Emmanuel Levy&#x27;s lab

lifesciencesphd.unige.chUniversity of Geneva - PhD School of Life Sciences | Welcome to the PhD School in Life Sciences at the Faculties of Medicine and ScienceThe University of Geneva Faculties of Medicine and Science join their forces to offer an outstanding study and research environment in Life Sciences. Highly motivated students with a Master’s degree o...

Glad my voice could contribute to this special issue of Molecular Cell on AI in molecular biology. I see a lot of promise though some perils do exist! Several other voices' opinions to read there: Ellen Zhong, Jianyi Yang, Quan Chen, Alan Wong and Judith Zaugg. www.cell.com/molecular-ce...

Molecular Cell@cp-molcell.bsky.social

Artificial intelligence is rapidly transforming molecular biology. In this issue of Molecular Cell, we highlight recent advances at the intersection of AI and molecular biology, spanning structure prediction, design, genome engineering, and functional genomics. www.cell.com/molecular-ce...

Emmanuel Levy's lab reposted

Jana Helsen

@helsenjana.bsky.social

Looking to do a PhD in evolutionary cell biology, chromosomes & centromeres? 🧬🔬 The winter call for the UNIGE PhD recruitment is open, and my lab is among those recruiting through the Molecular Biosciences program! 🗓️ Apply by Nov 1st: lifesciencesphd.unige.ch

It took a while, but here we are. Our micDROP paper is out in @natcomms.nature.com, led by @atargt.bsky.social. She asked whether the sequence of a disordered region can self-recognize specifically. She measured this for ten IDRs in living yeast cells. www.nature.com/articles/s41...

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Out of 10 IDRs, 8 colocalized indiscriminately, whereas TDP43 and UBQ2 formed spatially distinct condensates. In TDP43 a segment forming a transient α-helix (see work by @nicolasluxfawzi.bsky.social) determined self-recognition specificity as a truncated mutant co-localized with all other IDRs.

Congratulations to Atar, Alex and Benjamin. With a system called micDROP, there is only one way to end a thread!

micDROP (_M_ultivalent _I_DRs forming _C_onstitutive _DROP_lets) consists of IDRs of interest fused to a fluorescent protein and to a mini-ferritin (12-mer) scaffold. We express them in yeast, quantify the dilute phase in 1000s of cells, which in turn enables inferring Csat for a particular IDR.

@martinpacesa.bsky.social

The Csat we measured span about two orders of magnitude, and stickier sequences condensed at lower concentration (R = -0.72). See doi.org/10.1002/pro.... for our latest stickiness scale

Emmanuel Levy's lab reposted

Martin Pacesa

21 Sept

ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...

@sophiemartinlab.bsky.social

Amazingly clever use of supramolecular protein self-assemblies as in vivo reporters and sensors

Changyang Linghu@changyanglinghu.bsky.social

What if you could record cytosolic activities or archive proteins on an intracellular tape across time? 📼 Introducing: 🔍 CytoSense records protease & kinase signaling activities 📦 CytoCatch archives cytosolic proteins along CytoTape Preprint: doi.org/10.64898/202... 🧵Thread (1/7)

Emmanuel Levy's lab reposted

Sophie G Martin

3 Mar

You are finishing your PhD and looking to continue in science? The Martin lab @biology-unige.bsky.social has an open postdoctoral position in cell biology to study cell-cell fusion. For more information, please consult mocel.unige.ch/research-gro.... Thanks for reposting!

mocel.unige.chContact/Job - Department of Molecular and Cellular Biology - UNIGE

Emmanuel Levy's lab reposted

European Conference on Computational Biology

@eccb-europe.bsky.social

4 Mar

📣 #ECCB2026 proceedings deadline extended to 16 March 13:00 CET Submit to 1 of our 6️⃣ sessions: 🔹 Genomics 🔹 Transcriptomics & gene regulation 🔹 Proteins & structural biology 🔹 Systems biology 🔹 Environmental bioinformatics 🔹 ELIXIR Communities 👉 More info: eccb2026.org/call-proceedings

9 Feb

In 2017 we showed that homomers evolve on the edge of supramolecular self-assembly. Here we show how to exploit this vulnerability so that ALL homomers can become bona fide drug-🎯. Delighted that Aim 3 of our @erc.europa.eu finally polymerized! Manuscript: 👉 rdcu.be/e27bT

@krishnanyamuna.bsky.social

9 Feb

This has only possible thanks to the herculean work of Ella Livnah in @london_lab who led the work, and the contributions from our many colleagues at @weizmanninstitute.bsky.social and @biology-unige.bsky.social.

Emmanuel Levy's lab reposted

Yamuna Krishnan

17 Dec 2025

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

bioRxivpreprint@biorxivpreprint.bsky.social

Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1

Emmanuel Levy's lab reposted

Paul & Virginie - Centriole Lab

@centriolelab.bsky.social

10 Dec 2025

We’re excited to announce the opening of the Geneva Expansion Microscopy Facility (GenExM)! GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging. Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations. 👉 www.unige.ch/genexm/

Emmanuel Levy's lab reposted

Rosana Collepardo

@rcollepardo.bsky.social

5 Dec 2025

Our Science paper is out! Huge congratulations to @huabin-zhou.bsky.social, Mike Rosen, and the brilliant @janhuemar.bsky.social @juliamaristany.bsky.social and @kieran-russell.bsky.social from our group News: bit.ly/4avnkAr and bit.ly/3XBGVHS Great perspective by @vram142.bsky.social +K Zhang

Di Jiang@dijiang319.bsky.social

@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.

science.orgMultiscale structure of chromatin condensates explains phase separation and material propertiesThe structure and interaction networks of molecules within biomolecular condensates are poorly understood. Using cryo–electron tomography and molecular dynamics simulations, we elucidated the structur...

Emmanuel Levy's lab reposted

David Drubin

@drubin.bsky.social

2 Dec 2025

Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published: journals.biologists.com/jcs/article/... The result of a fantastic Iwasa-Drubin lab collaboration. @margotriggi.bsky.social @jiwasa.bsky.social movie.biologists.com/video/10.124...

Emmanuel Levy's lab reposted

EMBL

@embl.org

27 Nov 2025

Anthony A. Hyman will become EMBL’s next Director General. He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999. www.embl.org/news/people-...

Emmanuel Levy's lab reposted

Miguel Correa

@m-correa-m.bsky.social

27 Oct 2025

Hot off the press! Our paper, “Global comparative structural analysis of responses to protein phosphorylation”, is now out in Nature Communications! www.nature.com/articles/s41...

nature.comGlobal comparative structural analysis of responses to protein phosphorylation - Nature CommunicationsPhosphorylation is central to protein regulation, yet its structural mechanisms remain poorly understood. Here, the authors conduct a global, systematic analysis of phosphorylated versus non-phosphory...

nature.comAssistant Professor with tenure-track for Quantitative Cell Biology (80-100%) - Bern, Canton of Bern (CH) job with University of Bern, Institute of Cell Biology | 12844963Assistant Professor with tenure-track for Quantitative Cell Biology (80-100%) at the University of Bern, Switzerland.

16 Oct 2025

Molecular Armor: Simple Rules to Keep Proteins (Re)Soluble💧 Check our preview of a cool study on how proteins stay soluble (or not) after desiccation—from the labs of S. Fried, @alexholehouse.bsky.social and @shaharsu.bsky.social in @cp-cellsystems.bsky.social www.sciencedirect.com/science/arti...

Emmanuel Levy's lab reposted

Benjamin Towbin

@betowbin.bsky.social

30 Sept 2025

Tenure-track Assistant Professorship in #Quantitative #Cell #Biology at the ICB @unibern. Apply until 17 October. Combination of theory/computation and experiments particularly encouraged. Please repost! www.nature.com/naturecareer...

Benjamin Towbin@betowbin.bsky.social

Exciting opportunity for TT-Ass #Professorship in Quantitative Cell Biology @unibe.ch @izb-unibern.bsky.social! Applicants combining experimental and computational approaches/theory are particularly encouraged. Great colleagues, environment, infrastructure. What's not to like? tinyurl.com/42f3p863

tinyurl.comAssistant Professor with tenure-track for Quantitative Cell Biology (80-100%) - Bern, Switzerland job with University of Bern, Institute of Cell Biology | 12840798Assistant Professor with tenure-track for Quantitative Cell Biology (80-100%) at the University of Bern, Switzerland.

Emmanuel Levy's lab reposted

Paul & Virginie - Centriole Lab

@centriolelab.bsky.social

15 Sept 2025

Be our new colleague! 🎉 The Dept of Molecular and Cellular Biology at the University of Geneva is hiring an Assistant Professor or Associate Professor. 👉 More details here: lnkd.in/e8Z9eAm4 👉 Our department: mocel.unige.ch Please feel free to share this opportunity with your network.

Emmanuel Levy's lab reposted

Molecular Systems Biology

@molsystbiol.org

7 Oct 2025

10/2025 Issue ➡️ www.embopress.org/toc/17444292... reduced genomes, adaptive mutations under stress, xenobiotics and gut microbiome, DMS analysis, TF effector metabolites Cover: proteins can agglomerate with limited impact on cell by @elevylab.bsky.social

5 Oct 2025

@molsystbiol.org picked a neat cover for this month's issue 🙃 - Great work from Tal Levin, Hector Garcia-Seisdedos, many more colleagues (doi.org/10.1038/s443...) and great matching cover, too!

genengnews.comAssay IDs Agglomerates for Intracellular EngineeringProtein agglomerates are reversible, so can serve as a regulatory mechanism for intracellular engineering.

3 Oct 2025

Nice to see Tal's work featured in biotech news ! www.genengnews.com/topics/biopr...

Emmanuel Levy's lab reposted

Martin Steinegger 🇺🇦

@martinsteinegger.bsky.social

21 Sept 2025

MMseqs2-GPU sets new standards in single query search speed, allows near instant search of big databases, scales to multiple GPUs and is fast beyond VRAM. It enables ColabFold MSA generation in seconds and sub-second Foldseek search against AFDB50. 1/n 📄 www.nature.com/articles/s41... 💿 mmseqs.com

nature.comGPU-accelerated homology search with MMseqs2 - Nature MethodsGraphics processing unit-accelerated MMseqs2 offers tremendous speedups for homology retrieval from metagenomic databases, query-centered multiple sequence alignment generation for structure predictio...

Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...

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This work has been a long and exciting journey, taking my lab into yeast proteomics and protein functions. All possible thanks to the great work of Tal Levin, Hector Garcia-Seisdedos and @arseniylobov.bsky.social in particular. Also big thanks to our collaborator Ohad Medalia at ZurichU.

doi.orgProtein aggregate or agglomerate: similar punctate structure with distinct biological profiles | Molecular Systems BiologyEMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

And cool to see our work featured in the journal! doi.org/10.1038/s443... Thanks Rui Sun and Yu Liu ☺️