Giovanni D’Angelo

#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics #neuroscience #BrainAtlas

nature.comThe lipidomic architecture of the mouse brain - NatureA spatial lipidomic atlas of the mouse brain reveals more than 500 biochemical territories that mirror cell types and connectivity, capture oligodendrocyte heterogeneity and ventricular zonation, and ...

The work was led by Luca Fusar Bassini, together with my friend and co-senior author Gioele La Manno and a superb team across our labs. Paper: www.nature.com/articles/s41... @Nature @EPFL_en #lipids #ScienceTwitter

The 3D atlas, data and analysis tools are open and were built with lipid-related brain disorders in mind, rare or common. Explore it: lbae-v2.epfl.ch #OpenScience #OpenData

lbae-v2.epfl.chLipid Brain Atlas Explorer

All of these were studied without a high-resolution reference for healthy lipid architecture. With the atlas we can now ask which lipizones a mutation alters, whether a disease erases a territory or shifts its composition, and which circuits are exposed when a lipid class disappears.

Beyond basic biology, many neurological diseases turn out to be lipid diseases: rare ones that start from a single failing enzyme or transporter, and common ones. #neurodegeneration #RareDisease #lysosomaldisease

Lipizones also respond to physiological state. During pregnancy they are extensively remodelled across cortex and white matter, and in white matter their patterns appear to retain the order in which tracts were myelinated.

In our analyses, gene expression predicts only part of this landscape, so membrane composition has to be measured directly rather than inferred from the transcriptome.

Lipizones follow neither cell-type nor anatomical boundaries. The same lipizone can extend from a neuron's cell body to its distant axon terminals, or cut across several cell types sharing a location, capturing relationships that a map built around cell bodies would miss.

Lipids alone define more than 500 biochemical territories with distinct compositions, which we call lipizones. #SpatialOmics #MassSpectrometryImaging

8 Sept

Do not miss this fantastic symposium #lipidtime

latsis2026.epfl.chEPFL Latsis Symposium 2026Join us in Lausanne to connect with the global community shaping the future of cell understanding and engineering.

28 Aug

Registration is still open for the EPFL Latsis Symposium 2026, "Decoding the Cell: Modeling, Predicting, and Engineering Cellular States." 29–30 Oct, Olympic Museum, Lausanne. Quake, Haniffa, Engelhardt, Liberali, Paluch, Kundaje and more. Abstracts close 15 Sept. latsis2026.epfl.ch/event/1/

Giovanni D’Angelo reposted

Pavel Barahtjan

@pavelbarahtjan.bsky.social

18 June

Replying to @pavelbarahtjan.bsky.social

Big shoutout to all the authors @nikagorsek.bsky.social, @jean-maillat.bsky.social and @giodang.bsky.social . I also want to sincerely thank our editor @sanniejculbertson.bsky.social for her patience and guidance throughout the process.

This is our new story on ether lipids and ferroptosis in neurons. A collaboration started by Howard Riezman and between us and Harayama lab.

Antonino Asaro@antonino-asaro.bsky.social

Very happy to share our work on Ether lipid remodeling and ferroptosis. This was a very fruitful collaboration with @harayamajrlab.bsky.social . Many thanks to @giodang.bsky.social for the support and guidance, and to Howard Riezman, where part of this story began. www.biorxiv.org/content/10.6...

biorxiv.orgEther lipid remodeling during neuronal differentiation prevents ferroptosisFerroptosis is a form of cell death driven by iron-dependent lipid peroxidation, with specific lipid species playing key roles in modulating susceptibility. Among these, ether lipids have shown conflicting effects, being linked to both protection and sensitization. Here, we dissect the relationship between lipid structure and ferroptosis sensitivity and explain how ether lipids exert context-dependent effects. Ether lipids can promote ferroptosis through a metabolic bias towards the accumulation of polyunsaturated acyl chains and ethanolamine head groups, whereas this pro-ferroptotic tendency is counterbalanced by the anti-ferroptotic vinyl ether moiety introduced by plasmanylethanolamine desaturase 1. We show that this protective effect is critical for preventing ferroptosis in hiPSC-derived neurons, which accumulate otherwise pro-ferroptotic ether lipids during differentiation. This effect is not solely due to its antioxidant properties but also stems from the reprogramming of mitochondrial respiration. The lack of vinyl ether bonds leads to multiple mitochondrial defects, including increased mitochondrial reactive oxygen species (ROS), lower membrane potential, and abnormal cristae structures. These findings indicate that vinyl ether bonds in ether lipids offer dual ferroptosis resistance by scavenging ROS and minimizing its production at the mitochondrial level. The disruption of this system in Caenorhabditis elegans leads to iron-induced death and impaired motility. Thus, our study reveals ether lipid structural remodeling as a key regulator of ferroptosis sensitivity in neurons. ### Competing Interest Statement The authors have declared no competing interest. Deutsche Forschungsgemeinschaft, AS 647/1-1 Agencia Estatal de Investigación, PID2023-146930NB-I00 Japan Science and Technology Agency, JPMJER2101, JPMJFR230H, JPMJND2305, 25H01425, 25H01426, JPMJAP2505 National Research Agency French government, ANR-25-CE44-1525 Agencia Estatal de Investigación (AEI)-Spain, PID2021-123336NB-C21, PID2024-158644NB-C21 Swiss National Science Foundation, 185898, 184949 CNRS/Inserm ATIP-Avenir, ANR-15-IDEX-01

Giovanni D’Angelo reposted

Martin Weigert

@maweigert.bsky.social

2 Mar

Excited to share our new paper (CVPR 2026 🚀): "MuViT: Multi-Resolution Vision Transformers for Learning Across Scales in Microscopy" which enables local predictions to use global context. Great work led by @albertdm.bsky.social & another fun collab w @gioelelamanno.bsky.social! @scadsai.bsky.social

19 Dec 2025

Join us for the 2026 Glycolipid & Sphingolipid Biology Gordon Research Conference (GRC). 📍 Renaissance Tuscany Il Ciocco (Italy) 🗓️ March 22 - 27, 2026 Theme: "Molecular Codes of Cell Identity and Recognition" #LipidResearch #Sphingolipids #GRC2026 #ScienceConference #Lipidtime

19 Dec 2025

Interested in attending both? You must submit a separate application for the GRS! Don't miss this chance to present your work.

This GRC is held in conjunction with the "Glycolipid and Sphingolipid Biology" Gordon Research Seminar (GRS).

Held at the Renaissance Tuscany Il Ciocco, the remote location fosters a deep sense of camaraderie. Enjoy the breathtaking views, great food, and a focused environment perfect for scientific immersion.

The schedule is designed for interaction! • Daily Poster Sessions for all career stages. • Afternoon free time & communal meals for informal chats with leaders in the field. • "Short Talks" selected directly from poster abstracts.

@tafesselab.bsky.social Ronald Schnaar Julie Saba Ashley Cowart @gioelelamanno.bsky.social @nadlerlab.bsky.social Jurgen Seibel Markus Wenk

@larionmioara.bsky.social Junhua Xiao Tony Futerman Frances Platt Pilar Martinez Vittorio Maglione Museer Lone Marco Prinz Scott Summers @molcellbiophys-lab.bsky.social Eric Camerer Annarita Di Lorenzo Jens Bruening

Ewa Gurugul-Convey Sarah Spiegel @elisaoricchio.bsky.social Kivanc Birsoy Natalie Andrieu Alessandro Prinetti Thorsten Hornemann Maria Dolores Ledesma Rose Mary Boustany

@joostholthuis.bsky.social Gemma Fabrias Rick Proia Jin-ichi Inokuchi Fiona Watt LudgerJohannes @priscaliberali.bsky.social Wayne Lencer Chris Clarke Besim Ogretem Florian Winau @autumnyork.bsky.social @stephxie.bsky.social

The 2026 Glycolipid & Sphingolipid Biology features: Thierry Levade, Chiara Luberto Teresa Dunn Kentaro Hanada Yusuf Hannun Antonio Gomez-Munoz, @flofroehlich.bsky.social Rossella Venditti

The #GRC format is unique. We prioritize: ✅ Unpublished, cutting-edge research. ✅ Extensive discussion time after every talk. ✅ Informal networking across all career stages.It’s about building lasting collaborations and friendships in a supportive community.

In 2026, we focus on the basic science of glyco- and sphingolipids: #glycobiology #cellbiology #biochemistry #biophysics #molecularbiology #cancerimmunity #immunology #genetics. Register here: my.grc.org/event-applic...

my.grc.orgmy.grc.org

Giovanni D’Angelo reposted

docs.google.comSingle-cell and spatial metabolomics online day, December 10th, 2025

8 Dec 2025

Join us for 2nd edition of #SingleCellSpatialMetabolomicsDay at #EPFL on 10th December at 15:30 CET. Check out the website for more info: scmetabolomicsday.epfl.ch/index.html Register here: docs.google.com/forms/d/e/1F... #EPFL #SingleCell #Spatial #Metabolomics #omics #metabolism

8 Dec 2025

The event is organised by PhD Students and PostDocs of D’Angelo, La Manno, and Alexandrov Labs

The great line-up with Martin Giera, Peter Nemes, André Nadler, Jonathan Sweedler, Shane Ellis, Paola Tasca, Theodore Alexandrov Carsten Hopf, Lars Gruber, Melanie Bailey, Bishoy Wadie, Aline Martins, Reina Tei and others promises great talks and excellent discussions.

alleninstitute.org2026 Lake Conference: Modeling Life from Cells to TissuesJoin the Allen Institute for Cell Science and Circuit Neuroscience Basel in Seattle, Washington, April 20–22, 2026, for a 3 day conference, Modeling...

17 Nov 2025

The view from my high school class Windows

Giovanni D’Angelo reposted

allen institute

@alleninstitute.org

20 Oct 2025

#CellBio community, this one is for you! Applications are open for the #LakeConference on Modeling Life from Cells to Tissues – co-hosted with Circuit Neuroscience Basel! 📆 April 20-22, 2026 📍 Seattle, USA 🔬 All career stages welcomed. Apply to attend by 12/12: alleninstitute.org/events/aics-...

biorxiv.orgVPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repairPerturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,...

25 Oct 2025

Very interesting paper… congratulations

Holthuis Lab@holthuislab.bsky.social

Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...

Giovanni D’Angelo reposted

Holthuis Lab

@holthuislab.bsky.social

25 Oct 2025

Giovanni D’Angelo reposted

André Nadler

@nadlerlab.bsky.social

9 Oct 2025

Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...

Giovanni D’Angelo reposted

lauracapolupo.bsky.social

@lauracapolupo.bsky.social

16 Oct 2025

Happy to finally see The Lipid Brain Atlas out! Lipids are not boring at all so, check it out! Amazing team effort between computational and experimental work, led by @lucafusarbassini.bsky.social with @gioelelamanno.bsky.social and @giodang.bsky.social labs. Proud to be part of it. Lipids rule!

Gioele La Manno@gioelelamanno.bsky.social

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...

16 Oct 2025

This is a massive undertaking by a courageous group of experimentalists and computational scientists. I am honored to have contributed to this. #lipidtime chenges time zone today

Gioele La Manno@gioelelamanno.bsky.social

actu.epfl.chTwo life sciences ERC Starting Grants at EPFLMilena Schuhmacher and Gioele La Manno at EPFL’s School of Life Sciences have received European Research Council (ERC) Starting Grants. Former EPFL researcher Can Aztekin (now at Max Planck), is also ...

5 Sept 2025

So deserved!!!

Gioele La Manno@gioelelamanno.bsky.social

I am deeply honoured to have been recognized by the European Research Council with a #StartingGrant. @erc.europa.eu With this support, my team and I will launch #MOVIOLA. Our goal is to understand how human neural progenitors decide their fate during brain development.

5 Sept 2025

Congrats Milena… I wish I was there with you when this was announced….

Milena Schuhmacher@mschuhmacher.bsky.social

So honored to be awarded the ERC Starting Grant! I am very grateful for this support and looking forward to more exciting #lipidtime 🥳 Also, we will have positions available next year. So stay tuned!

Giovanni D’Angelo reposted

Nature Methods

@natmethods.nature.com

nature.comUnified mass imaging maps the lipidome of vertebrate development - Nature MethodsuMAIA is an analytical framework designed to enable the construction of metabolic atlases at high resolution using mass spectrometry imaging data.

uMAIA offers an analytical framework designed to enable construction of high-resolution metabolic atlases using mass spec imaging data. @gioelelamanno.bsky.social www.nature.com/articles/s41...

Giovanni D’Angelo reposted

Gioele La Manno

@gioelelamanno.bsky.social

Replying to @gioelelamanno.bsky.social

Proud of these advances, achieved in great company @EPFL : @giodang.bsky.social (co-PI), with Halima Schede & Leila Alieh leading the project, and the Oates lab bringing their zebrafish expertise [2/2]

nature.comUnified mass imaging maps the lipidome of vertebrate developmentNature Methods - uMAIA is an analytical framework designed to enable the construction of metabolic atlases at high resolution using mass spectrometry imaging data.

Happy to share our work on uMAIA, a framework for building metabolomic atlases from mass spectrometry imaging. With uMAIA, we mapped the lipidome of zebrafish development, uncovering spatially organized metabolic programs . www.nature.com/articles/s41... #developmentalbiology #MSI #lipidtime

@jeremybaskin.bsky.social

This is a brilliant work by Hannah Schede ad Leila Alieh and a great collaboration with @gioelelamanno.bsky.social

Giovanni D’Angelo reposted

Jeremy Baskin

5 Aug 2025

We are proud to be a founding contributor to lipidinteractome.org, a repository developed by @tafesselab.bsky.social & Schultz lab to increase accessibility to proteomics data from multi-functionalized lipid analogs! Check out the website & preprint: arxiv.org/abs/2507.23101 #lipidtime

lipidinteractome.orgThe Lipid Interactome Repository – Lipid Interactome Repository

Giovanni D’Angelo reposted

Paolo De Los Rios

@paolodelosrios.bsky.social

21 Aug 2025

A no-miss opportunity to join EPFL. We are a vibrant (had to use it 😉) community working in all branches of basic sciences and engineering, and interdisciplinary studies are strongly encouraged. If you want more information, contact the committee heads, or feel free to DM me. tinyurl.com/bd27ky7p

tinyurl.comAssistant/associate Professor of AI-assisted Biophysics at the Ecole polytechnique fédérale de Lausanne (EPFL) and Group Leader at the Paul Scherrer Institute (PSI)The School of Basic Sciences (Physics, Chemistry and Mathematics) at EPFL and the Paul Scherrer Institute (PSI) jointly seek to appoint a Tenure Track Assistant or tenured Associate Professor in AI-As...

Giovanni D’Angelo reposted

André Nadler

@nadlerlab.bsky.social

21 Aug 2025

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

biorxiv.orgMolecular Regulation and Physiological Role of 1 GOLPH3-mediated Golgi retentionThe Golgi complex serves as the central hub of the biosynthetic pathway, where anterograde and retrograde trafficking converge. How cargo and Golgi-resident proteins traverse this organelle has long b...

27 June 2025

We , @lbm-epfl.bsky.social and @gisouvggoot.bsky.social #EPFL together with and tf Sean Munro and John Briggs have today released two complementary preprints on GOLPH3 mediated intra-Golgi recycling #CellBiology #MembraneTrafficking www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

Giovanni D’Angelo reposted

Sphingolipid Biology

@slbiology.bsky.social

24 Apr 2025

The joint FEBS Special Meeting on Sphingolipid Biology & 13th International Ceramide Conference is just one month away!! Make sure to submit your abstract and register before the deadlines to secure your spot! www.linkedin.com/events/febss...

linkedin.comFEBS Special Meeting on Sphingolipid Biology: breaking boundaries | LinkedIn