Genes & Development

🚨 NEW ISSUE ALERT!!! 🚨 New Research articles online now at Genes & Development! Also in this issue, two additions to our collection of Reviews on Cancer Metabolism, and more... Click here to learn more: ➡️ https://genesdev.cshlp.org/content/40/19-20.toc

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Decoding anterior–posterior patterning cues into embryo-wide binary fate decisions through recruitment-mediated targeting By Xiao et al. and Zhuo Du ➡️ https://ow.ly/635Y5100YEZ #patterning #Wnt #Celegans

🆕 ADVANCE ONLINE 🆕 RESEARCH COMMUNICATION: MCM10 and RECQL4 have cooperative and redundant roles in activating the CMG helicase during the replication initiation By Bektash et al. and Masato Kanemaki ➡️ https://ow.ly/3QFg50ZXOwN #DNA #DNAreplication #helicase

🆕 ADVANCE ONLINE 🆕 RESEARCH COMMUNICATION: Chromosomal requirements for formation of multivalent human nucleoli By Krystyna Giemza, Hazel Mangan, and Brian McStay ➡️ https://ow.ly/4BEy50ZXOf8 University of Galway #chromosome #nucleolar #ribosome

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Sharp cell type boundaries emerge from coordinated morphogen signaling By Li et al. and Peggy Myung ➡️ https://ow.ly/zY3p50ZXNVU Yale University #morphogen #WNT #Hedgehog #patterning

🆕 ADVANCE ONLINE 🆕 REVIEW: Architectural logic of the 3D genome: mechanisms of dysregulation and emerging cancer therapeutics By Smith et al. and Yu (Sunny) Liu ➡️ https://ow.ly/XRqA50ZW4Gm Yu-Sunny-Liu Rebecca Smith Academic Affairs @ Fox Chase #cancer #epigenetics #chromatin

ON THE COVER: MYC-PVT1-derived Firefox and Honeybadger regulate MYC-driven oncogenesis Artwork by by Jianhua Zhao Learn more in these complementary studies by Anindya Bagchi’s group: ➡️ https://ow.ly/NSQn50ZZsHq

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Mitotic MAX bookmarking drives MYC-dependent hypertranscription at TBP-bound promoters By Gonzalez et al. and Pablo Navarro ➡️ https://ow.ly/IzFu50ZXNvJ Pablo Navarro Institut Pasteur | 130 years of biomedical research #transcription #transcriptionfactor #MYC

🎙 G&D Voices: Author Lluis Morey 🎙 G&D continues to inspire scientists and publish influential research. G&D author, Lluis Morey, tells us why he chooses to publish in G&D.

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: mTOR inactivation governs adaptive survival to ribosome biogenesis deficiency By Fan et al. and Marikki Laiho ➡️ https://ow.ly/Ck5R50ZW4ZO Johns Hopkins University #cancer #ribosome #translation #mTOR

🌟 G&D SPOTLIGHT 🌟 G&D is pleased to present a collection of recent articles on gene regulation, RNA processing, and chromatin. Learn more about the molecular mechanisms shaping gene expression and cell function: ➡️ https://genesdev.cshlp.org/site/misc/molregulation.xhtml

🆕 ADVANCE ONLINE 🆕 REVIEW: Regulatory circuits that build and sustain noninfectious granulomas By Ridky et al. and Thomas Leung ➡️ https://ow.ly/UI7O50ZW4IQ University of Pennsylvania #cancer #inflammation #granuloma

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Multiple quality control checkpoints safeguard small nuclear RNA biogenesis and prevent assembly of aberrant spliceosomes By Ma et al. and ens Lykke-Andersen ➡️ https://ow.ly/aZAB50ZW4wA UC San Diego #RNA #RNAdecay #RNAsplicing

RESEARCH PAPER: Nuclear type I myosins actively support nucleolar and nuclear structure and function By Peng et al. and Brian Freeman ➡️ https://genesdev.cshlp.org/content/40/19-20/1765.abstract #genome #nucleus #myosin

RESEARCH PAPER: Human PIF1 clears secondary DNA structures by coupled DNA unwinding and rewinding activities By Jayachandran et al. and Petr Cejka ➡️ https://genesdev.cshlp.org/content/40/19-20/1747.abstract Petr Cejka Institute for Research in Biomedicine Università della Svizzera italiana #DNA

🎙️ G&D Voices: Author Anindya Bagchi🎙️ Two complementary studies, one complete story. G&D Author, Anindya Bagchi, tells us about why G&D was the right home for their work. Learn more here: ➡️ genesdev.cshlp.org

We spoke with four researchers who have repeatedly chosen Review Commons as a preprint #PeerReview platform for their own work. 🧪 Learn why they decided on Review Commons here: https://www.embo.org/features/why-i-chose-review-commons/ #LifeSciences #research #publishing #preprint

RESEARCH PAPER: Honeybadger, a PVT1-derived micropeptide, is a critical negative regulator of RAS–MAPK signaling in MYC-driven tumors By Paithane et al. and Anindya Bagchi ➡️ https://genesdev.cshlp.org/content/40/19-20/1706.abstract And: ➡️ https://genesdev.cshlp.org/content/40/19-20/1688.abstract

RESEARCH PAPER: Firefox, a protein encoded by circular PVT1, is essential for MYC-driven oncogenesis By Tiwari et al. and Anindya Bagchi ➡️ https://genesdev.cshlp.org/content/40/19-20/1688.abstract Also read: ➡️ https://genesdev.cshlp.org/content/40/19-20/1706.abstract #cancer #MYC #KRAS #lncRNA

CANCER METABOLISM REVIEW: Dangerous liaisons: interactions between cancer cells and adipocytes as drivers of cancer progression By Carolina Dehesa Caballero and Almut Schulze ➡️ https://genesdev.cshlp.org/content/40/19-20/1598.full Almut Schulze Deutsches Krebsforschungszentrum (DKFZ) #cancer

OUTLOOK: Cycling off: a novel mechanism for differential cell cycle-dependent histone gene expression By Lauren Hodkinson & Erica Larschan ➡️ https://genesdev.cshlp.org/content/40/19-20/1575.full Also read: ➡️ https://genesdev.cshlp.org/content/40/19-20/1649.abstract @ericalarschan.bsky.social

RESEARCH PAPER: Temporal gating dictates stress-induced transcript export from the nucleus By Helton et al. and Stephanie Moon ➡️ https://genesdev.cshlp.org/content/40/19-20/1724.full Stephanie Moon #mRNA #stress #RNAexport

📽️ G&D Tapes 📽️ G&D Author, Kei Ishiguro, tells us about how the MEIOSIN-STRA8 interaction reinforces meiotic transcription and facilitates meiotic progression. Read the full story: ➡️ https://genesdev.cshlp.org/content/40/19-20/1629.full Ishiguro Lab #celldivision #transcription #development

RESEARCH PAPER: Multimerization of ELAV in Drosophila is essential for directing neuronal alternative splicing and polyadenylation programs By Dix, McQuarrie, Bräuer et al. and Matthias Soller ➡️ https://genesdev.cshlp.org/content/40/19-20/1669.abstract Matthias Soller #RNA #neuron #Drosophila

📽️ G&D Tapes 📽️ G&D Authors in the Higuchi-Sanabria lab tell us about how the neuronal expression of the chromatin reader BET1 influences aging. Read the full story: ➡️ https://genesdev.cshlp.org/content/40/17-18/1523.full The University of Southern California @uscleonarddavis.bsky.social #aging

RESEARCH PAPER: MEIOSIN retains a STRA8-independent activity that contributes to meiotic gene activation across vertebrates By Shimada et al. and Kei-ichiro Ishiguro ➡️ https://genesdev.cshlp.org/content/40/19-20/1629.full Ishiguro Lab #celldivision #transcription #vertebratedevelopment

Study reveals a new way the developing heart controls its growth ➡️ https://ow.ly/iniL50ZU5sW Read the full story on #GenesDev: ➡️ https://ow.ly/Xy6A50ZU5t2

RESEARCH PAPER: rRNA 5′ETS processing contributes to nucleolar organization and nuclear architecture By Mendoza-Figueroa et al. and Kathy Fange Liu ➡️ https://genesdev.cshlp.org/content/40/19-20/1614.abstract @kathyliulab.bsky.social University of Pennsylvania Penn Medicine #RNA #nucleus #genome

CANCER METABOLISM REVIEW: Lysosomal metabolism in pancreatic cancer and its crosstalk with host physiology By Cheng et al. and Costas Lyssiotis ➡️ https://genesdev.cshlp.org/content/40/19-20/1578.full Caleb Cheng Lyssiotis Lab #pancreaticcancer #metabolism #lysosome

📽️ G&D Tapes 📽️ G&D Authors, Jeongjin Kim & Amit Behera, tell us about how they used CRASP-seq to identify RBM39 as a splicing regulator controlling IRE1α–XBP1 signaling in an adaptive response to proteotoxic stress. Read the full story: ➡️ https://genesdev.cshlp.org/content/40/17-18/1448.full #RNA

RESEARCH PAPER: Differential control of both cell cycle-regulated and quantitative histone mRNA expression by Drosophila Mute By Geisler et al. and Robert Duronio ➡️ https://genesdev.cshlp.org/content/40/19-20/1649.abstract Mark Geisler #histone #replication #mRNA #Drosophila

🆕 ADVANCE ONLINE 🆕 CANCER METABOLISM REVIEW: Dangerous liaisons: interactions between cancer cells and adipocytes as drivers of cancer progression By Carolina Dehesa Caballero and Almut Schulze ➡️ https://ow.ly/lFIS50ZRaTF #cancer #adipocytes #metabolism

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Nuclear type I myosins actively support nucleolar and nuclear structure and function By Peng et al. and Brian Freeman ➡️ https://ow.ly/UNrp50ZRaHs #genome #nucleus #myosin

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Human PIF1 clears secondary DNA structures by coupled DNA unwinding and rewinding activities By Jayachandran et al. and Petr Cejka ➡️ https://ow.ly/IFke50ZRacV Petr Cejka Institute for Research in Biomedicine Università della Svizzera italiana #DNA #DNArepair

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Honeybadger, a PVT1-derived micropeptide, is a critical negative regulator of RAS–MAPK signaling in MYC-driven tumors By Paithane et al. and Anindya Bagchi ➡️ https://ow.ly/9HXs50ZR96x Also read about Firefox: ➡️ https://ow.ly/LsW750ZR96p

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Firefox, a protein encoded by circular PVT1, is essential for MYC-driven oncogenesis By Tiwari et al. and Anindya Bagchi ➡️ https://ow.ly/yESB50ZR92i Also read about Honeybadger: ➡️ https://ow.ly/WsCF50ZR92k #cancer #MYC #KRAS #lncRNA

🎙️ G&D Voices: Author Oliver Hobert 🎙️ What sets G&D apart? Here is what G&D author, Oliver Hobert had to say! Learn more here: ➡️ genesdev.cshlp.org

🆕 ADVANCE ONLINE 🆕 CANCER METABOLISM REVIEW: Lysosomal metabolism in pancreatic cancer and its crosstalk with host physiology By Cheng et al. and Costas Lyssiotis ➡️ https://ow.ly/ByRW50ZRatT Caleb Cheng Lyssiotis Lab #pancreaticcancer #metabolism #lysosome

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Temporal gating dictates stress-induced transcript export from the nucleus By Helton et al. and Stephanie Moon ➡️ https://ow.ly/Q5mn50ZR8fg Stephanie Moon #mRNA #stress #RNAexport

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Multimerization of ELAV in Drosophila is essential for directing neuronal alternative splicing and polyadenylation programs By Dix et al. and Matthias Soller ➡️ https://ow.ly/jspT50ZPTe1 Matthias Soller David McQuarrie The University of Manchester #Drosophila

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Differential control of both cell cycle-regulated and quantitative histone mRNA expression by Drosophila Mute By Geisler et al. and Robert Duronio ➡️ https://ow.ly/WVfT50ZPT2y Mark Geisler #histone #replication #mRNA #Drosophila

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: MEIOSIN retains a STRA8-independent activity that contributes to meiotic gene activation across vertebrates By Shimada et al. and Kei-ichiro Ishiguro ➡️ https://ow.ly/zmPg50ZPSkH Ishiguro Lab #celldivision #transcription #vertebratedevelopment

We are saddened by the loss of G&D's long-time Editor, Terri Grodzicker. When Terri stepped down as Editor in 2022, friends and colleagues wrote about her contributions to the research community. We are re-visiting these pieces, and thinking of her. ➡️ https://genesdev.cshlp.org/content/37/1-2.toc

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: rRNA 5′ETS processing contributes to nucleolar organization and nuclear architecture By Mendoza-Figueroa et al. and Kathy Fange Liu ➡️ https://ow.ly/ty5R50ZOM7h @kathyliulab.bsky.social University of Pennsylvania Penn Medicine #RNA #nucleus #genome

RESEARCH PAPER: A conserved Notch–Meis1–Pbx cascade specifies secretory progenitors into spatially diverse intestinal best4+ cells By Sur, Segal et al., and Jeffrey Farrell ➡️ https://genesdev.cshlp.org/content/40/17-18/1553.abstract Jeff Farrell Abhinav Sur #intestine #pHsensing #Notch

RESEARCH PAPER: Neuronal expression of bromodomain proteins alters neuronal health and peripheral protein homeostasis to promote longevity By Dutta et al., Gilberto Garcia and Ryo Higuchi-Sanabria ➡️ https://genesdev.cshlp.org/content/40/17-18/1523.full @usc.edu @uscleonarddavis.bsky.social

OUTLOOK: An antisense antidote to oncogenic poison exons By René Arvola and Guramrit Singh ➡️ https://genesdev.cshlp.org/content/40/17-18/1367.full Also read: ➡️ https://genesdev.cshlp.org/content/40/17-18/1508.full Guramrit Singh #RNA #splicing #cancer

RESEARCH PAPER: Targeting EZH2 oncogenic splicing: decoding the regulatory network and antisense correction By Islam et al. and Mohammad Alinoor Rahman ➡️ https://genesdev.cshlp.org/content/40/17-18/1508.full #RNA #splicing #cancer