Immunology Podcast

🎧 Tune into the next episode featuring Dr. @ejohnwherry.bsky.social from @upenn.edu! He dives into how #TCell exhaustion develops during chronic infections and cancer, and why it may serve as a protective adaptation rather than simply a dysfunctional immune state. 👉 https://bit.ly/4ypXvKI

🤩 Get ready for an exciting conversation with one of the leading minds in the field! Next week, we're talking to Dr. Dan Littman at the NYU Grossman School of Medicine about #TCell development and microbiome-immune interactions. Dr. Littman's latest work: https://go.nature.com/4sYqnZ5

Scientists in Dr. @jamesreading.bsky.social lab at @u@ucl.ac.ukound that BATF-expressing regulatory T cells expand across blood and lung tissues during early lung #cancer development. 🫁 More on the study: https://go.nature.com/4ipKD2d Listen to the discussion: https://bit.ly/4ypXvKI

Low-dose Pseudomonas aeruginosa LPS enhances lung-resident NK cell activity through C3aR1 signaling, providing microbiota-dependent protection against bacterial #pneumonia in mice. 🫁 More on their findings: https://go.nature.com/3VPamse 🎙️ Listen to the discussion: https://bit.ly/4ypXvKI

Dr. Nicolas Veland and team at @kingscollegelondon.bsky.social found that tissue-resident γδ T cells depend on #TCell receptor signaling for their rapid, innate-like responses to tissue stress and cancer. Read more: https://go.nature.com/3VRFGqf 🎧 Tune in: https://bit.ly/4ypXvKI

Researchers with Dr. Patrick Ho, and Andrew Vu at @ucsfdc.bsky.social identified an IRF4 regulatory element that drives inflammatory reprogramming and loss of suppressive function in human #Treg cells. 🔬 https://go.nature.com/3TVpMup Listen now: https://bit.ly/4ypXvKI

🥼 Our next guest is Dr. John Wherry (@ejohnwherry.bsky.social) from @pennmedicine.bsky.social! His lab investigates the fundamental biology of #TCell exhaustion in chronic infections and cancer. His latest work: https://bit.ly/3TxEF64

Dr. Aaron Fleming and team at @universitypress.cambridge.org found that gut infections send activated CD4+ T cells to the brain’s borders, where they establish long-lived immune memory against intestinal #microbes. 🦠 📃 https://go.nature.com/4xGRgBF ▶️ Listen now: https://bit.ly/4yiewap

Danielle Isakov, Chhiring Lama, and scientists at @weillcornell.bsky.social found that interferon-α reshapes hematopoietic stem cell differentiation in #myeloproliferative neoplasms. 🩸 🥼 https://go.nature.com/4AiXtX5 🎧 Join the conversation: https://bit.ly/4yiewap

Scientists with Cristhian Cadena in Dr. Vishva Dixit's lab discovered that IRF2 restrains inflammation by limiting IRF1-driven immune gene expression, revealing a transcriptional switch that regulates #InnateImmune responses. 🧬 🧫 https://bit.ly/4hndK65 🎙️ Tune in: https://bit.ly/4yiewap

Scientists with Leeana Peters in the Brusko lab at @ufresearch.bsky.social used multimodal profiling to reveal distinct inflammatory and differentiation states of CD8+ T cells across pancreatic lymph nodes and tissue in #Type1Diabetes. 🔬 https://bit.ly/3TSQ6VQ 🎧 Tune in: https://bit.ly/4yiewap

🎧 Tune into our discussion with Dr. Merav Cohen at Tel Aviv University on how her lab uses single-cell technologies to decode communication between immune cells and surrounding tissues, including physical interactions that reprogram #macrophages and neutrophils. Listen now 👉 https://bit.ly/4yiewap

🤔 Curious about cellular crosstalk between #immune cells and surrounding tissues? Then stay tuned for next week's episode featuring Dr. Merav Cohen at Tel Aviv University, where we deep dive into decoding interactions using single-cell technologies! Her latest work: https://bit.ly/47dxYck

Scientists with @davidemarotta.bsky.social at @unisr.bsky.social found that platelet-derived serotonin promotes blood clotting and lung dysfunction during #SARSCoV2 infection, helping explain greater disease severity with age. 🩸 🔬 https://bit.ly/4hdgEst Tune in: https://bit.ly/3VE92Ik

Dr. Pil Soo Sung and team, including Min Gu Kim, discovered that IgA binding to liver #myeloid cells is associated with IL-1-linked inflammation and liver injury in alcohol-associated liver disease. 🌡️ Read more: https://bit.ly/4ymtlJb 🎙️ Listen to the discussion: https://bit.ly/3VE92Ik

💡 An unexpected connection! Researchers found that ILC2-derived serotonin amplifies airway inflammation and activates sensory neurons to promote #asthma and cough hypersensitivity. 🫁 More on the study: https://bit.ly/4xJAfrj Listen now: https://bit.ly/3VE92Ik

Researchers with Alexa Semon at @childrensphila.bsky.social found that early-life C. difficile exposure alters intestinal #StemCell behavior and leaves lasting changes in gut development. 🧫 Read more: https://bit.ly/4rhvTW2 🎧 Tune in: https://bit.ly/3VE92Ik

🔔 The wait is over! Tune into our discussion with Dr. Roger Geiger at @irbbellinzona.bsky.social on the metabolic regulation of #TCell function and engineering bacteria to deliver therapeutic payloads directly to tumors. 🦠 Listen now! https://bit.ly/3VE92Ik

📢 Stay tuned for Dr. Roger Geiger from @irbbellinzona.bsky.social! His lab studies molecular regulations underlying #TCell activation and anti-tumor activity, aiming to provide detailed insights into T cell functionality that can be translated into the clinic. 🧫 Latest work: https://bit.ly/3SCeRoT

Shi Yue and scientists found that responses to CAR T cell therapy for #GBM are associated with the surrounding immune environment, with NK cells linked to response and Tregs and suppressive myeloid cells linked to resistance. @keck.usc.edu 🧪 https://bit.ly/46zh87k Tune in: https://bit.ly/4qLZ8A0

Dr. Dana Silverbush with Nelson Freeburg and scientists at @pennmedicine.bsky.social found that expandable granulocyte-monocyte progenitors provide a scalable platform for engineering #macrophages that can target blood and solid tumors. 🧫 🥼 https://bit.ly/4xDPxy2 Listen now: https://bit.ly/4qLZ8A0

Dr. Fabiana Corsi-Zuelli and scientists at @ox.ac.uk describe a recombinant #shingles vaccine associated with lower long-term risks of several cardiovascular outcomes, supporting studies of its potential cardioprotective effects. 💉 📃 https://go.nature.com/4zPB0Ax Tune in: https://bit.ly/4qLZ8A0

Researchers with Ruxiao Yang-Fischer in Dr. Sankar Ghosh's lab at @columbiaup.bsky.social found that an #IBD-associated long noncoding RNA promotes immune tolerance by enhancing Treg function and limiting inflammatory T cell responses. 🔬 https://bit.ly/4qMivJ8 Listen now: https://bit.ly/4qLZ8A0

🎤 Next episode has dropped! Dr. Martin Prlic at @fredhutch.org joins us on the podcast to talk about how #TCells behave and adapt across healthy, inflamed, and diseased human tissues. 🎧 Tune in now: https://bit.ly/4qLZ8A0

✅ Next up is our conversation with Dr. Martin Prlic at @fredhutch.org! The Prlic Lab primarily studies T cell and innate-like T cell responses in mucosal tissues and looks into how the human immune system responds to infections, #vaccines and cancer. 💉 Their latest work: https://bit.ly/3Ssw1Fj

Elya Shamskhou and team at @seattlechildrens.org found that Mycobacterium #tuberculosis persists in lymph nodes by forming infected monocyte-derived niches that evade recognition by Mtb-specific T cells. 😷 🥼 https://bit.ly/4qlzr9b Take a listen! https://bit.ly/3SQ08GQ

Scientists at @ucsfdc.bsky.social with Alyssa Indart and Huiyun Lyu discovered that engineering regulatory T cells with a self-sustaining IL-2 signaling system improves their persistence to prevent autoimmune #diabetes in mice. 🐀 🧪 https://bit.ly/4wtplod Listen in: https://bit.ly/3SQ08GQ

Scientists with Jeannette Nilsen, Kine Sand, and Hana Al-Khabbaz at @uio.no and Riyadh Elm University found that fusing therapeutic antibodies to albumin reduces their transfer across the #placenta, limiting fetal drug exposure. 📄 https://bit.ly/4gQnwgt Tune in: https://bit.ly/3SQ08GQ

Investigators at @utaustin.bsky.social with Cole Maguire have found that chronic viruses frequently reactivate during severe COVID-19, with distinct patterns associated with inflammation, disease severity, recovery, and long #COVID. 🔬 https://go.nature.com/4hdJ0EP Listen now: https://bit.ly/3SQ08GQ

The next episode is out! Dr. @miriammerad.bsky.social at the Icahn School of Medicine at Mount Sinai discusses how myeloid progenitors and #macrophages shape the TME, and how dendritic cells support tertiary lymphoid structures and anti-tumor immunity. Listen now! https://bit.ly/3SQ08GQ

Researchers with Dr. Qiushuang Wu at @rockefeller.edu found that arginine availability regulates MHC class I #antigen presentation, influencing antiviral immunity and cancer development. 📃 https://bit.ly/4bpEY8z 🎧 Listen now: https://bit.ly/3RBBVUf

Dr. Grozdan Cvijetic and scientists at the NIH discovered that disrupted dendritic cell development promotes gut dysbiosis that drives inflammatory dendritic cell expansion and systemic #autoimmunity. 🧪 Check out the study: https://go.nature.com/4fIs08y Tune in: https://bit.ly/3RBBVUf

Scientists at @harvardmed.bsky.social found that TCR specificity and antigen presentation context determine #RegulatoryTCell differentiation and phenotype, providing a framework for antigen-specific immune tolerance. 🔬 Read more: https://bit.ly/4bqWucx Tune in: https://bit.ly/3RBBVUf

A Phase I/II trial led by Dr. Shabir Madhi at the University of the Witwatersrand shows that a maternal hexavalent Group B #Streptococcus vaccine is safe and elicits robust antibody responses in both mothers and infants. 💉 Read more: https://go.nature.com/4hSXQRh Listen now: https://bit.ly/3RBBVUf

🔔 The next episode is out! Dr. Pere Santamaria at @ucalgarymed.bsky.social discusses how his lab studies the mechanisms underlying autoimmune diseases, with a focus on regulatory T cell biology and antigen-specific immune tolerance. Listen now! https://bit.ly/3RBBVUf

🎉 Our next guest is Dr. Pere Santamaria from @ucalgary.bsky.social Tune into the discussion to learn all about his research on immunogenetics and immunopathogenesis of #autoimmune disorders. Check out their latest work: https://bit.ly/4fPvO6N

📢 The next episode is out! Dr. Brian Brown at the Icahn School of Medicine at Mount Sinai discusses how his lab develops innovative technologies to study the immune system and advance new therapeutics, from #TCell engineering to mRNA-based medicines. 🎧 Tune in! bit.ly/3RFD39g

Investigators with Dr. Yuting Jessy Tan at @stanfordmedicine.bsky.social explore restoring macrophage clearance of senescent #neutrophils reverses age-related decline across multiple organs in mice by blocking EP2 signaling. Read the study 🔬 https://bit.ly/3RAIVAI Tune in 🎙️ https://bit.ly/3RFD39g

Investigators at @cedarssinaihsu.bsky.social found that gut bacteria promote anti-tumor immunity by converting tryptophan into indoles that enhance immune responses and inhibit #melanoma growth. Read more 👉 https://bit.ly/4vUX9KM Listen in 👂 https://bit.ly/3RFD39g

Researchers with Rintaro Shibuya at the Icahn School of Medicine at Mount Sinai discovered that activation of sensory neurons in the skin suppresses allergic airway inflammation through a vagus nerve–mediated neuroimmune reflex. Read more 📄 https://bit.ly/3S0DpYc Tune in 🎧 https://bit.ly/3RFD39g

Scientists with Dr. Maria Grazia Cusi at the University of Siena have found evidence that #Sindbis virus can invade the human central nervous system and cause neurological disease. 🧠 Read more👉 https://bit.ly/4ynUefS Listen in 🎧 https://bit.ly/3RFD39g

Next week, Dr. Brian Brown from the Icahn School of Medicine at Mount Sinai will be joining us to discuss his lab's work on identifying factors that control immunity and translating these findings into strategies against #cancer or viruses. 🔬 Check out their latest work: https://bit.ly/4fd915L

Neil Savage, Shan Grewal, and Muhammad Vaseem Shaikh at @mcmasteruniversity.bsky.social led the discovery of a dual-targeting CAR-T therapy that achieved durable #glioblastoma control in preclinical models. 🔬 https://go.nature.com/4poFlGe 🎙️ https://bit.ly/3T2vFoL

Scientists led by @chrischiulab.bsky.social at @imperialcollegeldn.bsky.social have discovered that stronger innate immune responses predispose people to #influenza symptoms. 😷 Read more: https://go.nature.com/3Tg3mmE Tune in: https://bit.ly/3T2vFoL

Check out this week's episode featuring Dr. Andrew Hogan at @maynoothuniversity.ie! He discusses how #obesity reshapes the immune system and how #GLP1 therapies are transforming treatment. 🎧 Tune in now: https://bit.ly/3T2vFoL

AI-predicted spatial transcriptomics unlocks breast cancer biomarkers from pathology: Cell www.cell.com/cell/fulltex...

ADP-ribosylation factor 1 sustains #RegulatoryTcell function and mucosal immune homeostasis in #UlcerativeColitis www.mucosalimmunology.org/article/S193...

In this @nature.com study, researchers found that a fungal long non-coding RNA suppresses rice #immunity by sequestering a host microRNA, revealing a new RNA-based host-pathogen interaction. 🍚 Read the study: https://go.nature.com/4uu41ie Listen to the discussion: https://bit.ly/4aVo01y

Drs. Leo James and Tyler Rhinesmith at @mrclmb.ac.uk have discovered that TRIM21 directs antibody-bound pathogens into a newly identified #autophagy pathway that promotes intracellular pathogen clearance. 🔬 https://bit.ly/4oVjS7n 🎙️ https://bit.ly/4aVo01y

Drs. Leilei Chen and Larry Ng at the National University of Singapore have found that DDX6 suppresses dsRNA-driven #InnateImmunity by limiting RNA editing, and that its loss enhances anti-tumor immune responses. 🧬 📄 https://bit.ly/444iV3b 🎙️ https://bit.ly/4aVo01y