Giulia Palermo

Want to know everything about #ArtificialIntelligence, #DeepLearning, and #CompChem to study and engineer #GeneEditing systems — from #CRISPR-Cas proteins to base and prime editors, and #RNA Guided Transposons? Check out our new piece in @NatureSMB ! www.nature.com/articles/s41...

🚀Excited to share our new paper #NatureCommunications 🎉! We uncover a 🧨 #CrypticPocket in #CRISPR #Cas9 that forms transiently on super short timescales not trapped by #cryoEM! 🧬This pocket enables metal ions to regulate #DNA cleavage! 🔗 hhttps://www.nature.com/articles/s41467-026-78458-0

Monday at #ACSFall2026: 5 of 12 Giulia Palermo ( @giuliapalermo.bsky.social ) presents “Graph attention networks to decode molecular dynamics simulations.”

🚨Don't miss your chance to join us @KeystoneSymp #KSStructuralBio27 featuring exceptional leaders in #biophysics, #cryoEM, #NMR, #imaging & #AI. ⏳ Scholarship Award: June 30 💰 Early-Bird Registration ends soon! 🎤With keynote from @fraserlab.com & outstanding speakers! 🏹 www.keystonesymposia.org

Excited to co-organize the @keystonesymposia.bsky.social on Integrative Structural Biology with Alex De Marco @NewYorkStructuralBiology and Niccolò Banterle @embl.org! ⭐️Stellar speakers & keynote by @fraserlab.com! keystonesymposia.org/conferences/... RETWEET&APPLY #KSStructuralBio27 #CryoEM #AI

Our new Cas12a review article with DavidTaylor lab @utaustin.bsky.social is out @NatureReviewsMolBiol! This was great collaboration between @AakashSaha, and the Taylor lab members @jacquelyn_wrong and @fregoso_ocampo! www.nature.com/articles/s41...

Check out our new review on Graph #NeuralNetworks in #MolecularDynamics! We show how #AI is used for #ForceField development, free-energy, and analysis - including our attention-based GNN workflow - and how you can integrate your favorite AI into #compchem! www.sciencedirect.com/science/arti...

Thrilled to share that I’ll be joining @uclacb.bsky.social as Professor in July 2026! Grateful to my amazing students, postdocs, colleagues @UCR, collaborators, and mentors. A new chapter begins, advancing #compchem, #AI to explore #RNA, #DNA, #CRISPR, and emerging directions in #Biophysics.

Developed by the multi-talented @pabloarantes.bsky.social & @SouvikSinha members of my lab: ParametrizANI brings #MachineLearning - based #ForceField parametrization available to everyone Available on Github: github.com/palermolab/P...

🚀 Many thanks to @SDSC_UCSD and @HPCwire for highlighting our work using @NSF supercomputers to uncover how “jumping genes” can transform #GeneEditing technologies! www.sdsc.edu/news/2025/PR... #Supercomputing #HPC #CRISPR #RNA #CompChem

✨Best way to end the week! Just learned from Kevin Freedman @ucriverside.bsky.social that, at the end of the exam, students in his Dynamics of Biological Systems class draw their favorite professor. Guess who got picked... ♥️♥️♥️ #biophysics #TeachingJoy #STEM #LoveScience

So exciting to be @proteinsociety.bsky.social meeting with my lab!

🔬🧬 Excited to be at the @proteinsociety.bsky.social meeting in SF! Curious how #NeuralNetworks can decode biomolecular mechanisms? Don’t miss the poster by ChinmaiPindi and AmunPatel ! #Proteins #AI #CRISPR #DNA

New paper from our lab just out @pnas.org! 🚀 Using free energy simulations, #AIphaFold and #cryoEM refinement, we uncovered a key conformational change in a paradigm-shifting #CRISPR-associated #transposon capable of precise gene knock-ins. 🔍🧬 www.pnas.org/doi/epub/10....

Thrilled to join #ACSSpring2025 and meet my friends! Don't miss my talk on how #AI & #EnhancedSampling can describe gene editing & refine #cryoEM maps. We’ll be presenting our latest research on #CRISPR-associated transposon systems + other exciting advancements! #compchem #RNA #compchem #RNA

#BPS2025 waiting for the national lecture 🥳 @giuliapalermo.bsky.social @labvanni.bsky.social @sriraksha.bsky.social @sesamedusa.bsky.social

🚀 Exciting new poster from our lab at #BPS2025! 🧬 @Ahsan09966804 showcases how #MolecularDynamics & #AI can enhance #CryoEM map refinement. 📍 Catch it at Board 18 (1824-Pos) today, don’t miss out! #Biophysics #CompBio

Carolina Sarto @carosarto.bsky.social, a brilliant student from the University of Buenos Aires, will be presenting her work on #RNA synthesis in #DengueVirus🦠 at #BPS2025. Don’t miss her poster today L3074-Pos (LB13). She’s looking for a postdoc, and I have no doubt she’ll thrive!

Excited to be at #BPS2025! 🚀 Our lab is contributing to the #cryoEM symposium, showcasing how computational methods and AI are revolutionizing cryo-EM analysis. See you there! 🔬💡 #Biophysics #AI Read our papers to know more: www.nature.com/articles/s41... www.biorxiv.org/content/10.1...

New paper from our lab @elife.bsky.social . We show how #DirectedEvolution reshaped #CRISPR for expanding DNA recongition. This is work by Kazi Hossain, an incredibly talented student visiting my lab from the Czub lab, now in Orozco's lab & Lukasz Nierzwicki. doi.org/10.7554/eLif...

New paper from our lab @naturecomms.bsky.social! We reveal the dynamics and mechanism of target DNA traversal in #CRISPR Cas12a, a conundrum in the field! nature.com/articles/s41... #compchem We thank the amazing #HPC resources of PSC #Anton2 and SDSC

Do you want to know why #ABE 8e is the most efficient adenine base editor? Read our paper with the amazing Audrey Lapinaite! @narjournal.bsky.social The dimerization of TadA8e and its exclusive interactions with #CRISPR Cas9 boost #BaseEditing efficiency! academic.oup.com/nar/article/...

Happy Bluesky! Nel blu dipinto di blu 🩵🩵🩵