María Fernández-Casañas

Our @costerlab.bsky.social review is out! It’s a great read on the impact of DNA secondary structures on eukaryotic replication fork progression - a totally unbiased opinion, of course! www.sciencedirect.com/science/arti... @adityasethi.bsky.social @billiedelpino.bsky.social

Arrived at Worcester college in Oxford for the Ludwig AtoZ DNA secondary structures conference. Looking forward to great science, catching up with colleagues and some punting too!

How are mitotic chromosomes built? Our Review @cp-trendsgenetics.bsky.social revisits the classical chromosome scaffold model and connects it to condensins, topoIIα, and physical forces. We propose interphase chromatin domains as “building blocks”🧩of chromosomes: authors.elsevier.com/a/1nmwrcQbJI...

We’re hiring! 🧬 We're looking for a Postdoctoral Training Fellow to join our group at the ICR in London and work on chromatin biology, transcription regulation and AML. Curious about how histone modifications shape gene regulation and cell identity? Come join us! jobs.icr.ac.uk/vacancies/15...

And that’s a wrap! A huge thank you to everyone who joined us for UK DNA 2026, from our speakers and session chairs to everyone who presented, asked questions and shared their research. Thank you for making it such an engaging and enjoyable conference.

Beautiful paper by Akshay Jayachandran @cejkalab.bsky.social and co-workers delineating the functional divergence of yeast and human PIF1. It was a pleasure making a small contribution to the study @gdsc-sussex.bsky.social @sussex.ac.uk! www.genesdev.org/cgi/doi/10.1....

Our recent review on i-motifs reflects on our current insights on i-motifs and methodological challenges! #DNA

Great to be back in Cambridge for this year's GSN. Some amazing talks and so great to reconnect with colleagues and to make new acquaintances. #GSN #genomestability #chromatin #DNA

I really enjoyed putting this review together - great teamwork! Check it out if you’re curious to learn more about the immediate consequences of replication forks encountering DNA secondary structures! We hope it’s a useful resource for the field of genome replication and stability.

Registrations are now open!!

Our new review, looking into the roles of SWI/SNF in the chromatin environment around centromeres, is just out in Open Biology! @kezlane.bsky.social @thedownslab.bsky.social

Contact us to join our group with support of a Juan de la Cierva post-doctoral fellowship (#JDC2025) and delve into the mechanisms that protect genome integrity during replication using advanced genomics and AI-based modelling of replication fork structures! 📢 t.co/lA3HGPYM8w

🧪📣 PhD studentship available! Please repost. Our lab has a fully funded PhD position, starting Oct 2026. We provide a supportive environment and top notch facilities, helping you develop into an independent scientist. Project details: tinyurl.com/CosterPhD How to apply: tinyurl.com/ApplyICR

My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

Online Now: Biochemical reconstitution of sister chromatid cohesion establishment during DNA replication Online now:

Now out! Led by @susana-sousa.bsky.social and Noa Amin, and thanks to our collaborators in the Harrington @icr.ac.uk and Stucki and Choudhary @jc4-jyoti.bsky.social labs www.cell.com/cell-reports...

Checkout our latest research in @natcomms.nature.com rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team

A fantastic week of science (and nature) at the CSHL Eukaryotic DNA Replication & Genome Maintenance meeting ! #cshldnarep

Genome Centre throughout the years! @gdsc-sussex.bsky.social #GDSC #Brighton #ArchiveShot

So pleased to see my PhD project published, great work by everyone involved! Together we uncovered how regulation of the BTRR complex is crucial to protect centromeres during mitosis.

Looking forward to the next Helicase Conference! #HelicasesandNucleicAcidBasedMachines #Lisboa2025

Great to be at the Helicase Conference in Lisbon this week! 🧬 #HelicasesandNucleicAcidBasedMachines #CentroDeCongressos #Lisboa2025 #Unwinding @costerlab.bsky.social

New lab member joining is a great excuse to eat out and take a new lab photo 🎉🍜📷