Grainger Lab

Grainger Lab

@graingerlab.bsky.social

Bacterial chromosome biology, gene expression, pathogenicity... and football. www.graingerlab.com

494 followers329 following11 posts

Grainger Lab
@graingerlab.bsky.social

If you're interested in doing a PhD we have a lot of potential projects available in the lab. Topics cover bacterial pathogens, antibiotic resistence mechanisms, and fundemental mechanisms of gene regulation. More details here www.findaphd.com/phds/?Keywor... 🧪🥼🔬

findaphd.comgrainger birmingham PhD Projects, Programmes & Scholarships - 5 PhDs ListedFindAPhD. Search Funded PhD Projects, Programmes & Scholarships in grainger birmingham. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
Grainger Lab
@graingerlab.bsky.social

A new pre-print out - we show that promoters and terminators of transcription are frequently coupled, throughout the bacteria, and this is regulatory. www.biorxiv.org/content/10.6...

biorxiv.orgWidespread coupling of promoters and terminators of transcription in bacteriaTranscription underpins the expression of genetic information and is viewed as a series of independent initiation and termination events. In bacteria, promoters and terminators of transcription are th...
Grainger Lab
@graingerlab.bsky.social

Two post-doctoral positions open in our lab. We're looking for people with expertise in molecular microbiology and/or genome-scale tools. Initially 3 yrs, posts could be extended for upto 8 yrs. If you'd like to know more about us take a look at www.graingerlab.com www.jobs.ac.uk/job/DQY475/r...

jobs.ac.ukResearch Fellow (Postdoctoral) at University of BirminghamExplore an exciting academic career as a Research Fellow (Postdoctoral). Don't miss out on other academic jobs. Click to apply and explore more opportunities.
Grainger Lab
@graingerlab.bsky.social

In our most recent work David Forrest has discovered a widespread mechanisms linking transcription initiation to DNA supercoiling... www.nature.com/articles/s41...

nature.comThe bacterial RNA polymerase-associated CarD protein couples promoter activity to DNA supercoiling - Nature CommunicationsThe transcription factor CarD facilitates the activation of transcription in many bacteria and in Rhodobacter sphaeroides, CarD compensates for suboptimal promoter DNA sequences. Here, the authors sho...
Grainger Lab
@graingerlab.bsky.social

@ewarman.bsky.social has followed up on her discovery of bidirectional promoters in bacteria by defining their basic rules for regulation and links to gene expression noise... academic.oup.com/nar/article/...

academic.oup.comBidirectional promoters in Escherichia coli: regulatory rules and implications for gene expression noiseAbstract. In prokaryotes, bidirectional promoters are pseudo-symmetrical DNA sequences that stimulate divergent transcription. Ubiquitous, and far more lik
Grainger Lab
@graingerlab.bsky.social

Our lab is offering 3 PhD projects this year across 3 different topics: antibiotic resistance mechanisms, evolution of pathogenic bacteria, and fundamental mechanisms of gene regulation. www.findaphd.com/phds/?Keywor...

findaphd.comgrainger birmingham PhD Projects, Programmes & Scholarships - 3 PhDs ListedFindAPhD. Search Funded PhD Projects, Programmes & Scholarships in grainger birmingham. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.

Grainger Lab reposted

Thiago Carvalho
@cyrilpedia.bsky.social

'We show that the VqmAj homologs can indeed detect (host autoinducer) DPO and, in response, activate the lytic pathway. Our observation indicates that jVP882 is a member of a large family of globally-dispersed quorum-sensing-responsive temperate phages.' www.biorxiv.org/content/10.1...

biorxiv.orgA family of linear plasmid phages that detect a quorum-sensing autoinducer exists in multiple bacterial speciesTemperate phages oscillate between lysogeny, a genomic maintenance state within a bacterial host, and lytic replication, in which the host is killed, and newly made phage particles are released. Succe...

Grainger Lab reposted

Nature Microbiology
@natmicrobiol.nature.com

🚨 Out now! West African South American pandemic Vibrio cholerae encodes multiple distinct phage defence systems #MicroSky 🦠 #Phage @mblokesch.bsky.social www.nature.com/articles/s41...

nature.comWest African–South American pandemic Vibrio cholerae encodes multiple distinct phage defence systems - Nature MicrobiologyThe West African–South American lineage of Vibrio cholerae contains multiple distinct anti-phage defence systems that provide resistance to various phage families, including vibriophage ICP1, a key pr...

Grainger Lab reposted

ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ
@nizet.bsky.social

Fascinating new PLoS Biology paper from George Schaible et al in the Hatzenpichler Lab at Montana State “𝘈𝘴 𝘵𝘩𝘦 𝘰𝘯𝘭𝘺 𝘦𝘹𝘢𝘮𝘱𝘭𝘦 𝘰𝘧 𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘢 𝘵𝘩𝘢𝘵 𝘦𝘹𝘩𝘪𝘣𝘪𝘵 𝘰𝘣𝘭𝘪𝘨𝘢𝘵𝘦 𝘮𝘶𝘭𝘵𝘪𝘤𝘦𝘭𝘭𝘶𝘭𝘢𝘳𝘪𝘵𝘺, 𝘔𝘔𝘉 𝘱𝘳𝘰𝘷𝘪𝘥𝘦 𝘢𝘯 𝘪𝘮𝘱𝘰𝘳𝘵𝘢𝘯𝘵 𝘦𝘹𝘢𝘮𝘱𝘭𝘦 𝘰𝘧 𝘱𝘰𝘴𝘴𝘪𝘣𝘭𝘦 𝘮𝘦𝘤𝘩𝘢𝘯𝘪𝘴𝘮𝘴 𝘣𝘦𝘩𝘪𝘯𝘥 𝘵𝘩𝘪𝘴 𝘱𝘳𝘰𝘧𝘰𝘶𝘯𝘥 𝘴𝘵𝘦𝘱 𝘪𝘯 𝘭𝘪𝘧𝘦’𝘴 𝘦𝘷𝘰𝘭𝘶𝘵𝘪𝘰𝘯𝘢𝘳𝘺 𝘩𝘪𝘴𝘵𝘰𝘳𝘺 𝘰𝘯 𝘌𝘢𝘳𝘵𝘩”

scitechdaily.comThese Tiny Magnetic Bacteria Act Like a Single Body – And Could Explain the Origins of Complex LifeTiny magnetic bacteria that live in tightly bound groups are showing scientists how life might have evolved complex, multicellular forms. These rare bacteria can’t survive alone – they depend on one a...

Grainger Lab reposted

Tom McLean
@tommclean.bsky.social

Super excited to share the peer-reviewed version of the KorAB paper. Amazing to work such talented collaborators and thanks to the reviewers for making the work even better! www.nature.com/articles/s41...

nature.comKorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid - Nature MicrobiologyStructural and single-molecule analyses show the CTPase, KorB, is a sliding DNA clamp that interacts with a clamp-locking protein KorA to inhibit gene expression over distances of more than 1 kb in th...
Grainger Lab
@graingerlab.bsky.social

If you're interested in chromosome biology (DNA folding, gene regulation, replication, polymer modelling and more) we're organising the below this autumn. It'd be great to see you there. Please share if you can. :-)

Grainger Lab
@graingerlab.bsky.social

PhD projects available in our lab all listed in the below link. All focus on bacterial gene regulation, in the context of basic understanding, disease, or antibiotic resistance. Deadlines in January... www.findaphd.com/phds/?Keywor...

findaphd.comgrainger birmingham PhD Projects, Programmes & ScholarshipsFindAPhD. Search Funded PhD Projects, Programmes & Scholarships in grainger birmingham. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.

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