MRC Weatherall Institute of Molecular Medicine

MRC Weatherall Institute of Molecular Medicine

@imm.ox.ac.uk

The MRC WIMM is a research institute at the University of Oxford with 5 core research areas: rare diseases, haematology, immunology and infection, stem cells and developmental biology and cancer biology. www.imm.ox.ac.uk

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MRC Weatherall Institute of Molecular Medicine reposted

University of Oxford
@ox.ac.uk

Today is the last time the sun will set in Oxford after 6pm. The next time the sun sets after 6pm will be in March 2027. And so the early evenings begin. 📷 Instagram | ObservingOxford

MRC Weatherall Institute of Molecular Medicine
@imm.ox.ac.uk

#BloodCancerAwarenessMonth🧪 This week, we revisit Vyas Group research showing how blood stem cells can “remember” inflammation, offering new insights into blood cancer development. #BloodCancerResearch #AcademicSky

imm.ox.ac.ukStudy reveals blood stem cells can ‘remember’ inflammationResearchers have discovered that some human blood stem cells retain a lasting “memory” of inflammation, a finding that could help explain links between ageing, chronic disease, and blood cancers
MRC Weatherall Institute of Molecular Medicine
@imm.ox.ac.uk

🏆 Congratulations to #MRCWIMM researchers Ilija Ilievski, Poorva Jain & Karolina Kunnapuu, who won a £5,000 prize at a Health x AI Hackathon at Google’s London HQ! Their AI-powered tool aims to identify delays in patient care and predict potential bottlenecks. 🧪 #AcademicSky #AI

imm.ox.ac.ukMRC WIMM researchers win Health x AI Hackathon with tool to tackle delays in patient careThree MRC WIMM researchers have won a £5,000 prize at a Health x AI Hackathon held at Google’s London headquarters, after developing an AI-powered tool designed to identify delays in patient care.
MRC Weatherall Institute of Molecular Medicine
@imm.ox.ac.uk

#WIMMReads 🧪 Can AI turn routine pathology images into molecular information? A new review from Kexin Xu, Hashem Koohy and Agne Antanaviciute explores advances in predicting spatial gene expression directly from tissue images. #SpatialTranscriptomics #DigitalPathology #MRCWIMM #AcademicSky

sciexplor.comPredicting spatial transcriptomics from histology images: Progress, challenges, and directionsSpatial transcriptomics (ST) maps gene expression within intact tissues, but its cost and technical complexity limit broad adoption. A growing body of deep-learning methods now seeks to infer ST direc...
MRC Weatherall Institute of Molecular Medicine
@imm.ox.ac.uk

For #BloodCancerAwarenessMonth, we’re revisiting #MRCWIMM #bloodcancer research every Monday. This week: Prof Beth Psaila and colleagues’ work on personalised CAR T cell therapy for myeloproliferative neoplasms. @rdm.ox.ac.uk @medsci.ox.ac.uk #AcademicSky 🧪

imm.ox.ac.ukNew personalised therapy targets chronic blood cancerA new form of CAR T cell therapy has been designed to find and destroy the cancer-driving cells responsible for a group of blood cancers known as myeloproliferative neoplasms (MPNs), while leaving hea...

MRC Weatherall Institute of Molecular Medicine reposted

Radcliffe Department of Medicine
@rdm.ox.ac.uk

DPhil and MSc applications are now open! Ready to take the next step in your research career? Take a look at our video of top tips to help you prepare a competitive application www.youtube.com/watch?v=Onu8... The deadline for applications is 1st December at 12noon. @imm.ox.ac.uk @ox.ac.uk

youtube.comTop Tips for Making a Good DPhil ApplicationYouTube video by Radcliffe Department of Medicine Oxford University
MRC Weatherall Institute of Molecular Medicine
@imm.ox.ac.uk

For #BloodCancerAwarenessMonth, we are highlighting blood cancer research from across #MRCWIMM every Monday. This week, hear from Prof Thomas Milne as he discusses his latest article in Blood on gene regulation in KMT2A rearranged acute lymphoblastic #leukaemia. #BloodCancerResearch #AcademicSky 🧪

bloodpodcast.transistor.fmBlood Podcast | MYB driven ALL and Venetoclax-Azacitidine damage to Bone MarrowIn this week's episode, Blood editor Dr. James Griffin interviews Drs. Thomas Milne and Dominique Bonnet on their latest articles published in volume 147 issue 24 of Blood. Dr. Milne discusses how ...
MRC Weatherall Institute of Molecular Medicine
@imm.ox.ac.uk

Congratulations to Professor Marella de Bruijn on receiving funding from the UKRI Medical Research Council to explore how the first blood #stemcells acquire their remarkable regenerative potential, with the aim of informing future stem cell therapies. 🧪 @rdm.ox.ac.uk @medsci.ox.ac.uk

imm.ox.ac.ukProfessor Marella de Bruijn receives MRC Programme AwardCongratulations to Professor de Bruijn, who has been awarded funding from the UKRI Medical Research Council to investigate how the first blood stem cells formed in the embryo acquire their exceptional...
MRC Weatherall Institute of Molecular Medicine
@imm.ox.ac.uk

#WIMMReads 🧪 A new review from the Bannard Group explores how #BCells are selected in germinal centers and how diverse, lasting antibody immunity develops. https://onlinelibrary.wiley.com/doi/10.1111/imr.70169  #Immunology #MRCWIMM @medsci.ox.ac.uk @ndm.ox.ac.uk

onlinelibrary.wiley.comGerminal Center Selection and Plasma Cell DifferentiationGerminal centers (GCs) are specialized microenvironments in which B cells undergo affinity maturation through iterative cycles of somatic hypermutation, proliferation and selection, generating antibo...
MRC Weatherall Institute of Molecular Medicine
@imm.ox.ac.uk

Congratulations to Professor Beth Psaila, who has received the 2026 Janet Rowley Award from the International Society for Experimental Hematology! https://www.imm.ox.ac.uk/news/psaila-2026-iseh-janet-rowley-award  @rdm.ox.ac.uk @medsci.ox.ac.uk @ox.ac.uk

imm.ox.ac.ukProfessor Bethan Psaila wins ISEH Janet Rowley AwardCongratulations to Professor Psaila, who has received the 2026 Janet Rowley Award from the International Society for Experimental Hematology, in recognition of her outstanding contributions in the field of experimental haematology.
MRC Weatherall Institute of Molecular Medicine
@imm.ox.ac.uk

#WIMMReads 🧪  Simon Davis et al. review how agonistic antibodies can activate immune receptors and their potential to deliver safer and more effective immunotherapies for cancer and autoimmune disease. https://www.nature.com/articles/s41573-026-01442-2 #Immunology  @ndm.ox.ac.uk @medsci.ox.ac.uk

nature.comRealizing the potential of agonistic antibody immunotherapy - Nature Reviews Drug DiscoveryAgonistic antibodies initiate signalling by the receptors they target, mimicking the activities of native ligands. This Review discusses the clinical successes and failures of agonistic antibodies and explains how recent mechanistic insights should broaden the scope and improve the safety and efficacy of immunotherapies based on these agents.
MRC Weatherall Institute of Molecular Medicine
@imm.ox.ac.uk

As we say goodbye to summer this #BankHoliday, let’s take a quick look at what we’ve been up to at the #MRCWIMM over summer 2026. 👇 https://www.imm.ox.ac.uk/news/summer-of-engagement  @medsci.ox.ac.uk @rdm.ox.ac.uk 🧪

imm.ox.ac.ukA summer of science and engagementThis summer, researchers at the MRC WIMM have taken part in a variety of public engagement activities, leading a stand at Cheltenham Science Festival and welcoming students for the Institute's summer work experience programme.
MRC Weatherall Institute of Molecular Medicine
@imm.ox.ac.uk

Congrats to Prof KJ Patel, who has received the Buchanan Medal, which recognises distinguished contributions to the biomedical sciences. 🧪 https://www.imm.ox.ac.uk/news/kj-patel-royal-society-buchanan-medal  @royalsociety.org @rdm.ox.ac.uk @medsci.ox.ac.uk @cancerresearchuk.org  @ukri.org

imm.ox.ac.ukProfessor KJ Patel awarded Royal Society Buchanan MedalCongratulations to Professor Patel, who has received the Buchanan Medal, which recognises distinguished contributions to the biomedical sciences.

MRC Weatherall Institute of Molecular Medicine reposted

University of Oxford
@ox.ac.uk

Today is the last day this year that the sun will set after 8pm in Oxford 🌅 Enjoy it while it lasts 🥲 📷 Instagram | Juncao_Oxford

MRC Weatherall Institute of Molecular Medicine
@imm.ox.ac.uk

#WIMMReads🧪 Ho Group's new study has uncovered an immune signature that may help explain the early stages of idiopathic #PulmonaryFibrosis (IPF), a condition that causes progressive scarring of the lungs. https://www.imm.ox.ac.uk/news/early-immune-events-lung-fibrosis @medsci.ox.ac.uk @ndm.ox.ac.uk

imm.ox.ac.ukNew research maps immune events in early stages of lung fibrosisA new study led by the Ho Group has uncovered a striking immune signature that may help explain what happens in the early stages of idiopathic pulmonary fibrosis (IPF), a serious condition that causes scarring of the lungs and makes breathing difficult.
MRC Weatherall Institute of Molecular Medicine
@imm.ox.ac.uk

#WIMMReads 🧪 From the Rehwinkel Group: new study suggests MDA5 can act as a cellular “guard”: during viral infection, it senses disruption to the cell’s own RNA processing — not only viral RNA. #Immunology #Academicsky @rdm.ox.ac.uk @medsci.ox.ac.uk

nature.comLoss of cellular RNA homeostasis contributes to MDA5 activation during virus infection - Nature ImmunologyMDA5 detects double-stranded RNA during viral infections. This work shows that MDA5 binds aberrant host RNA induced during viral infection. Rescue of aberrant cytoplasmic RNA during infection abrogate...
MRC Weatherall Institute of Molecular Medicine
@imm.ox.ac.uk

#WIMMReads 🧪 From the Marella de Bruijn Group: a new study identifies markers that distinguish blood #StemCells from blood progenitor cells, providing new insight for developing stem cell therapies. #Haematology #AcademicSky @medsci.ox.ac.uk @rdm.ox.ac.uk

cell.comResolving hematopoietic stem versus progenitor cell potential in the mouse dorsal aorta by differential Runx1 +110 enhancer activityDuring embryonic development, the specification of hematopoietic stem cells (HSCs) and progenitor cells (HPCs) critically depends on the transcription factor Runx1. Anselmi et al. describe a Runx1 enh...
MRC Weatherall Institute of Molecular Medicine
@imm.ox.ac.uk

That’s a wrap on Work Experience 2026! After two weeks exploring haematology, genome engineering and life in our labs, our students finished today with group presentations and certificates of completion. Congratulations to them all, and a huge thank you to everyone at WIMM who made it possible! 👏