Dr. Todd Ewing PhD.

Dr. Todd Ewing PhD.

@ewingt-phd.bsky.social

Drug Discovery / Aging / Fitness Convincing myself that aging is simply loss of regulation/repair and CAN BE reversed! I wrote a book! BIOLOGICAL YOUTH http://amazon.com/dp/1535584459

490 followers1.2K following625 posts

Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Dietary #flavonoid apigenin a defender of the #aging #brain? bioengineer.org/apigenin-a-c... — in parsley, chamomile, celery — scavenges free radicals to preserve lipids, proteins, #DNA — activates Nrf2 repair pathway, supporting #autophagy, #mitophagy, #proteostasis, #glutathione & DNA repair

bioengineer.orgApigenin, a Common Plant Flavonoid, Emerges as a Multi-Target Defender ofA new review in Molecular Biology Reports details how the dietary flavonoid apigenin combats oxidative stress, neuroinflammation, mitochondrial dysfunction, and protein aggregation linked to
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Apigenin in neurodegeneration, brain health 🧪 link.springer.com/article/10.1... @atanas-g-atanasov.bsky.social @bakersm11.bsky.social @jngljane.bsky.social @mfamyfuerza.bsky.social @esiobhanmitchell.bsky.social @neurowithmelike.bsky.social @eisch.bsky.social @arxivofourminds.bsky.social

link.springer.comTherapeutic potential of apigenin in neurodegenerative diseases and brain health - Molecular Biology ReportsNeurodegenerative disorders are characterized by progressive neuronal loss and remain a major global health concern, largely due to their complex and multifactorial nature. These conditions, including...
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Facial biomarker model of #aging & #cancer #mortality risk www.thelancet.com/journals/lan... — highest-risk quartile had > 3X mortality of lowest — could enhance risk stratification when traditional biomarkers unavailable #health #research #technology 🧪🛟🤳🔬📸

thelancet.comFoundation artificial intelligence models for health recognition by use of face photographs (FAHR-Face): a model development and validation studyA single foundation model can generate inexpensive, scalable facial biomarkers that capture both biological ageing and disease-related mortality risk. The foundation model enabled effective training by use of relatively small clinical datasets. Routine quantitative facial analysis could enhance risk stratification when traditional biomarkers are unavailable.
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

#metabolomic signature predicts mortality in 4 cohorts 🧪🧬🛟🩺🩸🔬 ajcn.nutrition.org/article/S000... @atanas-g-atanasov.bsky.social @bakersm11.bsky.social @mljtpa.bsky.social @jngljane.bsky.social @mfamyfuerza.bsky.social @erlangen.bsky.social @esiobhanmitchell.bsky.social @neurowithmelike.bsky.social

ajcn.nutrition.orgA metabolomic signature of the Mediterranean diet predicts mortality in 4 independent cohortsThe Mediterranean diet (MedDiet) reduces cardiovascular disease, type 2 diabetes, and other chronic diseases. Adherence has mainly been assessed using self-reported questionnaires, and no previous stu...
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

#longevity fixation syndrome?! www.menshealth.com/health/a7413... — when people become miserable trying to be perfect with health — another nonsense word for obsessive compulsive disorder? ( #orthorexia is another nonsense example) — I prefer to follow longevity fixation and enlightened excursion

menshealth.comLongevity Hacks Are Now Making People Sick. Inside the Shocking Journey of One Man's Health Experiment Gone Wrong.Jason Wood thought he was doing everything right to live longer. That was the problem.
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Researchers @yaleschoolofmed.bsky.social find #taurine may reduce #aging #inflammation medicine.yale.edu/news-article... — moderate calorie restriction incr. taurine & decr. inflammation — paradoxically, aging incr. taurine & incr. inflammation — innate immune #macrophage has role in both effects

medicine.yale.eduStudy Reveals Amino Acid Can Diminish Age-Related InflammationTaurine controls an inflammatory response of the innate immune system. Manipulating it could be a target for inflammaging.
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Curiously, potassium ALSO appears to be anti- #inflammatory! "Restoring intracellular K+ with potassium chloride (KCl), which blocks #inflammasome activation, did not prevent #taurine efflux" 🧪

Dr. Todd Ewing PhD. reposted

Ying Cao
@neuralgrndstate.bsky.social

Replying to @ewingt-phd.bsky.social

Guess what? Like the 'rejuvenation factors' OSKM that are embryonic neural and promote cancer, SRSF1 is also embryonic neural and promotes cancer. Means what?

Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Chinese researchers develop plasma metabolite model of #aging www.science.org/doi/10.1126/... — laser desorption/ionization mass spectrometry (LDI-MS) — identified 56 representative age-associated metabolites — accelerated aging by model associates with chronic disease, mortality #longevity 🧪🧬🛟🩺📈

science.orgMetabolomic aging and mortality clocks based on ensemble learning identify systemic aging risk across the human life span in 18,476 individualsPlasma metabolomic profiling across the human life span yields two aging metrics linked to chronic disease and mortality.
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Researchers @harvard.edu suspect they found #longevity gene? wyss.harvard.edu/news/reversi... — typical cell reprogramming via de-differentiation risks cancer — cell age of donor correlates with gene expression profile — cell age reduced via up-regulation of SRSF1 splicing factor #aging #gerosky

wyss.harvard.eduReversing age by reprogramming gene expression networksBy Benjamin Boettner (BOSTON) — Every organ and tissue progressively loses function and integrity as it ages. In fact, researchers have identified “hallmarks of aging” that not only present specific p...
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Screen identifies SRSF1 as aging regulator🧪🧬 www.nature.com/articles/s43... @atanas-g-atanasov.bsky.social @bakersm11.bsky.social @mljtpa.bsky.social @jngljane.bsky.social @mfamyfuerza.bsky.social @42ndhumanbeing.bsky.social @erlangen.bsky.social @diana180.bsky.social @esiobhanmitchell.bsky.social

nature.comTranscriptomic reprogramming screen identifies SRSF1 as a regulator of aging - Nature AgingPlesa, Jung and colleagues conduct an in vitro transcriptomic reprogramming screen and identify splicing factor SRSF1 as capable of reducing transcriptomic age without loss of cell identity; they then...
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Extracellular vesicles (EVs) in the tumor microenvironment — transport functional cargo, including RNA, proteins, lipids— mediate cellular communication — biomarker of #tumor drug resistance Can EVs be engineered to reverse drug resistance via bioactive cargo? #health #science #research 🧪

oae-evcna.bsky.social@oae-evcna.bsky.social

🚀Can #extracellularvesicles help overcome tumor #drug #resistance? This Review provides a multidimensional view of EV-mediated resistance mechanisms, #biomarker potential, #engineered delivery platforms, and future #clinical applications. 📚 www.oaepublish.com/articles/evc... @ewingt-phd.bsky.social

Dr. Todd Ewing PhD. reposted

Voyager.Learner.Servant
@funkyzulu.bsky.social

This right here 👇🏽

Dr. Todd Ewing PhD.@ewingt-phd.bsky.social

Senescence, Exercise, Aging in the Heart🧪🧬 onlinelibrary.wiley.com/doi/10.1111/... @atanas-g-atanasov.bsky.social @bakersm11.bsky.social @mljtpa.bsky.social @jngljane.bsky.social @mfamyfuerza.bsky.social @42ndhumanbeing.bsky.social @erlangen.bsky.social @diana180.bsky.social @dricks.bsky.social

onlinelibrary.wiley.comChronic Senolytic Treatment and/or Aerobic Exercise Reduce Senescence and Improve Myocardial Function During Aging in the HeartMiddle aged mice (12-months-old) administered senolytics and/or aerobic exercise for 9 months showed a significantly lower accumulation of senescent cardiomyocytes and improved myocardial function co....
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Exercise is a natural #senolytic! bioengineer.org/senolytic-dr... Mouse study spanning entire second half of life — aerobic exercise worked as well as drugs to suppress cell senescence in heart — both interventions preserved heart function I highly recommend regular strength + endurance training

bioengineer.orgSenolytic Drugs and Aerobic Exercise Each Rejuvenate the Aging Mouse HeartA nine-month study in mice shows that chronic senolytic treatment and aerobic exercise each reduce senescent cell markers in the aging heart and improve myocardial function, though combining the two
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Senescence, Exercise, Aging in the Heart🧪🧬 onlinelibrary.wiley.com/doi/10.1111/... @atanas-g-atanasov.bsky.social @bakersm11.bsky.social @mljtpa.bsky.social @jngljane.bsky.social @mfamyfuerza.bsky.social @42ndhumanbeing.bsky.social @erlangen.bsky.social @diana180.bsky.social @dricks.bsky.social

onlinelibrary.wiley.comChronic Senolytic Treatment and/or Aerobic Exercise Reduce Senescence and Improve Myocardial Function During Aging in the HeartMiddle aged mice (12-months-old) administered senolytics and/or aerobic exercise for 9 months showed a significantly lower accumulation of senescent cardiomyocytes and improved myocardial function co....
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Big dogs, little dogs, #aging, #epigenome & #transposons www.nature.com/articles/d41... — Study of ~900 dogs from ~120 breeds — Big dogs die earlier, accumulate epigenetic changes faster — gene promoters gain methylation — introns & transposons lose methylation (activate) via @nature.com

nature.comBig dogs age faster than little ones — rogue ‘jumping genes’ might be to blameStudy of almost 900 dogs from roughly 120 breeds finds that rapid ageing of large canines is linked to changes in the epigenome.
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Btw I consider transposable elements to be a cause of age-related #genome instability for us humans! Our nuclei employ piwi-RNA and Dicer RNAse along with nightly re-methylation to suppress transposable elements The immortal freshwater hydra happen to have exceptional piwi-RNA/Dicer machinery 🧬

Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Chinese researchers notice link between gut #microbe, #metabolite & #atherosclerosis www.nature.com/articles/d41... — stool levels of Bacteroides uniformis often depleted in those with heart disease compared with healthy individuals — blood levels of metabolite C15 pentadecanoic acid also depleted

nature.comRevealed: how this common gut microbe protects against heart diseaseIntestinal bacterium secretes a molecule that reduces cholesterol production, according to a mouse study.
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

C15 fatty acid alleviates atherosclerosis🧪🧬🩺 www.nature.com/articles/s41... @atanas-g-atanasov.bsky.social @bakersm11.bsky.social @mljtpa.bsky.social @jngljane.bsky.social @mfamyfuerza.bsky.social @42ndhumanbeing.bsky.social @erlangen.bsky.social @diana180.bsky.social @esiobhanmitchell.bsky.social

nature.comA gut microbial odd-chain fatty acid alleviates atherosclerosis in mice - NatureThe administration of Bacteroides uniformis in mice can mitigate atherosclerosis via pentadecanoic acid, which directly inhibits HMG-CoA reductase to promote hepatic cholesterol clearance.
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Have you gotten your #flu #shot yet? I just received #mflusiva yesterday Yes, I'm well north of age 50! My body is beginning to ache 24 hrs later, so the #mRNA in my arm is working exquisitely! #pharmaceutical #vaccine #health #research #saveslives 🧪🛟🧬🩺📈

Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Can your #brain make new #neurons? www.nature.com/articles/d41... In the 1990s: — Researchers could see cells that had incorporated BrdU, meaning that they had originated from dividing cells — Some were non-neuronal cells, but the team identified others as neurons

nature.comCan your brain grow new neurons? How researchers are solving a century-old puzzleScientists have debated for decades whether the human brain sprouts new neurons throughout life. What would it mean if it could — and how much evidence is enough?
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Potentially, every tissue in the human body can fully replace itself with new cells over time — Perhaps we need to find the optimal #lifestyle conditions to achieve it — Perhaps we can awake every morning the same biological age we were the day preceding! #aging #longevity #healthpolicy 🧪🧬🩺📊

Dr. Todd Ewing PhD. reposted

Princess Vimentin PhD | Cancer Biologist
@princess-vimentin.bsky.social

Lately, I have been hearing that PhDs are not real doctors. It is infuriating to hear. But did you know- The word doctor comes from the Latin docere: “to teach.” A doctor was, quite literally, a teacher. Not a physician. Not a medical practitioner. A teacher. 🧪 valeman.medium.com/why-phd-has-...

valeman.medium.comWhy “PhD” Has Nothing to Do With Medicine: The Surprising Origins of the DoctorateWe tend to think of the title “Doctor” as something belonging to physicians, stethoscopes, and white coats. But long before modern medicine…
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Critique of #senolytic #vaccine claim 🧪🧬 link.springer.com/article/10.1... @atanas-g-atanasov.bsky.social @bakersm11.bsky.social @mljtpa.bsky.social @jngljane.bsky.social @mfamyfuerza.bsky.social @42ndhumanbeing.bsky.social @erlangen.bsky.social @diana180.bsky.social @esiobhanmitchell.bsky.social

link.springer.comTreatment benefit does not establish senolysis or lifespan extension - Journal of Translational MedicineJournal of Translational Medicine -
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Great points Another important issue is how all my drug discovery clients rely on Chinese contract-research organizations for out-sourcing of chemical synthesis and biochemical analysis I would guess that US Pharma out-sources 80% of synthesis/analysis to Chinese CROs 🧪

Princess Vimentin PhD | Cancer Biologist@princess-vimentin.bsky.social

China emerges as a power while we slip behind. "China has moved well beyond trying to become faster & better at drug development. It now wants to discover important new medicines in China, develop them there and build companies that sell them around the world." 🧪 www.biospace.com/business/chi...

biospace.comChina’s surging biotech sector represents both competition and lifeline for the USAs Chinese companies push beyond “me-too” drugs and the country lays out a new five-year plan targeting a $522 billion–strong biotech industry by 2030, experts say more predictable funding and regulat...
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Pharmacological Activation of AMPK Extends Lifespan 🧪🧬 onlinelibrary.wiley.com/doi/10.1111/... @atanas-g-atanasov.bsky.social @gmpinglish.bsky.social @mljtpa.bsky.social @jngljane.bsky.social @mariaoconnor.bsky.social @mfamyfuerza.bsky.social @carnegielemon.deferredreality.com @eh-neeld.bsky.social

onlinelibrary.wiley.comDirect Pharmacological Activation of <fc>AMPK</fc> Extends Lifespan in Yeast, Worms and FliesAMP-activated protein kinase (AMPK) is a key evolutionarily conserved sensor of energy homeostasis, which is implicated in metabolic health and disease, as well as in ageing. Here, we show that direc....
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Can aging be treated like a disease? www.cnn.com/health/can-a... My heroes Drs Nir Barzilai & Daniel Belsky weigh in #TLDR — Longevity clinics can only measure aging biomarkers, but no medical interventions available — Focus on healthy lifestyle: #exercise, #nutrition, #sleep, #socialization

cnn.comCan aging be treated like a disease? Scientists are starting to find out | CNNAs research into longevity advances, scientists are finding new ways to test a once-speculative idea: that aging itself could become a target of medicine.
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Excellent study! In the competition of genome replication in the gut, pathobionts devote genes for microtoxins instead of complex carbohydrate catabolism We all need to reduce dietary refined carbs in order to promote diverse eutrophic gut microbiome

This post is unavailable.
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Older adults still taking common drugs, despite new guidelines www.sfchronicle.com/health/aging... — medicines are like barnacles, easy to start, hard to stop — #benzodiazepines for insomnia, anxiety — #antibiotics for uncomplicated diverticulitis — #aspirin for primary prevention #aging 🧪🩺📊🧬🛟

sfchronicle.comGuidelines changed on these common drugs. Many older adults still take themNew research shows how hard it can be to stop medications once they become routine, even after medical advice shifts.
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Why tech billionaires don't ask theoretical physicists for #longevity advice www.theguardian.com/science/2026... “We’re a blink of an eye compared with the age of the universe. If I spend that blink of an eye trying to extend it to two blinks of an eye, I’m not sure it's a worthwhile thing” 🧪

theguardian.comTech billionaires trying to live for ever? That’s a waste of time, says physicistExclusive: Prof Jim Al-Khalili says he will offer solution to ‘arrow of time’ problem in Royal Institution lectures

Dr. Todd Ewing PhD. reposted

P. Inglish
@gmpinglish.bsky.social

Good!

Dr. Todd Ewing PhD.@ewingt-phd.bsky.social

Early-life sugar restriction slows biological aging 🧪🩺📊🧬🛟 www.pnas.org/doi/10.1073/... @atanas-g-atanasov.bsky.social @gmpinglish.bsky.social @mljtpa.bsky.social @jngljane.bsky.social @flipturns.bsky.social @mfamyfuerza.bsky.social @carnegielemon.deferredreality.com @neurowithmelike.bsky.social

pnas.orgEarly-life sugar restriction causally reduces adult cancer incidence and slows biological aging | PNASExcess sugar consumption is implicated in multiple cancers through insulin resistance, chronic inflammation, and metabolic reprogramming, yet wheth...
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

More evidence added #sugar accelerates #aging theconversation.com/babies-born-... — Britain’s postwar sugar rationing reduced infant exposure — Rationing ended September 1953 & infant exposure 2X — Incr. sweetness preference — Incr. 5 types of cancer: breast, prostate, liver, rectal, lung #health

theconversation.comBabies born under sugar rationing grew into adults with lower cancer riskBritain’s postwar sugar rationing was an accidental experiment. Decades on, it’s revealing how early diet shapes cancer risk, ageing and eating habits for life.
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Can #nutrients in our foods mimic calorie restriction and increase our #healthspan? 🧪 theconversation.com/can-nutrient... — No evidence yet for #supplements spermidine, urolithin A, resveratrol — Overwhelming evidence for whole #plantbased foods via Prof Justin Roberts @us.theconversation.com

theconversation.comCan nutrients in our foods mimic calorie restriction and increase our healthspan?Researchers are investigating whether food compounds can imitate calorie restriction. The strongest evidence still comes from cells and animals.
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Why is #cysteine amino acid so toxic to cells? www.rockefeller.edu/news/40469-c... — intracellular cysteine stored as glutathione — excess cysteine frees iron from ferritin — excess iron in mitochondria damages iron-sulfur proteins — mitochondria fail — cell death #health #supplement #aging

rockefeller.eduThe Rockefeller University » Why high levels of the amino acid cysteine are toxic to cellsThe findings explain why the cell prefers glutathione, and may lead to new therapies for certain types of neurodegeneration and cancers.
Dr. Todd Ewing PhD.
@ewingt-phd.bsky.social

Cysteine excess triggers mitochondrial iron cell death 🧪 www.nature.com/articles/s42... @atanas-g-atanasov.bsky.social @gmpinglish.bsky.social @mljtpa.bsky.social @jngljane.bsky.social @flipturns.bsky.social @mfamyfuerza.bsky.social @carnegielemon.deferredreality.com @neurowithmelike.bsky.social

nature.comCysteine excess triggers a mitochondrial iron-dependent cell death - Nature MetabolismUsing a genome-wide CRISPR screen, the authors demonstrate that excess cysteine drives mitochondrial iron accumulation and iron–sulfur cluster failure, triggering a distinct iron-dependent cell death ...