Epigenome Technologies

New from Epigenome Technologies: the first fully validated Single-Cell CUT&Tag kit Fully compatible with 10x Chromium® (ATAC), Fluent PiP-seq®, or BD Rhapsody #Epigenetics #SingleCell #CUTandTag Find out more at: u.epigenome.us/NYjSGQao

Epigenetics Update - HP1 can act independently of H3K9 methylation to promote heterochromatin focus formation, gene repression, and organogenesis www.cell.com/molecular-ce... Jan Padeken and Susan E. Mango in Molecular Cell #Epigenetic #HP1 #Chromatin #H3K9 #Heterochromatin -- epigenometech.com

Epigenetics Preprint - A new epigenetic framework for DNA methylation, hydroxymethylation, and gene expression during brain aging www.biorxiv.org/content/10.6... ocanassr.bsky.social and Willard M. Freeman (omrf.bsky.social) in bioRxiv #Epigenetics #DNAm #Brain #Aging --- epigenometech.com

New Epigenome Technologies Blog! epigenometech.com/blog/posts/2... "Linking Chromatin Organization and Congenital Heart Disease" A single-cell study links TBX5 haploinsufficiency and altered chromatin organization to congenital heart disease #Epigenetics #Blog #Chromatin #CHD #TBX5

Epigenetics Update - Deep dynamical models of single-cell multiomic velocities predict loss-of-function and rescue perturbations in B cells www.nature.com/articles/s41... darkobar.bsky.social and Christina S. Leslie in Nat Biotech #Epigenetics #SingleCell #MultiOmics --- epigenometech.com

Epigenetics Update - A temporal single cell atlas of dynamic chromatin accessibility during murine lung maturation www.nature.com/articles/s41... #Epigenetics #SingleCell #Chromatin #Lung --- Gain deeper insights into gene regulation; epigenometech.com

Epigenetics Update - A PRMT5-ANGPTL4 axis in brain endothelial cells regulates cerebellar inhibitory synaptogenesis and motor coordination www.science.org/doi/10.1126/... #Epigenetics #PRMT5 #Synaptogenesis #Chromatin --- High-resolution insights without cell sorting; epigenometech.com

Epigenetics Review - Leveraging genomic deep learning models for the prediction of noncoding variant effects www.nature.com/articles/s41... poojakathail.bsky.social, Ayesha Bajwa, & Nilah M. Ioannidis (ucberkeleyofficial.bsky.social) in Nat Genet #Epigenetics #Review --- epigenometech.com

Epigenetics Review - Integration by parts: The multi-layered mechanisms of cis-regulatory control www.cell.com/molecular-ce... jcornwallscoones.bsky.social, jamesbriscoe.bsky.social, and joadelas.bsky.social in Mol Cell #Epigenetics #Chromatin #Review --- Empower your research: epigenometech.com

Download our poster to learn how we applied Droplet Paired-Tag to Alzheimer's disease post-mortem brain tissue to reveal specific cellular changes and potential therapeutic targets #Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics #Alzheimers u.epigenome.us/I8R4vBn2

Epigenetics Update - Establishing Polycomb regulatory landscapes in human early development www.nature.com/articles/s41... Keliang Wu/Zi-Jiang Chen (Shandong University) and Wei Xie (tsinghuauniversity.bsky.social) in Nat Genet #Epigenetics #Polycomb #Chromatin #Development --- epigenometech.com

Epigenetics Update - Altered sperm DNA methylation provides an epigenetic route from overweight and older men to intergenerational disease transmission www.pnas.org/doi/full/10.... Jacquetta Trasler & histone3.bsky.social (McGill University) in PNAS #Epigenetics #DNAm --- epigenometech.com

Epigenetics Update - Environmental chemical mixtures reprogram mammary epithelial development to epigenetic states associated with breast cancer www.pnas.org/doi/full/10.... #Epigenetics #Cancer #BreastCancer #DNAm --- High-resolution insights without cell sorting; epigenometech.com

Learn how we used Droplet Paired-Tag to assess RNA expression and histone mods in brain cells and PBMCs to identify novel cell-type-specific CREs and heritability factors linked to Alzheimer's disease #Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics u.epigenome.us/I8R4vBn2

Epigenetics Update - NNMT enhances hyperandrogenism in polyendocrine metabolic ovarian syndrome through epigenetic remodelling www.nature.com/articles/s42... Hongbo Yang & Hefeng Huang (fudanuniversity.bsky.social) in Nat Metab #Epigenetics #PMOS #Chromatin --- Find out more: epigenometech.com

Epigenetics Preprint - Dissection of Polycomb complexes reveals canonical PRC1-independent 3D chromatin interactions www.biorxiv.org/content/10.6... mileshuseyin.bsky.social and andersshansen.bsky.social (mit.edu) in bioRxiv #Epigenetics #Chromatin #PRC1 #Polycomb --- epigenometech.com

Epigenetics Update - Molecular mechanism of residue-specific nucleosome acetylation www.cell.com/molecular-ce... Marisa Müller (lmu.de) and Sebastian Eustermann (embl.org) in Molecular Cell #Epigenetics #Nucleosomes #Chromatin #H4K16 --- Discover the breakthrough at epigenometech.com

Download our poster to learn how we used single-cell CUT&Tag and Droplet Paired-Tag to profile PBMCs, generating over 70,000 single-cell profiles and identifying vast numbers of cis-regulatory elements. #Epigenetics #SingleCell #DropletPairedTag #PairedTag #Multiomics u.epigenome.us/I8R4vBn2

Epigenetics Update - Regulation of target gene expression by chromatin-associated protein-coding transcripts in plants www.science.org/doi/10.1126/... Lu Han / Yuxiang Yuan and Yijun Qi (tsinghuauniversity.bsky.social) in Science #Epigenetics #Chromatin #Plants --- epigenometech.com

Epigenetics Update - Multiplexed single-cell reduced representation bisulfite sequencing for genome-wide DNA methylation profiling www.nature.com/articles/s41... #Epigenetics #DNAm #SingleCell --- High-resolution insights without cell sorting; epigenometech.com

Epigenetics Update - Single-cell CRISPR screen maps epigenetic regulators of lineage specification and malignancies in human HSPCs www.cell.com/cell-stem-ce... #Epigenetics #Chromatin #CRISPR #StemCells #HSPCs --- Perfect for cancer, immunology, and aging research; epigenometech.com

New Epigenome Technologies Blog! epigenometech.com/blog/posts/2... "A New Multi-omic Epigenetic Study Describes Human Adult Hippocampal Aging at the Single-Cell Level" #Epigenetics #Chromatin #SingleCell #Aging #MultiOmics #BrainAging #DNAm #ChromatinAccessibility

Epigenetics Update - The histone variant H2A.Z regulates sex differences in Alzheimer’s disease pathophysiology www.cell.com/neuron/abstr... Luca A. Hategan/Jian Qi Luo and ivazovkic.bsky.social (utm.utoronto.ca) in Neuron #Epigenetics #H2AZ #Alzheimers #Chromatin --- epigenometech.com

Epigenetics Update - Brain DNA methylation, APOE genotype and Alzheimer's disease neuropathology in a large postmortem cohort www.nature.com/articles/s43... Guanhong Miao & Jinying Zhao (usf.edu) in Nat Aging #Epigenetics #DNAm #APOE #Alzheimers --- Discover the breakthrough: epigenometech.com

Epigenetics Update - SUMO2 deletion changes chromatin accessibility and enhances cytotoxic T cell activation and tumor infiltration www.science.org/doi/10.1126/... Yuan Chen (ucsdmedschool.bsky.social) in Science Advances #Epigenetics #SUMO2 #Chromatin --- Gain deeper insights; epigenometech.com

Epigenome Technologies offers an end-to-end Single-Cell Paired-Tag service, the first multiomic assay that simultaneously captures RNA expression and epigenetic marks from preparation to data analysis #Epigenetics #SingleCell #PairedTag #Multiomics u.epigenome.us/vyZjktjA

Epigenetics Update - Long-term immunoprophylaxis by TLR9 ligand mediates macrophage-ILC cross-talk against respiratory viral infection www.science.org/doi/10.1126/... #Epigenetics #Chromatin #ViralInfections --- High-resolution insights without cell sorting; epigenometech.com

Epigenetics Update - Epigenetic insights into extreme longevity in the world's oldest terrestrial animal, Jonathan www.science.org/doi/10.1126/... Stephen W. Clark (Kallel Foundation) in Science Advances #Epigenetics #Aging #DNAm #Jonathan --- Cancer, immunology, and aging; epigenometech.com

New from Epigenome Technologies: Paired-Tag - the first single-cell multiomic assay that simultaneously captures RNA expression and epigenetic marks #Epigenetics #SingleCell #PairedTag #Multiomics Find out more at: u.epigenome.us/pCTHvQHK

Epigenetics Update - Epigenetic aging and transposon dysregulation reflect size-related lifespan compression in dogs www.science.org/doi/10.1126/... blaisemariner.bsky.social/ Brianah M. McCoy & smacklab.bsky.social (Arizona State Univ.) in Science #Epigenetics #Aging #Dogs --- epigenometech.com

Epigenetics Update - Mechanistic insights into chromatin modulation by the "orphan" remodeler ATRX www.cell.com/molecular-ce... codyz.bsky.social and yangliu9.bsky.social (University of Hong Kong) in Molecular Cell #Epigenetics #Chromatin #ATRX --- Discover the breakthrough at epigenometech.com

New Epigenome Technologies Blog! epigenometech.com/blog/posts/2... "Droplet Paired-Tag Identifies Potential Therapeutic Targets for Heart Failure" #Epigenetics #Chromatin #HeartFailure #PairedTag #EpigenomeTech

Epigenetics Update - Alzheimer's disease target and drug discovery by leveraging multiomics and electronic health data www.nature.com/articles/s41... Feixiong Cheng (@clevelandclinic.bsky.social) in Nature Neuroscience #Epigenetics #Alzheimers #MultiOmics #Chromatin --- epigenometech.com

Epigenetics Update - Histone lactylation scarring transmits metabolic and epigenetic memory across the gut-liver axis www.cell.com/cell-metabol... #Epigenetics #Chromatin #Lactylation #EpigeneticMemory #Metabolism #GutLiverAxis --- High-resolution insights without cell sorting; epigenometech.com

Epigenome Technologies offers an end-to-end Single-Cell CUT&Tag service Our expert scientists run the entire workflow on your samples - from preparation to data analysis #Epigenetics #SingleCell #CUTandTag Find out more at: u.epigenome.us/Xz86EjGJ

Epigenetics Update - Metabolic reprogramming of pathogenic CD4+ T helper cells attenuates inflammatory bowel disease in mice www.science.org/doi/10.1126/... #Epigenetics #Chromatin #Metabolism #IBD #Inflammation --- Perfect for cancer, immunology, and aging research; epigenometech.com

Epigenetics Update - Spatially resolved genome architecture in mouse embryonic development www.cell.com/developmenta... Xiang Li (CAS) in @Developmental Cell #Epigenetics #Chromatin #SpaceA --- Empower your research with high-res epigenetic insights at epigenometech.com

New from Epigenome Technologies: the first fully validated Single-Cell CUT&Tag kit Fully compatible with 10x Chromium® (ATAC), Fluent PiP-seq®, or BD Rhapsody #Epigenetics #SingleCell #CUTandTag Find out more at: u.epigenome.us/NYjSGQao

Epigenetics Update - Chromatin accessibility trajectories reveal pre-cancerous epigenetic priming and an acid-driven immunotherapy-resistant gastric cancer subtype www.cell.com/cancer-cell/... #Epigenetics #Chromatin #Cancer #EpigeneticPriming #Immunotherapy --- epigenometech.com

Epigenetics Review – Arginine methylation in immunoregulation: Mechanisms and therapeutic targeting www.cell.com/cell-chemica... Song-Iee Han & Akiyoshi Fukamizu (Univ. Tsukuba) in Cell Chem Biol #Epigenetics #Review #ArginineMethylation #Chromatin --- Gain deeper insights; epigenometech.com

Epigenetics Update - Intestinal epithelial GSK3β governs fumarate-dependent neutrophil reprogramming to promote colorectal cancer www.nature.com/articles/s43... #Epigenetics #Chromatin #CRC #Cancer --- High-resolution insights without cell sorting; epigenometech.com

Epigenetics Preprint – Single-Nucleus Multi-Omic Atlas Maps Regulatory Architecture and Non-Coding Variant Effects across Adult Human Tissues www.biorxiv.org/content/10.6... #Epigenetic #Preprint #SingleCell #MultiOmic --- Perfect for cancer, immunology, and aging research; epigenometech.com

Epigenetics Update - An epigenetic program dictates MYC amplification dynamics that promote transient, extrachromosomal, and inherited genomic events www.cell.com/molecular-ce... Benjamin Ferman & Johnathan Whetstine in Mol Cell #Epigenetics #MYC #ecDNA #KDM4C #Chromatin --- epigenometech.com

Epigenetics Update - Maternal obesity imprints methylation marks in oocytes to drive intergenerational metabolic dysfunction www.nature.com/articles/s42... #Epigenetics #DNAm #Obesity #Metabolism #Oocytes --- Discover the breakthrough at epigenometech.com

Epigenetics Update - Single-allele nanoscale mapping of regulatory variants www.nature.com/articles/s41... Thomas A. Milne, Jim R. Hughes, and jojdavies.bsky.social (ox.ac.uk) in Nature Genetics #Epigenetics #Chromatin #Regulation --- Gain deeper insights into gene regulation; epigenometech.com

Epigenetics Update - Single-molecule chromatin tracing reveals a diversity of megabase heterochromatin domains www.nature.com/articles/s41... Dania Camila Pulido-Barrera and Susan E. Mango (unibas.ch) in NSMB #Epigenetics #Chromatin #Heterochromatin --- High-resolution insights; epigenometech.com

New Epigenome Technologies Blog! u.epigenome.us/RIPipZpR "Promoter Reinforcement Revealed as a New Therapeutic Resistance Mechanism" Analyzing chromatin conformation in treatment-resistant cancer cells identifies promoter reinforcement as a resistance mechanism. #Epigenetics #Chromatin #Cancer

Epigenetics Update - Type 2 immune history trains lung macrophages for viral disease tolerance www.nature.com/articles/s41... payalyokota.bsky.social and khannakm.bsky.social (NYU Grossman School of Medicine) in nature.com #Epigenetics #Chromatin --- Cancer, immunology, aging; epigenometech.com

Epigenetics Update - Reactivation of the embryonic ζ-globin gene ameliorates severe forms of α-thalassemia www.nature.com/articles/s41... Christian Babbs, Mira T. Kassouf, Douglas R. Higgs in Nat Genet #Epigenetics #Chromatin #Thalassemia --- Empower your research at epigenometech.com

Epigenetics Update - Population-scale immune multiome atlas reveals regulatory disease mechanisms www.nature.com/articles/s41... Mark J. Daly and Ramnik J. Xavier in nature.com #Epigenetics #Chromatin #Multiome #Disease --- Discover the breakthrough at epigenometech.com