Wilhelm Lab

Wilhelm Lab

@labwilhelm.bsky.social

Research group studying metabolic and dietary control of mucosal immunology - led by Dr. Christoph Wilhelm at the University of Bonn

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Wilhelm Lab
@labwilhelm.bsky.social

How does obesity disrupt ILC2 function and adipose tissue hoemostasis? In our latest study, we identify acetyl-CoA carboxylase 1 (ACC1) as a critical metabolic regulator of adipose ILC2 maintenance and function.

cell.comAdipose ILC2s depend on acetyl-CoA carboxylase 1 to maintain metabolic healthKaragiannis and Theodorou et al. show that excess lipids in obesity impair adipose ILC2s via acetyl-CoA carboxylase 1 (ACC1). Deletion of ACC1 disrupts the citrate shuttle and the NAD+/NADH balance, i...
Wilhelm Lab
@labwilhelm.bsky.social

Thanks so much for invitation Steffi!

Scheu Lab@scheu-immuno-lab.bsky.social

Special thanks to our keynote speakers Claudia Kemper from the NIH and Christoph Wilhelm @labwilhelm.bsky.social from Bonn University - inspiring talks 👏🏼👏🏼 about the cell autonomous function of the complement system and about how nutrition impacts our barrier immunity& immune metabolism!!

Wilhelm Lab
@labwilhelm.bsky.social

Lipid metabolism and redox balance are linked in type 2 immunity! We found that allergen-induced #ILC2s and #Th2 cells require cysteine-driven glutathione synthesis to prevent #ferroptosis and support #lipid metabolism and expansion of type 2 immune cells in #asthma.

Wilhelm Lab
@labwilhelm.bsky.social

Our new paper out in Immunity @cp-immunity.bsky.social Congratulations to first author Chantal Wientjens! www.cell.com/immunity/ful...

cell.comTolerance to ferroptosis facilitates lipid metabolism and pathogenic type 2 immunity in allergic airway inflammationImmune cells must modulate their metabolism to adapt to tissue constraints. Wientjens et al. show that allergen-induced ILC2s and Th2 cells require cysteine-driven glutathione synthesis to prevent fer...

Wilhelm Lab reposted

Cluster of Excellence ImmunoSensation
@immunosens.bsky.social

Hurray! ImmunoSensation will go on! 🥳 The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded! Let us #celebrate 7 more years of #immunology in #Bonn 🎉 www.immunosensation.de/news/immunos...

immunosensation.deExcellence Strategy Funds Bonn Cluster for Immune ResearchThe Bonn Cluster of Excellence ImmunoSensation will be funded for a further seven years as part of the Excellence Strategy of the German federal and state…

Wilhelm Lab reposted

sfb1454.bsky.social
@sfb1454.bsky.social

Kicking off the 2nd funding period of our SFB1454 on #metaflammation ! Lots of great discussions and visiting our #healthybition at the #museumkoenig in Bonn! Go and visit the exhibition until end of October 2025!

Wilhelm Lab reposted

Cluster of Excellence ImmunoSensation
@immunosens.bsky.social

🚨 Open #position! The group of Christoph Wilhelm at the University Hospital Bonn is looking for a Postdoctoral fellow (m/f/d) – metabolic and nutritional regulation of immunity Application deadline is February 10! Visit our website for more information. #job #postdoc #science #immunology

Wilhelm Lab
@labwilhelm.bsky.social

We are hiring! 📣Interested in how host metabolism, diets, #fasting and #ketogenesis affect the immune response? 👇We are offering a #postdoc position to work on the interplay of host metabolism and immunity. Apply by email or DM directly.

Wilhelm Lab reposted

sfb1454.bsky.social
@sfb1454.bsky.social

What defines the #WesternLifestyle and how does it impact our health and the planet? 🌍 “What the Health – Eine Welt. Deine Gesundheit!” explores these connections! Visit our #healthybition and the accompanying program 📍 @museumkoenig until 26.10.2025 #unibonn #metaflammation #unistiftung

Wilhelm Lab reposted

Jan Siemens
@jansiemens.bsky.social

My inaugural post on Bluesky - quite fittingly, I'm thrilled to share our first study on heat acclimation, which identifies a neuronal mechanism that drives heat tolerance in mice. (www.nature.com/articles/s41... ) Here is the gist 🧵 (1/n):

nature.comThermally induced neuronal plasticity in the hypothalamus mediates heat tolerance - Nature NeuroscienceAmbroziak, Nencini, Pohle and colleagues identify a slowly emerging plasticity mechanism in a discrete set of hypothalamic preoptic neurons that is triggered by long-term heat exposure and that drives...
Wilhelm Lab
@labwilhelm.bsky.social

Really glad we pulled this of together! @wachtenlab.bsky.social, Andreas Schlitzer and all PIs from #Metaflammation

sfb1454.bsky.social@sfb1454.bsky.social

After the celebrations of making it into the second funding period, we are now ready for a fresh start in this community - stay tuned for more information about #metaflammation #obesity from our @sfb1454.bsky.social funded by the @dfgpublic.bsky.social www.sfb1454-metaflammation.de

Wilhelm Lab
@labwilhelm.bsky.social

Ever wondered how fasting is benefiting the adaptive immune response? In @Nature we show that #ketogenesis promotes the function of #tcell in severe respiratory viral infections by providing #ketonebodies BHB as carbon source. Final edited version: www.nature.com/articles/s41...

nature.comImpaired ketogenesis ties metabolism to T cell dysfunction in COVID-19 - NatureThe ketone body β-hydroxybutyrate can be used as an alternative carbon source by T cells to maintain their function during severe respiratory viral infections, including infection with&...

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