JAMA Psychiatry

Among people with #ParkinsonDisease and mood dysfunction, #Psilocybin was associated with lower systemic markers of inflammation and mitochondrial stress after treatment. ja.ma/4sdWunj

💬 Viewpoint: Evaluation of large language models in #MentalHealth care should reflect the realities of psychiatric practice and should not rely on isolated institutional efforts. ja.ma/4ibY4S6

Among patients with major depressive disorder, #MachineLearning predicted relapse with moderate accuracy, but the best model used only clinical relapse risk factors. Multimodal data did not improve prediction. ja.ma/4Bp5IS4

Among patients with major depressive disorder, #MachineLearning predicted relapse with moderate accuracy, but the best model used only clinical relapse risk factors. Multimodal data did not improve prediction. ja.ma/4873R6R

A Veterans Crisis Line #CaringLetters intervention was not associated with changes in #Suicide mortality among high-risk veterans who contacted the crisis line, although the previous parent trial found greater health care use among recipients. ja.ma/4hVkx5S

Among adults taking #GLP1 receptor agonists who were drinking at initiation, nearly half reported drinking less alcohol during the first 3 months after starting treatment. ja.ma/4s9rdSL

💬 Viewpoint: Current laws governing #ArtificialIntelligence in mental health may be difficult to enforce because key terms such as therapy, self-help, companion chatbot, and intended use are not clearly defined. ja.ma/4s2IOf3

Online #SportsBetting legalization was associated with more mental health-related outpatient visits and prescription use, suggesting greater demand on the behavioral health system as gambling access expands. ja.ma/4zv4Gls

Among older adults, #ADHD was associated with increased risk of later mild cognitive impairment or dementia, and higher genetic liability was also associated with greater risk. ja.ma/4yhzcOW

Among older adults, #ADHD was associated with increased risk of later mild cognitive impairment or dementia, and higher genetic liability was also associated with greater risk. ja.ma/4rTD1Io

💬 Viewpoint: For older adults in Africa, voice-first #MentalHealth care may better match routine phone use and literacy realities than app-based or text-based services. ja.ma/477YKmD

💬 Viewpoint: For older adults in Africa, voice-first #MentalHealth care may better match routine phone use and literacy realities than app-based or text-based services. ja.ma/3VVzBZM

Among older adults, #ADHD was associated with increased risk of later mild cognitive impairment or dementia, and higher genetic liability was also associated with greater risk. ja.ma/4hKq3s1

Developmental changes in GRIN2A expression may help explain the timing of psychosis in #Schizophrenia and support stage-specific and genetically informed treatment approaches. ja.ma/4yvYbz6

A context-sensitive road map for #MentalHealth system scale-up indicates that governance, supervision, referral pathways, monitoring, and local adaptation are necessary for sustainable implementation. ja.ma/4hqhhyY

US #MentalHealth and #SubstanceUseDisorder expenditures totaled $174 billion in 2021-2023, or 7.0% of all medical spending, with ambulatory services accounting for the largest share. ja.ma/4hmVBFt

Maternal #PlacentalGrowthFactor trajectories diverged in the third trimester in pregnancies where children were later diagnosed with #ADHD, while endothelin-1 did not differ. ja.ma/4yPn6wW

💬 Viewpoint: In #Psychiatry, care for #Deaf and hard-of-hearing patients requires clinical competency because hearing loss, signed language, and social bluffing can complicate the Mental Status Examination and affect diagnosis. ja.ma/47cOyJh

💬 Viewpoint: A special collection in #Psychiatry highlights early-career investigators studying clinical equity, structural #MRI and machine learning, ultraprocessed foods and depression, and placental growth factor trajectories. ja.ma/4rrJolZ

Structural #MRI with machine learning estimated individual delay discounting in college-aged participants, with white matter volumes showing stronger performance than gray matter volumes. ja.ma/3TMXbXY

In patients with #Depression and high #UltraprocessedFoods intake, a low-ultraprocessed-food diet was feasible and acceptable, and depressive and anxiety symptoms were lower during the intervention period vs a regular diet. ja.ma/4xIUhBI

Interview with Laura Fässler, MSc, author of Psychological Interventions Targeting Auditory Hallucinations in Persons With Psychotic Disorders: A Systematic Review and Meta-Analysis. Hosted by John Torous, MD. ja.ma/4romkoa

Many studies using #Neurodivergent or #Neurodiverse terminology identified participants through self-report or self-identification, and some did not specify any diagnosis. Precise diagnostic descriptors may improve clinical research and practice. ja.ma/471eTKf

📝 Viewpoint: #Cannabis commercialization is a modifiable public health exposure shaped by policies on access, potency, labeling, and marketing. Regulating these features may reduce psychiatric risk beyond legalization status alone. 10.1001/jamapsychiatry.2026.2869

📝 Viewpoint: High-dose #psychedelic #clinicaltrials remain poorly masked, which limits isolation of pharmacological effects from expectancy effects. More aggressive active comparators and reduced disclosure may strengthen causal inference. ja.ma/4gX0swJ

Among women with #BulimiaNervosa, structural #MRI identified lower nucleus accumbens volume and lower temporal cortical surface area vs healthy control individuals, supporting altered reward and social cognition circuits. ja.ma/477nBql

In a Danish cohort, parental similarity for #PsychiatricDisorders was substantial and was associated with higher prevalence and higher family-based heritability than expected under random mating. ja.ma/3TpVqjj

💬 Viewpoint: In #Psychiatry, large language models should be used as clinical instruments, with clinician accountability and source-grounded verification before output influences care. ja.ma/4xeSxQq

💡 Special Communication: In psychiatry, #PolygenicScores, rare variant testing, and #Pharmacogenomics may have value when used selectively to inform diagnosis, prognosis, monitoring, and medication safety rather than population-wide screening. ja.ma/3UD8l1I

Among adults with serious mental illness, #GLP1 receptor agonists vs #SGLT2 inhibitors were associated with lower mortality and fewer major cardiovascular events, with greater absolute benefit in serious mental illness. ja.ma/4r3cmZy

💬 Viewpoint: Family-based care for #Psychosis may need to address the digital home, where #SocialMedia and #ArtificialIntelligence shape symptom interpretation, conflict, treatment beliefs, and relapse warning signs. ja.ma/4A0j7zd

GLP-1 receptor agonist use and misuse were common among people with #EatingDisorders, with many reporting adverse events, underscoring the need for pharmacovigilance as availability increases. ja.ma/3SaIDkj

The FDA approved gepirone extended release for #Depression based on 2 positive trials despite 11 negative or inconclusive trials, highlighting the agency's use of regulatory flexibility and trial-level statistical significance. ja.ma/4g6sYM8

Systemic interleukin-6 inhibition demonstrated treatment-sensitive outcomes and clinically meaningful effect sizes in patients with difficult-to-treat #Depression and low-grade #Inflammation. ja.ma/4qkzTVg

Exposure to #ChildhoodTrauma was linked to #BipolarDisorder in part via reduced volume of the hippocampus and thinner cortex in the medial orbitofrontal and superior frontal gyrus. ja.ma/4zpGgKW

In individuals at clinical high risk for #psychosis, reduced temporal stability of EEG microstates was associated with earlier conversion and increased positive symptom severity. ja.ma/4gitPrI

In a cohort study, #PolygenicScores identified more patients at risk for #ADHD, #Depression, and #Schizophrenia than recurrent copy number variants, while both methods were complementary for risk assessment in #Autism. ja.ma/4gBALkZ

Family genetic risk scores across 18 psychiatric disorders indicated six correlated factors: psychotic, externalizing, anxiety, neurodevelopmental, mood, and eating disorders. ja.ma/4zpGgdU

Individualized, connectivity-based targeting of accelerated transcranial magnetic stimulation produced significantly greater antidepressant effects than scalp-based targeting in adults with treatment-resistant #Depression. ja.ma/4hzMkdA

Is brain circuit targeted TMS better than standard clinical TMS for treating depression? New study led by Joe Taylor @braincircuits.bsky.social out today in @jamapsychiatry.com says yes! Connectivity- vs Scalp-Based Targeting of Accelerated TMS for Depression jamanetwork.com/journals/jam...

🚨 Now out in @jamapsychiatry.com 🚨 Are people with depression less responsive to rewards on social media, just like in the lab? Actually…quite the opposite! 🧵 📄 Read the paper here: jamanetwork.com/journals/jam...

Had a lot of fun discussing our recent paper on the @jamapsychiatry.com podcast! 🎧 Listen on the podcast website here: jamanetwork.com/learning/audio-player/19077115 🟢 Spotify: open.spotify.com/episode/5iGB... 🍎 Apple podcasts: podcasts.apple.com/us/podcast/t...

Congrats to @danmirea.bsky.social who led a new paper published in @jamapsychiatry.com! "The Reinforcement Effect of Social Media Likes in Depression". jamanetwork.com/journals/jam...

Thresholds are necessary for clinical decisions, but how do we set them? This question always comes up as a challenge for the clinical utility of dimensional psychopathology models. Fortunately, there are principled solutions! Our new paper lays them out. Led by Yuliya Kotelnovika & Roman Kotov

In #StimulantUseDisorder trials, no medication significantly outperformed placebo for abstinence, but cabergoline supported greater reduced cocaine use when nonabstinence outcomes were included. ja.ma/4zpGdie

Disease development trajectories in #MentalDisorders vary by diagnosis at first contact, sex, and age, with younger patients exhibiting more diagnostic shifts and psychiatric contacts, highlighting the need for targeted preventive care. ja.ma/4zpGd1I

💬 Viewpoint: #Suicide risk models are advancing, but health systems often lack the infrastructure needed to select, implement, recalibrate, and sustain them in routine care. ja.ma/4zqL9Dz

Among young adults at varying #ManiaRisk, greater left ventrolateral prefrontal cortex activation during reward expectancy was associated with lower delay discounting, consistent with greater sensitivity to reward value. ja.ma/45wROP5

💬 Editorial: Connectivity-based targeting for transcranial magnetic stimulation demonstrated greater antidepressant effects and precision than scalp-based approaches in adults with treatment-resistant #Depression. ja.ma/4g1LvZU

💬 Editorial: Reduced temporal stability of #EEG microstates shows promise as a scalable biomarker for predicting clinical outcomes in individuals at high risk for psychosis. ja.ma/3SfpXzG