Marcos Castro e Silva, PhD 🇧🇷

Our paper on the evolutionary history and genetic diversity of Indigenous Americans is featured on the cover of @nature.com

Our study also challenges traditional dynamics in science, especially in cutting-edge research fields. The Global South is not only the subject of scientific research, it also leads, shapes, and drives it.

Our paper on the evolutionary history and genetic diversity of Indigenous Americans is featured on the cover of @nature.com

I hope this work helps highlight the importance of including historically underrepresented and marginalized populations in genomic research.

🚨 Check out our new paper in Nature! In our new study, we sequenced 128 high-coverage genomes from Indigenous peoples across Latin America and uncovered their unique genetic diversity and history. 👇🧵 www.nature.com/articles/s41...

Also, check out the accompanying research briefing in Nature: www.nature.com/articles/d41...

🚨 Check out our new paper in Nature! In our new study, we sequenced 128 high-coverage genomes from Indigenous peoples across Latin America and uncovered their unique genetic diversity and history. 👇🧵 www.nature.com/articles/s41...

Our study shows that the history of the Americas was dynamic, complex, and shaped by multiple internal migrations, and long-term adaptation. It also highlights how much we still miss when Indigenous peoples are left out of genomic research.

🚨 Check out our new paper in Nature! In our new study, we sequenced 128 high-coverage genomes from Indigenous peoples across Latin America and uncovered their unique genetic diversity and history. 👇🧵 www.nature.com/articles/s41...

We show this signal likely persisted in the Americas for over 10,000 years. Remarkably, several Australasian-linked regions show signs of natural selection. This suggests they are not just remnants of an ancient admixture event, but some variants aided local adaptation.

🚨 Check out our new paper in Nature! In our new study, we sequenced 128 high-coverage genomes from Indigenous peoples across Latin America and uncovered their unique genetic diversity and history. 👇🧵 www.nature.com/articles/s41...

We also found evidence that many populations still preserve strong genetic continuity with ancient peoples from the same regions. For example, present-day Andean and Southern Cone groups remain closely related to ancient populations that lived there thousands of years ago.

🚨 Check out our new paper in Nature! In our new study, we sequenced 128 high-coverage genomes from Indigenous peoples across Latin America and uncovered their unique genetic diversity and history. 👇🧵 www.nature.com/articles/s41...

We found that the genetic structure of Indigenous peoples closely follows geography. Populations from the Andes, Amazon, Chaco, Southern Cone, Mesoamerica, and northern Mexico each form distinct genetic clusters. These patterns also reveal long-term regional continuity.

🚨 Check out our new paper in Nature! In our new study, we sequenced 128 high-coverage genomes from Indigenous peoples across Latin America and uncovered their unique genetic diversity and history. 👇🧵 www.nature.com/articles/s41...

We generated 128 new high-coverage genomes from 45 Indigenous populations across 8 countries, representing 28 language families. We then combined them with published ancient and present-day genomes to build one of the most comprehensive genomic datasets for Indigenous Americans.

🚨 Check out our new paper in Nature! In our new study, we sequenced 128 high-coverage genomes from Indigenous peoples across Latin America and uncovered their unique genetic diversity and history. 👇🧵 www.nature.com/articles/s41...

🚨 Our new paper is out in Science! We analyzed 2,723 high-coverage whole genomes from Brazilians to explore how five centuries of colonization, forced migration, and admixture have shaped genetic diversity and impacted health. 📄 science.org/doi/10.1126/... 🧵👇

www.eurekalert.org/news-release...

🚨 Our new paper is out in Science! We analyzed 2,723 high-coverage whole genomes from Brazilians to explore how five centuries of colonization, forced migration, and admixture have shaped genetic diversity and impacted health. 📄 science.org/doi/10.1126/... 🧵👇

Huge thanks to the incredible team behind this effort. Proud to have contributed to the DNA do Brasil project and to shed light on Brazil’s rich genetic history. 🔗 Read the paper: science.org/doi/10.1126/... 🧵Thanks for reading! RTs appreciated. #genomics #Brazil #SciComm

🚨 Our new paper is out in Science! We analyzed 2,723 high-coverage whole genomes from Brazilians to explore how five centuries of colonization, forced migration, and admixture have shaped genetic diversity and impacted health. 📄 science.org/doi/10.1126/... 🧵👇

📉 Genomic data reveals the demographic toll of colonization: Massive effective population size declines Regional differences in genetic isolation Long IBD segments in Amazonas (northern Brazilian state) reveal deep founder effects and recent inbreeding

🚨 Our new paper is out in Science! We analyzed 2,723 high-coverage whole genomes from Brazilians to explore how five centuries of colonization, forced migration, and admixture have shaped genetic diversity and impacted health. 📄 science.org/doi/10.1126/... 🧵👇

🌍 Brazilian genomes are a mosaic of haplotypes from Indigenous American, African, and European ancestors. We uncovered fine-scale structure — some individuals were formed by admixture between African populations that likely never met on the continent itself.

🚨 Our new paper is out in Science! We analyzed 2,723 high-coverage whole genomes from Brazilians to explore how five centuries of colonization, forced migration, and admixture have shaped genetic diversity and impacted health. 📄 science.org/doi/10.1126/... 🧵👇

💥 Of these new variants, >36,000 are potentially deleterious — affecting immunity, metabolism, and fertility. Many are rare and ancestry-specific. We found correlations between ancestry proportions and deleterious variant burden.

🚨 Our new paper is out in Science! We analyzed 2,723 high-coverage whole genomes from Brazilians to explore how five centuries of colonization, forced migration, and admixture have shaped genetic diversity and impacted health. 📄 science.org/doi/10.1126/... 🧵👇

🇧🇷 Brazil is home to the world’s largest recently admixed population — shaped by millions of Europeans, enslaved Africans, and Indigenous peoples. Yet, its genomic diversity remains underrepresented in global databases. We set out to change that.