Keating Lab (@keatinglab.bsky.social)

Keating Lab

@keatinglab.bsky.social

MIT biology lab using computational and experimental methods to study protein structure, function, and interactions

120 followers 315 following2 posts

@keatinglab.bsky.social

Here’s a preprint from the Keating Lab: www.biorxiv.org/content/10.6.... Foster Birnbaum and Amy E. Keating demonstrate that sequence design models, such as ProteinMPNN, are limited because they were trained only on native sequences.

biorxiv.orgbiorxiv.org

Keating Lab

@keatinglab.bsky.social

18 Jan

Birnbaum and Keating present PottsMPNN, a sequence design model that learns a sequence-energy landscape from multiple sequence alignments. PottsMPNN outperforms other sequence design models and is a drop-in alternative to ProteinMPNN. Here’s the code: github.com/KeatingLab/P....

github.comGitHub - KeatingLab/PottsMPNN: Code for running PottsMPNN to generate sequences and predict energiesCode for running PottsMPNN to generate sequences and predict energies - KeatingLab/PottsMPNN

You are up to date.