Leann Tilley

"Reaction hijacking of enzymes to generate potent therapeutic modulators in situ" spkl.io/63328A2hIp @leanntilley.bsky.social & colleagues @cp-trendsbiochem.bsky.social

Can enzymes be made to self-destruct for therapeutic purposes? “Reaction-hijacking of enzymes to generate potent therapeutic modulators in situ”. Very pleased that our Review is part of the 50th anniversary special edition of Trends in Biochemical Science. doi.org/10.1016/j.ti...

Amazing Public Lecture by Nobel Laureate Donna Strickland, Nobel Prize in Physics in 2018, at RMIT’s Capitol Theatre. Strickland pioneered chirped pulse amplification for lasers, enabling innovations such as laser eye surgery. She gave an inspirational talk about her love of photons.

Congratulations from all the Tilley Lab to Nutpakal Ketprasit (@nkprst) who submitted his thesis today on reaction hijacking of tRNA charging enzymes of Plasmodium & bacteria. This work will guide development of new treatments. Co-supervised by Stanley Xie and Stuart Ralph (@sturalph). @UniMelb

Congratulations to Tayla Field, Stawell Secondary College, 2025 winner of the Chris & Marli Tilley Scholarship. Thanks to the Program run by Andrew McGuickan CEO. #Youthrive_Victoria is an amazing organisation supporting young rural and regional Victorians and their communities.

A fantastic meeting #LorneProteins2025

I had the great pleasure and honour of Chairing a Special session @LorneProteins. A History of the Lorne Conference on Protein Structure and Function. The event marked the 50th Anniversary. 5 decades of Lorne-inspired protein science in Australia - remembered by 5 amazing colleagues.

Inspirational women discussing science @LorneProteins and life at 7.30 am in Lorne, as part of the #GWB breakfast network.

Congratulations to @FrancesBiophys on the award of the 2025 Leach Lecture Medal of the Lorne Proteins Conference. Frances gave an inspirational talk about NMR and of a life lived fully. What a wonderful role model for women in science! @LorneProteins

Great talk from Hannah Shafaat UCLA on how to make a minimal metaloprotein @lorneproteins.bsky.social

"Two-thirds of the staff of the President’s Malaria Initiative, an organization founded by former President George W. Bush, have been fired, including some of the most senior and respected scientists working on malaria control in the world..." www.nytimes.com/2025/02/01/h...

The ASTMH has written an open Letter to Secretary of State, Marco Rubio, calling on America to sustain its leadership in global health security. www.astmh.org/blog/january... A concerted effort is needed to fight infectious diseases, including emerging diseases that affect the entire world.

Please read this important article from the New York Times by @stephanienolen.bsky.social . The shut down of Programs on HIV, TB and malaria for 90 days and the attack on the agenda of USAID is a very sad day for people who benefit from and care about global health initiatives.

Excited to see our study published in @PLOSPathogens. Multi-stage activity & single oral dose killing of P. falciparum in vivo. Structural basis for improved potency and selectivity of this reaction-hijacking inhibitor are revealed. doi.org/10.1371/journal.ppat.1012429

2.2 billion #malaria cases and 12.7 million deaths have been averted since 2000 Find out more in the new WHO World Malaria Report 2024: 👉 bit.ly/4g31og6

The Biomolecular Horizons 2024 (BMH2024) Congress welcomed registrants from 44 countries to share new developments in biomolecular research, innovation and education. The Congress made possible by the work of some many amazing colleagues. Read the Report in the AB: lnkd.in/gbA7Hf_E Page 31-37.

An amazing cryoEM structure of the membrane-assembled lysosomal mTORC complex from the Hurley lab. @jimhurley.bsky.social www.biorxiv.org/content/10.1...

Wonderful to hear inspirational speakers from @YouthriveVic at the breakfast at Parliament of Victoria, this morning. Thanks to Maree Edwards, Speaker of the Victorian Legislative Assembly, for hosting, and to Andrew McGuckian for organising the event.

Congratulations to Frances Separovic on being awarded a Docteur Honoris Causa from the University of Bordeaux. @FrancesBiophys

Congratulations to the team.

So lovely to join the celebrations for the 2024 L’Oréal-UNESCO For Women in Science celebration. Congratulations to the amazing award winners. Great to catch up with wonderful @Women in Science. @DrMistyJenkins

Stories & Structures – New Connections. #BMH2024 featured an exhibition building on >60,000 yrs of Indigenous tradition in a collaboration with Microscopy Australia. Rich visual parallels between #Indigenous artworks and the microscopic world. Thanks to Jenny Whiting @Sydney_Uni

Excellent session on emerging pathogens! Lots to be scared about.

Everything you always wanted to know about Publishing but were too scared to ask. Great session.

Thanks Laura Edgington-Mitchell. Thanks Beth and Lou. Thanks Tony Chiovitti, GTAC. @LauraEM_Lab

Brilliant #BMH2024 High School Holiday Program. From microbial machines to gene editing therapies Amazing presentations from Dr. Alexis Komor, University of California San Diego, Dr. Melinda Jingqi Wang & Dr. Rhys Grinter, University of Melbourne. @Rhys__G @KomorLab

Alexis Komor (@Komor_Lab) is a leader in #precision #genome_editing. She has developed new base editing methods that overcome problems with off target genome changes. Her work greatly advances efforts towards gene editing repair of genetic mutations.

Caixia GAO is at the forefront of developing CRISPR-modified rice and wheat strains to secure the world’s food supplies. She wowed us with stories of “scarless” and base editing strategies. Her team’s mildew resistant wheat has achieved registration. #Bmh2024

Rich asks us to use our influence for the good of Society. He points to a need for all scientists to advocate to the public and to politicians about science-based solutions to the world’s challenges. #BMH2024

Erinna (@erinna_lee) and Marilyn Anderson in conversation with Nobel Prize winner, Sir Rich Richards. Rich says: Embrace your “failed” experiments. If you repeatedly get an unexpected result, Nature is trying to tell you something.

@PetroTerblanche, CEO Afrigen, advocates the medicines that Africa’s population could be manufactured on the African continent. RNA Technology offers the possibility of leap-frogging barriers to manufacture, but problems remain with respect to gaining IP and licences. #BMH2024

Sage words from the Future of RNA Technology Panel @bmh2024Melb. Thanks to Amanda Caples, Victoria’s Lead Scientist, Australia Catherine Mills, Monash Bioethics Institute Steve Rockman, CSL/Seqiris, Australia Claire Borg, Moderna, Australia @traude_beilharz

Photo of the successful bid team for @BMH2024Melb in Seoul in 2018. Here we are 6 years later. Our dream realised!

Great overview of and insights into RNA vaccines from Norbert Paradise at @bmh2024Melb Plenary Talk

Good times at the BMH2024 mixer! (@BMH2024Melb)

A very sage Indigenous Perspectives in BioMolecular Science Panel fielded questions about how to work with Indigenous patients, colleagues and sample in a respectful way. Amazing insights. How to be a good ally. Build on deep consultation. Such important work. Amazing insights.

Misty Jenkins AO (@DrMistyJenkins @WEHI_research) gave a Plenary Talk on #CAR-T therapies, and #brain_cancer. She is so amazing, I got a bit emotional! @DrMistyJenkins @WEHI_research.

Wow. The Indigenous Perspectives in BioMolecular Science stream @BMH2024Melb has been amazing . The Day showcased top #Indigenous researchers covering topics from #Cancer and #Immunology, to #Climate Change to #Genomics, to #Education. @UniMelbPoche @KimiHenare

Birrarung by night. SNAP SHOT MELBOURNE! Take a selfie with an iconic Melbourne feature whilst you enjoy @BMH2024Meb. Submit your images at https://forms.gle/k2WyxWQAEwzcBFoCA to win great prizes.

The @BMH2024Melb Career Development Event is amazing. What a terrific line-up of speakers. Some photos from the event. . @Komor_Lab @DrDanDries @SomeBlondeSci @gl_alisa @SarahGarnish