Giulio Maria Pasinetti, MD, PhD

A new analysis from @paullacaze.bsky.social, et al. @monashuniversity.bsky.social suggests low-dose aspirin may be linked to dramatically lower risk of #Dementia in older adults w/ certain genetic characteristics. @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Researchers Sergey A. Kozin, et al. developed and tested a synthetic peptide, HAEE, in preclinical trials as a potential treatment for #Alzheimers. In this study, they discovered human blood contains an endogenous replica of this peptide. Learn More @pnasnexus.org 👉 academic.oup.com/pnasnexus/ar...

While external mechanical trauma has been implicated in initiating tau propagation in #Alzheimers, the role of intrinsic mechanical forces in tau accumulation is largely unexplored. Dr. Crary, et al. propose a biomechanical cascade hypothesis. 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

A new study by researchers Demet Araç, et al. at U of Chicago shows how two proteins interact to help protect survival of neurons involved in sensing touch. Findings represent a step toward better understanding mechanisms of neuroprotection. @currentbiology.bsky.social 👉 www.cell.com/current-biol...

Findings by researchers Seth Frietze, Kimberley Bruce, @csniemeyerphd.bsky.social, et al. @cuanschutz.bsky.social highlight a mechanism linking #HerpesSimplexVirus type 1 infection w cellular states associated w #NeurodegenerativeDisease risk. @plos.org Pathogens 👉 journals.plos.org/plospathogen...

With evidence from human cell cultures, post-mortem brain samples & mice, researchers Li-Huei Tsai, et al. @picowerinstitute.bsky.social show APOE4 gene variant suppresses molecular signaling needed for oligodendrocytes to myelinate neurons. @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...

Eddie Lee, et al. @tnrlab.bsky.social @pennmedicine.bsky.social provide rare human evidence clearing amyloid plaques may have long-term effects on biological processes driving #Alzheimers; suggests removing amyloid early & extensively may slow progression. @jama.com 👉 jamanetwork.com/journals/jam...

Global Incidence of All-Cause Dementia: A Meta-Analysis ➡️ Results showed that #Dementia cases will likely more than double, as global population ages; 24.7 million new cases of dementia by 2050, up from 11.4 million in 2023." Full Study @jamaneurology.com 👉 jamanetwork.com/journals/jam...

Researchers Giovanni D’Angelo, Gioele La Manno, et al. at EPFL uncover hidden layer of organization in brain by creating 1st detailed 3D map of its lipids, fatty molecules essential for brain structure & communication. @nature.com 👉 www.nature.com/articles/s41... Lipid Brain Atlas 👉 lbae-v2.epfl.ch

We are INCREDIBLY EXCITED to share that @scottrussophd.bsky.social has been appointed Chair of #NashNeuroscience at Icahn Mount Sinai. Dr. Russo is a distinguished neuroscientist, visionary leader & mentor. We couldn't be happier for the Department of Neuroscience! Congratulations, Dr. Russo! 🎉

In this cohort study from Tharick Pascoal, et al. convergent clinical & genetic evidence revealed #ADHD associated w/ increased risk of late-life cognitive impairment supporting need for targeted monitoring & integrated care in this population. @jamapsychiatry.com 👉 jamanetwork.com/journals/jam...

Study by George Tofaris, et al. @ox.ac.uk shows that a distinct population of human #Microglia can selectively remove harmful clumps of the #Parkinsons -causing protein alpha-synuclein from dopamine-producing neurons. Learn More in Science Translational Medicine 👉 www.science.org/doi/10.1126/...

Very Interesting Study! Here, gentle compression of the tibia promoted healing and improved motor and cognitive recovery after a #BrainInjury or #Stroke by activating newly discovered bone-to-brain signaling axis. Nature Neuroscience 👉 www.nature.com/articles/s41...

Researchers @unibirmingham.bsky.social discover targeting P2X7 receptor in human brain tissue directly suppresses damaging #Neuroinflammation, positioning existing P2X7 antagonist drugs for rapid repurposing across a spectrum of disorders. @brain1878.bsky.social 👉 academic.oup.com/brain/articl...

My deepest thanks and congratulations to Dr. Greta Strong for her exceptional leadership in organizing the MIPO ’s 15th Power of Partnerships, Scholarships and Hall of Fame Gala. This milestone event celebrated 15 years of community impact. Again, congratulations, Dr. Strong.

Normal aging & #Alzheimers change how diff brain regions communicate w each other. New study from @jorittmo.bsky.social, et al. reveals these alterations follow distinct patterns, w disease-related shifts distinguishable from those linked to normal aging. Nature Neuro www.nature.com/articles/s41...

Yesterday, I had a fantastic time presenting a keynote at The 14th #Microbiome & #Probiotics R&D and Business Collaboration Forum. The Forum highlights how #Genomics, #SyntheticBiology, and advanced #Bioengineering are rapidly transforming microbiology. A Huge Thank You to the organizers!

Fantastic! The mechanistic basis of #Aging remains unresolved. Here, Ali Doğa Yücel, Adrian Molière & Vadim Gladyshev shift the focus of aging science from simple cumulative damage to a loss-of-identity model characterized by predictable epigenetic drift. @nature.com 👉 www.nature.com/articles/s41...

Excited about attending the Microbiome & Probiotics R&D & Business Collaboration Forum. Tomorrow, Oct. 1, 9am (PT), I will present the keynote “Role of the Immune T Regulatory Cells in Mood Disorders and #AlzheimersDisease Phenotype as a therapeutic target in Altered #GutBrain Axis cross-talking”.

Researchers Joshua Emmerson, Hao Hu, Vivek Savani, David Holtzman, et al. @washumedicine.bsky.social have dvlpd a potential antibody-based approach to reducing #Neurodegeneration in diseases known as tauopathies, including #Alzheimers. Learn More in Neuron | Cell Press 👉 www.cell.com/neuron/fullt...

Researchers Suborno Jati, Xu Chen, Sushil Mahata, et al. @ucsdmedschool.bsky.social ID'd a naturally occurring peptide, a small protein fragment called catestatin, that may help counter several key processes driving #Neurodegeneration. @moltherapy.bsky.social 👉 www.sciencedirect.com/science/arti...

Research led by @mountsinainyc.bsky.social, featured in landmark collection of 9 papers, represents one of largest & most comprehensive applications of single-cell genomics to human brain disease research. Learn More 👉 www.mountsinai.org/about/newsro...

I am deeply honored to have received an EPN NYFW Icons and Excellence Award. My sincere gratitude to the EPN organization, Hubert Delany (CEO & Co-Founder) and Magdaline Delany (President & Co-Founder) for this wonderful honor. Congratulations to all of my fellow honorees!

In this study, Giuseppe Lanza, Filippo Caraci, et al. investigated the association between habitual dietary (poly)phenol intake, cognitive status, and circulating inflammatory biomarkers in older adults. Learn More in @mdpiopenaccess.bsky.social | Antioxidants 👉 www.mdpi.com/2076-3921/15...

In this new paper, the #PasinettiLab sheds light on physiological connections between digestive and genitourinary systems, explore how endocrine and immune networks exert dual control across compartments, and analyze correlations between dysbiosis and disease states. 👉 doi.org/10.1080/1949...

Mark Your Calendars 🗓 10 Days Away! On Oct. 1-2, join industry leaders, researchers, and innovators to facilitate collaboration in the rapidly evolving field of #Microbiome research and #Probiotic development. Learn More | Register Here 👉 global-engage.com/conferences/...

Researchers Sweta Ghosh, Venkatakrishna Rao Jala, et al. have ID'd a way that a natural compound, produced by gut bacteria, may help protect the intestine & potentially guide new treatment approaches for #CrohnsDisease and #UlcerativeColitis. Nature Communications 👉 www.nature.com/articles/s41...

Researchers Bing Ren, et al. uncover sweeping changes in how the human brain controls and organizes its #Genome beginning in midlife, offering new clues to why aging sharply increases risk of #Alzheimers and other #NeurodegenerativeDiseases. Learn More @science.org www.science.org/doi/10.1126/...

Researchers Alan Saghatelian, et al. @salkinstitute.bsky.social created first #Microprotein atlas of human frontal cortex with & without #AlzheimersDisease, then find a link between a microprotein & brain immune cell dysfunction in #Alzheimers. Learn More: Nature Aging www.nature.com/articles/s43...

Researchers Leon Aksman, et al. have uncovered evidence that two neighboring types of brain tissue, superficial white matter and gray matter, may work together to support thinking abilities later in life. Learn More @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Researchers @cakizil.bsky.social, et al. @columbiamed.bsky.social ID astrocyte-derived fibronectin as a primary driver of #BloodBrainBarrier breakdown in carriers of the APOE ε4 allele - offer a potential non-amyloid therapeutic target for #Alzheimers. Nature Aging 👉 www.nature.com/articles/s43...

I am deeply honored to have been recognized at the 2026 EPN Magazine Icons and Excellence Gala. It was an unforgettable evening. Thank you to EPN Magazine for this incredible honor, and congratulations to my fellow honorees.

I am incredibly proud to share that I have been chosen to receive an EPN NYFW Icons and Excellence Award this coming Friday night. To be acknowledged alongside such a distinguished group of leaders is truly an honor. Learn More 👉 epnofny.com/epnmag/blog/...

Caitlin Finney, et al. demo APOE ε4 acts as systemic immune modulator that creates early vulnerability to #Neurodegeneration & shifts focus toward targeted, early preventative interventions before #CognitiveDecline. @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Increased #Inflammation is assoc w/ aging & implicated in decreased function in aging tissues. Tan, et al. @stanfordmedicine.bsky.social explored changes in older tissue-resident macrophages & how these cells may contribute to aging phenotypes in mice. @science.org 👉 www.science.org/doi/10.1126/...

Researchers Hao Hu, Peter Bor-Chian Lin, Carisa Zeng, Jason Ulrich, David Holtzman, et al. @washumedicine.bsky.social found blocking immune cells in body’s lymph nodes significantly reduces Alzheimer’s-like neurodegeneration in mice. Learn More in Nature Neuroscience www.nature.com/articles/s41...

In a new study, researchers Nicola Johnstone & Kathrin Cohen Kadosh provide new insight into the #Gut #Brain axis offering some of the strongest evidence yet that the #Microbiome may play a role in shaping human neurochemistry. Learn More in Molecular Psychiatry 👉 www.nature.com/articles/s41...

Researchers Carlos Diaz-Salazar, Franck Polleux, et al. have found, for first time, that human #Microglia, much like human neurons, mature far more slowly than comparable cells in other animals. @zuckermanbrain.bsky.social Learn More in Neuron | @cellpress.bsky.social 👉 www.cell.com/neuron/fullt...

Mark Your Calendars 🗓 One Month Away! On October 1-2, join industry leaders, researchers, and innovators to facilitate collaboration in the rapidly evolving field of #Microbiome research and #Probiotic development. Learn More | Register Here 👉 global-engage.com/product/micr...

Here, Arsenio Paez, et al. investigated if nonrapid eye movement SP-SO activity is assoc w/ CSF orexin & whether these oscillatory features moderate assoc btwn #Orexin, #Cognition, #NeuropsychiatricSymptom severity & #Alzheimers biomarkers. @greenjournal.bsky.social www.neurology.org/doi/10.1212/...

Researchers Gareth S. A. Wright, et al. have dvlpd new way to turn ordinary antibodies into tiny disease-fighting molecules that can work inside human cells, potentially opening new paths for treating #Alzheimers, #Parkinsons, #Huntingtons, and motor neurone disease. www.nature.com/articles/s41...

In this study, Brad Dickerson, Mark Eldaief, Alexandra Touroutoglou, et al. examined whether baseline cortical atrophy predicts progression to #Dementia in patients w/ #MildCognitiveImpairment because of #EarlyOnsetAlzheimersDisease. @greenjournal.bsky.social 👉 www.neurology.org/doi/10.1212/...

I am thrilled to announce that the #PasinettiLab 's latest paper, "The cervicovaginal #Gut #Microbiota axis as a key determinant of systemic physiology", has been officially accepted for publication in Gut Microbes. MORE TO COME!

According to researchers Kaleen Hayes, Daniel Harris, Kevin McConeghy, et al. older adults who received #Shingles vaccine after entering skilled nursing facility were less likely to be diagnosed w/ #Dementia over following four years. Annals of Internal Medicine 👉 www.acpjournals.org/doi/10.7326/...