Oscar Marín Lab

cell.comA postnatal molecular switch drives activity-dependent maturation of parvalbumin interneuronsNeuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...

1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social @wellcometrust.bsky.social

9/10 In sum, our findings reveal a postnatal molecular switch that drives the activity-dependent maturation of parvalbumin interneurons, a critical population for cortical function. Funded by the @wellcometrust.bsky.social

10/10 Here’s the paper @cellcellpress.bsky.social if you want to dig in www.cell.com/cell/fulltex... That’s it. Thanks for sharing! @devneuro.bsky.social @mrc-cndd.bsky.social @kingsioppn.bsky.social @kingscollegelondon.bsky.social @wellcometrust.bsky.social

7/10 PGC-1alpha cooperates with ERR-gamma to directly regulate the transcription of many PV-enriched genes. Incidentally, it also seems involved in repressing genes that are typically enriched in other cells, like SST interneurons

8/10 Importantly, this mechanism also allows PV interneurons to regulate their mitochondrial content and function, which may also contribute to their maturation

5/10 What are the mechanisms regulating the protracted maturation of cortical interneurons? We found that this process requires neuronal activity and is mediated by the transcriptional modulator PGC-1alpha

6/10 How is this achieved? We discovered that PGC-1alpha regulates the expression of most genes that are typically enriched in mature PV interneurons

3/10 Several unique properties distinguish PV interneurons: They exert a very tight control over the output of pyramidal cells; are fast-spiking, meaning they can fire action potentials at very high frequencies; are covered by perineuronal nets, and have many mitochondria

4/10 Interestingly, while PV interneurons are generated in the embryo, they are late bloomers: in humans, for example, it takes more than two years for PV interneurons to acquire their mature properties

@martijnselten.bsky.social

2/10 PV interneurons are a type of inhibitory neuron in the cortex, characterized by their expression of the calcium-binding protein parvalbumin. These neurons play a crucial role in regulating neuronal activity and are involved in #memory, sensory processing, and motor control

Oscar Marín Lab reposted

Martijn Selten

15 July 2025

🚨 New Paper Alert! 🚨 I’m very happy to share our newest paper in Cell, led by the brilliant Monika Moissidis. We show that PGC1a regulates the maturation of PV+ interneurons in an activity-dependent manner. Link below 👇 www.cell.com/cell/fulltex... @cellpress.bsky.social @marinlab.bsky.social

Oscar Marín Lab reposted

Centre for Developmental Neurobiology

@devneuro.bsky.social

4 June 2025

We're #hiring for a new role as Senior #ExecutiveAssistant to our fantastic Director and Managing Director! Deadline 23 June @marinlab.bsky.social www.kcl.ac.uk/jobs/116505-...

kcl.ac.ukSenior Executive Assistant

Oscar Marín Lab reposted

Daniel Ibrahim

@danielibrahim.bsky.social

27 May 2025

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...

rdcu.beConservation of regulatory elements with highly diverged sequences across large evolutionary distancesNature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...

Oscar Marín Lab reposted

Denis Jabaudon

@djabaudon.bsky.social

28 May 2025

Still openings, check it out!

Denis Jabaudon@djabaudon.bsky.social

🧠Job Opening!🧠 We are opening 2️⃣! positions – bioinformatics / molecular biology – in a project studying how temporal patterns set up connectivity in human brain tissue. @institutimagine.bsky.social. Full details below, contact me for details if interested. And please retweet (re-bluesky?)!

Oscar Marín Lab reposted

Hetan Shah

@hetanshah.bsky.social

28 May 2025

On the value of investing in curiosity driven research - which in this case contributed to the personalised gene therapy for a rare disease on.ft.com/45rXI50 @anjahuja.bsky.social

Oscar Marín Lab reposted

Raticos de Ciencia

@raticosdeciencia.bsky.social

11 May 2025

🎙️[49] ENTENDER EL CEREBRO PARA REGULARLO 👨‍🔬 con #OscarMarínParra @MarinLab Alteraciones durante el desarrollo de nuestro🧠 pueden ser la causa de desordenes psiquiátricos como #autismo, #epilepsia, #bipolaridad o #esquizofrenia #Neurociencias (1/3)

Oscar Marín Lab reposted

Cedric Boeckx

@cedricboeckx.bsky.social

15 May 2025

Great @nature.com paper on the early stages of human cortical development, led by @qianxuyu.bsky.social from C. Walsh’s lab, in collaboration with @drmingyaoli.bsky.social A wonderful new resource to probe area & layer specification 🧪🧠🧬

nature.comSpatial transcriptomics reveals human cortical layer and area specification - NatureMultiplexed error-robust fluorescence in situ hybridization (MERFISH) together with deep-learning-based nucleus segmentation enabled the construction of a highly detailed and informative spatially res...

Xuyu Qian@qianxuyu.bsky.social

Today in @nature.com , we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specification of human cortical layers and areas. We built an interactive browser to explore the spatial data: walshlab.org/research/cor... Paper link below 👇

Oscar Marín Lab reposted

Debby Silver

@debbysilver.bsky.social

14 May 2025

Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

nature.comA human-specific enhancer fine-tunes radial glia potency and corticogenesis - NatureHARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...

Oscar Marín Lab reposted

@jamesbriscoe.bsky.social

1/10 Our latest research, led by @martijnselten.bsky.social, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @nature.com www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu

Oscar Marín Lab reposted

James Briscoe

7 May 2025

Meet the 2025 @dev-journal.bsky.social Pathway to Independence (PI) fellows Eight developmental and stem cell biologists transitioning from postdoc to principal investigator journals.biologists.com/dev/pages/pi...

journals.biologists.comPI Fellows 2025 | Development | The Company of BiologistsPI Fellows 2025 | Development | The Company of Biologists .align{ margin-right: 10px; margin-left: 0px; } .left { float: left; width: 15%; } .right {...

9/10 In sum, our findings identify a previously unknown form of interneuron plasticity and strengthen the idea that neuropeptide signalling plays crucial roles in maintaining neural circuit stability. Funded by the magnificents @erc.europa.eu and Rosetrees Trust

10/10 Here’s the paper @nature.com if you want to dig in www.nature.com/articles/s41... That’s it. Thanks for sharing! @devneuro.bsky.social @mrc-cndd.bsky.social @kingsioppn.bsky.social @kingscollegelondon.bsky.social @erc.europa.eu

nature.comnature.com

7/10 For PV interneurons, Vgf is the critical gene modulating the plasticity of inhibitory inputs received from other PV interneurons

8/10 Importantly, this mechanism also regulates the connectivity of PV interneurons during learning, for example, in a fear-conditioning paradigm

5/10 How is this achieved? We found that PV interneurons induce the expression of two genes encoding multiple neuropeptides, Scg2 and Vgf, in response to increased activity

nature.comBidirectional perisomatic inhibitory plasticity of a Fos neuronal network - NatureNovel experiences in mice lead to opposing effects on inhibition of Fos-activated hippocampal CA1 pyramidal neurons by parvalbumin- and cholecystokinin-expressing interneurons, revealing the role...

6/10 Incidentally, the Greenberg lab described a few years ago that hippocampal pyramidal cells use Scg2 to modulate the inhibition they receive from PV and CCK interneurons. You can find their paper here www.nature.com/articles/s41...

3/10 Neuronal activity operates within a tightly controlled range for the optimal functioning of #brain circuits. When synaptic connectivity and network activity are modified, such as when we are learning, compensatory mechanisms are needed to maintain stability

4/10 Using experimental manipulations, we found that PV interneurons scale the inhibition they receive to maintain stability. When the activity of a PV interneuron increases, it “requests” more inhibitory inputs from other PV+ interneurons, effectively rebalancing its activity