses for Hemodialysis ca. 2026 from @asnpublications.bsky.social #Nephpearls #VascularAccessPearls #KidneyWk #NephSky 👉 journals.lww.com/jasn/fulltex...

Going Beyond Survival: Kidney Transplantation in the Older Population ca. 2026 from @asnpublications.bsky.social #Nephpearls #KidneyWk #NephSky 👉 www.kidneynews.org/view/journal... 👉 pubmed.ncbi.nlm.nih.gov/42173346/

SECONDS checklist for the interpretation of kidney ultrasound #Nephpearls #NephSecrets #NephSky 👉 www.us.elsevierhealth.com/nephrology-s...

Point-of-care ultrasound #POCUS training in #nephrology: a position statement by the International Alliance for POCUS in Nephrology ca. 2024 from @nephrothaniel.bsky.social @myadla.bsky.social #Nephpearls #KidneyWk #NephSky 👉 pubmed.ncbi.nlm.nih.gov/39502372/

More GDMT ≠ zero trade-offs #Nephpearls #KidneyWk #NephSky ⚠️ In CKM, optimizing therapy can also mean navigating a higher risk of hyperkalemia ✅ The goal isn’t to back off - it’s to monitor, manage, and keep patients on the therapies that change outcomes 👉 pubmed.ncbi.nlm.nih.gov/42265997/

Vascular endothelial growth factor inhibitor (VEGFi) induced hypertension ca. 2026 from @akdhjournal.bsky.social @gudnephron.bsky.social @sabinekaram.bsky.social @priti899.bsky.social #Nephpearls #OncoNephrology 🦀 #NephSky 👉 pubmed.ncbi.nlm.nih.gov/42405920/

Primary Aldosteronism and the Kidneys ca. 2026 from @akdhjournal.bsky.social @hswapnil.medsky.social #Nephpearls #NephSky 👉 pubmed.ncbi.nlm.nih.gov/42397322/

If you're coming to @asnkidney.bsky.social #KidneyWk do not miss this session "Too Many Therapies for Diabetic Kidney Disease: What a Great Problem to Have!" #Nephpearls #NephSky 🗓️ 25 Oct ⏰ 9:30 AM MDT 📍 Four Seasons Ballroom 1, Convention Center 👉 asn-online.org/education/ki...

Approach to hematuria ca. 2026 from @ajkd.bsky.social #Nephpearls #NephSky 👉 pubmed.ncbi.nlm.nih.gov/42767705/

PRO/CON debate: nonsteroidal (finerenone) vs. steroidal (spironolactone/ eplerenone) mineralocorticoid receptor antagonists in CKD: progress, pragmatism, and remaining uncertainties ca. 2026 from @ckj-era.bsky.social #Nephpearls #Cardiorenal #NephSky 👉 pubmed.ncbi.nlm.nih.gov/42682722/

C3G Glomerulopathy: Mechanistic Targets 🎯 of Potential Novel Therapies from @kdigo.org #Nephpearls #NephSky 👉 kdigo.org/infographics/

IgA Nephropathy #IgAN: Pathophysiology and Mechanistic Targets 🎯 of Potential Novel Therapies from @kdigo.org #Nephpearls #NephSky 👉 kdigo.org/infographics/

Treatment with maximally tolerated RAASi alone does not sufficiently slow the rate of eGFR decline in high-risk patients with IgA nephropathy #IgAN, leaving patients at risk of ESKD ca. 2026 from @asnpublications.bsky.social #Nephpearls #NephSky 👉 pubmed.ncbi.nlm.nih.gov/42584957/

Clinical conditions related to LVADs that may arise during hemodialysis #Nephpearls #NephSky 👉 link.springer.com/book/10.1007...

Call 📢 for papers: "The Jerry Yee: Clinical Challenges in Diagnosis and Treatment in Nephrology" #Nephpearls #NephSky 🗓️ Deadline for submissions: 15 October 2026 👉 www.sciencedirect.com/special-issu...

Impact of proteinuria levels on long-term kidney outcomes in IgA nephropathy: a meta-analysis ca. 2026 from @glomcon.org Rare Kidney Disease journal #Nephpearls #NephSky 👉🏼 link.springer.com/article/10.1...

Ten tips for the diagnosis and management of nephrotic syndrome ca. 2026 #Nephpearls #NephSky 👉🏼 pubmed.ncbi.nlm.nih.gov/42707999/

Classic course of whole-kidney GFR and UAE according to the natural (proteinuric) pathway of #Diabetic #Kidney Disease (DKD) ca. 2017 #Nephpearls #NephSky 👉🏼 pubmed.ncbi.nlm.nih.gov/28143897/

Adults with #IgAN are at greater risk of adverse kidney outcomes versus nonglomerular CKD and substantially higher risks of heart failure and death compared with no CKD ca. 2026 from @KIReports #Nephpearls #RKDSummit #NephSky 👉🏼 pubmed.ncbi.nlm.nih.gov/42027552/

Not all #IgAN therapies are created equal #Nephpearls #RKDSummit #NephSky 👉🏼 pubmed.ncbi.nlm.nih.gov/40928891/

Dipstick hemoglobinuria is associated with histologic markers of active disease in #IgAN and may provide clinically relevant information to complement current assessment of disease activity in #IgAN ca. 2026 #Nephpearls #RKDSummit #NephSky 👉🏼 pubmed.ncbi.nlm.nih.gov/42628835/

Microscopic hematuria as a risk factor for #IgAN progression: considering this biomarker in selecting and monitoring patients ca. 2023 #Nephpearls #RKDSummit #NephSky 👉🏼 pubmed.ncbi.nlm.nih.gov/38053974/

Targeting B cells in immune-mediated kidney diseases: conclusions from @kdigo.org Controversies Conference ca. 2026 #Nephpearls #RKDSummit #NephSky 👉🏼 pubmed.ncbi.nlm.nih.gov/42034308/

Colloids vs Crystalloids #Nephpearls #AKIinICU #NephSky 👉 shop.lww.com/Handbook-of-...

Thank you for the kind words and the wonderful hospitality! It was an absolute honor to present at the Renal Research Forum and engage with such a fantastic group of colleagues at Mayo Clinic 🙏 #NephSky

Kidney Health Guidance on Cardiovascular-Kidney-Metabolic (CKM) Syndrome ca. 2026 from @asnpublications.bsky.social #Nephpearls #NephSky #Cardiorenal 👉 pubmed.ncbi.nlm.nih.gov/42684397/

Hypomagnesemia: Outpatient management #Nephpearls #NephSky 👉 shop.lww.com/Manual-of-Ne...

Syndrome of Inappropriate Antidiuresis (SIAD): From Pathophysiology to Management ca. 2023 #Nephpearls #NephSky 👉🏼 pubmed.ncbi.nlm.nih.gov/36974717/

Lower Time Averaged-Proteinuria (TA-P) was associated with progressively reduced risk of kidney failure in adults with IgA Nephropathy #IgAN in the US ca. 2026 from @glomcon.org Rare Kidney Disease Journal #Nephpearls #NephSky 👉 link.springer.com/article/10.1...

In ADPKD, probenecid reduced tolvaptan-induced polyuria and nocturia while preserving its disease-modifying effects 🔑 A potential strategy to make tolvaptan more tolerable - and a new window into renal water homeostasis #Nephpearls #NephSky 👉 pubmed.ncbi.nlm.nih.gov/42298327/

Phase 3 proteinuria and eGFR data for available and emerging IgA Nephropathy #IgAN therapeutics (as of August 3, 2026) #Nephpearls #GlomConHawaii 🌊 #NephSky 👉 pubmed.ncbi.nlm.nih.gov/41895685/

VISIONARY: Sibeprenlimab in IgA nephropathy #IgAN ✅ Proteinuria reduction ✅ Preservation of kidney function #Nephpearls #GlomConHawaii 🌊 #NephSky #VisualAbstract by @alexgr23.bsky.social

nsMRAs in CKM Syndrome: Disease-Specific Deep Dives www.medscape.org/viewarticle/... via @MedscapeCME #Nephpearls #NephSky

Targeting BAFF and APRIL in IgA Nephropathy reachmd.com/programs/fro... via @ReachMD #Nephpearls #NephSky

Save the date #WCN27 🇲🇾 #ISNWCN 🇲🇾 #NephSky

Urea vs. tolvaptan for hospitalized patients with SIADH ca. 2026 #Nephpearls #NephSky 👉🏼 pubmed.ncbi.nlm.nih.gov/42455009/

Kick, Sweat, Protect: Kidney Health Through the Lens of Soccer (Football) ca. 2026 #Nephpearls #WorldCup #WorldCup2026 #NephSky 👉🏼 www.kidneymedicinejournal.org/article/S259...

Enthusiasm for EGDT has waned as 3 large, multicenter trials failed to reproduce the results of the Rivers trial #Nephpearls #AKIinICU #NephSky 🔑 Current Surviving Sepsis guidelines recommend an initial bolus of 30 mL/kg to be followed by additional fluid to maintain and improve perfusion

Obesity in CKD: Treatment algorithm ca. 2026 from @ndt-era.bsky.social @saynanorouzi.bsky.social @rahaai.bsky.social #Nephpearls #NephSky 👉 pubmed.ncbi.nlm.nih.gov/42446420/

The kidney in the middle: @kdigo.org guidelines address multiple key components of cardiovascular-kidney-metabolic syndrome ca. 2026 from @Kidney_Int #Nephpearls #Cardiorenal #NephSky 👉🏼 pubmed.ncbi.nlm.nih.gov/42191113/

When shock is refractory to initial fluid resuscitation, it is appropriate to consider vasopressor support #Nephpearls #AKIinICU #NephSky 📌 Distributive shock requires alpha-adrenergic stimulation to promote vasoconstriction and raise SVR

Screening algorithms in septic shock #Nephpearls #AKIinICU #NephSky ⚠️ SIRS may be highly sensitive but lacks specificity ⚠️ qSOFA may lack sensitivity for early sepsis or septic shock 🔑 These limitations highlight the importance of high clinical suspicion for shock 👉 shop.lww.com/Handbook-of-...

The fundamental problem in shock is "inadequate end-organ perfusion" #Nephpearls #AKIinICU #NephSky 📌 Low cardiac output (CO) ✔️ Hypovolemic ✔️ Cardiogenic ✔️ Obstructive 📌 Low systemic vascular resistance (SVR) aka Distributive: Sepsis

The Role of APRIL and the 4-Hit Process in the Pathogenesis of IgA Nephropathy #Nephpearls #NephSky reachmd.com/programs/med...