Jon Mosser

Jon Mosser

@jonmosser.com

Pediatric infectious disease doc | global health researcher | modelling disease burden and intervention coverage from local to global scales | #vaccines, #VPDs, #NTDs, #malaria, #anemia, #hemoglobinopathies, #geospatial analysis | he/him | opinions my own

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New GBD 2023 estimates of the burden of #Chagas disease, a #NTD caused by T. cruzi and transmitted by triatomine bugs, blood, or congenitally. The chronic phase, often decades after infection, causes severe heart failure, arrhythmias, and megaviscera. #GBD2023 #ChagasDisease #NTDs #IDSky

thelancet.comGlobal, regional, and national burden of Chagas disease, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023The GBD 2023 Chagas disease estimates are notably higher than previous GBD estimates, reflecting additional data and methodological improvements, and those published by the Pan American Health Organiz...

Found a #vaccine mural downtown in #YorkPA while home for the holidays. I believe that these murals are based on drawings by Lewis Miller, Pennsylvania Dutch folk artist from the early 19th century.

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This one might be my favorite. I feel like they might be missing one key reason why the smallpox vaccine isn't given anymore... No more smallpox! (Thanks to #vaccines!)

Found a #vaccine mural downtown in #YorkPA while home for the holidays. I believe that these murals are based on drawings by Lewis Miller, Pennsylvania Dutch folk artist from the early 19th century.

And then, ironically, there was a "natural foods" store distributing these pamphlets inside the market just across the street. Did you know that polio is caused by DDT? And here I was thinking it was caused by a virus this whole time!

Jon Mosser reposted

The Pediatric Infectious Diseases Society has issued the following statement on our deep concerns regarding the Advisory Committee on Immunization Practices December meeting and its impact on public health in the United States. pids.org/2025/12/05/p...

Jon Mosser reposted

The ACIP decision to discontinue the recommendation for a universal hepatitis B birth dose vaccine will cause harm. As the federal government continues to fail children's health, families can rely on our nation's physicians to continue to put children's health first.

Jon Mosser reposted

Friends, Yesterday and today, I watched many hours of the CDC’s meeting of the Advisory Committee on Immunization Practices (ACIP). It was painful. But we learned a lot. That bad news is that our kids are going to pay the price for RFK jr’s views. insidemedicine.substack.com/p/analysis-o...

insidemedicine.substack.comAnalysis of the latest ACIP meeting at the CDC: Vaccines—and rigorous science—are increasingly under attack.A close look at how the CDC’s vaccine advisory committee under RFK Jr. again changed high-stakes recommendations without solid evidence.
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Multiple members including Hibblen, Pagano, Meissner abstain, noting that they don't actually know what they're voting on or what the ramifications would be of a vote either way.

Blackburn clarifies that she is voting "yes for VFC to have coverage for what it needs to have coverage for", though it's unclear what that means nor whether that's what is actually being voted on. Final vote is 7 yes, 4 abstain.

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Malone in midst of the vote, after several people have already voted: "what is at hand is the vote to adopt the ACIP recommendations into the Vaccines for Children program". Has to be corrected: "It is actually to approve the VFC resolution that was presented yesterday".

Meanwhile a totally different slide is shown indicating that the "purpose of the resolution is to update the Recommended Vaccination Schedule and Intervals section to reflect the updated ACIP recommendations about the use of Hepatitis B vaccine".

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Malone calls for a bathroom break and has to be reminded that there's a third vote. There's now a third vote but several members, including Malone, do not appear to have any idea what the language is that they're voting on or what it would entail. Absolute scenes.

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#ACIP votes 6-4 to recommend that children could just get one dose of vaccine and then have post-vaccination serologic testing to see if more vaccines should be given. Multiple members remind the committee that there have been no studies or evidence to understand if this strategy would work.

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Joseph Hibbeln: "This has a great potential to cause harm, and I simply hope that this committee will accept its responsiblity when this harm is caused -- and I vote no." Roger Malone: "Roger that."

Now, after a bewildering discussion where members of the ACIP committee appear to not understand the difference between live viral vaccines like yellow fever and inactivated vaccines like hepatitis B, the committee votes on a recommendation to deviate from the established 3-dose primary series.

Dr. Cody Meissner, #pediatric #id doctor (the only one on #ACIP), reflecting on the committee's mandate to first do no harm: "We are doing harm by changing this wording, and I vote no."

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Timeliness is currently underexamined due to inconsistent definitions, poor data quality (like missing birth dates), and a lack of fine-scale estimates to track how timeliness varies within countries.

This article calls on global stakeholders to standardize definitions of timeliness and integrate timeliness into routine monitoring, so that all children can optimally benefit from the protection of vaccines.

Current #immunization programs primarily track vaccination coverage (the percentage of children vaccinated), but this metric hides critical gaps like doses given too early or too late. Vaccination #timeliness -- receiving doses within the optimal, age-appropriate window -- is not as well tracked.

Timeliness is important everywhere, but may be particularly important in places with relatively high coverage, to make sure that children are protected by vaccines before they are exposed to vaccine-preventable diseases.

Seattle has one of the biggest Somali populations in the country. I've had the privilege to work with loving, hardworking Somali families and patients + caring, brilliant Somali doctors during my time here. They belong here in our communities. Bigotry and xenophobia do not.

New GBD 2023 estimates of the burden of #Chagas disease, a #NTD caused by T. cruzi and transmitted by triatomine bugs, blood, or congenitally. The chronic phase, often decades after infection, causes severe heart failure, arrhythmias, and megaviscera. #GBD2023 #ChagasDisease #NTDs #IDSky

thelancet.comGlobal, regional, and national burden of Chagas disease, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023The GBD 2023 Chagas disease estimates are notably higher than previous GBD estimates, reflecting additional data and methodological improvements, and those published by the Pan American Health Organiz...
View full thread

New GBD 2023 estimates of the burden of #Chagas disease, a #NTD caused by T. cruzi and transmitted by triatomine bugs, blood, or congenitally. The chronic phase, often decades after infection, causes severe heart failure, arrhythmias, and megaviscera. #GBD2023 #ChagasDisease #NTDs #IDSky

thelancet.comGlobal, regional, and national burden of Chagas disease, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023The GBD 2023 Chagas disease estimates are notably higher than previous GBD estimates, reflecting additional data and methodological improvements, and those published by the Pan American Health Organiz...
View full thread

To get better estimates, we need improved data quality, including adequate coding to prevent misclassification of Chagas deaths and better estimates of the true population at risk. Sustained funding for screening, treatment, and improved data collection is crucial to mitigate #Chagas disease burden.

Thank you to our multinational team of GBD 2023 Chagas Disease Collaborators, the RAISE Study, and our NTDs team at IHME for collaborating to produce this critical, updated analysis!

New GBD 2023 estimates of the burden of #Chagas disease, a #NTD caused by T. cruzi and transmitted by triatomine bugs, blood, or congenitally. The chronic phase, often decades after infection, causes severe heart failure, arrhythmias, and megaviscera. #GBD2023 #ChagasDisease #NTDs #IDSky

thelancet.comGlobal, regional, and national burden of Chagas disease, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023The GBD 2023 Chagas disease estimates are notably higher than previous GBD estimates, reflecting additional data and methodological improvements, and those published by the Pan American Health Organiz...
View full thread

Cases in non-endemic locations increased 46.2%, primarily due to prevalence amongst people who have migrated from endemic countries. Improved awareness about #Chagas disease and systems to improve access to diagnosis & treatment for these individuals in non-endemic locations are needed.

Prevalence also shifted to older age groups, peaking at 45–65 years in 2023. This reflects decreasing incidence in endemic locations. Health systems must prepare for chronic care needs as the burden of disease shifts to older populations.

New GBD 2023 estimates of the burden of #Chagas disease, a #NTD caused by T. cruzi and transmitted by triatomine bugs, blood, or congenitally. The chronic phase, often decades after infection, causes severe heart failure, arrhythmias, and megaviscera. #GBD2023 #ChagasDisease #NTDs #IDSky

thelancet.comGlobal, regional, and national burden of Chagas disease, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023The GBD 2023 Chagas disease estimates are notably higher than previous GBD estimates, reflecting additional data and methodological improvements, and those published by the Pan American Health Organiz...

We estimated 10.5 million global prevalent cases in 2023. There has been major progress: age-standardised mortality dropped by 72.5% from 1990–2023. This success reflects strong vector control and socioeconomic development in endemic regions. #GlobalHealth #NTDs

I had the chance to speak with @npr.org before this announcement, on this critical moment for #vaccination. "The world is going to have to pick a trajectory," [Mosser] says. "Are we going to turn our backs on one of the most remarkable public health achievements that the world has ever seen?"

npr.orgThe good news (154 million deaths avoided) and bad news about childhood vaccinesA new study points out success stories — and potential obstacles — to bringing vaccines to the world's children.

"Whatever progress we’ve made could be reversed if we don’t maintain and build on our successful #immunization efforts to date.” - Prof. Art Reingold, @berkeleypublichlth.bsky.social. Read more @statnews.com

STAT@statnews.com

Vaccine hesitancy and misinformation is eroding public confidence in immunization, a new study found www.statnews.com/2025/06/24/v...

Bill Moss of @ivac-hopkins.bsky.social on the challenges to come: "...the study’s analysis took place prior to the shifts in U.S. federal funding... “The situation is even more challenging, I think, in the coming years than is even outlined in this analysis,” Moss told STAT."

"Falling global #vaccine coverage, an increase in the numbers of children receiving no vaccines, and delays in vaccination mean that more children will be hospitalised, permanently damaged and die from fully preventable diseases if the trend is not reversed." - Prof. Andrew Pollard

Science Media Centre UK@smclondon.bsky.social

expert reaction to study looking at global childhood vaccination coverage www.sciencemediacentre.org/expert-react...

Jon Mosser reposted

Replying to @jonmosser.com

The evidence couldn't be more clear: * #Vaccines are safe. * #Vaccines are effective. * #Vaccines save lives. This is the moment for a renewed global commitment to immunization at all levels.