The Journal of Physiology

Recent #research by Jackson T. Levine and colleagues investigates disrupted bilateral co-ordination of soleus motor units during early subacute #stroke #rehabilitation 🧠 ⚙️ Read their findings👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

'Can diet determine glucocorticoid efficacy? Metabolic control of mitochondrial homeostasis in dystrophic muscle' Anusha Liaqat and Salman Ahmad examine the recent work of Vorwald et al. (2026) in this #JournalClub article🎓️ 📜 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

In this study, Angelina Rogliardo from @umontpellier.bsky.social and collaborators observed that deletion of the sodium leak channel #NALCN in #dopamine neurons alters D2R-mediated signalling and psychostimulant responsiveness 🧠 Read the #research👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Tim Hibberd from @flindersuniversity.bsky.social and co-authors present this #Opinion article discussing the recent work of Barboi and Macefield in renaming the autonomic nervous system 💭 💡 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Dr. Aaron Grossberg's research on #PancreaticCancer cachexia and its relationship with cardiac dysfunction was published in @jphysiol.bsky.social and received Editor's Choice honors for August! Learn more: https://bit.ly/4dSs3ND

'Beyond CO2 reactivity: The integrated role of systemic circulation in exercise-induced cerebral blood flow responses' Shigehiko Ogoh highlights the recent work of Simpson et al. (2026) in this #Perspective article ✍️ 💭 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Emmet A. Francis from @ucsandiego.bsky.social and colleagues observed that interplay between store-operated #calcium entry and #mitochondrial phosphate handling modulates force and #fatigue during exercise 🔬 🚴 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Read this recent #JournalClub by KarLee Lefebvre from @facmed-umontreal.bsky.social and co-authors, examining the work of Topham et al. (2026) ✍️ 🎓️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

In this study, Lili Salinas from @ucdavis.bsky.social and collaborators examine #mitochondrial dynamics and repair differences in two mouse models of Friedreich's #ataxia 🔬 🫀 Read the findings👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

A. K. Guzmán-Aguayo from @ucm.es and colleagues observed that early #kidney injury occurs in the absence of detectable perirenal adipose tissue remodelling in the Munich Wistar Frömter rat model of chronic kidney disease💉 🔬 Read the #research👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Lydia L. Simpson from @uniinnsbruck.bsky.social et al. investigated the mechanisms regulating #cerebral perfusion during running #exercise and the influence of foot strike-induced pulsatility oscillations, CO2 reactivity and BP ⚙️ 🏃‍➡️ Read the study: 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Joelina Lienau presents this #JournalClub titled 'Uncovering strategies to rescue muscle mass in ageing' which examines the work of Carvalho et al. (2026) ✍️ 👇️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

William Bechtel from @ucsandiego.bsky.social and Leonardo Bich from @ehu.eus present this #TopicalReview: 'The last-step integrator thesis: Heterarchical control of the mammalian gastrointestinal tract' 📜 💡 Read it here👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Using a maximal elastance analysis, #research by Cheng-Yuan Lai and co-investigators finds that #myostatin-dependent detrusor remodelling mediates contractility impairment in #diabetic rats’ bladder 🔬 🔎 Read the article: physoc.onlinelibrary.wiley.com/doi/10.1113/...

K. K. Lange and collaborators examined the effects of #exercise followed by a low-carbohydrate diet on peak fat oxidation and #mitochondrial coupling control and efficiency in healthy trained men 🔎 🚴 Read the findings👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

'The ageing #kidney remembers its nutritional beginnings'💭 Kieran M. Short and John F. Bertram from @monashuniversity.bsky.social offer this #Perspective on the recent study by Pires et al., (2026) ✍️ Read it here👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

'Metabolism meets modulation: Lactate's redox-driven control of NMDARs' Cullan Voelkner of @brocku.ca and co-authors examine the recent study by Fiumelli et al. (2026) in this #JournalClub article🎓️ ✍️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

🎓️ EDITOR'S CHOICE🎓️ Pereira Pires and colleagues show that early malnutrition of the fetus shifts the #renal proteome towards mitochondrial/redox metabolism and is accompanied by histopathological lesions in the kidney🔬 Read the article💡 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Latest issue now live🎉 The cover image comes from the work of Emmet A. Francis and colleagues and depicts model predictions of peak contractile force during the final repetition of a resistance training set 📸 Read all articles here📖 physoc.onlinelibrary.wiley.com/toc/14697793...

In this study, Sophia T. Jenz and collaborators observed that #motor unit discharge properties are modestly influenced by #menstrual cycle–related fluctuations in sex #hormone concentrations 📆 🔎 Read it here👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

#Research by Tamzin Zawadzki and colleagues finds that slow #calcium removal contributes to impaired #lusitropic response to β-adrenergic stimulation in HFpEF mice 🫀 🔬 Read the article here👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Celebrating 100 years of the Chinese Association for Physiological Sciences (CAPS) 🎓️ 🎉 Yun Wang from @pku1898.bsky.social and colleagues discuss the pivotal role of CAPS in building physiology in China in this editorial 📜 Read it here👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Lia Gander from @usi.ch and colleagues present an eikonal #model with re-excitability for fast simulations in cardiac #electrophysiology ⚡️ 🫀 Read the research 👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Marie Haghebaert and collaborators present a comparative study of lumped heart models for #personalized medicine through sensitivity and identifiability analysis 🫀 💉 Read the article📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...

'Advancing #aortic stenosis assessment: Validation of fluid–structure interaction models against #4D flow MRI data' 🔬 💻️ Read the latest #research by Alberto Zingaro and colleagues 📜 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Sofia Botti from @usi.ch and colleagues performed in silico #modelling of multi-electrode arrays for enhancing cardiac drug testing on #hiPSC-CM heterogeneous tissues 🔬 🔎 Read the article👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Abdullah A. Al-Shammari and collaborators examined the utility of local #capillary supply indices and offer insights from #computational image-based modelling 🔎 📸 Read the article📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...

#Research by Francesca Duca and collaborators performs #computational analysis to assess #hemodynamic forces in descending thoracic aortic aneurysms🫀 🔎 Read their findings👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Efraín Magaña and colleagues conduced ensemble #learning of the atrial fibre orientation with physics-informed #neural networks ⚙️ 🫀 Read the #research👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

In this study on #pharmacological autonomic stimulation, Diego Candia-Rivera and colleagues from @institutducerveau.bsky.social modelled the time-resolved modulations of #cardiac activity in rats 🫀 💻️ Read the article👇️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Paolo Melidoro from @kings-bmeis.bsky.social and collaborators offer insights into enhancing #stroke risk stratification in atrial fibrillation through non-Newtonian blood #modelling and Gaussian process emulation 💻️ 🫀 Read the #research👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

'Elucidating the #cellular determinants of the end-systolic pressure-volume relationship of the heart via #computational modelling' 🔬 🫀 Read the latest research from Francesco Regazzoni and colleagues, featuring on the cover of this special issue 💡 physoc.onlinelibrary.wiley.com/doi/10.1113/...

See the work of all previous Nobel Prize winners that have published in The Journal of Physiology here!📖🎉 physoc.onlinelibrary.wiley.com/hub/journal/...

Congratulations to the laureates!🎉 Among the three award recipients, Karl Deisseroth and Georg Nagel have previously published their research in @jphysiol.bsky.social 📖 📜by Karl Deisseroth physoc.onlinelibrary.wiley.com/doi/10.1113/... 📜by Georg Nagel physoc.onlinelibrary.wiley.com/doi/10.1113/...

Following evaluation in a 60-day head-down bed rest study on #arterial function, Alessandro Giudici from @carimmaastricht.bsky.social and collaborators provide a constitutive #modelling framework for applications to in vivo longitudinal data 💡 🔬 physoc.onlinelibrary.wiley.com/doi/10.1113/...

🎓️ EDITOR'S CHOICE🎓️ In this study, Karoline Horgmo Jæger from @simularesearch.bsky.social and colleagues determined properties of human-induced pluripotent stem cell-derived #cardiomyocytes using spatially resolved #electromechanical metrics 🫀 ⚙️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

In this #LetterToTheEditor, Fernando Wesley Cavalcanti de Araújo and Roberto Refinetti discuss the recent work of Chang et al. (2026) into the differential effects of sex and age on daily and infradian rhythms of mice✉️ ✍️ 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Call for Papers📣 "#Neurovascular Networks as Master Regulators of Brain and Systemic Health" 🧠 We welcome research on neurovascular regulation, brain-body communication, inflammation, redox signalling, and cross-organ microvascular integration. physoc.onlinelibrary.wiley.com/hub/journal/...

'A step beyond the cage: How #infradian and #circadian research in mice translates to humans' Evan C. Ciecko from @udelaware.bsky.social and co-authors examine the recent work of Chang et al. (2026) ✍️ 💭 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

In this opening Editorial, Natalia Trayanova @jhu.edu and Christian Vergara introduce the articles included in the latest special issue, 'Computational modelling of the cardiovascular system: From cell to circulation' 📜 🎓️ Read it here👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

'Computational modelling of the cardiovascular system: From cell to circulation', was organised and edited by Professors Natalia Trayanova @jhu.edu and Christian Vergara (Politecnico di Milano, Italy) 🎓️ Cover image by Regazzoni et al.📸 physoc.onlinelibrary.wiley.com/toc/14697793...

#Research by Lauren Glassburn and colleagues observed that hippocampal long-range #GABAergic neurons target hippocampal-projecting cells of the #supramammillary area 🧠 🔬 Read their findings💡 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Ryan J. Sprenger from @uwmadscience.bsky.social and co-investigators observed that amyloid beta plaque pathology induces #chemosensory deficits and increases #apnoeas in the 5XFAD mouse model of Alzheimer's disease 🧠 🔎 Read the study👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Enrique Velasco and collaborators found no evidence for homotopic #hyperalgesia to C fibre stimulation after transcutaneous high-frequency stimulation in humans 🧠 ⚙️ Read the #Research👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

How do alcohol, opioids, nicotine, cannabis & psychostimulants reshape brain circuits? 🧠 ⚙️ Submit your latest research to this special issue which focuses on drug-induced changes in neural and glial physiology and their links to behaviour 💊 🔬 🔗 physoc.onlinelibrary.wiley.com/hub/journal/...

In this recent review, Volker Dietz and Linard Filli from @uzh-ch.bsky.social discuss the impact of the #brainstem in normal and impaired human movement control ⚙️ 🧠 Read the article👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Senior Editor Professor Paul Greenhaff discusses his career, his hopes for the future of physiology and his work with @physoc.bsky.social's Policy Team in this blog post, part of the #150voices of physiology series! 🎓️ 📣 Read it here👇️ www.physoc.org/blog/profess...

🚨 LAST CHANCE TO APPLY 🚨 Applications for our Future Leaders Scheme close on 30 November. Gain valuable experience engaging with scholarly research, learn from established experts, and contribute to the scientific community. 🔗 buff.ly/2o4qDNq

#Research by Parisa Iloun and collaborators examines sublayer- and pathway-specific control of #CA1 input processing by VIP #interneurons 🔬 🧠 Read the article👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

'Integrating vascular microstructure into coronary physiology: Beyond autoregulation' Clarissa Campo Dall'Orto examines the recent work of Eden et al. (2026) in this #JournalClub article 💭 ✍️ Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...