Thomas Frank reposted
We are sharing tools and knowledge to create and use virtual realities for (adult) (zebra)fish. Great work by Alex Javier, Sriram Narayanan and others. www.biorxiv.org/content/10.6...
Thomas Frank
Thomas Frank reposted
We are sharing tools and knowledge to create and use virtual realities for (adult) (zebra)fish. Great work by Alex Javier, Sriram Narayanan and others. www.biorxiv.org/content/10.6...
Thomas Frank reposted
"Using molecular markers, tract tracing, and quantitative comparisons of cellular 12 distribution patterns, we report a detailed neuroanatomical atlas of the adult Danionella dracula (βDracula fishβ) telencephalon." New #Danionella work from Perelmuter & Bass at Cornell π @danionella.bsky.social
Atlas of adult Danionella fish telencephalon reveals retention of larval characters https://www.biorxiv.org/content/10.64898/2026.09.23.753900v1
Thomas Frank reposted
We had amazing talks at the #ECRO2026 symposium "Modulation of chemosensation" organized by @modolfor.bsky.social members @silkesachse.bsky.social and @katrinvogt.bsky.social. Big thanks to all speakers: Nilay Yapici, Markus Knaden, @frankfishlab.bsky.social and Markus Rothermel
Thomas Frank reposted
πΈ Postdoc Position (m/f/d) in Neurobiology! The project focuses on how smell shapes feeding behavior in poison frogs and is conducted in collaboration with Prof. Jennifer Stynoski (Costa Rica). ππΏ . For more information and to apply, please use the link below. www.uni-giessen.de/de/ueber-uns...
Thomas Frank reposted
1/8 New preprint alert! How are signals from the heart encoded in the brain? What could be the functional implications of cardioception? We found that neurons in the posterior insular cortex are precisely tuned to heartbeats, and that this cardio-insular coupling supports emotion coding in mice.
Exciting new results from our neighbors in the @mace-lab.bsky.social! Using functional ultrasound imaging, they look at brain-wide activity patterns in response to arousing events, showing propagation from subcortical regions to the cortex, and find a surprisingly weak modulation by noradrenaline!
1/8. New preprint! Using fUSi in head-fixed miceπ, we found that arousal events trigger a brain-wide wave of activity ππ§ . Surprisingly, this pattern was preserved during opto manipulations of the locus coeruleus, pointing to a minor role for noradrenergic tone. www.biorxiv.org/content/10.6...
Thomas Frank reposted
Arousal elicits a brain-wide hemodynamic wave independent of locus coeruleus noradrenergic tone https://www.biorxiv.org/content/10.64898/2026.03.06.710089v1
Thomas Frank reposted
In @elife.bsky.social: Pallium-encoded valence-specific chemosensory amplification of eye-body coordination in larval zebrafish doi.org/10.7554/eLif...
Thomas Frank reposted
Out now in @ebiomedicine.bsky.social π¨. Hunger often affects our mood, but is this a conscious or a subconscious process? Using continuous glucose monitoring, we show that differences in mood are driven by hunger ratings, not just glucose. #neuroskyence π©Ί www.thelancet.com/journals/EBI...
Thomas Frank reposted
Thomas Frank reposted
π I am very glad to share that our paper on the rapid isotropic light-sheet microscope has just been published in Nature Biotechnology @natbiotech.nature.com. π Read the full article: www.nature.com/articles/s41...
Thomas Frank reposted
Massive FOMo seeing the posts of people heading to #SfN2025, all that beach...ehm.. science Iβm missing π If youβre there, go say hi to the brilliant Bruno Pilcher and the INSS crew, who just built my lab a custom multiphoton microscope with a spatial light modulator that is pure chefβs kiss π¨βπ³πβ¨
Independent NeuroScience Services INSS was registered as a company on 14th November 2016, which means it's our 9th birthday today! As a birthday present we've treated ourselves to an SfN exhibitor booth for the first time ever. Come and say hello at Booth #3327
Thomas Frank reposted
New work from Baier Lab π§ π π to paper: www.sciencedirect.com/science/arti...
How does a fish know when to blend in? Scientists identified a key circuit controlling camouflage in zebrafish β from cells in the retina sensing light to nerve cells in the brain controlling the release of a hormone that pales the skin to match bright backgrounds. www.bi.mpg.de/news/2025-11...
Thomas Frank reposted
Ohhh, that looks cool, also quite a few nice refs to the immune role of neuropeptides, including in the gut
The evolutionary origins of synaptic proteins and their changing roles in different organisms across evolution β a Review by Jeffrey J. Colgren & Pawel Burkhardt @jeffcolgren.bsky.social @pawelburkhardt.bsky.social #neuroscience #neuroskyence www.nature.com/articles/s41...
Thomas Frank reposted
New paper with @gili-ezranevo.bsky.social & Silvia Henriques from @ribeirocarlitos.bsky.social's lab out in @currentbiology.bsky.social. Appetite, driven by amino acid need π₯π reshapes olfactory receptor expression so flies πͺ° seek bacteria π¦ and fermented cues π₯« to restore nutritional balance βοΈ.
π¦ Microbes for dinner, anyone? When fruit flies go short on nutrients, their brains literally change the way they smell the world, helping them sniff out the microbes they need to survive. π Article: tinyurl.com/yw4rfph2 π Paper: tinyurl.com/3j4avr4x @currentbiology.bsky.social
Thomas Frank reposted
First neurons didnβt appear overnight. We trace their roots to ancient secretory cells - showing how lifestyle & behavior shaped the evolution of first synapses.π§ π #Evolution #Neuroscience Our latest in @natrevneuro.nature.com Link: rdcu.be/eMX3E @jeffcolgren.bsky.social @msarscentre.bsky.social
Thomas Frank reposted
Thomas Frank reposted
Our latest study on the neurobiology of collective behavior is now posted as a preprint, led by UCSD PhD student Jo-Hsien Yu @anitajhyu.bsky.social @ucsandiego.bsky.social @danionella.bsky.social www.biorxiv.org/content/10.1...
Thomas Frank reposted
The most universally agreed upon property that sets emotion/affect apart from everything else is valence: approach/avoid; pleasant/unpleasant. Here they target its computation in flies, where you can really figure out the biology. We know so little about how valence is computed by brains. Exciting!
How is valence computed in the brain? Check out our new preprint about a single cell that integrates excitatory and inhibitory input across modalities according to valence and impacts behavioral decisions. An exciting collaboration across many labs. Enjoy reading! www.biorxiv.org/content/10.1...
Thomas Frank reposted
How is valence computed in the brain? Check out our new preprint about a single cell that integrates excitatory and inhibitory input across modalities according to valence and impacts behavioral decisions. An exciting collaboration across many labs. Enjoy reading! www.biorxiv.org/content/10.1...
Thomas Frank reposted
Ever wonder if there are spatial maps in the brain outside the hippocampal-entorhinal regions? In this preprint, we describe a novel spatial map in the orbitofrontal cortex (OFC) that preserves the topological arrangements and distance between locations. However, ... www.biorxiv.org/cgi/content/...
Thomas Frank reposted
Want to image the adult zebrafish brain? Here's a nifty design that I made with the help of a talented master's student, Corey Steinhauser. Supporting files here! morgridge.org/research/lab...
Non-invasive longitudinal imaging reveals aging-associated changes in neuroimmune cells in adult zebrafish https://www.biorxiv.org/content/10.1101/2025.09.23.676912v1
Thomas Frank reposted
Check out this exciting study led by Anh-Tuan Trinh from our lab, where we investigated how thalamocortical-like circuits in the zebrafish pallium receive, represent, and integrate sensory information: π doi.org/10.1101/2025...
Thomas Frank reposted
Replying to @mace-lab.bsky.social
We currently have open positions for PhD and Postdocs! Interested in learning fUS: please apply! brainwidenetworks.uni-goettingen.de/open-positio...
Exciting new results now published in Science: responses to visual objects are boosted in the brain's spatial navigation system. Read more in the thread below! Congratulations to all the authors!!
Thrilled to share that our work is now published in Science! β¨ We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! π§ www.science.org/doi/10.1126/... π§΅1/
Thomas Frank reposted
Physik studieren? Oder ein anderes Fach? In GΓΆttingen geht jetzt beides, mit dem "Bachelor InterdisziplinΓ€r", der Physik mit spannenden Disziplinen Eurer Wahl, wie z.B. KΓΌnstlicher Intelligenz, Philosophie, Neurowissenschaften, ... kombiniert. www.uni-goettingen.de/de/studium/6...
Thomas Frank reposted
A. James Hudpseth, who died 16 August at age 79, devoted his 50-year career to untangling how the ear converts sound into electrical signals. By @callimcflurry.bsky.social www.thetransmitter.org/hearing/reme...
Thomas Frank reposted
New preprint on common algorithms and evolutionary inventions that may account for apparent idiosyncratic encoding of odor concentration across species millions of years apart by taking advantage of divisive normalization: steered by Yang Shen, @arkarupbanerjee.bsky.social and Saket Navlakha. 1/3
Thomas Frank reposted
π to original research: www.nature.com/articles/s42...
Recent work from our lab: Niepukolie Nipu shows that methylene blue, at recommended concentrations used in embryo medium, affects metabolism and behaviour in larvae. These findings point to an overlooked confound relevant to larval zebrafish use in (eco)toxicity testing and the zebrafish community.
Exciting opportunity! Strongly encourage to apply.
Have you ever wondered how memories are processed downstream of the #hippocampus and how this is affected by #Alzheimer's? We believe we may find some answers by riding all the way down the fornix to the mammillary body. Apply here for a fully-funded #PhD with us: ovgu.b-ite.careers/56yvk
Thomas Frank reposted
π¨New(ish) preprint In mice, visual objects are encoded in the navigation syst, not much in the visual cx, certainly because they are used for orientation. This new version now includes cool comp work from @dlevenstein.bsky.social using @kenmiller.bsky.social's SSNs. www.biorxiv.org/content/10.1...
Thomas Frank reposted
Order matters: neurons in the human brain fire in sequences that encode information www.nature.com/articles/d41...
Very exciting work! Congratulations to the entire team.
(I forgot to ask in the thread:) Please consider turning on the sound for this post. The sniffs & spikes are sonified by converting the event times to MIDI. Kick drum=inhalation times Piano=spike times, where each note signifies the spike of a given unit (code & preprint on the method soon)
Thomas Frank reposted
Starter packs are great, but they can only have 150 accounts on them. Check out my much larger list of Brain and Mind researchers here - and let me know if you would like to be added! #neuroskyence #psychscisky bsky.app/profile/mica...
Thomas Frank reposted
Flushed cheeks, racing hearts, nervous tummies - all the stuff of where emotion meets interoception (the feeling of what's happening in our bodies). Which brain region seems to be involved? You guessed it, Insula! It's Day 5 of Insula week; let's talk about emotion & interoception. (A thread).
I suspect that someone is doing the right experiment to figure these mysterious neurons do - stay tuned! And circle back tomorrow to hear about the Insula as the region of the brain where emotions and body feelings combine. kids.frontiersin.org/articles/10....
Thomas Frank reposted
Aversive stimulus-tuned responses in the CA1 of the dorsal hippocampus www.nature.com/articles/s41...
Thomas Frank reposted
We're happy to share the extension of the ZETA-test into a full-fledged statistical family. ππ¨βπ©βπ§βπ¦ Now you can also include more cells in your GCaMP data, and perform two-sample comparisons, all binning-free! With Jorrit Montijn and Alexander Heimel. www.biorxiv.org/content/10.1... #neuroscience
Thomas Frank reposted
Synaptic Zn2+ contributes to deleterious consequences of spreading depolarizations https://www.biorxiv.org/content/10.1101/2023.10.27.564408v1
Thomas Frank reposted
π±π£ BlueSky-ers: WE NEED YOUR HELP!!! π All of you who ever liked a lecture of mine... All of you who liked one of the courses I teach in... All of you I work(ed) with in one way or another... All of you who see my desperation! π PLEASE re-post! π careers.humantechnopole.it/o/postdoc-in...
Thomas Frank reposted
In our new pre-print, we found that "fear profiles" can be decoded from the ventral visual stream whether participants report being afraid of the stimuli or not. It is the interaction between the prefrontal and visual cortices that seemed to support subjective fear www.biorxiv.org/content/10.1...
Thomas Frank reposted
Thomas Frank reposted
Iβm hiring!! Want to join our team? We need another software engineer! π₯ hit me up on Linkedin β¬οΈ
Thomas Frank reposted
Thomas Frank reposted
Differential encoding of odor and place in mouse piriform and entorhinal cortex https://www.biorxiv.org/content/10.1101/2023.10.05.561119v1
Thomas Frank reposted
Thomas Frank reposted
Brain state transitions primarily impact the spontaneous rate of slow-firing neurons - now out in CellReports doi.org/10.1016/j.ce... #neuroskyence #compneuro