loschmidtlab.bsky.social

We had several reasons to celebrate, and 𝗦𝘁𝗮𝗻𝗶𝘀𝗹𝗮𝘃 𝗠𝗮𝘇𝘂𝗿𝗲𝗻𝗸𝗼's successful defense of his Habilitation Thesis was one of them! 🥂✨ We look forward to having a new Associate Professor at Loschmidt Labs! 🎓🔬 📸 David Damborsky

Our 𝗔𝘂𝘁𝘂𝗺𝗻 𝗢𝘂𝘁𝗿𝗲𝗮𝗰𝗵 𝗦𝗲𝗺𝗶𝗻𝗮𝗿 took place on Oct 16th! We enjoyed rich discussions on drug discovery, thrombolytics, luciferase, lab robotics, agentic systems & de novo binders, alongside great team time & wonderful hotel hospitality. 🔬💡 📸 Kaja Sedlackova

🚀 Busy conference season at Loschmidt Labs! 𝗗𝗮𝘃𝗶𝗱 𝗕𝗲𝗱𝗻𝗮𝗿 presented FireProt at Horizons 2026, 𝗗𝗮𝗻𝗶𝗲𝗹 𝗣𝗹𝘂𝘀𝗸𝗮𝗹 shared his work on fluorescent proteins at SynBio 2026, and 𝗝𝗮𝗻 𝗖𝗲𝘀𝗻𝗲𝗸 presented Alzheimer's research at ICRC Days. Thanks to #CLARA 🇪🇺🔬

We were delighted to host 𝗠𝘆𝗸𝗵𝗮𝗶𝗹𝗼 𝗚𝗶𝗿𝘆𝗰𝗵 from VTT Technical Research Centre of Finland for a one-month research exchange at Loschmidt Laboratories. Thank you for the collaboration and inspiring discussions! 👏 #Research #Biotechnology #ComputationalBiology

NEW ARTICLE in 𝗔𝗖𝗦 𝗖𝗮𝘁𝗮𝗹𝘆𝘀𝗶𝘀 (@pubs.acs.org)! 🧬 Our study on haloalkane dehalogenase LinB shows how screening with oversized substrates reveals beneficial mutations far from the active site that enhance dynamics and efficiency. 🔗 pubs.acs.org/accacs/artic...

Huge congrats to 𝗦𝘁𝗮𝗻𝗶𝘀𝗹𝗮𝘃 𝗠𝗮𝘇𝘂𝗿𝗲𝗻𝗸𝗼 on delivering his habilitation lecture on machine learning in protein engineering 🧬✨ We’re now one step closer to welcoming another Associate Professor to the @LoschmidtLabs team (@masarykuniversity.bsky.social) ! 🎊🎓

Researchers from CIIRC CTU & Loschmidt Laboratories met in Prague for the 𝟵𝘁𝗵 𝗝𝗼𝗶𝗻𝘁 𝗪𝗼𝗿𝗸𝘀𝗵𝗼𝗽! 🧪🤖 Topics covered enzyme engineering, ML, molecular simulations, & AI tools. Great chance to connect teams, including #CLARA colleagues. 📸 Recap & photos: www.clara-center.eu/news/9th-joi...

Our postdoc Sérgio Marques attended the 𝟯𝗿𝗱 𝗕𝗶𝗼𝗘𝘅𝗰𝗲𝗹 𝗖𝗼𝗻𝗳𝗲𝗿𝗲𝗻𝗰𝗲 𝗼𝗻 𝗔𝗱𝘃𝗮𝗻𝗰𝗲𝘀 𝗶𝗻 𝗕𝗶𝗼𝗺𝗼𝗹𝗲𝗰𝘂𝗹𝗮𝗿 𝗦𝗶𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻𝘀 and presented his research. 🧬 "It was an inspiring few days filled with excellent science and great discussions!" says Sérgio. 🚀 Supported by Horizon Europe #CLARA.

🧬 Great discussions at our joint workshop with MSD Animal Health! Experts shared insights on biotherapeutics and protein stabilization, while Loschmidt Labs showcased computational protein design and microfluidic screening. Thanks to everyone involved! 🙌 #CLARA

New article published in 𝗔𝗖𝗦 𝗖𝗮𝘁𝗮𝗹𝘆𝘀𝗶𝘀! 📢🧬 In our latest study, we introduced Brnoteplase, a promising new thrombolytic candidate, while demonstrating the impact of multiobjective enzyme engineering in overcoming trade-offs in therapeutic protein design. 🧠🩸 pubs.acs.org/accacs/artic...

We celebrated our new ACS Catalysis paper, "𝗨𝗻𝗰𝗼𝘃𝗲𝗿𝗶𝗻𝗴 𝗙𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹 𝗗𝗶𝘀𝘁𝗮𝗻𝘁 𝗠𝘂𝘁𝗮𝘁𝗶𝗼𝗻𝘀 𝗯𝘆 𝗨𝗹𝘁𝗿𝗮-𝗛𝗶𝗴𝗵-𝗧𝗵𝗿𝗼𝘂𝗴𝗵𝗽𝘂𝘁 𝗦𝗰𝗿𝗲𝗲𝗻𝗶𝗻𝗴 𝗼𝗳 𝗗𝗲𝗵𝗮𝗹𝗼𝗴𝗲𝗻𝗮𝘀𝗲𝘀"! 🧪 Lead author Hana Faldynova highlighted this 10-year effort by 30 co-authors. Congrats to all! 👏 #ACSCatalysis #Biology #Biochemistry #uHTS #Enzymology

Our team attended the 7th #EnzymeML Workshop in Rüdesheim, Germany. PhD student Martin Richter presented his work on resolving enzymatic mechanisms from ligand-binding data using machine learning. Great discussions and inspiring atmosphere! 🤝 #MachineLearning #Enzymology #CLARA

It was a pleasure hosting 𝗡𝗶𝗸𝗶𝘁𝗮𝘀 𝗚𝗲𝗼𝗿𝗴𝗶𝗼𝘂 (Center for Interdisciplinary Biosciences, Kosice) at Loschmidt Laboratories! His 2-week exchange focused on protein engineering and computational study of AChE/BChE in neurodegenerative disorders. Thanks to COZYME COST Action CA21162 for supporting us!

Our new paper on 𝗙𝗶𝗿𝗲𝗣𝗿𝗼𝘁𝗔𝗦𝗥 𝟮.𝟬 is out in 𝗕𝗿𝗶𝗲𝗳𝗶𝗻𝗴𝘀 𝗶𝗻 𝗕𝗶𝗼𝗶𝗻𝗳𝗼𝗿𝗺𝗮𝘁𝗶𝗰𝘀! 🧬📖 Engineered for evolution-guided protein design, it combines ancestral sequence reconstruction with future mutation prediction & generative VAEs in one web tool. Try it here: loschmidt.chemi.muni.cz/fireprotasr/

Our PhD student Martin Sitte joined the 𝗖𝗖𝗣𝟰-𝗕𝗖𝗔 𝗣𝗿𝗼𝘁𝗲𝗶𝗻 𝗖𝗿𝘆𝘀𝘁𝗮𝗹𝗹𝗼𝗴𝗿𝗮𝗽𝗵𝘆 𝗦𝘂𝗺𝗺𝗲𝗿 𝗦𝗰𝗵𝗼𝗼𝗹 in Norwich for advanced crystallography training. “An intense, challenging, and fun week!” says Martin, who now heads to Yeshiva University in NYC. Safe travels!

In just a few days, we’re opening registration for our 𝗛𝗮𝗻𝗱𝘀‑𝗼𝗻 𝗖𝗼𝗺𝗽𝘂𝘁𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗘𝗻𝘇𝘆𝗺𝗲 𝗗𝗲𝘀𝗶𝗴𝗻 𝗖𝗼𝘂𝗿𝘀𝗲— a training event for anyone looking to advance their skills in protein engineering. 🚀 Seats fill up fast every year, so make sure to secure yours as soon as registration goes live! 🔬

Karen at ECCB 2026! 🎉🇨🇭 Karen Pailozian presented TmProt 1.0, a fast ML tool that helps researchers identify and rank stable proteins for experiments. Supported by Horizon Europe #CLARA 🤝

𝗦𝗰𝗶𝗲𝗻𝗰𝗲 & 𝗧𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆 𝗙𝗲𝘀𝘁𝗶𝘃𝗮𝗹 wrapped up! Thanks to everyone who visited our booth — we explored brain health, early signs of stroke, and tried fun hands‑on activities. Grateful to ICRC and Horizon Europe #CLARA for the support. 🔬🧠✨ #Science #BrainHealth #StrokeAwareness #ICRC #HorizonEurope

Everything’s packed and ready! Join us tomorrow at the 𝗦𝗰𝗶𝗲𝗻𝗰𝗲 𝗙𝗲𝘀𝘁𝗶𝘃𝗮𝗹 at Brno Exhibition Center, Pavilion A2. We’ll showcase our Alzheimer’s and stroke research, including the molecular models we work with. 🔬🧠 We look forward to seeing you! 📸 Irena Halikova

Our PhD student 𝗔𝗹𝗶𝗮𝗸𝘀𝗮𝗻𝗱𝗿𝗮 𝗞𝘂𝗿𝘀𝗶𝘁 presented at #AAIC2026 in London! 🧠🇬🇧 Her research identified existing drugs that bind to ApoE4, with 2 compounds successfully blocking its toxic clumping—a promising step toward new Alzheimer’s therapies. 🔬✨ #Alzheimers #Neuroscience #DrugDiscovery

Great hosting Abdulkadir Yayci (Ruhr-Universität Bochum) at Loschmidt Labs! 🧪 He spent 3 weeks working with our computational protein engineering tools, & we can't wait to share the results! 🚀 Thanks to COZYME - COST action CA21162 for funding research exchanges like this. 🤝 #ProteinEngineering

Yesterday, we gathered for our summer barbecue! 🌭🧀 Great food, but even better company and conversations. It was a wonderful opportunity to celebrate our research interns, Rehmadanta Sitepu & Abdulkadir Yayci, as their stay comes to an end.☀️ 📸 Sarka Nevolova

Ready to take your enzyme engineering skills to the next level? 🧬 Registration opens 𝗦𝗲𝗽𝘁𝗲𝗺𝗯𝗲𝗿 𝟭𝟲, 𝟮𝟬𝟮𝟲 for our 8th Hands-on Computational Enzyme Design Course! 🚀 ⏳Early-bird discounts apply! Don't miss out. 📍Learn more here: loschmidt.chemi.muni.cz/academy/

Big congratulations to 𝗗𝗮𝘃𝗶𝗱 𝗛𝗮𝗿𝗱𝗶𝗻𝗴-𝗟𝗮𝗿𝘀𝗲𝗻 (DTU Biosustain) on successfully defending his PhD thesis on machine learning for enzyme development, co-supervised by our Stanislav Mazurenko! 🎓✨ It was a pleasure hosting David at Loschmidt Labs. Wish you all the best next! 🧪🧬

Máš vystudovanou přírodovědu a láká tě výzkum, který má reálný dopad na léčbu rakoviny? 🔬 Do proteomické laboratoře naší spolupracovnice Lenky Hernychové na Masarykově onkologickém ústavu v Brně hledají aktuálně novou kolegyni/kolegu na pozici Výzkumný pracovník junior! 🧪 www.mou.cz/vyzkumny-pra...

On Friday, we celebrated the acceptance of our FireProt ASR 2.0 manuscript in Briefings in Bioinformatics and the award of a new GAČR grant supporting our collaboration with Aleksandra Marsavelski's team.🥂 📷 Irena Halikova

Our team member, 𝗦𝗲𝗿𝗴𝗶𝗼 𝗠𝗮𝗿𝗾𝘂𝗲𝘀, attended the conference Quitel 2026 in Coimbra, Portugal, last week! Sergio presented our work on CAVER, CaverDock, and Caver Web in an invited plenary lecture and an oral presentation, highlighting their applications in protein tunnel analysis and ligand transport.

Summer barbecue at Loschmidt Laboratories! 🍔🔥 A big thank you to Irena Halikova and everyone involved in organizing this wonderful event! We enjoyed delicious food, refreshing drinks, and great conversations with colleagues. 📷 Karolina Sedlackova

We were pleased to welcome 𝗔𝗹𝗲𝗸𝘀𝗮𝗻𝗱𝗿𝗮 𝗠𝗮𝗿𝘀𝗮𝘃𝗲𝗹𝘀𝗸𝗶 from the University of Zagreb for 𝗙𝗮𝗿𝗮𝗻𝗲𝗵 𝗛𝗮𝗱𝗱𝗮𝗱𝗶’s defense and to show her around our lovely city of Brno. Thank you for your visit, Aleksandra! We look forward to many more opportunities to work together.🤝✨ 📸 Stanislav Mazurenko

The names of our newest PhD graduates have appeared on the "Walk of Fame" in front of the red Campus building. ✨ We are proud of their achievements and wish them all the best on their next journey! 🚀

🎓 Congratulations to 𝗣𝗮𝘃𝗲𝗹 𝗞𝗼𝗵𝗼𝘂𝘁 on the successful defense of his PhD thesis, Machine Learning for Computational Protein Design, at @recetox.bsky.social, Masaryk University! His work applies state-of-the-art ML to protein engineering. #PhD #MachineLearning #ProteinEngineering

🏆 Congratulations to our doctoral students! At the @recetox.bsky.social 𝗗𝗼𝗰𝘁𝗼𝗿𝗮𝗹 𝗖𝗼𝗻𝗳𝗲𝗿𝗲𝗻𝗰𝗲 𝟮𝟬𝟮𝟲, Daniel Pluskal's poster on engineering Renilla reniformis GFP ranked among the top three posters, and Martin Sitte successfully passed his doctoral state examination.🎓👏

🏆 Success for high school students at Loschmidt Laboratories! Monika Dlouhá won 🥈 2nd place and Amálie Steklá 🥉 3rd place in Molecular Biology at the national SOČ competition in Olomouc. Congratulations to the students and their supervisors! 👏🔬 #MolecularBiology #STEM #YoungScientists #SOC

Summer Starts with Beach Volleyball! 🏐☀️ The first beach volleyball match of the summer took place this Monday, bringing together players from Pavel Dvořák’s Microbial Bioengineering Laboratory and the Loschmidt Laboratories. Many thanks to Martin Sitte for organizing this event!

🔥 Last Friday, we celebrated a major milestone as 𝗙𝗮𝗿𝗮𝗻𝗲𝗵 𝗛𝗮𝗱𝗱𝗮𝗱𝗶 and 𝗝𝗮𝗻 𝗠𝗶𝗰𝗮𝗻 earned their PhDs! Despite the chilly weather, we enjoyed a great BBQ, good conversations, and a toast to their achievements. 🍖🍻 Congratulations and best wishes for the future! ✨🎉 📸 Sarka Nevolova

🏆 Great success at ISBC & ISLS 2026 in Rayong, Thailand! 🎉 In a highly competitive field, 𝗞𝗮𝗿𝗼𝗹𝗶𝗻𝗮 𝗦𝗲𝗱𝗹𝗮𝗰𝗸𝗼𝘃𝗮 received the Outstanding Poster Presentation Award and 𝗠𝗮𝗿𝘁𝗶𝗻 𝗦𝗶𝘁𝘁𝗲 the Outstanding Oral Presentation Award. 👏 Congratulations to both!

🔬 Our PhD student Pavel Kohout spent a month at Chalmers University 🇸🇪 in the Zelezniak Lab, exploring whether molecular dynamics and ML-based methods (SAMt, BioEmu, BBFlow) can explain experimental observables. Supported by #CLARA. 📸 Pavel Kohout #ResearchInternship #ComputationalBiology

🎓 Congratulations to Dr. 𝗙𝗮𝗿𝗮𝗻𝗲𝗵 𝗛𝗮𝗱𝗱𝗮𝗱𝗶 on successfully defending her PhD thesis, Integrating Machine Learning with Structural Protein Analysis! Her work bridged structural biology, ML, and explainable AI, resulting in 3 publications and an invited conference talk. 👏🔬 #PhDDefense #MachineLearning

Secondary school student Amalie Stekla won three awards at the Conference of Young Life Scientists 2026 for her research on bioluminescence in the brittle star Amphiura filiformis. 🥇 Audience Award 🥇 1st Place (Chemistry–Physics–Informatics) 🌍 Main Prize (100,000 CZK) Congratulations!

🎓 Congratulations to 𝗝𝗮𝗻 𝗠𝗶𝗰𝗮𝗻 on earning his PhD! His thesis, Molecular Modeling and Bioinformatics in the Study of Thrombolytics, marked the successful completion of his doctoral studies, which included 13 publications, international research stays, and outstanding scientific achievements. 👏🔬