L Brielmaier

For those wishing to slash government medical research spending: "Just because our lives are finite, doesn’t mean that they’re worthless.” Ben Strauss

Brain Disease Is Pervasive in N.F.L., New Estimate Suggests www.nytimes.com/2026/10/28/s... Also, a 4x risk of A.L.S. Versus the general population.

DIYers assembled Halloween decorations with wood, crafts, readily available electrical parts, some elbow grease, and a few hours of time. www.designnews.com/electronics/...

The provocative new theory that could explain aging and disease Could disruptions in the flow of energy through mitochondria cause everything from type 2 diabetes to Alzheimer’s? www.scientificamerican.com/article/the-...

First-of-Its-Kind Vaccine Ushers in New Hope for Cancer Patients www.nytimes.com/2026/10/23/w... Two years after entering the trial, those who received the vaccine were far less likely to have had the cancer come back at all or, worse, spread far in the body.

Creating 'satellite maps' of thousands of proteins across tissue could transform drug therapies medicalxpress.com/news/2026-10... via @medical_xpress "By mapping a drug candidate together with the brain's protein responses, we could see whether it changes the biology we intended to change,"

Doctors’ offices are charging patients 10 times more by claiming to be hospitals wapo.st/3VR97ZH usually the doctor’s office won’t budge, and the patient has no choice but to pay the bill.

Here are the best robot videos of the week!

Ready for organoids? Five questions to ask before making the switch Organoids may offer physiologically relevant models—but they also introduce new demands. five practical questions that can help determine whether your lab is ready. www.science.org/content/arti...

This week’s poll results 60% of PharmaVoice readers who don’t believe the industry will ever meaningfully reshore generic drug production.

TNTs in disease: Highways of pathology Neurodegenerative disorders: From aggregate spread to putative networked proteostasis TNTs have been extensively implicated in the intercellular transfer of aggregation-prone proteins. www.cell.com/neuron/fullt...

A critical PHP vulnerability may take websites down today crying wolf? We'll see later today... www.theverge.com/tech/1015257...

Black Market Retatrutide Linked to Multiple Deaths though the FDA is aware of the dubious retatrutide trade, the Fed's lax attitude toward bootleg peptides throughout the 2nd Trump admin is arguably a principle factor contributing to the rise of sketchy knockoffs. futurism.com/health-medic...

Prosthetics are baby steps to exoskeletons. So I can walk again.

Tongue exercises for ALS patients show promise in a preclinical study Nichols & her team hope to move tongue exercise toward human clinical trials within the next several years through collaborations @ Mizzou's NextGen Precision Health. medicalxpress.com/news/2026-10... via @medical_xpress

(The Atlantic) A tale of Susan Collins... www.theatlantic.com/politics/202...

We’re looking at a crossroads with many, many different paths that we have to pursue.” Dr. Fernando Vieira on why ALS TDI is expanding: a new 33,000 sq ft lab in early 2027 and double our science team. Hear more at our Town Hall this Wed, 3 PM ET: www.als.net/als-town-hall/

HSV-1 activates powerful antiviral defenses in the brains specialized immune cells, called microglia. But this response may come at a cost. As these cells shift toward fighting infection, they lose the ability to maintain a healthy brain. medicalxpress.com/news/2026-10...

FDA launches rare disease framework initiative | RAPS The agency will hold a workshop on 28 October to solicit feedback on the initiative. Based on this internal and external feedback, the FDA said it may revise existing regulations or implement new www.raps.org/resource/fda...

For women academics, feeling devalued can be a fatal career blow | Science | AAAS “It speaks to the subtle experiences of women not feeling like they belong.” www.science.org/content/arti...

NIH gives Barrow Neurological Institute another $25.3M for ALS study ktar.com/arizona-heal... “We built ALL ALS around the idea that accelerating research and drug development in ALS requires broad participation, collaboration and easy access to high-quality clinical data and biological samples,”

Spot can observe its surroundings from any direction, so it doesn’t really have a “head.” That makes it much more difficult to answer the question: How would Spot wear a hat? ICRA is the flagship conference of IEEE RAS. For upcoming RAS conferences: buff.ly/HK7a619 RAS site: buff.ly/SGkmGwO

This special issue assembles eleven contributions spanning AD, PD, HD, and ALS/FTD, illustrating how glial biology intersects with protein aggregation, clearance, metabolic dysfunction, and intercellular communication. www.sciencedirect.com/science/arti...

When avoiding eating avocado toasts doesn't even begin to cover your rent, you'd wish everyone understood:

These words talked their way into the dictionary. Do you know their meaning? wapo.st/4jlgQZD 5/9

Nasal delivery of ALS treatment in tiny cell-made sacs delays disease onset in mice medicalxpress.com/news/2026-10... via @medical_xpress "Our research grew from a simple idea—instead of forcing a drug to find its way into the brain, give it a vehicle that already knows how to get there,"

U.S. Medicare Open Enrollment Resources medicareadvocacy.org/medicare-ope...

Organs-on-a-chip are improving, and the FDA is requesting chip data as well as animal testing data on some new drugs. Changing huge systems takes time, resources, and policy, but we may be on a path to reduce animal testing in drug development. buff.ly/BQOKBNu

3 stats that will determine the outcome of Ohio State vs. Indiana Indiana, which hasn't lost at home in two and a half seasons since Curt Cignetti took over in 2024, will enter the matchup as a slight underdog to the Buckeyes. buckeyeswire.usatoday.com/story/sports...

AI Has a Darker Side in Healthcare, Expert Says www.medpagetoday.com/practicemana... The "gigification" of healthcare jobs may also be coming, warned Khan. For example, nursing platforms that are algorithmically managed might have nurses bidding for their shifts

Biosimilars: FDA finalizes guidance on postapproval manufacturing changes | RAPS FDA has since determined that the principles that apply to manufacturing changes for biosimilars are relevant to interchangeable biosimilars” www.raps.org/resource/bio...

If you cannot do great things, do small things in a great way. Napoleon Hill

Here is a GOOD HEART...

Sound on.......quite something.

ARPA-H to expedite clinical trials with SURPASS and other AI related programs www.jdsupra.com/legalnews/ar... Build a phaseless design engine by integrating digital twins and other predictive models into trial design, simulating clinical and operational outcomes before launch.

What is NIH Leadership Trying to Hide from Researchers & the Public? A NIH proposal to conceal reviewer rankings of investigator-initiated research grants is ripe for misuse & demands a collective response (by October 13). joshuasweitz.substack.com/p/what-else-...

Lou Gehrig’s Disease Clinical Trial Pipeline Gains Momentum: 75+ Companies Lead the Charge in Pioneering New Treatments | DelveInsight www.abnewswire.com/pressrelease...

September's Ozone Hole Was the Biggest It Has Been in 25 Years www.smithsonianmag.com/smart-news/s...

Will AI scoop your science? Some researchers see a gloomy future www.nature.com/articles/d41... In response, researchers who are worried that AI tools might scrape their unpublished work and scoop them are limiting their use of such tools.

Regenerating lost neurons and restoring neural circuits following neurological injury or disease is becoming increasingly feasible owing to advances in stem cell technologies.  www.sciencedirect.com/science/arti...

Medicare Open Enrollment slides from earlier this week : medicareadvocacy.org/wp-content/u...

"One of my goals early in my ALS diagnosis was to share what I learn along the way to help others navigate this horrible disease." Meet Steve Hughes, Bridging Voice Ambassador, diagnosed with ALS in 2022. Office hours: Tuesdays 4:30pm ET, bridgingvoice.org/office-hours #AACAwarenessMonth #AAC #ALS

Can your brain grow new neurons? How researchers are solving a century-old puzzle www.nature.com/articles/d41...

How to spend $25 billion on science: OpenAI’s staggeringly rich research charity gets under way www.nature.com/articles/d41...

How to respond to hate speech without fuelling it further www.nature.com/articles/d41...

TDP-43 and ALS - what's wrong with my membranes? The membrane deformations observed in situations of TDP-43 misexpression strongly suggest a functional link between TDP-43 and membrane dynamics. www.sciencedirect.com/science/arti...

Shawn is a ND graduate.

The FBI Anti-Corruption Squad Was Circling Susan Collins — Until Trump Got in the Way Confession: The donor, an ex-defense contractor, told agents his company won millions in federal contracts by bankrolling campaigns of powerful politicians. www.propublica.org/article/fbi-...