Thomas Frank

Thomas Frank

@frankfishlab.bsky.social

522 followers305 following5 posts

Thomas Frank reposted

Thomas Frank reposted

"Using molecular markers, tract tracing, and quantitative comparisons of cellular 12 distribution patterns, we report a detailed neuroanatomical atlas of the adult Danionella dracula (β€œDracula fish”) telencephalon." New #Danionella work from Perelmuter & Bass at Cornell 🐟 @danionella.bsky.social

bioRxiv Neuroscience@biorxiv-neursci.bsky.social

Atlas of adult Danionella fish telencephalon reveals retention of larval characters https://www.biorxiv.org/content/10.64898/2026.09.23.753900v1

Thomas Frank reposted

1/8 New preprint alert! How are signals from the heart encoded in the brain? What could be the functional implications of cardioception? We found that neurons in the posterior insular cortex are precisely tuned to heartbeats, and that this cardio-insular coupling supports emotion coding in mice.

biorxiv.orgbiorxiv.org

Exciting new results from our neighbors in the @mace-lab.bsky.social! Using functional ultrasound imaging, they look at brain-wide activity patterns in response to arousing events, showing propagation from subcortical regions to the cortex, and find a surprisingly weak modulation by noradrenaline!

Emilie MacΓ©@mace-lab.bsky.social

1/8. New preprint! Using fUSi in head-fixed mice🐭, we found that arousal events trigger a brain-wide wave of activity 🌊🧠. Surprisingly, this pattern was preserved during opto manipulations of the locus coeruleus, pointing to a minor role for noradrenergic tone. www.biorxiv.org/content/10.6...

Thomas Frank reposted

Thomas Frank reposted

Massive FOMo seeing the posts of people heading to #SfN2025, all that beach...ehm.. science I’m missing 😭 If you’re there, go say hi to the brilliant Bruno Pilcher and the INSS crew, who just built my lab a custom multiphoton microscope with a spatial light modulator that is pure chef’s kiss πŸ‘¨β€πŸ³πŸ’‹βœ¨

Bruno Pichler@brunopichler.bsky.social

Independent NeuroScience Services INSS was registered as a company on 14th November 2016, which means it's our 9th birthday today! As a birthday present we've treated ourselves to an SfN exhibitor booth for the first time ever. Come and say hello at Booth #3327

Thomas Frank reposted

New work from Baier Lab 🧠 🐟 πŸ”— to paper: www.sciencedirect.com/science/arti...

sciencedirect.comMolecular delineation of a retina-dependent photoneuroendocrine pathway in zebrafishMany vertebrates, including fish, amphibians, and reptiles, dynamically adjust their body color to the perceived brightness of the ambient background.…
MPI for Biological Intelligence@mpiforbi.bsky.social

How does a fish know when to blend in? Scientists identified a key circuit controlling camouflage in zebrafish – from cells in the retina sensing light to nerve cells in the brain controlling the release of a hormone that pales the skin to match bright backgrounds. www.bi.mpg.de/news/2025-11...

Thomas Frank reposted

Ohhh, that looks cool, also quite a few nice refs to the immune role of neuropeptides, including in the gut

Nature Reviews Neuroscience@natrevneuro.nature.com

The evolutionary origins of synaptic proteins and their changing roles in different organisms across evolution β€” a Review by Jeffrey J. Colgren & Pawel Burkhardt @jeffcolgren.bsky.social @pawelburkhardt.bsky.social #neuroscience #neuroskyence www.nature.com/articles/s41...

Thomas Frank reposted

New paper with @gili-ezranevo.bsky.social & Silvia Henriques from @ribeirocarlitos.bsky.social's lab out in @currentbiology.bsky.social. Appetite, driven by amino acid need πŸ₯šπŸ– reshapes olfactory receptor expression so flies πŸͺ° seek bacteria 🦠 and fermented cues πŸ₯« to restore nutritional balance βš–οΈ.

Champalimaud Research@champalimaudr.bsky.social

🦠 Microbes for dinner, anyone? When fruit flies go short on nutrients, their brains literally change the way they smell the world, helping them sniff out the microbes they need to survive. πŸ‘‰ Article: tinyurl.com/yw4rfph2 πŸ”— Paper: tinyurl.com/3j4avr4x @currentbiology.bsky.social

Thomas Frank reposted

Thomas Frank reposted

The most universally agreed upon property that sets emotion/affect apart from everything else is valence: approach/avoid; pleasant/unpleasant. Here they target its computation in flies, where you can really figure out the biology. We know so little about how valence is computed by brains. Exciting!

Katrin Vogt@katrinvogt.bsky.social

How is valence computed in the brain? Check out our new preprint about a single cell that integrates excitatory and inhibitory input across modalities according to valence and impacts behavioral decisions. An exciting collaboration across many labs. Enjoy reading! www.biorxiv.org/content/10.1...

Thomas Frank reposted

How is valence computed in the brain? Check out our new preprint about a single cell that integrates excitatory and inhibitory input across modalities according to valence and impacts behavioral decisions. An exciting collaboration across many labs. Enjoy reading! www.biorxiv.org/content/10.1...

biorxiv.orgA multisensory, bidirectional, valence encoder guides behavioral decisionsA key function of the brain is to categorize sensory cues as repulsive or attractive and respond accordingly. While we have some understanding of how sensory information is processed in the sensory pe...

Thomas Frank reposted

Ever wonder if there are spatial maps in the brain outside the hippocampal-entorhinal regions? In this preprint, we describe a novel spatial map in the orbitofrontal cortex (OFC) that preserves the topological arrangements and distance between locations. However, ... www.biorxiv.org/cgi/content/...

biorxiv.orgThe orbitofrontal cortex forms a context-generalized spatial schema that preserves topology and distanceFlexible and efficient navigation requires the brain to construct maps that are both topological, preserving the relationships between locations, and schematic, enabling generalization across environm...

Thomas Frank reposted

Want to image the adult zebrafish brain? Here's a nifty design that I made with the help of a talented master's student, Corey Steinhauser. Supporting files here! morgridge.org/research/lab...

morgridge.orgA 3D-Printable device for non-invasive neuroimaging of adult zebrafish - Morgridge Institute for ResearchShort Summary: This device is designed for use with an upright multiphoton microscope for neuroimaging of the adult and juvenile zebrafish. It allows for fast and reproducible mounting of fish
bioRxiv Neuroscience@biorxiv-neursci.bsky.social

Non-invasive longitudinal imaging reveals aging-associated changes in neuroimmune cells in adult zebrafish https://www.biorxiv.org/content/10.1101/2025.09.23.676912v1

Thomas Frank reposted

Exciting new results now published in Science: responses to visual objects are boosted in the brain's spatial navigation system. Read more in the thread below! Congratulations to all the authors!!

Emilie MacΓ©@mace-lab.bsky.social

Thrilled to share that our work is now published in Science! ✨ We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭 www.science.org/doi/10.1126/... 🧡1/

Thomas Frank reposted

Physik studieren? Oder ein anderes Fach? In GΓΆttingen geht jetzt beides, mit dem "Bachelor InterdisziplinΓ€r", der Physik mit spannenden Disziplinen Eurer Wahl, wie z.B. KΓΌnstlicher Intelligenz, Philosophie, Neurowissenschaften, ... kombiniert. www.uni-goettingen.de/de/studium/6...

uni-goettingen.deStudiengang Physik interdisziplinΓ€r - Georg-August-UniversitΓ€t GΓΆttingenWebseiten der Georg-August-UniversitΓ€t GΓΆttingen

Thomas Frank reposted

New preprint on common algorithms and evolutionary inventions that may account for apparent idiosyncratic encoding of odor concentration across species millions of years apart by taking advantage of divisive normalization: steered by Yang Shen, @arkarupbanerjee.bsky.social and Saket Navlakha. 1/3

doi.orgAn evolutionarily conserved scheme for reformatting odor concentration in early olfactory circuitsUnderstanding how stimuli from the sensory periphery are progressively reformatted to yield useful representations is a fundamental challenge in neuroscience. In olfaction, assessing odor concentration is key for many behaviors, such as tracking and navigation. Initially, as odor concentration increases, the average response of first-order sensory neurons also increases. However, the average response of second-order neurons remains flat with increasing concentration – a transformation that is believed to help with concentration-invariant odor identification, but that seemingly discards concentration information before it could be sent to higher brain regions. By combining neural data analyses from diverse species with computational modeling, we propose strategies by which second-order neurons preserve concentration information, despite flat mean responses at the population level. We find that individual second-order neurons have diverse concentration response curves that are unique to each odorant β€” some neurons respond more with higher concentration and others respond less β€” and together this diversity generates distinct combinatorial representations for different concentrations. We show that this encoding scheme can be recapitulated using a circuit computation, called divisive normalization, and we derive sufficient conditions for this diversity to emerge. We then discuss two mechanisms (spike rate vs. timing based) by which higher order brain regions may decode odor concentration from the reformatted representations. Since vertebrate and invertebrate olfactory systems likely evolved independently, our findings suggest that evolution converged on similar algorithmic solutions despite stark differences in neural circuit architectures. Finally, in land vertebrates a parallel olfactory pathway has evolved whose second-order neurons do not exhibit such diverse response curves; rather neurons in this pathway represent concentration information in a more monotonic fashion on average, potentially allowing for easier odor localization and identification at the expense of increased energy use. ### Competing Interest Statement The authors have declared no competing interest.

Thomas Frank reposted

πŸ”— to original research: www.nature.com/articles/s42...

nature.comMethylene blue at recommended concentrations alters metabolism in early zebrafish development - Communications BiologyMethylene Blue is an antifungal additive widely used in zebrafish embryo medium. At recommended concentrations, it exerts acute metabolic effects. This represents a previously unappreciated confound i...
mennigenlab.bsky.social@mennigenlab.bsky.social

Recent work from our lab: Niepukolie Nipu shows that methylene blue, at recommended concentrations used in embryo medium, affects metabolism and behaviour in larvae. These findings point to an overlooked confound relevant to larval zebrafish use in (eco)toxicity testing and the zebrafish community.

Exciting opportunity! Strongly encourage to apply.

Oliver Barnstedt@obarnstedt.bsky.social

Have you ever wondered how memories are processed downstream of the #hippocampus and how this is affected by #Alzheimer's? We believe we may find some answers by riding all the way down the fornix to the mammillary body. Apply here for a fully-funded #PhD with us: ovgu.b-ite.careers/56yvk

Thomas Frank reposted

Very exciting work! Congratulations to the entire team.

Matt Smear@mattsmear.bsky.social

(I forgot to ask in the thread:) Please consider turning on the sound for this post. The sniffs & spikes are sonified by converting the event times to MIDI. Kick drum=inhalation times Piano=spike times, where each note signifies the spike of a given unit (code & preprint on the method soon)

Thomas Frank reposted

Flushed cheeks, racing hearts, nervous tummies - all the stuff of where emotion meets interoception (the feeling of what's happening in our bodies). Which brain region seems to be involved? You guessed it, Insula! It's Day 5 of Insula week; let's talk about emotion & interoception. (A thread).

Nicole Rust@nicolecrust.bsky.social

I suspect that someone is doing the right experiment to figure these mysterious neurons do - stay tuned! And circle back tomorrow to hear about the Insula as the region of the brain where emotions and body feelings combine. kids.frontiersin.org/articles/10....

Thomas Frank reposted

We're happy to share the extension of the ZETA-test into a full-fledged statistical family. πŸ“ˆπŸ‘¨β€πŸ‘©β€πŸ‘§β€πŸ‘¦ Now you can also include more cells in your GCaMP data, and perform two-sample comparisons, all binning-free! With Jorrit Montijn and Alexander Heimel. www.biorxiv.org/content/10.1... #neuroscience

Thomas Frank reposted

πŸ˜±πŸ“£ BlueSky-ers: WE NEED YOUR HELP!!! πŸ™ All of you who ever liked a lecture of mine... All of you who liked one of the courses I teach in... All of you I work(ed) with in one way or another... All of you who see my desperation! 😜 PLEASE re-post! πŸ™ careers.humantechnopole.it/o/postdoc-in...

careers.humantechnopole.itPostdocs in Artificial IntelligenceHuman Technopole (HT) is an interdisciplinary life science research institute, created and supported by the Italian Government, with the aim of developing innovative strategies to improve human health

Thomas Frank reposted

Cited more than 1300 times, 'The behaviour and ecology of the zebrafish, Danio rerio' by Spence et al. (2007) highlights the special abilities of a small cyprinid found on the Indian subcontinent. A more recent take by Parichy (2015) expands on this in the context of evolution. #ZebrafishFunFacts