The Interactive Fly

The Interactive Fly

@interactivefly.bsky.social

The Interactive Fly (https://www.sdbonline.org/sites/fly/aimain/1aahome.htm) is a cyberspace guide to Drosophila Development. Special sites describe Drosophila as a model of human diseases, stress response, neural circuits, evolution, and behavior

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The Interactive Fly
@interactivefly.bsky.social

Lee, U., Arsala, D., Xia, S., ...., Zhou, Q., Zhao, L., Long, M. (2024). The three-dimensional genome drives the evolution of asymmetric gene duplicates via enhancer capture-divergence. Sci Adv, 10(51):eadn6625 www.science.org/doi/10.1126/...

science.orgThe three-dimensional genome drives the evolution of asymmetric gene duplicates via enhancer capture-divergenceThe 3D genome influences new gene evolution by altering gene expression via the general mechanism of enhancer capture-divergence.
The Interactive Fly
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Cruz, J., Urena, E., Iniguez, L. P., Irimia, M., Franch-Marro, X., Martin, D. (2024). E93 controls adult differentiation by repressing broad in Drosophila. Proc Natl Acad Sci U S A, 121(51):e2403162121 www.pnas.org/doi/10.1073/...

pnas.orgE93 controls adult differentiation by repressing broad in Drosophila | PNASIn Drosophila melanogaster, successful development relies on the precise coordination of both spatial and temporal regulatory axes. The temporal ax...
The Interactive Fly
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Stavrovskaya, I., Morin, B. K., Madamba, S., Alexander, C., Romano, A., Alam, S., Pavlov, L., Mitaishvili, E., Peixoto, P. M. (2025). Mitochondrial ROS modulate presynaptic plasticity in the Drosophila neuromuscular junction. Redox Biol, 79:103474 www.sciencedirect.com/science/arti...

sciencedirect.comMitochondrial ROS modulate presynaptic plasticity in the drosophila neuromuscular junctionThe elevated emission of reactive oxygen species (ROS) from presynaptic mitochondria is well-documented in several inflammatory and neurodegenerative …
The Interactive Fly
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Avetisyan, A., Barria, R., Sheehan, A., Freeman, M. R. (2024). An Ionic Sensor acts in Parallel to dSarm to Promote Neurodegeneration. bioRxiv, www.biorxiv.org/content/10.1...

biorxiv.orgAn Ionic Sensor acts in Parallel to dSarm to Promote NeurodegenerationHow neurons to sense when they are terminally dysfunctional and activate neurodegeneration remains poorly defined. The pro-degenerative NAD+ hydrolase dSarm/SARM1 can act as a metabolic sensor by dete...
The Interactive Fly
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Chabot, B. J., Sun, R., Amjad, A., ...., Core, L., O'Neill, R. J., Mellone, B. G. (2024). Transcription of a centromere-enriched retroelement and local retention of its RNA are significant features of the CENP-A chromatin landscape. Genome Biol, 25(1):295 link.springer.com/article/10.1...

link.springer.comTranscription of a centromere-enriched retroelement and local retention of its RNA are significant features of the CENP-A chromatin landscape - Genome BiologyBackground Centromeres depend on chromatin containing the conserved histone H3 variant CENP-A for function and inheritance, while the role of centromeric DNA repeats remains unclear. Retroelements are...
The Interactive Fly
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Shen, Y., Liu, K., Liu, J., Shen, J., Ye, T., Zhao, R., Zhang, R., Song, Y. (2025). TBP bookmarks and preserves neural stem cell fate memory by orchestrating local chromatin architecture. Mol Cell, 85(2):413-429. www.cell.com/molecular-ce...

cell.comTBP bookmarks and preserves neural stem cell fate memory by orchestrating local chromatin architectureShen et al. reveal that TBP, via recruiting chromatin remodeler EP400 and increasing local chromatin accessibility, achieves mitotic retention on Drosophila neural stem cell (NSC) chromosomes. TBP act...
The Interactive Fly
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Simkhada, B., Nazario-Yepiz, N. O., Freymuth, P. S., Lyman, R. A., Shankar, V., Wiggins, K., Flanagan-Steet, H., Basu, A., Weiss, R. J., Anholt, R. R. H., Mackay, T. F. C. (2025). A Drosophila model of mucopolysaccharidosis IIIB. Genetics, 229(3) academic.oup.com/genetics/art...

academic.oup.comA Drosophila model of mucopolysaccharidosis IIIBMucopolysaccharidosis IIIB is caused by defects in α-N-acetylglucosaminidase, which is part of the enzymatic pathway that breaks down heparan sulfate. To g
The Interactive Fly
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Strilbytska, O. M., Semaniuk, U., ...., Gospodaryov, D. V., Bayliak, M. M., Lushchak, O. (2024). 2,4-Dinitrophenol is toxic on a low caloric diet but extends lifespan of Drosophila on nutrient-rich diets. Biogerontology, 26(1):27 link.springer.com/article/10.1...

link.springer.com2,4-Dinitrophenol is toxic on a low caloric diet but extends lifespan of Drosophila melanogaster on nutrient-rich diets without an impact on metabolism - BiogerontologyUncouplers of mitochondrial electron transport chain, such as 2,4-dinitrophehol (DNP), can mimic calorie restriction by decreasing efficiency of adenosine triphosphate (ATP) synthesis. However, DNP is...
The Interactive Fly
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Xia, D., Chen, Y., Fu, X., Liu, H. Y., Sun, M. Y., Wang, F., Zhang, Y., Liu, C. F., Liu, J. Y. (2025). Overexpression of α-synuclein in Pigment Dispersing Factor neurons alters sleep-wake pattern by regulating lipid metabolism in Drosophila. Sleep, 48(3) academic.oup.com/sleep/articl...

academic.oup.comOverexpression of α-synuclein in Pigment Dispersing Factor neurons alters sleep–wake pattern by regulating lipid metabolism in DrosophilaAbstract. Parkinson’s disease (PD) is a complex neurodegenerative disorder, characterized by the aggregation of α-synuclein (α-syn). Current research incre
The Interactive Fly
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Qu, Q., Chen, Y., Wang, Y., Long, S., Wang, W., Yang, H. Y., ...., Jiang, C., Guo, H., Shui, G., Deng, X., Zhang, C. S., Lin, S. C. (2025). Lithocholic acid phenocopies anti-ageing effects of calorie restriction. Nature, 643(8070):192-200 www.nature.com/articles/s41...

nature.comLithocholic acid phenocopies anti-ageing effects of calorie restriction - NatureLithocholic acid is one of the metabolites upregulated during calorie restriction, and treatment of mice, worms and flies with this bile acid alone can reproduce the health benefits of calorie restric...
The Interactive Fly
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Wang, Y., Chen, Q., Wu, C., Ding, Y., Yuan, L., Wang, Z., Chen, Y., Li, J., Liu, Z., Xiao, K., Liu, W. (2025). SASH1 is a novel binding partner to disassemble Caskin1 tandem SAM homopolymer through heterogeneous SAM-SAM interaction. Febs j, 292:1763-1780 febs.onlinelibrary.wiley.com/doi/10.1111/...

febs.onlinelibrary.wiley.comFEBS PressCalcium/calmodulin-dependent serine protein kinase interaction protein 1/2 (Caskin1/2) is essential neuronal scaffold protein with tandem SAM domains that form homopolymers. We identified SASH1 as a ....
The Interactive Fly
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Zhao, S., Jiang, X., Li, N., Wang, T. (2024). SLMO transfers phosphatidylserine between the outer and inner mitochondrial membrane in Drosophila. PLoS Biol, 22(12):e3002941 journals.plos.org/plosbiology/...

journals.plos.orgSLMO transfers phosphatidylserine between the outer and inner mitochondrial membrane in DrosophilaPhospholipids are critical mitochondrial building blocks, but how are they transferred within mitochondria? These authors show that SLMO transfers phosphatidylserine (PS) from the outer to the inner m...
The Interactive Fly
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Hamamichi, K., Takahashi, Y. (2025). Stochastic variation in foraging traits within inbred lines of Drosophila. PloS one, 20(1):e0289864 journals.plos.org/plosone/arti...

journals.plos.orgStochastic variation in foraging traits within inbred lines of DrosophilaInvestigating the causes and consequences of niche partitioning in populations is a major goal in ecology and evolutionary biology. Previous studies have investigated genetic and environmentally induc...
The Interactive Fly
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Freed, G. S., Martinez, I. G., Lev, A., Anthony Cuadrado, A. M., Pischedda, A. (2025). Genetic Variation in Male Mate Choice for Large Females in Drosophila melanogaster. Ecology and evolution, 15(1):e70794 onlinelibrary.wiley.com/doi/10.1002/...

onlinelibrary.wiley.comGenetic Variation in Male Mate Choice for Large Females in <fi>Drosophila melanogaster</fi>We used hemiclonal analysis in Drosophila melanogaster to test for genetic variation in the strength of male mate choice for large females, a common male preference in insects. We found additive vari...
The Interactive Fly
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Zipper, L., Corominas-Murtra, B., Reiff, T. (2025). Steroid hormone-induced wingless ligands tune female intestinal size in Drosophila. Nature communications, 16(1):436 www.nature.com/articles/s41...

nature.comSteroid hormone-induced wingless ligands tune female intestinal size in Drosophila - Nature CommunicationsPregnancy induces a significant increase of intestinal epithelium to cope with metabolic demands. Here, Zipper et al. use Drosophila to show that the conserved Crooked legs/ZNF267 transcription factor...
The Interactive Fly
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Zheng, T., Long, K., Wang, S., Rui, M. (2025). Glial-derived TNF/Eiger signaling promotes somatosensory neurite sculpting. Cell Mol Life Sci, 82(1):47 link.springer.com/article/10.1...

link.springer.comGlial-derived TNF/Eiger signaling promotes somatosensory neurite sculpting - Cellular and Molecular Life SciencesThe selective elimination of inappropriate projections is essential for sculpting neural circuits during development. The class IV dendritic arborization (C4da) sensory neurons of Drosophila remodel t...
The Interactive Fly
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Pang, M. M., Chen, F., Xie, M., Druckmann, S., Clandinin, T. R., Yang, H. H. (2025). A recurrent neural circuit in Drosophila temporally sharpens visual inputs. Curr Biol, 35(2):333-346. www.cell.com/current-biol...

cell.comA recurrent neural circuit in Drosophila temporally sharpens visual inputsPang et al. use voltage imaging and dynamical modeling to probe the response properties, circuitry, and function of the Drosophila visual interneurons L1 and L2. They show that recurrent feedback critically shapes how L1 and L2 process visual information over time, sharpening intensity changes and compensating for motion-induced temporal blurring.