Ellenberg Lab

Our work on NPC biogenesis is now out! Wanlu Zhang investigated the role of FG-Nups in NPC reassembly, pore dilation, and the nuclear envelope remodelling using acute depletions, correlative EM, and MINFLUX imaging 💫. Thanks, Wanlu and all the collaborators!

🔬🧬 New in @natcomms.nature.com‬: Nanoscale 3D DNA tracing in non‑denatured cells maps the #3Dgenome at nm‑resolution and reveals Cohesin‑dependent dynamic loops! 🚀 #OpenAccess  www.nature.com/articles/s41... @ellenberglab.bsky.social @jungmannlab.bsky.social #Genomics #SuperResolution

Our new non-denaturing nanoscale 3D DNA tracing technology provides single-cell (and sister-chromatid specific!) readout of chromatin structure with 10kb genomic resolution - Check it out! www.nature.com/articles/s41... Congratulations to Kai and Oyvind!!

This seems like a really important paper comparing chromosome tracing methods, demonstrating that classical denaturing DNA-FISH and chromosome tracing leads to substantial distortion of 3D genome structure, likely due to the high-temperatures involved (70-90C): www.nature.com/articles/s41...

Check out Andi's #Bluetorial for a summary of our findings 🙌

Did you know that DNA must form overlapping loops to give rise to the well-known X-shape of chromosomes? 🧬🧪 New research from EMBL's Ellenberg Group provides new insights into the process of chromosome formation. @ellenberglab.bsky.social @andibrunner.bsky.social www.embl.org/news/science...

Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social! Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩 www.sciencedirect.com/science/arti...

Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social! Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩 www.sciencedirect.com/science/arti...

We are #hiring! We have two open postdoc/research scientist positions to join our #ERC funded project MITOFOLD to resolve the organization of mitotic chromosomes! 1) experimental biologist shorturl.at/LjGEM 2) data scientist shorturl.at/nDdhQ Please share! 🙌 We look forward to your application! 🤩

Congratulations to @andibrunner.bsky.social and the team, and many thanks to the lab of Jan-Michael Peters for support! We found that the interphase and mitotic chromatin loop organization have more in common than previously thought: In both stages big loops are built first, small ones second

My first own project is published: Despite major differences in chromosome shape during #interphase and #mitosis, the underlying #loop-extruder based organization is highly similar A new data resource and new insights into human chromatin biology! 🧬🥳

Our excellent postdoc Wanlu Zhang is at #CellBio24 and will talk about her unpublished NPC biogensis work tomorrow! Check it out and say hello 🙌🏼

We are now on Bluesky! Follow us for exciting #Science around #CellDivision and nuclear organization, illuminated using advanced #imaging #technology - like our last preprint on mitotic chromosome structure and organization: tinyurl.com/yaznnkku