Seth Thomas Scanlon

Seth Thomas Scanlon

@immunoeditor.bsky.social

Editor, Science Immunology science.org/journal/sciimmunol 🇺🇸 + 🇳🇱 & based in 🇪🇺 Twitter: x.com/ImmunoEditor

2.9K followers255 following226 posts

Seth Thomas Scanlon
@immunoeditor.bsky.social

Be sure to check out the current issue of #Science #Immunology! New content is added each week!

Science Magazine@science.org

The October 2026 issue of #ScienceImmunology is out! This month's cover depicts immune cells (red) and epithelial cells (blue) in malignant ascites from a patient with gastric cancer. Learn about this research and more: https://scim.ag/4iXeoZ2

Seth Thomas Scanlon
@immunoeditor.bsky.social

My dream of being a … *gulp* … podcast guest has finally come true! Thanks, @boron110.bsky.social for the fun & freewheeling conversation!

Sar Crespi@boron110.bsky.social

Looking back at the first 10 years of Science Immunology—this week on the @science.org podcast. Editor @immunoeditor.bsky.social explores how the field has changed since the inception of the journal and talks about a special series of reviews on immune memory www.science.org/content/podc...

Seth Thomas Scanlon
@immunoeditor.bsky.social

So far in March, we've featured papers on: • how inflammatory #ILC2 migrate • engineering #CAR-TCells to restore #checkpoint sensitivity • capturing the earliest events of #TCell #development • how certain dietary antigens recognized by #Tregs help mediate #OralTolerance New content every week!

Science Magazine@science.org

The March 2026 issue of #ScienceImmunology is out! This month's cover highlights how intestinal regulatory T cells in mice recognize food-derived antigens such as the maize protein αZein and suppress immune responses to them. Learn about this research and more: https://scim.ag/4rL6F1I

Seth Thomas Scanlon
@immunoeditor.bsky.social

Out now in #Science #Immunology! 👇

Casanova Lab@casanovalab.bsky.social

1/ We are excited to report in @sciimmunology.bsky.social that human complete and selective LFA-1 deficiency causes isolated Epidermodysplasia Verruciformis (EV). This surprising phenotype revealed a surprising mechanism 🙂 www.science.org/doi/10.1126/...

Seth Thomas Scanlon
@immunoeditor.bsky.social

Check it out! New content each week!!!

Science Magazine@science.org

The February 2026 issue of #ScienceImmunology is out! This month's cover highlights how the cohesin complex shapes genome organization in dendritic cells to regulate their differentiation and function. https://scim.ag/4agVpT8

Seth Thomas Scanlon
@immunoeditor.bsky.social

The January 2026 issue of #Science #Immunology is out now! Thanks to Rioka Hayama for another fantastic cover!!!

Science Magazine@science.org

The January 2026 issue of #ScienceImmunology is out! This month's cover depicts the repopulation of resident cardiac macrophages after chemotherapy, protecting the heart against subsequent injury. Learn more about this research and more: https://scim.ag/3NsLjqu

Seth Thomas Scanlon
@immunoeditor.bsky.social

Happy 2026!!! #Science #Immunology will celebrate its 10th anniversary this year! 🎉 We start with a look back at our Editors’ Choice of articles published in 2025! This free sample collection will be available online to read until the end of February 2026! bit.ly/SciImm_free #ScienceImmuno10gy

Seth Thomas Scanlon
@immunoeditor.bsky.social

#Science #Immunology will be sponsoring a prize for the best poster presentation! The abstract deadline is fast approaching though, so don't delay! I hope to see many of you in marvelous Ghent this coming March!

Science Magazine@science.org

In partnership with @vibtrainconf.bsky.social, #ScienceImmunology is organizing #Type2Immunity26 in Ghent 9–10 March 2026, bringing together leaders in the field of #Type2Immunity. Check out our lineup here: vibbio.tech/3UwmTNk 🗓️15 DEC: Travel grant deadline 🗓️8 JAN: Abstract deadline

Seth Thomas Scanlon
@immunoeditor.bsky.social

The latest issue of #Science #Immunology is out now! This week: • evaluating large language models ( #LLMs ) / #AI as potential #systems #vaccinology tools • de novo #thymus #regeneration in the #axolotl! New content every week!!!

Science Magazine@science.org

The December issue of #ScienceImmunology is out! This month's cover highlights the juvenile axolotl's ability to regenerate its thymus after complete removal—possibly making it an exception among vertebrates. Learn about this research and more: https://scim.ag/4anWlqv

Seth Thomas Scanlon
@immunoeditor.bsky.social

This week in #Science #Immunology, Lambrecht & Hammad labs (@viblifesciences.bsky.social) use #Danish Nat'l Patient & Prescription Registries + mouse models to show that maternal #allergy & neonatal #RSV infection synergize via FcR-mediated allergen uptake to drive development of early life #asthma!

science.orgMaternal allergy and neonatal RSV infection synergize via FcR-mediated allergen uptake to promote the development of asthma in early lifeMaternal IgG transfer and neonatal infection synergize via Fc receptor pathways to promote allergic TH2 immunity.
Seth Thomas Scanlon
@immunoeditor.bsky.social

Nov issue of #Science #Immunology out now! This week: exTH17 cells sustain #IL17 –independent rheumatoid #arthritis; CXCR4+ mesodermal progenitors → rostral blood vessels, prodefinitive hematopoiesis, & postnatal tissue #macrophages; & how #Bcells acquire antigens from #parasites! scim.ag/4qQA6Q6

Seth Thomas Scanlon
@immunoeditor.bsky.social

Now in #Science #Immunology: Hirahara lab reports activated #TH2 cells store LC-UFAs present in inflamed #lung within #lipid droplets. Subsequent catabolism via #microlipophagy induces ST2-hi effector & memory TH2 cell phenotypes, exacerbating #type2 #airway #inflammation! #asthma #immunometabolism

science.orgLipolysis-microlipophagy cascade regulated by adipose triglyceride lipase drives pathogenic adaptive type 2 immunityEnzymatic and autophagic catabolism of lipid droplets after unsaturated fatty acid uptake induces pathogenic TH2 cells.
Seth Thomas Scanlon
@immunoeditor.bsky.social

Recently in #Science #Immunology: Kalinichenko, Huemer, @boztugk.bsky.social, & colleagues report than #sphingolipid #metabolism & protein #palmitoylation play critical roles in the killing of target cells by #cytotoxic #lymphocytes!

science.orgProtein palmitoylation and sphingolipid metabolism control regulated exocytosis in cytotoxic lymphocytesProtein palmitoylation and sphingolipid metabolism control lytic granule release in cytotoxic lymphocytes via membrane targeting of SNAP23.
Seth Thomas Scanlon
@immunoeditor.bsky.social

Thanks, @natrevimmunol.nature.com, for highlighting this exciting recent paper in #Science #Immunology!

Nature Reviews Immunology@natrevimmunol.nature.com

Highlight of Science Immunology paper by @thepenkpanther.bsky.social, Alexander Rudensky and colleagues @mskcancercenter.bsky.social @scripps.edu @wcm-imp.bsky.social #immunology #immunosky #neurosky

nature.comSkin Treg cells set the tone for neuronal activation - Nature Reviews ImmunologyA study in Science Immunology reports that regulatory T cells in the skin modulate neuronal tone directly through their production of the opioid enkephalin.
Seth Thomas Scanlon
@immunoeditor.bsky.social

This week in #Science #Immunology! 👇

Kilian Schober@kischober.bsky.social

If the immune system is an army... ... would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest? I’d go with the team. Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...

Seth Thomas Scanlon
@immunoeditor.bsky.social

David Baker & colleagues develop an #IL21 mimic (21h10) that is more stable & shows x-reactivity against both human & murine #IL21R. 21h10 promotes potent antitumor responses in mice and in human #melanoma tumor explants, expanding low-affinity CD8 #TCells & #TH1 cells & reducing #Tregs in #tumors!

science.orgDesign of a potent interleukin-21 mimic for cancer immunotherapyA de novo IL-21 mimic, 21h10, exhibits improved stability and potent antitumor activity in vivo compared with native IL-21.
Seth Thomas Scanlon
@immunoeditor.bsky.social

Now in #Science #Immunology: Deshpande, Klose, & al at Charité—Universitätsmedizin Berlin report that #ILC2 resident in #PNS communicate with neurons via #IL13 to maintain #nerve structure & pain thresholds. Mice lacking ILC2 or whose neurons are Il4ra-KO exhibit #hypersensitivity & #gait defects!

science.orgGroup 2 innate lymphoid cells regulate nociceptive and gait functions of the peripheral nervous systemILC2-neuron cross-talk contributes to the maintenance of nerve structure and function of the peripheral nervous system.
Seth Thomas Scanlon
@immunoeditor.bsky.social

Now in #Science #Immunology: @griffithslab.bsky.social report that when #CD8 #TCells encounter their targets, #nucleus localizes to the #ImmuneSynapse (IS) & facilitates delivery of newly synthesized cytokines to the IS. They find nuclear polarization represents key step in #CTL -mediated killing!

science.orgNuclear polarization to the immune synapse facilitates an early transcriptional burstCytotoxic T lymphocyte target recognition triggers rapid nuclear polarization to the immune synapse and an early transcriptional burst of cytokines.
Seth Thomas Scanlon
@immunoeditor.bsky.social

Now in #Science #Immunology, @drtesutherland.bsky.social & al report chitinase-like proteins (CLPs) make distinct contributions to airway pathology independent of #IL13- & #IL17 –mediated signaling in 🐀 #asthna model! CLPs orchestrate airway #ECM remodeling, & can be both protective & detrimental!

science.orgAllergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteinsAllergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.
Seth Thomas Scanlon
@immunoeditor.bsky.social

The September issue of #Science #Immunology is out! This week: METTL1 m⁷G RNA modification of NAD+ #metabolism → #macrophage -mediated #inflammation; proenkaphalin+ #Tregs restrain skin inflamm via control of #nociception; #RNA helicase DDX55 is regulator of naïve #TCell homeostasis scim.ag/3HKC5DP

Seth Thomas Scanlon
@immunoeditor.bsky.social

Heads up: @science.org 's immunology editor @sarahhross.bsky.social and I will both be attending the @iuis-online.bsky.social 19th International Congress next week in the ever enchanting city of #Vienna! We hope to see many of you there!

iuis2025.orgHome - IUIS 2025IUIS 2025 ACCREDITED WITH 26 CME CREDITSThe 19th International Congress of Immunology (IUIS 2025), Vienna, Austria 17/08/2025 – 22/08/2025, has been accredited by the European Accreditation Council fo...
Seth Thomas Scanlon
@immunoeditor.bsky.social

The cover depicts an hourglass with beneficial (blue) & pathogenic (orange) microbiota drawn as sand. Transferred Tregs lining the hourglass cause the “sand” to flow in reverse, highlighting their ability to undo some of the effects of inflammaging by restoring gut barrier integrity!

Seth Thomas Scanlon
@immunoeditor.bsky.social

Out now in #Science #Immunology: Eric Vivier (@univ-amu.fr), Hui Peng, Zhigang Tian (USTC, Hefei), & colleagues report that #FetalLiver #InnateLymphoidCell ( #ILC ) progenitors in mice continue contributing to ILC #hematopoiesis into adulthood in a #BoneMarrow –independent manner!

science.orgInnate lymphoid cells originate from fetal liver–derived tissue-resident progenitorsFetal liver–derived ILC progenitors seed peripheral tissues and generate local ILCs independently of the bone marrow throughout life.
Seth Thomas Scanlon
@immunoeditor.bsky.social

In #Science #Immunology, @tobiasplowman.bsky.social, Kassiotis, & al report canonical #IL13RA1 expression is negatively regulated by E2 #estrogen & also describe a primate-specific RTE-derived IL-13Rα1 isoform that antagonizes the canonical receptor & attenuates responsiveness to #IL4 and #IL13!

science.orgPrimate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responsesCo-option of primate-specific retroelements creates an alternative IL-13Rα1 subunit that tunes type 2 immune responses.
Seth Thomas Scanlon
@immunoeditor.bsky.social

These 2 processes together fine-tune #type2 immune responses & may help explain why, for example, #IgE sensitization & development of #allergic disorders are more prevalent in males & certain groups with groups sharing genetic ancestry. #SexDifferences in #Immunity #HumanImmunology #RTEexonization

Seth Thomas Scanlon
@immunoeditor.bsky.social

Out now in #Science #Immunology: using a forward genetic of #ion #channels & #transporters, @stefanfeske.bsky.social & colleagues identified chloride nucleotide-sensitive channel 1A (CLNS1A) to be a critical regulator of #CD4 #TCell proliferation & differentiation!

science.orgCLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunityCLNS1A promotes autoimmunity through epigenetic and transcriptional regulation of DNA repair and cell cycle progression in CD4 T cells.
Seth Thomas Scanlon
@immunoeditor.bsky.social

Recently in #Science #Immunology: Van der Veeken & al @ IMP @viennabiocenter.bsky.social generated 🐁 w auxin-inducible degradable #Foxp3! Tissue #Tregs minimally unaffected @ homeostasis but highly dependent on continuous Foxp3 activity in models of #autoimmunity, #viral #infection, & #cancer !

science.orgInducible protein degradation reveals inflammation-dependent function of the Treg cell lineage–defining transcription factor Foxp3Acute Foxp3 protein depletion selectively affects Treg cells responding to type 1 inflammation.