Timothy Hinks

Timothy Hinks

@hinkslab.bsky.social

The Hinks Lab investigate the immunopathogenesis of airway diseases and pulmonary infections.

589 followers214 following9 posts

Timothy Hinks
@hinkslab.bsky.social

Simon and Fleur's new paper is out in The Lancet Respiratory Medicine! ORACLE2 pooled 6,500+ asthma patients from 22 RCTs. 🧪 Blood eosinophils + FeNO = key predictors of asthma attacks 💨 Reversibility = lower risk? Open access: www.thelancet.com/journals/lan... #asthma #ORACLE2

thelancet.comInflammatory and clinical risk factors for asthma attacks (ORACLE2): a patient-level meta-analysis of control groups of 22 randomised trialsBlood eosinophil count, FeNO, asthma attack history, disease severity, low lung function (low FEV1%), and symptoms (ACQ-5 score) are key predictors of asthma attacks. Conversely, we found that moderat...
Timothy Hinks
@hinkslab.bsky.social

Out today - a new role for MAIT cells. We've shown MAIT cells are antibacterial; antiviral; and promote tissue repair. In this paper from our group we show MAIT cells are recruited and activated to protect tissues in sterile lung injury, and potentially in IPF - enjoy! doi.org/10.1016/j.ce...

Timothy Hinks reposted

Prof Sheena Cruickshank
@sheencr.bsky.social

This has taken such a long time to retract - the fraudulent study on potential of hydroxychloroquine as a COVID-19 treatment has done so much harm however not sure the incoming trump administration will take any note 😔🧪 www.science.org/content/arti...

science.orgInfamous paper that popularized unproven COVID-19 treatment finally retractedStudy on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds

Timothy Hinks reposted

Eduardo Villablanca
@ejvillablanca.bsky.social

Beyond classical immunity: Mast cells as signal converters between tissues and neurons: Immunity www.cell.com/immunity/ful...

cell.comBeyond classical immunity: Mast cells as signal converters between tissues and neuronsMast cells act as “signal converters,” translating immunological and tissue signals into host-protective behaviors. They sense antigen and possibly toxins driving avoidance behavior, which can prevent inflammation and tissue damage. Beyond classical immunity, mast cells rapidly activate antigen expulsion responses and initiate nociception. These reflexes promote host-protective behavior and maintain tissue integrity.
Timothy Hinks
@hinkslab.bsky.social

Editors pick this month in Allergy - Our new species-level study from @OxfordBRC shows severe #asthma microbiome is dominated by H. influenzae, M. catarrhalis and S. pneumoniae, driving neutrophilic inflammation, airway proteases and disrupting regulatory immune responses: doi.org/10.1111/all....

doi.orgSpecies‐level, metagenomic and proteomic analysis of microbe‐immune interactions in severe asthmaPaired long-read metagenomic sequencing and proteomics in sputum and nasal lavage identified a single dominant respiratory pathogen (H. influenzae more than M. catarrhalis and S. pneumoniae) in 23% o...

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