The Jackson Laboratory

jax.orgOverlooked ‘off switch’ in lung tumors may explain why immunotherapy doesn't work for everyoneA new study shows that lung tumors can disable a key immune-alarm gene without mutating its DNA and that the pattern tracks with how well patients respond to treatment.

A new study in @science.org, led by JAX’s @olgaanczukow.bsky.social, reveals how some lung tumors sabotage STAT2, a key immune-alarm gene, through RNA splicing. The different isoforms produced by this process were associated with how well lung cancer patients respond to immunotherapy.

Every specialized in your body cell began with the same remarkable potential. 🧬 The new Basics of iPSCs Learning Path from JAX Genomic Education is an approachable course that explores everything from the fundamentals of stem cells to iPSC applications. Check it out ➡️ https://bit.ly/4dS6CfE

JAX is recruiting faculty in aging, systems immunology, and computational biology to help accelerate discoveries that improve human health. https://go.jax.org/276n55 #AcademicSky

Endometriosis pain has now been biologically mapped. In a new Nature Communications study, JAX researchers looked at samples from the EndoRISE biorepository and found nerves and immune cells interact in lesions to amplify pain signaling. . https://bit.ly/4ic321p

A state-mandated biorepository of endometriosis biospecimens aims to broaden how researchers approach the chronically understudied disease. A new paper in Frontiers in Reproductive Health describes the core components of the EndoRISE model and how it can be adapted by others. https://bit.ly/3WexWi9

nbcconnecticut.comEndoRISE Patient Day aims to raise awareness surrounding endometriosis and women's healthEndoRISE Patient Day is a free, full-day event at UConn Health bringing patients, caregivers, researchers and advocates together to discuss women’s health across every stage of life. Tickets are avail...

Learn more about UConn Health's EndoRISE Patient Day this Saturday ⤵️

JAX is inviting applications for faculty positions at our Maine and Connecticut campuses to accelerate discoveries that improve human health. www.jax.org/facultyjobs #AcademicSky

Do your best ideas happen at the intersection of disciplines? JAX is recruiting faculty to join a collaborative research environment supported by advanced scientific services and data science initiatives. https://go.jax.org/276n55 #AcademicSky

Do your best ideas happen at the intersection of disciplines? JAX is recruiting faculty in aging, systems immunology, and computational biology to join a collaborative research community in Bar Harbor, Maine. https://go.jax.org/276n55 #AcademicSky

Nearly 450 experts gathered in NYC for the inaugural JAX-NYSCF Conference, marking 20 years of iPSCs and a new chapter for stem cell science. 🧬 Read the full recap and see photos from the event: https://www.jax.org/news-and-insights/2026/september/inaugural-jax-nyscf-stem-cell-conference

One wrong letter in your DNA can cause a rare disease. Gene editing lets us go in and fix it. 🧬 Here’s a quick break down CRISPR, base editing & prime editing. Learn more about how JAX scientists are using these techniques to correct rare disease mutations in the lab: https://bit.ly/3VPcUGA

JAX is recruiting faculty in aging, systems immunology, and computational biology to help accelerate discoveries that improve human health. https://go.jax.org/276n55 #AcademicSky

Day one of the 2026 JAX-NYSCF Conference is underway! 🧬 We’ve kicked things off hearing from leaders in the field, engaging panel discussions and plenty of opportunities to make connections. It’s already been a great day of ideas, collaboration and conversation — and we’re just getting started.

18 Sept

🚨⏳ Registration closing for the 2026 JAX–NYSCF Conference at The Rockefeller University in New York, September 23 - 24. Don’t miss it! Register today: https://go.jax.org/jax-nyscf-conf

@jaxeducation.bsky.social

16 Sept

Science moves faster with the right team and resources. JAX is recruiting faculty in aging, systems immunology, and computational biology to join a collaborative research environment supported by advanced scientific services and data science initiatives. https://go.jax.org/276n55 #AcademicSky

The Jackson Laboratory reposted

JAX Genomic Education

8 Sept

Explore interactive, free resources developed by #RareDisease experts at @jax.org! 👇 ⏱️ 15 MINUTES | Learn about the complexity of rare disease & the unique challenge it presents. Explore the patient journey—from diagnosis to research to drug development: education.learning.jax.org/the-complexi...

education.learning.jax.orgThe Complexity of Rare DiseaseLearn about the complexity of rare disease and the unique difficulty it presents to patients and families by exploring the patient journey—from diagnosis to research to drug development.

10 Sept

Faculty recruitment is open at JAX. We're seeking researchers working in aging, systems immunology, and computational biology to join our Bar Harbor campus and help advance discoveries in genetics, genomics, and human health. https://go.jax.org/276n55 #AcademicSky

7 Sept

🚨⏳ Registration closing for the 2026 JAX–NYSCF Conference at The Rockefeller University in New York, September 23 - 24. Don’t miss it! Register today: https://go.jax.org/jax-nyscf-conf

jax.orgCerebral palsy might be a collection of symptoms, not its own diseaseA JAX-led study of more than 5,000 people is challenging long-held assumptions about cerebral palsy genetics.

A JAX-led study published today in @cellpress.bsky.social of more than 5,000 people is challenging long-held assumptions about cerebral palsy genetics. 🧬🧪

cell.comA phenotypic paradigm for cerebral palsy geneticsCerebral palsy (CP) is frequently linked to Mendelian disease-associated genes, but no accepted model of its genetic architecture exists. We present a phenotypic model showing statistical evidence of ...

Read the full paper in @cellpress.bsky.social www.cell.com/ajhg/fulltex...

jax.orgCerebral palsy might be a collection of symptoms, not its own diseaseA JAX-led study of more than 5,000 people is challenging long-held assumptions about cerebral palsy genetics.

Learn more on our website: www.jax.org/news-and-ins...

jax.orgCerebral palsy might be a collection of symptoms, not its own diseaseA JAX-led study of more than 5,000 people is challenging long-held assumptions about cerebral palsy genetics.

A JAX-led study published today in @cellpress.bsky.social of more than 5,000 people is challenging long-held assumptions about cerebral palsy genetics. 🧬🧪

The analysis does not rule out a true association of the remaining genes with CP, the authors said. It shows that sufficient evidence does not exist to establish a statistically significant association.

Further research will focus on building larger patient cohorts, conducting prospective studies of clinical utility and cost-effectiveness, and improving the accessibility of genomic and clinical data.

jax.orgCerebral palsy might be a collection of symptoms, not its own diseaseA JAX-led study of more than 5,000 people is challenging long-held assumptions about cerebral palsy genetics.

A JAX-led study published today in @cellpress.bsky.social of more than 5,000 people is challenging long-held assumptions about cerebral palsy genetics. 🧬🧪

The team also conducted whole-genome sequencing on 460 children from 453 families who had been diagnosed with CP and treated at Shriners Children’s hospitals around the U.S.

Genetic variants classified as pathogenic or likely pathogenic were identified in 70 families, involving 60 different genes. Only 16 of those 60 genes overlapped with genes that showed statistically significant evidence of association in the authors’ analysis of previously published studies.

jax.orgCerebral palsy might be a collection of symptoms, not its own diseaseA JAX-led study of more than 5,000 people is challenging long-held assumptions about cerebral palsy genetics.

A JAX-led study published today in @cellpress.bsky.social of more than 5,000 people is challenging long-held assumptions about cerebral palsy genetics. 🧬🧪

This study challenges some of those assumptions. The team examined genetic evidence from 21 studies involving 5,440 people diagnosed w/CP. Those studies reported potentially causal variants in a total of 515 genes. The new analysis found a statistically significant association with CP for only 89.

jax.orgCerebral palsy might be a collection of symptoms, not its own diseaseA JAX-led study of more than 5,000 people is challenging long-held assumptions about cerebral palsy genetics.

A JAX-led study published today in @cellpress.bsky.social of more than 5,000 people is challenging long-held assumptions about cerebral palsy genetics. 🧬🧪

Cerebral palsy (CP) is the most common motor disability in children, with up to 10,000 babies diagnosed in the United States every year. Unlike many other neuromotor diseases found in children, CP is nonprogressive, meaning that it does not worsen over time.

With rehab and PT, many patients can see improvements in their symptoms. While it has largely been linked to prematurity, temporary loss of oxygen to the brain, or other events at birth, research over the past decade has suggested that genetic factors contribute to CP in many children.

jax.orgCerebral palsy might be a collection of symptoms, not its own diseaseA JAX-led study of more than 5,000 people is challenging long-held assumptions about cerebral palsy genetics.

A JAX-led study published today in @cellpress.bsky.social of more than 5,000 people is challenging long-held assumptions about cerebral palsy genetics. 🧬🧪

Only a fraction of the hundreds of genes previously associated with cerebral palsy are strongly linked to this condition, according to a new study of data from more than 5,000 people led by researchers from The Jackson Laboratory (JAX).

The findings suggest cerebral palsy may be better described as a collection of symptoms that can occur in many different conditions because of genetic variants and environmental factors—not a single disease with genetic causes. The study appears today in the American Journal of Human Genetics.

jax.orgJAX and Connecticut State Community College educators advance genomics workforce training with online modulesGenomics in Action learning path brings applied science, career exploration, and workforce-ready skills to community college students.

JAX @jaxeducation.bsky.social & the Connecticut State Colleges and Universities (CSCU) system have completed development of Genomics in Action—a federally-funded series of 13 online modules designed to prepare undergraduate students for careers in bioscience, biotechnology and precision medicine. 🧬

Read the full story: www.jax.org/news-and-ins...

By connecting genomics concepts to workplace applications and career pathways, the initiative expands access to genomics education and helps strengthen the future bioscience workforce nationwide.

Genomics is shaping healthcare, biotechnology, and biomedical research, making a foundational understanding of the field increasingly valuable across a range of educational and career pathways. Yet many students encounter genomics as an abstract topic that lacks connection to their future careers.

@jaxeducation.bsky.social

2 Sept

🚨⏳ Registration closing for the 2026 JAX–NYSCF Conference at The Rockefeller University in New York, September 23 - 24. Don’t miss it! Register today: https://go.jax.org/jax-nyscf-conf

The Jackson Laboratory reposted

JAX Genomic Education

2 Sept

🧬 The next generation of genomic thinkers starts with curious students and the educators who inspire them. 📽️ See how @jax.org’s Teaching the Genome Generation (TtGG) program helps bring genomics to life in the classroom: www.youtube.com/watch?v=jovy... #STEMEducation #iTeachBio #SciEd

youtube.comHow One Teacher Can Inspire Thousands of Genomic ThinkersYouTube video by The Jackson Laboratory

jax.orgSkin is our most accessible organ. Could it reveal new clues about aging and frailty?How JAX scientists are investigating whether our skin microbiome could serve as a window into the biology of aging and frailty.

When it comes to aging skin, scientists think deeper than wrinkles. It's an organ with multitudes of microbes, immune cells, structural proteins, and chemical signals that constantly interact with one another. The skin microbiome could also serve as a window into the biology of aging and frailty. 🧪

jax.orgPainless skin patch offers new way to monitor immune healthMicroneedle patch samples key immune cells often missed in routine blood draws and biopsies

Such technologies could help scientists identify whether biological signs of frailty emerge before clinical decline becomes visible. Learn more on that project: www.jax.org/news-and-ins...

Get the full story on our website: www.jax.org/news-and-ins...

While many of the body's changes associated with aging occur in organs that are difficult to sample repeatedly, skin offers a unique advantage, Jalili said.

In theory, the skin’s microbes, inflammatory signals, immune cells, and other age-related changes could be monitored over time with minimally invasive technologies and little burden on patients.

In an article recently published in @science.org with Julia Oh, formerly of JAX and now a microbiologist and professor at Duke University, Jalili argues that skin is an accessible ecosystem that scientists may be able to sample repeatedly and relatively easily for clues into the biology of aging.

Jalili is investigating whether our skin microbiome could serve as a window into the biology of aging and frailty.

jax.orgThe Jackson Laboratory receives $4.6 million ASAP grant to build comprehensive stem cell toolkit for emerging Parkinson’s disease targetsSupported by an ASAP Collaborative Research Network grant, JAX-NYSCF researchers will create, validate, and share human stem cell models and data for emerging Parkinson’s disease targets.

JAX and JAX-NYSCF have landed a $4.6M grant from the @asapresearch.parkinsonsroadmap.org administered through the Michael J Fox Foundation for Parkinson's Research.

By creating and sharing these models, along with supporting datasets and protocols, the team will offer research laboratories worldwide new tools to investigate disease mechanisms, compare results, and identify potential paths toward new therapies.

Learn more: www.jax.org/news-and-ins...

JAX and JAX-NYSCF have landed a $4.6M grant from the @asapresearch.parkinsonsroadmap.org administered through the Michael J Fox Foundation for Parkinson's Research.

JAX-NYSCF researchers develop standardized research tools that will help researchers better understand how genetic factors associated with the disease affect the health and function of brain cells.