epithelial mechanics fan club

📚 Welcome to the Epithelial Mechanics Fan Club! 🌟 We're all about sharing research papers and threads. If you'd like to contribute, please send DM us! 💬 Our goal is to build a community that fosters knowledge sharing. Explore our previous 🧵 here 👇

Forgacs, G., Foty, R. A., Shafrir, Y., & Steinberg, M. S. (1998). Viscoelastic Properties of Living Embryonic Tissues: a Quantitative Study. Biophysical Journal, 74(5), 2227–2234. #EpithelialMechanics doi.org/10.1016/S000...

Farge, E. (2003). Mechanical Induction of Twist in the Drosophila Foregut/Stomodeal Primordium. Current Biology, 13(16), 1365–1377. #EpithelialMechanics doi.org/10.1016/S096...

Wörthmüller, D., Ziebert, F., & Schwarz, U. S. (2026). Modeling mechanochemical coupling in optogenetically activated cell layers. Biophysical Journal, 125(12), 3034–3047. #EpithelialMechanics doi.org/10.1016/j.bp...

Kasuba, K. C., Fläschner, G., Jain, A., Krieg, M., Sharma, U., Gensbittel, V., ..., Vassalli, M., & Müller, D. J. (2026). Advancing mechanobiology from single molecules to complex cellular systems. Nature Nanotechnology, 21(6), 761–771. #EpithelialMechanicsReview www.nature.com/articles/s41...

Vellutini, B. C., Cuenca, M. B., Krishna, A., Szałapak, A., Modes, C. D., & Tomancak, P. (2025). Patterned invagination prevents mechanical instability during gastrulation. Nature, 646(8085), 627–636. #EpithelialMechanics www.nature.com/articles/s41...

Yamamoto, T., Ishibashi, T., Mimori-Kiyosue, Y., Hiver, S., Tokushige, N., Tarama, M., Takeichi, M., & Shibata, T. (2025). Epithelial cell chirality emerges through the dynamic concentric pattern of actomyosin cytoskeleton. eLife, 14, e102296. #EpithelialMechanics doi.org/10.7554/eLif...

Hi! 👋 How do epithelial tissues feel fluid flow? 🌊 Kidney tubules, gut, airways and brain ventricles are lined by epithelia that are constantly sheared by flowing fluid. Let's dive in with few papers 🧵

Kim, H. J., Huh, D., Hamilton, G., & Ingber, D. E. (2012). Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow. Lab on a Chip, 12(12), 2165. #EpithelialMechanics doi.org/10.1039/c2lc...

Vasilyev, A., Liu, Y., Mudumana, S., Mangos, S., Lam, P.-Y., Majumdar, A., Zhao, J., Poon, K.-L., ..., Korzh, V., & Drummond, I. A. (2009). Collective Cell Migration Drives Morphogenesis of the Kidney Nephron. PLoS Biology, 7(1), e1000009. #EpithelialMechanics doi.org/10.1371/jour...

Mitchell, B., Jacobs, R., Li, J., Chien, S., & Kintner, C. (2007). A positive feedback mechanism governs the polarity and motion of motile cilia. Nature, 447(7140), 97–101. #EpithelialMechanics doi.org/10.1038/natu...

Duan, Y., Gotoh, N., ..., Wang, T., & Weinbaum, S. (2008). Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes. Proceedings of the National Academy of Sciences, 105(32), 11418–11423. #EpithelialMechanics doi.org/10.1073/pnas...

Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., ..., Ingber, D. E., & Zhou, J. (2003). Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nature Genetics, 33(2), 129–137. #EpithelialMechanics doi.org/10.1038/ng1076

Espina, J. A., Cordeiro, M. H., Milivojevic, M., Pajić-Lijaković, I., & Barriga, E. H. (2023). Response of cells and tissues to shear stress. Journal of Cell Science, 136(18), jcs260985. #EpithelialMechanicsReview doi.org/10.1242/jcs....

Bailles, A., Serafini, G., ..., Modes, C. D., & Tomancak, P. (2025). Anisotropic stretch biases the self-organization of actin fibers in multicellular Hydra aggregates. Proceedings of the National Academy of Sciences, 122(32), e2423437122. #EpithelialMechanics www.pnas.org/doi/10.1073/...

Citi, S., Fromm, M., Furuse, M., González-Mariscal, L., Nusrat, A., Tsukita, S., & Turner, J. R. (2024). A short guide to the tight junction. Journal of Cell Science, 137(9), jcs261776. #EpithelialMechanicsReview doi.org/10.1242/jcs....

Gross, B. J., Soltwedel, J. R., ..., Gomez, C., & Campàs, O. (2025). STRESS, an automated geometrical characterization of deformable particles for in vivo measurements of cell and tissue mechanical stresses. Scientific Reports, 15(1), 28599. #EpithelialMechanics www.nature.com/articles/s41...

Rawal, S., Keshavanarayana, P., Manoj, D., Khuntia, P., Banerjee, S., ..., Spill, F., & Das, T. (2025). Edge curvature drives endoplasmic reticulum reorganization and dictates epithelial migration mode. Nature Cell Biology, 27(10), 1660–1675. #EpithelialMechanics www.nature.com/articles/s41...

Tanida, S., Fuji, K., Lu, L., Guyomar, T., Lee, B. H., ..., Nonomura, M., & Sano, M. (2025). Predicting organoid morphology through a phase field model: Insights into cell division and lumenal pressure. PLOS Computational Biology, 21(8), e1012090. #EpithelialMechanics doi.org/10.1371/jour...

Choi, B. J., Chen, Y.-C., & Desplan, C. (2025). Retinal calcium waves coordinate uniform tissue patterning of the Drosophila eye. Science, 390(6775), eady5541. #EpithelialMechanics www.science.org/doi/10.1126/...

Lange, Z., Matthäus, F., & Qiu, M. (2025). Vertex models capturing subcellular scales in epithelial tissues. PLOS Computational Biology, 21(5), e1012993. #EpithelialMechanicsReview doi.org/10.1371/jour...

Hsiao, S., Mukenhirn, M., Werner, C., Honigmann, A., & Krieg, E. (2025). Reconfigurable Microenvironments Uncover Mechano‐Sensing Timescales and Direct Cell Polarity. Advanced Functional Materials, 35(49), e13028. #EpithelialMechanics advanced.onlinelibrary.wiley.com/doi/10.1002/...

Bresteau, E., Suva, E. E., Revell, C., Hassan, O. A., Grata, A., Sheridan, J., Mitchell, J., ..., Jensen, O. E., & Mitchell, B. (2025). Apical size reduction by macropinocytosis alleviates tissue crowding. Nature Communications, 16(1), 5338. #EpithelialMechanics www.nature.com/articles/s41...

Can mathematics explain how biological patterns are formed? Alan Turing thought so. Join me, @benswedlund.bsky.social, as we explore his reaction-diffusion theory and how it transformed our understanding of pattern formation and self-organisation.

Check out my latest thread for @epimechfc.bsky.social and dive into how a 70 yr old mathematical theory may explain pattern self-organisation in biology!

Lovely thread about how this decades old theory continues to help us understand developmental pattern 🧪

Can mathematics explain how biological patterns are formed? Alan Turing thought so. Join me, @benswedlund.bsky.social , as we explore his reaction-diffusion theory and how it transformed our understanding of pattern formation and self-organisation.

Toda, S., Guan, G., Tambo, M., Morita, H., & Lim, W. A. (2026). Coupling Mechanical Regulation with Biochemical Reaction-Diffusion Circuits Yields Robust Self-Organized Pattern Formation. Synthetic Biology. #EpithelialMechanics doi.org/10.64898/202...

Scholes, N. S., Schnoerr, D., Isalan, M., & Stumpf, M. P. H. (2019). A Comprehensive Network Atlas Reveals That Turing Patterns Are Common but Not Robust. Cell Systems, 9(3), 243–257.e4. #EpithelialMechanics doi.org/10.1016/j.ce...

Ramos, R., Swedlund, B., Ganesan, A. K., Morsut, L., Maini, P. K., Monuki, E. S., ..., Chuong, C.-M., & Plikus, M. V. (2024). Parsing patterns: Emerging roles of tissue self-organization in health and disease. Cell, 187(13), 3165–3186. #EpithelialMechanicsReview doi.org/10.1016/j.ce...

Green, J. B. A., & Sharpe, J. (2015). Positional information and reaction-diffusion: two big ideas in developmental biology combine. Development, 142(7), 1203–1211. #EpithelialMechanics doi.org/10.1242/dev....