Karolinska Institutet

The first large population-based study of its kind, published in @jamaneurology.com, links rituximab treatment for #MultipleSclerosis to a higher risk of inflammatory bowel disease, mainly Crohn’s disease. The absolute risk remains low. #IBD 🧪 nyheter.ki.se/vanlig-ms-be...

A study in @natgenet.nature.com led by @stefano-romeo.bsky.social identifies 60 genetic regions linked to liver fat, including 31 not previously reported. The findings shed new light on the genetics of #FattyLiverDisease. #Genetics 🧪 news.ki.se/major-study-...

KI researchers have mapped how atypical #BCells develop and change function over time. In @embojournal.org, they show that these cells arise from different precursors but converge on a shared late differentiation stage, helping clarify their roles in #Immunity 🧪 news.ki.se/immune-cells...

In a randomized trial of 900 patients with early-stage #CervicalCancer, robot-assisted radical hysterectomy reduced intraoperative complications compared with open surgery, but did not improve postoperative outcomes or recovery. Published in @jamasurgery.com. #Surgery 🧪 news.ki.se/similar-reco...

Growing up in a low-income family was associated with a 31 percent higher odds of moderate to severe coronary atherosclerosis ~ 50 years later, even after adjusting for adult risk factors. Published in @ahajournals.bsky.social 🧪 #CardiovascularHealth #HealthEquity news.ki.se/low-family-i...

Common chemicals called #phthalates, which are used in plastics, cosmetics and personal care products, may affect several different cell types in the human ovary, including cells from the ovary’s nervous system. New study published in @ebiomedicine.bsky.social 🧪 #fertility news.ki.se/phthalates-a...

The protein p11 interacts with numerous receptors targeted by commonly used medicines, opening new possibilities for treating conditions like pain, inflammation and depression. Study from KI, @scilifelab.se & @rockefeller.edu published in Science Advances 🧪 #Pharmacology news.ki.se/protein-foun...

A new study in @lancetgastrohep.bsky.social found that #aspirin did not reduce recurrence or death after curative-intent treatment of colorectal liver metastases. Notably, previous studies suggested benefits in other #ColorectalCancer settings. #CancerResearch 🧪 news.ki.se/aspirin-did-...

A nationwide study shows that #genetic testing can identify germline predisposition underlying childhood #leukemia. The findings, published in @natcomms.nature.com, could help enable more personalized treatment and long-term follow-up 🧪 news.ki.se/nationwide-s...

Researchers have developed a molecule that boosts cells’ ability to repair oxidative #DNADamage. In human liver cells and mice, it reduced liver injury caused by paracetamol toxicity and improved survival. Published in Advanced Science. #LiverResearch 🧪 news.ki.se/new-molecule...

A study in BMC Medicine found that older adults with healthier diets had blood biomarker profiles linked to more favourable ageing-related processes, including metabolism and inflammation. Insights into how diet may support healthy ageing. #Nutrition #Aging 🧪 news.ki.se/dietary-patt...

#GestationalDiabetes is becoming increasingly common in Sweden, especially among women with lower education, lower income, and those born outside Sweden, a new study shows. It also found differences in pregnancy outcomes between groups 🧪 #HealthEquity news.ki.se/new-study-re...

People with #addiction are at a significantly higher risk of both attempted #suicide and death by suicide, according to a new study. The study also shows that the risk of suicidal behaviour is elevated among relatives of people with substance use disorder 🧪 news.ki.se/addiction-is...

#Probiotic supplementation in very #PretermBabies was linked to a lower risk of both severe intestinal disease and death. This is shown by a new study published in @jamanetworkopen.com. The findings are based on data from nearly 4,700 babies born prematurely in Sweden 🧪 news.ki.se/probiotics-l...

A new review published in NEJM provides an updated overview of oesophageal cancer, highlighting recent advances in understanding its causes, prevention, and treatment 🧪 news.ki.se/recent-advan...

A new treatment for #MultipleSclerosis uses patients’ own red blood cells to help retrain the immune system. In a study published in @pnas.org, the approach showed good safety and tolerability, supporting further clinical development. #Immunology 🧪 news.ki.se/new-treatmen...

Older adults with #multimorbidity may respond differently to interventions aimed at preventing disability, depending on their disease combinations. Looking at patterns of multimorbidity could help make prevention more personalised. Study published in @nataging.nature.com 🧪 news.ki.se/disease-patt...

A new study in @lancetrh-europe.bsky.social suggests that classifying #breastcancer as either estrogen receptor(ER)-positive or ER-negative may overlook important biological differences between patients. Instead, exact ER levels may be important when choosing a treatment 🧪 news.ki.se/standard-bre...

An internet-based treatment supported by a therapist reduced depressive symptoms in adolescents with major depressive disorder at lower cost than usual care, a new study in BMJ Mental Health shows. The findings may help improve access to evidence-based care 🧪 #Depression news.ki.se/internet-bas...

Immunotherapy targeting tumour-associated macrophages depends on a functional molecular response system in these immune cells, reports a new study in @natcomms.nature.com 🧪 #CancerResearch #Immunotherapy news.ki.se/new-knowledg...

In future, a single blood test could provide a more comprehensive picture of #cancer than current methods. In a review article published in Genome Medicine, researchers describe how different biological signals can be analysed simultaneously from the same blood sample to detect and monitor cancer. 🧪