Johnston Lab

Johnston Lab

@inchinn.bsky.social

Neuroscientist fascinated by sensory physiology and how internal state modulates neural circuits https://johnstonlab.org/

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Johnston Lab
@inchinn.bsky.social

Postdoc opportunity! 🚀 Context-Dependent Learning in the Olfactory Bulb 🧠🧪 BBSRC-funded project at Leeds using 2-photon imaging🔬 to uncover how learning reshapes odour coding. Have you got a neuroscience PhD + in vivo recording experience? Apply: jobs.leeds.ac.uk/FBSBM1239 #Postdoc #Olfaction

jobs.leeds.ac.ukJob Opportunity at University of Leeds: Research Fellow in NeuroscienceOverview of the RoleAre you an ambitious researcher looking for your next challenge? Do you have an established background in Neuroscience? Do you want to further your career in one of the UK’s leadin...

Johnston Lab reposted

Nicole Rust
@nicolecrust.bsky.social

The superposition of these two studies — both incredible — reflect a snapshot of "one big thing" systems neuroscience has yet to resolve. In mice: 1. Task-related signals are everywhere. 2. Absent large swaths of "everywhere," suprisingly sophisticated learning & behavior remains.

Johnston Lab reposted

Johnston Lab
@inchinn.bsky.social

We're hiring! 🚀 Postdoctoral Fellow — Context-Dependent Learning in the Olfactory Bulb 🧠🧪 BBSRC-funded project at Leeds using 2-photon imaging🔬 to uncover how learning reshapes odour coding. Neuroscience PhD + in vivo recording experience? Apply: jobs.leeds.ac.uk/Vacancy.aspx... #Postdoc #Olfaction

jobs.leeds.ac.ukJob Opportunity at University of Leeds: Research Fellow in NeuroscienceOverview of the RoleAre you an ambitious researcher looking for your next challenge? Do you have an established background in Neuroscience? Do you want to further your career in one of the UK’s leadin...
Johnston Lab
@inchinn.bsky.social

🚨 New preprint from the lab: satiety impairs odour-guided food finding in mice. We show that insulin acts on PG cells in the olfactory bulb, inhibiting the Kv1.3 potassium channel, boosting their activity, and dampening olfactory nerve input 🧠🧪 doi.org/10.64898/202...

doi.orgInsulin controls olfactory gain at the first central synapse by regulating periglomerular neuron excitabilitySensory processing is dynamically tuned by internal state, yet how metabolic signals reshape the earliest stages of sensory circuits remains poorly understood. Here we identify a circuit mechanism by which satiety suppresses olfactory sensitivity at the first central synapse in the mouse olfactory bulb. Using a within-animal paradigm modelling fasted and glucose-induced sated states, we show that satiety impairs food-finding behaviour and reduces olfactory receptor neuron input to the olfactory bulb. Periglomerular (PG) cells, which co-express insulin receptors and the potassium channel Kv1.3, mediate this effect: insulin inhibits the low-voltage-activated Kv1.3 current in PG cells, increasing their spontaneous and odour-evoked activity. This heightened PG cell activity drives enhanced presynaptic inhibition of olfactory receptor neuron terminals, dampening sensory input before it reaches mitral cells. These findings establish insulin-dependent presynaptic inhibition of PG cells as a key locus of state-dependent sensory gain control. ### Competing Interest Statement The authors have declared no competing interest. Medical Research Council, https://ror.org/03x94j517, MR/V003747/1 Biotechnology and Biological Sciences Research Council, BB/ Z51679X/1
Johnston Lab
@inchinn.bsky.social

We're hiring! 🚀 Postdoctoral Fellow — Context-Dependent Learning in the Olfactory Bulb 🧠🧪 BBSRC-funded project at Leeds using 2-photon imaging🔬 to uncover how learning reshapes odour coding. Neuroscience PhD + in vivo recording experience? Apply: jobs.leeds.ac.uk/Vacancy.aspx... #Postdoc #Olfaction

jobs.leeds.ac.ukJob Opportunity at University of Leeds: Research Fellow in NeuroscienceOverview of the RoleAre you an ambitious researcher looking for your next challenge? Do you have an established background in Neuroscience? Do you want to further your career in one of the UK’s leadin...

Johnston Lab reposted

Venki Murthy
@neurovenki.bsky.social

Our paper on olfactory evidence accumulation is now officially published with the final clean version! With @luxorboero.bsky.social, Hao Wu, @josephdzak.bsky.social, @paulmasset.bsky.social, Farhad Pashakhanloo, @siddjakes.bsky.social, @btolooshams.bsky.social & Demba Ba.

nature.comPerception and neural representation of intermittent odor stimuli in mice - Nature CommunicationsAnimals navigate odor plumes by exploiting dynamic and intermittent cues. Here, the authors show that mice can discriminate among different fluctuating odor signals, and characterize their neural enco...

Johnston Lab reposted

Johnston Lab
@inchinn.bsky.social

📣 Looking to set up your own neuroscience🧠🧪 lab? We have a lectureship position available at the University of Leeds. 🚀 jobs.leeds.ac.uk/vacancy.aspx...

jobs.leeds.ac.ukJob Opportunity at University of Leeds: Lecturer in NeuroscienceSalary: Grade 8 (£51,753 – £59,966 p.a.)This role will be based on the university campus, with scope for it to be undertaken in a hybrid manner. We are also open to discussing flexible working arrange...

Johnston Lab reposted

Nature Methods
@natmethods.nature.com

SeeDB-Live is a tissue-clearing approach for live tissue slices or brains, improving image quality while having minimal effects on electrophysiological properties of neurons. @imailab.bsky.social www.nature.com/articles/s41...

nature.comIsotonic and minimally invasive optical clearing media for live cell imaging ex vivo and in vivo - Nature MethodsSeeDB-Live is a tissue-clearing approach for live samples such as tissue slices or the in vivo brain. It improves image quality while having minimal effects on electrophysiological properties of neuro...
Johnston Lab
@inchinn.bsky.social

Fantastic visit to the Centre for Developmental Neurobiology at Kings College. Impressive science underway.

Ana Dorrego Rivas@adorrego.bsky.social

Today we have @inchinn.bsky.social in the department! The room is packed for what we’re sure it’ll be an inspiring seminar.

Johnston Lab reposted

eLife
@elife.bsky.social

High-resolution #CryoET provides ‘compelling’ evidence for the true 3D architecture of glutamatergic synapses: a complex ‘synaptoplasm’ rather than the textbook postsynaptic density. buff.ly/hOYKjHH

Johnston Lab
@inchinn.bsky.social

Shreya @shreyac.bsky.social gave an excellent talk at this week's UKSN conference in beautiful Cambridge. bsky.app/profile/elis...

Elisa Galliano @elisagalliano.bsky.social

Olfaction geeks, come to Cambridge next month for a 30yrs old cross-disciplinary smell chat from philosophy to clinics to circuits 🧠👃 Headliner @dattalab.bsky.social on his lab's brand new olfactory maps study Networking lunches, fancy College dinner, student discount, plenty of coffee. Go register!

Johnston Lab reposted

Elisa Galliano
@elisagalliano.bsky.social

Olfaction geeks, come to Cambridge next month for a 30yrs old cross-disciplinary smell chat from philosophy to clinics to circuits 🧠👃 Headliner @dattalab.bsky.social on his lab's brand new olfactory maps study Networking lunches, fancy College dinner, student discount, plenty of coffee. Go register!

Johnston Lab reposted

Joseph D. Zak
@josephdzak.bsky.social

Now in its final form, our recent work on how olfactory transduction currents help ensure sparse sensory coding. Led by a post-bac Kai Clane Belonio and a graduate student, Eyerusalem Haile, this was a group effort by the entire laboratory. www.jneurosci.org/content/45/1...

jneurosci.orgAmplification of Olfactory Transduction Currents Implements Sparse Stimulus EncodingSensory systems must perform the dual and opposing tasks of being sensitive to weak stimuli while also maintaining information content in dense and variable sensory landscapes. This occurs in the olfa...

Johnston Lab reposted

Bozza Lab
@neuroboz.bsky.social

Check out our review comparing typical experimental to naturally-occurring odor concentrations. You might be surprised. www.jneurosci.org/content/45/1... Thanks to Matt and Betty for asking me to take part!

jneurosci.orgRecalibrating Olfactory Neuroscience to the Range of Naturally Occurring Odor ConcentrationsSensory systems enable organisms to detect and respond to environmental signals relevant for their survival and reproduction. A crucial aspect of any sensory signal is its intensity; understanding how...

Johnston Lab reposted

Dinu F Albeanu
@dinanthos.bsky.social

New preprint: a simple method (ADePT) for optical control and recording of activity by axially-decoupling the focal planes for widefield patterned photo-stimulation and two photon imaging. Proof-of-principle analysis of functional connectivity in the olfactory bulb. 1/7 #neuroscience

doi.orgAxially decoupled photo-stimulation and two photon readout (ADePT) for mapping functional connectivity of neural circuitsAll optical physiology in vivo provides a conduit for investigating the function of neural circuits in 3-D. Here, we report a new strategy for flexible, axially-decoupled photo-stimulation and two pho...

Johnston Lab reposted

Catherine Dulac
@dulaclab.bsky.social

Our latest findings on social behavior circuits is out: how does the brain responds to social isolation? Terrific work by @dingliu.bsky.social et al. uncovering a circuit with similar neural architecture as physiological needs (hunger, thirst, sleep..). Detailed thread soon. rdcu.be/ebo63

rdcu.beA hypothalamic circuit underlying the dynamic control of social homeostasisNature - New data on brain-wide circuits centred around two interconnected hypothalamic neuron populations provide significant mechanistic insights into the emergence of social need during social...

Johnston Lab reposted

Bob Pellegrino
@kingfunk.bsky.social

Alexander Fjaeldstad and I have a new chapter in the book Smell, Taste, Eat: The Role of the Chemical Senses in Eating Behaviour, edited by @LorenzoDStafford. Lots of great insights here. From our chapter, it’s clear that smell loss and its impact on ingestion remain vastly underexplored."

link.springer.comThe Effect of Olfactory Disorder (and Other Chemosensory Disorders) on Perception, Acceptance, and Consumption of FoodPeople with changes in the overall sensory experience of food often complain of taste disturbances, although the problem is normally caused by the loss of aroma in the food (thus an olfactory disorder...

Johnston Lab reposted

iBehave
@ibehave.bsky.social

🔊Major Breakthrough Researchers from @UniklinikBonn @unibonn.bsky.social @rwth.bsky.social reveal how single neurons respond to smells, images & words! This study in @natureportfolio.bsky.social bridges the gap between animal & human olfactory research!👃 📖 www.nature.com/articles/s41...

nature.comSingle-neuron representations of odours in the human brain - NatureHuman piriform and mediotemporal neurons encode odours, and signal how we perceive, rate and identify scents.

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