Laure Bindels

microbiomejournal.biomedcentral.comA blueprint for contemporary studies of microbiomes - MicrobiomeThis editorial piece co-authored by the Senior Editors at Microbiome aims to highlight current challenges in the field of environmental and host-associated microbiome research. We also take the opport...

New editorial at Microbiome 🦠 ! Co-authored by the Senior Editors, it aims to highlight current challenges in the field of environmental and host-associated microbiome research and provides a blueprint for contemporary studies of the microbiomes. microbiomejournal.biomedcentral.com/articles/10....

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We think that such efforts are essential to push the boundaries of our knowledge on microbiomes in a concerted, international effort. If your manuscript fit these expectations, please submit it to Microbiome ! @microbiomej.bsky.social With Joy Watts, Kevin Theis, Víctor Carrion, Adam Ossowicki,

Jana Seifert, Julia Oh, Yongqi Shao, Markus Hilty, Purnima Kumar, Falk Hildebrand, Connie Lovejoy, Paul Wigley, Ke Yu, Meiling Zhang, Tong Zhang, Jens Walter, Mahesh Desai, Sharon Huws, Lynn M. Schriml, Jacques Ravel, W. Florian Fricke, Emiley Eloe-Fadrosh, Charles Lee, Thomas Clavel

We take the opportunity to clarify our expectations for the articles submitted to the journal. At Microbiome, we are seeking studies that provide either new mechanistic insights into the role of microbiomes in health and environmental systems or substantial conceptual or technical advances.

@cancercachexia.bsky.social

Manuscripts need to meet high standards of language accuracy, quality of microbiome analyses, and data and protocol availability, including detailed reporting of wet-lab and in silico protocols, all of which can critically enhance transparency and reproducibility.

Laure Bindels reposted

Cancer Cachexia Society

11 Feb 2025

The Education Committee of the @CancerCachexia Society invites you to our seminar on February 12 at 12:00 pm EST with Anthony Coll of University of Cambridge, UK. Seminars are open to everyone, please share! See cancercachexiasociety.org for link.

Laure Bindels reposted

Cancer Cachexia Society

@cancercachexia.bsky.social

5 Feb 2025

tandfonline.comThe microbiota-derived bile acid taurodeoxycholic acid improves hepatic cholesterol levels in mice with cancer cachexiaAlterations in bile acid profile and pathways contribute to hepatic inflammation in cancer cachexia, a syndrome worsening the prognosis of cancer patients. As the gut microbiota impinges on host me...

🎉New article from our team demonstating that a #microbiota derived #bileacid improves hepatic #cholesterol levels in mice with cancer #cachexia! Congratulations to Morgane Thibaut & Martin Roumain! Thanks to our collaborators, the FNRS and the @welbio.bsky.social www.tandfonline.com/doi/full/10....

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Altogether, this work highlights the contribution of the gut microbiota to bile acid dysmetabolism and the therapeutic interest of the secondary bile acid TDCA for hepatic cholesterol homeostasis in the context of cancer cachexia.

More broadly, our work demonstrates the interest and relevance of microbial activity measurements using stable isotopes, an approach currently underused in the microbiome field.

In this manuscript, we established that (i) secondary bile acids are reduced in 3 mouse models of cancer cachexia, (ii) these alterations ensue from an altered bacterial metabolism of bile acids 🦠and