Lukas Milles (@lfmilles.bsky.social)

@lfmilles.bsky.social

First preprint from the lab, design & control your protein's amino acid, mRNA and DNA sequences all at once; driven by @blazejba.bsky.social and @ldornfeld.bsky.social, in great collaboration with Dexiong Chen and Karsten Borgwardt.

Lars Dornfeld@ldornfeld.bsky.social

Our paper, “Joint protein, mRNA and DNA sequence design and optimization with nucleotide-level Potts models,” has been accepted at NeurIPS 2026 and is now available on bioRxiv! Preprint: www.biorxiv.org/content/10.6... Code: github.com/blazejba/NuC... 1/11

biorxiv.orgJoint protein, mRNA and DNA sequence design and optimization with nucleotide-level Potts modelsProtein design typically generates amino acid sequences first and then translates them into DNA post-hoc limiting control over the nucleotide sequence via codon choice at design time. We introduce NuC...